Research
Zinc Gluconate
50 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulatory Patients With SARS-CoV-2 Infection: The COVID A to Z Randomized Clinical Trial.
RCT of 214 ambulatory patients with SARS-CoV-2 infection comparing high-dose zinc gluconate, ascorbic acid, both, or standard care. No significant difference in symptom duration or severity was found among the groups.
Effect of Supplementation of a Butyrate-Based Formula in Individuals with Liver Steatosis and Metabolic Syndrome: A Randomized Double-Blind Placebo-Controlled Clinical Trial.
RCT of 50 individuals with NAFLD and metabolic syndrome comparing a butyrate-based formula to placebo for 3 months. The active treatment group showed significant improvements in fatty liver index, hepatic steatosis index, and plasma lipid patterns compared to baseline and placebo.
The Efficacy of Cryotherapy and Zinc Gluconate in Management of Anogenital Warts: A Randomized Double-Blind, Split-Side, Placebo-Controlled Trial.
A randomized double-blind, split-side, placebo-controlled trial on 50 patients with anogenital warts assessed the efficacy of oral zinc gluconate combined with cryotherapy. The study found no significant advantage of zinc gluconate over placebo in reducing the number of genital warts, though patients in the zinc group reported more gastrointestinal adverse effects.
Regulation of NLRP3 inflammasome by zinc supplementation in Behçet's disease patients: A double-blind, randomized placebo-controlled clinical trial.
Double-blind, placebo-controlled RCT of zinc gluconate (30 mg/day) in 50 Behcet's disease patients over 12 weeks. Zinc supplementation significantly improved genital ulcers and reduced NLRP3 and caspase-1 gene expression, as well as serum IL-1β levels, suggesting its potential as an adjuvant therapy for inflammation and genital ulcers in BD.
Immunomodulatory and clinical responses to zinc gluconate supplementation in patients with Behçet's disease: A double-blind, randomized placebo-controlled clinical trial.
Double-blind, randomized placebo-controlled clinical trial investigating zinc gluconate supplementation in 50 Behçet's disease patients. Zinc supplementation significantly decreased TLR-2 mRNA and protein expression and improved nonocular IBDDAM score compared to placebo.
Zinc Gluconate Induces Potentially Cancer Chemopreventive Activity in Barrett's Esophagus: A Phase 1 Pilot Study.
This phase 1 pilot study investigates the chemopreventive effects of zinc gluconate in patients with Barrett's esophagus. Zinc-induced changes in mRNA, miRNA, and protein expression suggest potential cancer chemopreventive activity, warranting further clinical trials.
Effect of prenatal zinc supplementation on birthweight.
Double-blind RCT of 600 pregnant women in Ghana comparing combined zinc and iron supplementation to iron alone. No overall difference in mean birthweight was detected, but zinc-iron supplementation increased birthweight among anaemic and iron-deficient women.
No antioxidant beneficial effect of zinc supplementation on oxidative stress markers and antioxidant defenses in middle-aged and elderly subjects: the Zenith study.
Multicentre prospective intervention study with 387 middle-aged and elderly subjects randomized to receive 0, 15, or 30 mg zinc gluconate daily for 6 months. Zinc supplementation did not alter oxidative stress markers and antioxidant defenses, except for an increase in Cu/Zn superoxide dismutase activity.
Zinc lozenges: cold cure or candy? Solution chemistry determinations.
Meta-analysis of clinical trials from 1984 to 2004 on zinc gluconate lozenges for common colds. Found a statistically significant correlation between higher dosages of positively charged zinc species and reduced duration of colds.
Effect of treatment with zinc gluconate or zinc acetate on experimental and natural colds.
Two clinical trials with 554 subjects tested zinc gluconate and zinc acetate lozenges on experimental and natural colds. Zinc gluconate reduced the median duration of experimental colds by 1 day compared to placebo, but had no effect on symptom severity. Zinc acetate had no effect on duration or severity of symptoms in either cold type. Overall, zinc compounds showed little utility for common-cold treatment.
A novel treatment of diaper dermatitis in children and adults.
Prospective, open-label trial with 20 patients (10 infants/10 adults) assessing a zinc gluconate-taurine/zinc oxide and panthenol/glycerin/Butyrospermum parkii butter barrier cream for diaper dermatitis. Significant improvement in erythema was observed at 30 days, suggesting the cream is a promising treatment for mild-to-moderate diaper dermatitis.
Effects of zinc supplementation on superoxide dismutase activity and gene expression, and metabolic parameters in overweight type 2 diabetes patients: A randomized, double-blind, controlled trial.
RCT of 70 overweight T2DM patients comparing daily 50mg zinc gluconate supplementation to placebo for 8 weeks. Zinc supplementation increased SOD gene expression and enzyme activity, insulin levels, and reduced FBG, HbA1c, HOMA-IR, triglycerides, and total cholesterol.
Post-operative outcomes of surgical and chemical castration with zinc gluconate in dogs presenting to veterinary field clinics.
RCT comparing post-operative outcomes of chemical castration with zinc gluconate to surgical castration in 109 healthy adult male dogs. Chemical castration resulted in fewer cases requiring medical intervention compared to surgical castration, though proper follow-up care is recommended.
Medical treatment of traumatic anosmia.
Prospective randomized study on the effects of zinc gluconate and steroids in treating traumatic anosmia. Zinc gluconate showed a promising effect, with higher recovery rates of olfactory function compared to no treatment.
Drug delivery of zinc to Barrett's metaplasia by oral administration to Barrett's esophagus patients.
Barrett's esophagus patients were administered oral zinc gluconate (26 mg zinc twice daily) for 14 days. Barrett's biopsies showed effective zinc delivery with reduced levels of Znt-1 transport protein and PKC alpha isoform, indicating effects on intracellular signal transduction.
The efficacy of zinc supplementation in young children with acute lower respiratory infections: a randomized double-blind controlled trial.
This randomized double-blind controlled trial assessed the effectiveness of zinc gluconate supplementation in reducing respiratory morbidity in children under 5 with acute lower respiratory infections. Zinc supplementation significantly reduced the number of infection episodes and shortened recovery time compared to placebo.
The effect of Breezy candy on halitosis: a double-blind, controlled, and randomized study.
Double-blind, randomized study of 75 subjects with halitosis treated with Breezy candy containing zinc gluconate and propolis. Breezy candy showed a 60% reduction in malodor compared to 10% with regular candy, indicating its effectiveness in treating halitosis.
Antiplaque/antigingivitis efficacy and safety of a cetylpyridinium chloride/zinc gluconate mucoadhesive gel. Results of a 6-month clinical trial.
Controlled clinical trial evaluating a mucoadhesive gel containing cetylpyridinium chloride and zinc gluconate for gingival health. The gel showed statistically significant improvements in gingival health indices compared to a control gel over 6 months.
Anticalculus effect of a cetylpyridinium chloride/zinc gluconate mucoadhesive gel: results of a randomized, double-blind, controlled clinical trial.
This randomized, double-blind, controlled clinical trial investigated the anticalculus effect of a cetylpyridinium chloride/zinc gluconate mucoadhesive gel in 80 adults. The CPC/ZG group showed a 30% decrease in mean VMI score compared to a 0% decrease in the placebo group after three months, indicating a significant reduction in calculus.
Ineffectiveness of zinc gluconate nasal spray and zinc orotate lozenges in common-cold treatment: a double-blind, placebo-controlled clinical trial.
Double-blind, placebo-controlled clinical trial of zinc gluconate nasal spray and zinc orotate lozenges in 77 volunteers with common colds. The treatment did not reduce the duration or severity of common colds and caused olfactory region pain in some patients.
Demonstrating zinc and iron bioavailability from intrinsically labeled microencapsulated ferrous fumarate and zinc gluconate Sprinkles in young children.
This randomized controlled trial studied the bioavailability of zinc and iron from microencapsulated Sprinkles in 75 children aged 12-24 months. The study found that zinc in the form of Sprinkles has low bioavailability but provides adequate absorbed zinc, and there is no effect of zinc or ascorbic acid on iron absorption from the formulations.
[Observation on clinical efficacy of combined therapy of zinc supplement and jinye baidu granule in treating human cytomegalovirus infection].
RCT of 140 patients with HCMV infection comparing Jinye Baidu granule alone to combined therapy with zinc gluconate at varying doses. The combined therapy significantly increased the negative conversion rate of HCMV-IgM, with the optimal zinc dosage being 20 mg daily.
Zinc gluconate in the treatment of dysgeusia--a randomized clinical trial.
RCT involving 50 patients with idiopathic dysgeusia comparing zinc gluconate (140 mg/day) to placebo. Zinc improved gustatory function and reduced severity of dysgeusia and depression symptoms, with higher salivary calcium levels observed in the zinc group.
Efficacy of boric-complexed zinc and acetic-complexed zinc otic preparations for canine yeast otitis externa.
This 2-week, double-blinded, controlled clinical trial evaluated the efficacy of topical zinc gluconate complexed with boric acid (ZGB) or acetic acid (ZGA) versus a placebo in treating yeast otitis externa in dogs. ZGB significantly reduced the number of yeast organisms in affected ears.
[Assessment of the photosensitization potential of zinc gluconate].
Two open, monocentric studies assessed the photosensitizing potential of zinc gluconate in acneic volunteers. Volunteers were exposed to UVA and MED before and after zinc gluconate administration. Clinical and colorimetric evaluations showed zinc gluconate did not induce phototoxic or photosensitive reactions.
An open-label, single-center, phase IV clinical study of the effectiveness of zinc gluconate glycine lozenges (Cold-Eeze) in reducing the duration and symptoms of the common cold in school-aged subjects.
Phase IV study evaluating zinc gluconate glycine lozenges (Cold-Eeze) in school-aged children for common cold treatment and prevention. Therapeutic use reduced cold duration from 9.0 to 6.9 days, and prophylactic use reduced the number of colds by 25%. No adverse events or antibiotic use were reported.
Ineffectiveness of intranasal zinc gluconate for prevention of experimental rhinovirus colds.
RCT evaluating the effectiveness of intranasal zinc gluconate for prevention of experimental rhinovirus infection in 91 volunteers. Zinc treatment had no effect on total symptom score, rhinorrhea, nasal obstruction, or the proportion of infected volunteers who developed clinical colds.
Efficacy and safety study of two zinc gluconate regimens in the treatment of inflammatory acne.
Double-blind study on 67 patients with inflammatory acne comparing two zinc gluconate regimens over three months. Both regimens provided the same cumulative dose, and no significant difference was found in the reduction of superficial inflammatory lesions between the groups. The conventional regimen of two capsules daily was favored.
The Effect of Zinc Gluconate Supplementation on Symptoms and Tongue Epithelium Regeneration in Non-psoriatic Patients with Migratory Glossitis.
RCT evaluating zinc gluconate supplementation in 28 non-psoriatic patients with migratory glossitis. The test group received 20 mg/day of zinc gluconate and showed significant reduction in red atrophy area size and symptom intensity compared to controls. Filiform papillae regeneration occurred in 85.7% of the test group versus 23.1% of controls.
Intratesticular injection of a zinc-based solution for contraception of domestic cats: a randomized clinical trial of efficacy and safety.
RCT evaluating zinc gluconate as a permanent contraceptive for domestic male cats. Sixteen cats received intratesticular injections of either isotonic saline or zinc gluconate. By day 120, treated cats showed decreased testis size, azoospermia in 73% of cases, and reduced male behavior, though testosterone levels were unchanged.
Zinc absorption by young adults from supplemental zinc citrate is comparable with that from zinc gluconate and higher than from zinc oxide.
RCT using a double-isotope tracer method to compare zinc absorption from zinc citrate, zinc gluconate, and zinc oxide in 15 healthy adults. Zinc citrate absorption was comparable to zinc gluconate and higher than zinc oxide, suggesting zinc citrate as a useful alternative for preventing zinc deficiency and treating diarrhea.
Injection of a chemical castration agent, zinc gluconate, into the testes of cats results in the impairment of spermatogenesis: a potentially irreversible contraceptive approach for this species?
The study evaluated the efficacy of a single intratesticular injection of zinc gluconate solution as a sterilant for male cats. Histopathologic and ultrastructural evaluations showed impaired spermatogenesis, with azoospermia occurring in 73% of treated cats, indicating potential as a permanent sterilant.
Permanent contraception of dogs induced with intratesticular injection of a Zinc Gluconate-based solution.
RCT evaluating the efficacy of a single intratesticular injection of a Zinc Gluconate-based solution (Testoblock) to induce sterility in male dogs. Treated dogs showed increased testis width initially, but no significant difference from controls over time. Plasma testosterone concentrations decreased, and most treated dogs became azoospermic by 63 days post-treatment.
Use of zinc supplements to reduce upper respiratory infections in United States Air Force Academy cadets.
A seven-month randomized, double-blind, placebo-controlled trial involving 40 cadets evaluated the effectiveness of zinc gluconate (15mg/day) in reducing the risk of upper respiratory infections. Supplemented participants experienced significantly more symptom-free episodes than those in the placebo group, although no significant differences were found in physician-diagnosed cases.
The effect of zinc supplementation on the treatment of chronic hepatitis C patients with interferon and ribavirin.
RCT evaluating zinc supplementation in chronic hepatitis C patients undergoing IFN/ribavirin therapy. Zinc supplementation increased serum zinc levels and decreased certain adverse side effects, but did not affect virologic responses.
The pharmacokinetics of zinc from zinc gluconate: a comparison with zinc oxide in healthy men.
RCT comparing the pharmacokinetics of zinc gluconate and zinc oxide in 12 healthy men. Zinc gluconate showed 18.3% higher C(max) and 8.1% higher AUC(0-24h) compared to zinc oxide, suggesting improved zinc absorption with gluconate.
Effects of oral zinc supplementation on serum leptin levels in Ache males of eastern Paraguay.
RCT of oral zinc supplementation (50mg zinc gluconate) in Ache males to observe effects on serum leptin levels. No significant change in leptin levels was observed in the zinc-supplemented group compared to placebo.
Sugar-free zinc gluconate glycine lozenges (Cold-Eeze) do not adversely affect glucose control in patients with type 1 or type 2 diabetes mellitus.
RCT assessing the effects of sugar-free zinc gluconate glycine lozenges on glucose control in 48 patients with type 1 or type 2 diabetes. The study found no statistically significant changes in serum fructosamine levels, suggesting zinc lozenges can be safely used without affecting glycemic control.
Competitive reverse transcriptase-polymerase chain reaction shows that dietary zinc supplementation in humans increases monocyte metallothionein mRNA levels.
The study used competitive reverse transcriptase-polymerase chain reaction to show that dietary zinc supplementation in humans increases monocyte metallothionein mRNA levels. A dietary supplement of 50 mg zinc gluconate per day was given for 15 days, resulting in a significant increase in monocyte MT mRNA within 6 days, suggesting it could serve as a more useful assessment variable for zinc status than plasma zinc.
A double-blind study of the therapeutic efficacy of zinc gluconate on taste disorder.
Double-blind study of zinc gluconate on taste disorder in 98 patients. No significant difference in overall efficacy between zinc gluconate and placebo, but zinc gluconate showed significant superiority in patients with idiopathic and zinc-deficient taste disorder.
Zinc gluconate lozenges for common cold. A double-blind clinical trial.
Double-blind clinical trial comparing zinc gluconate lozenges (4.5 mg zinc) to placebo for common cold in 130 participants. No statistically significant differences were found in the duration and severity of the common cold between groups. A weak tendency towards more side-effects in the zinc group was noted.
Infection and immunity in Down syndrome: a trial of long-term low oral doses of zinc.
RCT of 64 children with Down syndrome receiving zinc gluconate or placebo for 6 months with crossover. Zinc supplementation increased serum zinc levels but had no effect on immune markers or clinical symptoms, except a trend toward fewer days of cough and fever.
Low doses of zinc gluconate for inflammatory acne.
Double-blind trial of low doses of zinc gluconate (200 mg/day) in patients with inflammatory acne. Zinc group showed a significantly different inflammatory score compared to placebo, suggesting zinc's action on inflammatory cells.
Adolescent pregnancy: associations among body weight, zinc nutriture, and pregnancy outcome.
Double-blind RCT in low-income, pregnant adolescents assessing zinc supplementation (30 mg zinc gluconate) versus placebo. Zinc supplementation improved pregnancy outcomes, reducing rates of prematurity and assisted respiration in infants of normal-weight mothers and extending gestational lengths in underweight multiparas.
The problems of taste in placebo matching: an evaluation of zinc gluconate for the common cold.
The study evaluates the blinding efficacy of zinc gluconate lozenges for common cold treatment, highlighting issues with placebo matching. Initial trials showed higher side effects and perceived active treatment in the zinc group. Adjustments improved placebo comparability in subsequent trials.
Two randomized controlled trials of zinc gluconate lozenge therapy of experimentally induced rhinovirus colds.
Two RCTs assessed zinc gluconate lozenge therapy in experimentally induced rhinovirus infection in adult volunteers. Zinc therapy did not reduce the severity or duration of cold symptoms, nor affect viral shedding or titers. Serum zinc levels increased, but zinc was not therapeutically useful for rhinovirus colds.
Reduction in duration of common colds by zinc gluconate lozenges in a double-blind study.
Double-blind, placebo-controlled clinical trial testing zinc gluconate lozenges for common colds. 86% of 37 zinc-treated subjects were asymptomatic after 7 days, compared to 46% of 28 placebo-treated subjects. Zinc lozenges shortened the average duration of common colds by about 7 days.
Effect of short term zinc supplementation on iron status of children with acute diarrhea.
This study investigated the effect of short-term zinc supplementation on hemoglobin and iron status in children with acute diarrhea. Sixty-two children received oral zinc gluconate for 2 weeks. The study found no significant changes in anemia prevalence, hemoglobin, serum iron, or ferritin levels, although total iron binding capacity increased slightly.
Lipid peroxidation in insulin-dependent diabetic patients with early retina degenerative lesions: effects of an oral zinc supplementation.
RCT of 22 insulin-dependent diabetic patients assessing the effects of 30 mg/day zinc gluconate supplementation on lipid peroxidation and antioxidant enzyme activity. Zinc supplementation corrected zinc deficiency and decreased lipid peroxidation, with different effects observed in patients with and without retinopathy.
Controlled trial of zinc supplementation in anorexia nervosa.
Randomized, double-blind, placebo-controlled trial of zinc gluconate supplementation in 35 female anorexia nervosa inpatients. Zinc supplementation resulted in a BMI increase rate twice that of the placebo group, with statistically significant results.