Research
Zinc Carnosine
45 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Carnosine/histidine-containing dipeptide supplementation improves depression and quality of life: systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of 18 RCTs with 776 participants found that histidine-containing dipeptide supplementation (anserine/carnosine, l-carnosine, β-alanine) significantly reduced depression scores and increased quality-of-life scores compared to placebo. The studies had small sample sizes and moderate to high risk of bias.
Effect of carnosine or beta-alanine supplementation therapy for prediabetes or type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis evaluated the effects of carnosine and beta-alanine supplementation on prediabetes and type 2 diabetes mellitus. The analysis of eight trials with 377 participants showed significant reductions in fasting blood glucose and hemoglobin A1c levels, and improved beta-cell function, suggesting potential benefits as adjunct therapies.
Carnosine supplementation improves cognitive outcomes in younger participants of the NEAT trial.
The NEAT trial examined the effects of carnosine supplementation (2g daily) on cognitive performance in a healthy adult population. Significant improvements in overall speed and efficiency were observed in the youngest age group (23-35 years) after 6 and 12 weeks of supplementation, with notable improvements in seven individual cognitive tests. Other age groups showed few or no significant improvements.
Effects of carnosine and histidine-containing dipeptides on biomarkers of inflammation and oxidative stress: a systematic review and meta-analysis.
Systematic review and meta-analysis of 9 trials with 350 participants assessing the effects of carnosine and histidine-containing dipeptides on inflammation and oxidative stress biomarkers. Supplementation significantly reduced CRP, TNF-α, and MDA levels and increased CAT levels, suggesting potential benefits in reducing inflammatory and oxidative stress biomarkers.
Histidine-containing dipeptide supplementation improves delayed recall: a systematic review and meta-analysis.
Systematic review and meta-analysis of RCTs on histidine-containing dipeptide supplementation, including carnosine, assessing cognitive performance. HCD supplementation significantly improved delayed recall performance, but had no effect on other cognitive tests. The effect was consistent in older adults without mild cognitive impairment.
Efficacy and Safety of Polaprezinc-Based Therapy versus the Standard Triple Therapy forEradication: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Systematic review and meta-analysis of randomized controlled trials evaluating the efficacy and safety of polaprezinc-based therapy versus standard triple therapy for eradication. The study included 3 trials with 396 participants, showing that polaprezinc, when added to triple therapy, improved eradication rates without increasing adverse events.
Efficacy and safety of polaprezinc in the treatment of gastric ulcer: A multicenter, randomized, double-blind, double-dummy, positive-controlled clinical trial.
Multicenter, randomized, double-blind, double-dummy, positive-controlled clinical trial comparing polaprezinc to rebamipide in the treatment of gastric ulcers. The effective treatment rates confirmed by gastroscopy were 81.48% for polaprezinc and 74.31% for rebamipide, with similar improvements in gastrointestinal symptoms and adverse events.
Comparison of the Efficacy of Polaprezinc Plus Proton Pump Inhibitor and Rebamipide Plus Proton Pump Inhibitor Treatments for Endoscopic Submucosal Dissection-induced Ulcers.
RCT comparing polaprezinc plus pantoprazole to rebamipide plus pantoprazole for healing ESD-induced ulcers in 210 patients. Polaprezinc treatment showed noninferiority in ulcer healing rate at 4 weeks compared to rebamipide treatment.
Carnosine and histidine-containing dipeptides improve dyslipidemia: a systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of 21 RCTs (18 pooled, n=913) examining the effects of carnosine and histidine-containing dipeptides on cardiovascular outcomes. HCD-supplemented groups showed lower total cholesterol and triglyceride levels compared to controls, suggesting potential benefits for lipid profiles.
Efficacy and Safety of Polaprezinc (Zinc Compound) on Zinc Deficiency: A Systematic Review and Dose-Response Meta-Analysis of Randomized Clinical Trials Using Individual Patient Data.
Systematic review and dose-response meta-analysis of RCTs using individual patient data to assess the efficacy of polaprezinc for zinc deficiency. Polaprezinc increased serum zinc concentration compared to placebo, with a significant dose-response relationship. All doses were tolerable, though gastrointestinal disorders were noted as adverse events.
A Patented Dietary Supplement (Hydroxy-Methyl-Butyrate, Carnosine, Magnesium, Butyrate, Lactoferrin) Is a Promising Therapeutic Target for Age-Related Sarcopenia through the Regulation of Gut Permeability: A Randomized Controlled Trial.
RCT evaluating a dietary supplement containing hydroxy-methyl-butyrate, carnosine, magnesium, butyrate, and lactoferrin on muscle mass, function, inflammation, and gut health in 59 elderly participants. The supplement improved skeletal muscle index, muscle function, and reduced inflammation markers and visceral adipose tissue compared to placebo.
A randomised trial of topical polaprezinc to prevent oral mucositis in patients undergoing haematopoietic stem cell transplantation (ToPaZ study).
Open-label randomised clinical trial comparing topical polaprezinc and sodium bicarbonate mouthwashes for preventing severe oral mucositis in 108 HSCT patients. No significant difference in incidence or duration of severe oral mucositis between the test and control arms.
Effect of Carnosine or β-Alanine Supplementation on Markers of Glycemic Control and Insulin Resistance in Humans and Animals: A Systematic Review and Meta-analysis.
Systematic review and meta-analysis evaluating the effect of carnosine or β-alanine supplementation on markers of glycemic control and insulin resistance in humans and animals. The analysis suggests that supplementation may reduce fasting glucose, HbA1c, and HOMA-IR in humans and rodents, and fasting insulin in humans, indicating potential therapeutic benefits.
Polaprezinc for prevention of oral mucositis in patients receiving chemotherapy followed by hematopoietic stem cell transplantation: A multi-institutional randomized controlled trial.
Multi-institutional RCT evaluating polaprezinc (PZ) lozenges for prevention of oral mucositis in patients undergoing chemotherapy followed by HSCT. The prevention group showed a significant reduction in the incidence of Grade ≥2 oral mucositis compared to the control group, with no significant differences in other adverse events or engraftment rates.
Zinc-L-carnosine prevented dysphagia in breast cancer patients undergoing adjuvant radiotherapy: Results of a phase III randomized trial.
Phase III randomized trial investigating the effect of zinc-l-carnosine on preventing dysphagia in breast cancer patients undergoing adjuvant radiotherapy.
Carnosine-Enriched Chicken Meat Improves Microvascular Function and Anti-Inflammatory Phenotype in Patients with Chronic Coronary Syndrome.
RCT of 38 patients with chronic coronary syndrome comparing carnosine-enriched chicken meat to regular chicken meat for 3 weeks. Carnosine-enriched chicken improved endothelium-dependent and independent vasodilation, reduced blood pressure, and decreased inflammatory cytokines.
Pharmacokinetics and Safety of Polaprezinc Granules Oral Administration in Healthy Chinese Volunteers Under Fasting and Fed Conditions.
The study demonstrated bioequivalence between generic and original polaprezinc granules by comparing pharmacokinetic profiles in 48 healthy Chinese subjects under fasting and fed conditions. Both formulations were well-tolerated with no serious adverse events.
Carnosine Supplementation Has No Effect on Inflammatory Markers in Adults with Prediabetes and Type 2 Diabetes: A Randomised Controlled Trial.
RCT of 41 adults with prediabetes or well-controlled type 2 diabetes examining the effects of 2 g/day carnosine supplementation on inflammatory markers over 14 weeks. Carnosine supplementation did not result in significant changes in inflammatory markers compared to placebo.
Carnosine supplementation improves glucose control in adults with pre-diabetes and type 2 diabetes: A randomised controlled trial.
RCT of 43 adults with prediabetes or T2DM comparing carnosine (2g) to placebo for 14 weeks. Carnosine supplementation decreased blood glucose levels at 90 and 120 minutes and total glucose area under the curve following an oral glucose tolerance test, with no significant changes in insulin levels.
Ergogenic effect of pre-exercise chicken broth ingestion on a high-intensity cycling time-trial.
This double-blind, placebo-controlled, crossover intervention study evaluated the ergogenic potential of pre-exercise ingestion of homemade chicken broth (CB) versus placebo on high-intensity cycling performance. Fourteen men ingested CB or placebo before an 8-minute cycling time trial. CB supplementation significantly improved mean power output by 5.2% compared to placebo and increased plasma carnosine and anserine levels post-exercise.
Effect of Oral carnosine supplementation on urinary TGF-β in diabetic nephropathy: a randomized controlled trial
RCT of 40 patients with diabetic nephropathy testing carnosine supplementation (2g/day) versus placebo for 12 weeks. Carnosine significantly decreased urinary TGF-β levels, indicating a potential renoprotective effect, while other renal function parameters remained unchanged.
Acute carnosine and β-alanine supplementation increase the compensated part of the ventilation versus work rate relationship during a ramp incremental cycle test in physically active men.
This randomized, double-blind, placebo-controlled study evaluated the acute effects of a single supplementation of carnosine and β-alanine on cardiorespiratory and metabolic response during a ramp cycle-ergometric test in 10 healthy males. The study found that while peak exercise parameters were unaffected, the compensated portion of the ramp test was significantly larger with supplementation, indicating a positive effect on exercise performance.
Comparison of zinc acetate hydrate and polaprezinc for zinc deficiency in patients on maintenance hemodialysis: A single-center, open-label, prospective randomized study.
This prospective, single-center, open-label, parallel-group trial compared zinc acetate hydrate (ZAH) and polaprezinc (PPZ) for zinc supplementation in maintenance hemodialysis patients with zinc deficiency. ZAH was found to be superior to PPZ in increasing serum zinc levels over 3 months, with a significant decrease in serum copper levels observed in the ZAH group.
Beneficial effect of polaprezinc on cardiac function post-myocardial infarction: A prospective and randomized clinical trial.
Prospective randomized clinical trial of 50 patients with acute myocardial infarction comparing polaprezinc to no polaprezinc post-percutaneous coronary intervention. Polaprezinc group showed higher zinc levels, reduced interleukin-6 levels, and improved ejection fraction, suggesting anti-inflammatory effects and improved cardiac function.
The effect of 12 weeks carnosine supplementation on renal functional integrity and oxidative stress in pediatric patients with diabetic nephropathy: a randomized placebo‐controlled trial
RCT investigating the effect of carnosine supplementation on urinary albumin excretion, tubular damage marker alpha 1‐microglobulin, and oxidative stress in pediatric patients with type 1 diabetes and nephropathy. Carnosine, a natural radical oxygen species scavenger, was used as an adjuvant therapy.
Zinc supplementation influences genomic stability biomarkers, antioxidant activity, and zinc transporter genes in an elderly Australian population with low zinc status.
A 12-week placebo-controlled intervention trial with 84 elderly volunteers in South Australia investigated zinc carnosine supplementation. The study found significant improvements in plasma zinc levels, reductions in DNA damage markers, and increased expression of zinc transporter genes in the supplemented group.
Effects of carnosine on polyamine levels in red blood cells of patients with hypertonic discirculatory encephalopathy.
RCT examining the effects of carnosine on polyamine levels in red blood cells of patients with hypertonic discirculatory encephalopathy. Carnosine addition normalized the content of putrescine and spermine, suggesting a positive effect on brain health.
Zinc-carnosine and vitamin E supplementation does not ameliorate gastrointestinal side effects associated with ciclosporin therapy of canine atopic dermatitis.
Prospective, double-blinded, placebo-controlled trial in 60 dogs with atopic dermatitis to assess if zinc-carnosine and vitamin E supplementation reduces gastrointestinal side effects during ciclosporin therapy. No significant difference in adverse events between groups, but placebo group had a lower total adverse event score.
Dietary supplementation with carnosine improves antioxidant capacity and meat quality of finishing pigs.
This study investigated the effect of dietary carnosine supplementation on antioxidant capacity and meat quality in pigs. Carnosine supplementation improved muscle pH, reduced drip loss, increased redness, enhanced glycogen concentration, and increased antioxidant enzyme activities, indicating improved antioxidant capacity and meat quality.
Treatment of Alzheimer's disease with a cholinesterase inhibitor combined with antioxidants.
RCT of 52 patients with moderate Alzheimer's disease comparing donepezil plus formula F (a combination of antioxidants and vitamins) to donepezil plus placebo over 6 months. Significant decreases in oxidative stress and homocysteine were observed in the formula F group, along with some improvements in MMSE II scores.
Carnosine [corrected] increases efficiency of DOPA therapy of Parkinson's disease: a pilot study.
Pilot study adding carnosine to Parkinson's disease treatment protocol, resulting in significant improvement of neurological symptoms and biochemical markers, with no change in platelets MAO B activity.
HIIT Augments Muscle Carnosine in the Absence of Dietary Beta-Alanine Intake.
RCT with 20 vegetarian men assigned to control or HIIT groups for 12 weeks. HIIT increased muscle carnosine content and improved total work done, VO2max, ventilatory thresholds, and lactate threshold, without dietary β-alanine intake.
Effect of carnosine supplementation on the plasma lipidome in overweight and obese adults: a pilot randomised controlled trial.
Pilot RCT investigating the effect of carnosine supplementation on the plasma lipidome in 24 overweight and obese adults. Carnosine maintained levels of trihexosylceramide, phosphatidylcholine, and free cholesterol compared to placebo, suggesting potential benefits on the plasma lipidome.
Zinc carnosine works with bovine colostrum in truncating heavy exercise-induced increase in gut permeability in healthy volunteers.
RCT with 8 volunteers using a 4-arm, double-blind, placebo-controlled crossover protocol to test zinc carnosine and bovine colostrum on exercise-induced gut permeability. Zinc carnosine and colostrum reduced gut permeability increases by 70% after 14 days, with additional benefits from combination treatment. Mechanisms included enhanced epithelial resistance and tight junction stabilization.
Oral treatment of pressure ulcers with polaprezinc (zinc L-carnosine complex): 8-week open-label trial.
Open-label trial of polaprezinc (zinc L-carnosine complex) in 14 patients with stage II-IV pressure ulcers. The PUSH score improved significantly over 8 weeks, with 11 patients healing within this period. Serum zinc levels increased, while serum copper levels and copper/zinc ratios decreased.
Does low serum carnosinase activity favor high-intensity exercise capacity?
The study investigated the effect of acute carnosine supplementation on high-intensity exercise capacity in a double-blind, placebo-controlled, crossover study with 12 men. Despite lower serum carnosinase activity in explosive athletes, carnosine supplementation did not improve cycling capacity at 110% maximal power output.
Efficacy of zinc-carnosine chelate compound, Polaprezinc, enemas in patients with ulcerative colitis.
This randomized, placebo-controlled trial evaluated the efficacy of Polaprezinc (PZ) enemas in 28 patients with active ulcerative colitis. The PZ group showed significant improvement in endoscopic scores and Mayo scores compared to baseline, with a higher clinical response or remission rate than the placebo group.
Carnosine treatment for gulf war illness: a randomized controlled trial.
RCT of L-carnosine supplementation in 25 Gulf War illness subjects over 12 weeks with dose escalation. Carnosine improved WAIS-R cognitive scores and decreased diarrhea associated with irritable bowel syndrome, but had no significant effect on fatigue, pain, or activity levels.
Polaprezinc prevents oral mucositis associated with radiochemotherapy in patients with head and neck cancer.
RCT investigating the effect of polaprezinc (zinc L-carnosine) on radiochemotherapy-induced oral mucositis in head and neck cancer patients. The polaprezinc group showed lower incidence rates of mucositis, pain, xerostomia, and taste disturbance, with less frequent use of analgesics and higher food intake compared to control.
Zinc carnosine, a health food supplement that stabilises small bowel integrity and stimulates gut repair processes.
The study examined the effects of zinc carnosine (ZnC) on gut injury and repair using in vitro and in vivo models, as well as a clinical trial with healthy volunteers. ZnC stimulated cell migration and proliferation, reduced gastric and small-intestinal injury, and prevented an increase in gut permeability caused by indomethacin in volunteers.
Assessing the Performance of Daily Intake of a Homotaurine, Carnosine, Forskolin, Vitamin B2, Vitamin B6, and Magnesium Based Food Supplement for the Maintenance of Visual Function in Patients with Primary Open Angle Glaucoma
This study assessed the effect of a supplement containing homotaurine, carnosine, forskolin, vitamins B1, B2, and B6, folic acid, and magnesium on visual function in patients with primary open angle glaucoma. Over 6 months, patients showed slowed progression of functional damage, improved visual function, and better quality of life.
Polaprezinc (Zinc-L-Carnosine Complex) as an Add-on Therapy for Binge Eating Disorder and Bulimia Nervosa, and the Possible Involvement of Zinc Deficiency in These Conditions: A Pilot Study.
Open trial of add-on polaprezinc in 29 patients with binge eating disorder or bulimia nervosa receiving antidepressants. Polaprezinc treatment reduced binge eating episodes, improved eating disorder psychopathology, and comorbid depressive symptoms. Zinc deficiency-related symptoms improved, and serum copper/zinc ratio decreased.
Carnosine and Beta-Alanine Supplementation in Human Medicine: Narrative Review and Critical Assessment
Narrative review assessing carnosine and beta-alanine supplementation in human medicine. The review highlights beneficial impacts on sarcopenia prevention, cognitive preservation, neurodegenerative disorders, diabetes mellitus parameters, oral mucositis symptoms, esophagitis regression, taste disorders post-chemotherapy, gastrointestinal mucosa protection, and Helicobacter pylori eradication support. Results in senile cataracts, cardiovascular disease, schizophrenia, and autistic disorders are inconclusive.
A comparison of the cellular actions of polaprezinc (zinc-L-carnosine) and ZnCl2.
The study compared the cellular actions of polaprezinc (zinc-l-carnosine) and ZnCl2 in rat thymocytes using flow-cytometric techniques. Both agents increased intracellular Zn(2+) levels and nonprotein thiol levels similarly, but ZnCl2 caused greater cell lethality under severe oxidative stress compared to polaprezinc.
Intestinal absorption of beta-alanine, anserine and carnosine in rats.
The study investigated the intestinal absorption of beta-alanine, anserine, and carnosine in rats using in vivo and in vitro methods. It found that anserine and carnosine were absorbed from the rat small intestine and partially hydrolyzed in vitro, with carnosine hydrolyzing faster than anserine.