Research
Zinc Acetate
32 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Randomized, multicenter, active-controlled open-label study of NPC-25, zinc histidine hydrate, (non-inferiority to NOBELZIN™, zinc acetate dihydrate) for patients with hypozincemia.
This randomized multicenter open-label trial evaluated the efficacy and safety of NPC-25, zinc histidine hydrate, in patients with hypozincemia. The study confirmed the non-inferiority of NPC-25 to NOBELZIN in maintaining target serum zinc concentrations, with NPC-25 showing a lower incidence of nausea and vomiting.
Zinc acetate lozenges for the treatment of the common cold: a randomised controlled trial.
RCT of zinc acetate lozenges in 253 participants to treat the common cold. No significant difference in recovery rate between zinc and placebo groups during the 10-day follow-up. Zinc participants recovered slower than placebo participants for 2 days after the intervention.
Comparative effects of three mucoadhesive gels containing lidocaine, zinc acetate, and tannic acid on the gag reflex of dental patients: a randomized double-blind clinical trial.
This randomized double-blind clinical trial compared the effects of mucoadhesive gels containing 2% lidocaine, zinc acetate, and tannic acid on the gag reflex of 228 dental patients. All three gels significantly decreased the gag reflex compared to placebo, with no significant difference in efficacy among the experimental groups.
Zinc supplementation in patients with acute myocardial infarction.
This single-centre prospective feasibility study evaluated zinc supplementation in patients with acute myocardial infarction. Patients were randomized to receive conventional treatment or conventional treatment plus zinc acetate. The study found no significant reduction in major adverse cardiovascular events or scar size with zinc supplementation.
Effect of Zinc Acetate Dihydrate (NobelzinR) Treatment on Anemia and Taste Disorders in Patients with Chronic Kidney Disease with Hypozincemia.
RCT involving 500 CKD patients across different stages to determine the frequency of serum zinc deficiency and evaluate the effects of zinc acetate dihydrate (NobelzinR) on hypozincemia, taste disturbances, and anemia.
Zinc acetate lozenges for treating the common cold: an individual patient data meta-analysis.
Individual patient data meta-analysis of three RCTs assessing zinc acetate lozenges for common cold treatment. Zinc lozenges reduced cold duration by approximately 2.73 to 2.94 days compared to placebo, with consistent effects across various patient subgroups.
The effectiveness of high dose zinc acetate lozenges on various common cold symptoms: a meta-analysis.
Meta-analysis of three randomized trials on zinc acetate lozenges for the common cold, administering zinc in doses of 80-92 mg/day. Zinc lozenges shortened the duration of various cold symptoms, including nasal discharge, nasal congestion, sneezing, scratchy throat, sore throat, hoarseness, cough, and muscle ache. No significant effect was found on headache and fever.
Effects of Zinc Acetate Hydrate Treatment on Serum Oxidative Stress Markers in Patients with Macular Drusen.
RCT measuring the effects of zinc acetate dihydrate supplementation on serum oxidative stress markers in 29 patients with early AMD. Zinc supplementation decreased MDA levels and increased SOD levels, with a significant reduction in the area of soft drusen.
Clinical assessment of topical erythromycin gel with and without zinc acetate for treating mild-to-moderate acne vulgaris.
Double-blind RCT comparing erythromycin gel with and without zinc acetate in 102 patients aged 13-25 with mild-to-moderate acne vulgaris. Both treatments significantly reduced acne lesions and severity, with no significant difference between the two formulations.
Effects of Zinc Acetate on Serum Zinc Concentrations in Chronic Liver Diseases: a Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial and a Dose Adjustment Trial.
This study evaluated zinc acetate (NPC-02) supplementation in zinc-deficient patients with chronic liver diseases. In a double-blind, randomized, placebo-controlled trial, zinc acetate increased serum zinc concentrations significantly compared to placebo. A dose adjustment study showed a dose-dependent increase in serum zinc levels in subjects with and without liver diseases.
The effect of zinc acetate and magnolia bark extract added to chewing gum on volatile sulfur-containing compounds in the oral cavity.
A double-blind RCT assessed the efficacy of a sugar-free chewing gum containing zinc acetate and magnolia bark extract on oral volatile sulfur-containing compounds (VSC) versus a placebo. The test gum significantly reduced VSC levels more than the control gum, with reductions observed at 10 minutes, one hour, and two hours after chewing.
Duration and severity of symptoms and levels of plasma interleukin-1 receptor antagonist, soluble tumor necrosis factor receptor, and adhesion molecules in patients with common cold treated with zinc acetate.
RCT of 50 volunteers with common cold symptoms comparing zinc acetate lozenges to placebo. Zinc group had shorter duration of cold symptoms and reduced severity scores, with significant changes in plasma zinc and inflammatory markers.
Effectiveness of zinc acetate injection in alleviating postweaning performance lag in pigs.
Four trials were conducted using 308 crossbred pigs to assess the effects of zinc acetate injection near weaning on serum zinc concentrations and performance. Zinc-injected pigs showed higher serum zinc concentrations postweaning, but mixed effects on growth performance metrics such as ADG and ADFI.
The long-term effect of a zinc acetate and chlorhexidine diacetate containing mouth rinse on intra-oral halitosis-A randomized clinical trial.
RCT of 46 adults with intra-oral halitosis comparing a zinc acetate and chlorhexidine diacetate mouth rinse to placebo over 6 months. The Zn/CHX rinse significantly reduced organoleptic scores and volatile sulphur compounds, showing effective long-term control of halitosis.
First-in-Human Trial of MIV-150 and Zinc Acetate Coformulated in a Carrageenan Gel: Safety, Pharmacokinetics, Acceptability, Adherence, and Pharmacodynamics.
This study evaluated the safety and pharmacokinetics of MIV-150 and zinc acetate in a carrageenan gel (PC-1005) in a placebo-controlled, double-blind trial with 20 healthy, HIV-negative women. The gel was well tolerated, with low systemic levels of MIV-150 and unchanged plasma zinc levels. Postdose cervicovaginal lavages showed anti-HIV and anti-human papillomavirus activity.
In Vitro Exposure to PC-1005 and Cervicovaginal Lavage Fluid from Women Vaginally Administered PC-1005 Inhibits HIV-1 and HSV-2 Infection in Human Cervical Mucosa.
In vitro study of PC-1005 gel containing MIV-150, zinc acetate dihydrate, and carrageenan (CG) on human cervical explants. The gel inhibited HIV-1 and HSV-2 infections, with CG providing a barrier effect. CVLs from a phase 1 trial also showed dose-dependent inhibition of these infections.
Chemical sterilisation of Bos indicus bull calves following intratesticular injection of zinc acetate: effects on semen quality and testicular changes.
RCT in Bos indicus bull calves assessing intratesticular administration of zinc acetate on semen quality and testicular changes. Zinc acetate treatment reduced sperm motility and testicular size, and caused histological changes such as germ cell depletion and interstitial fibrosis.
Comparison of different treatment modalities for oral halitosis.
RCT comparing the effects of a mouth rinse containing zinc acetate and chlorhexidine diacetate, with and without tongue scraping, on intra-oral halitosis in 21 subjects. The active rinse significantly reduced organoleptic scores and total volatile sulfur compounds compared to the inactive rinse, with or without tongue scraping.
Comparative analysis of some mouthrinses on the production of volatile sulfur-containing compounds.
This study compared the effect of three commercially available mouthrinses and zinc acetate on the production of volatile sulfur-containing compounds (VSC) in vivo. Zinc acetate showed the highest percentage reduction in VSC, significantly outperforming the other mouthrinses.
Treatment of Wilson's disease with zinc XVI: treatment during the pediatric years.
RCT evaluating zinc acetate doses for maintenance management of Wilson's disease in pediatric patients. Zinc was effective in controlling copper levels, improving neurologic scores, and maintaining liver function, with mild gastric disturbances in some patients. Zinc therapy affected cholesterol ratios, warranting further study.
Duration of symptoms and plasma cytokine levels in patients with the common cold treated with zinc acetate. A randomized, double-blind, placebo-controlled trial.
RCT of zinc acetate lozenges in 50 volunteers with the common cold. Zinc group had shorter duration of cold symptoms and decreased severity scores compared to placebo. Differences in cytokine levels were not significant.
Are zinc acetate lozenges effective in decreasing the duration of symptoms of the common cold?
The paper likely investigates the effectiveness of zinc acetate lozenges in reducing the duration of common cold symptoms, as indicated by the title. However, no abstract is available to provide specific findings.
Inhibition of erythromycin-resistant propionibacteria on the skin of acne patients by topical erythromycin with and without zinc.
Double-blind study assessing the effect of 4% erythromycin with and without 1.2% zinc acetate on erythromycin-resistant propionibacteria in acne patients. Both treatments significantly reduced total propionibacteria and erythromycin-resistant strains, and improved acne grade and lesion counts.
Topical erythromycin and zinc therapy for acne.
A double-blind, 12-week study compared the safety and efficacy of a formulation of 4% erythromycin plus 1.2% zinc acetate to its vehicle in treating acne. Seventy-three female patients started the study, with 39 completing one full year. Statistically significant differences were noted in acne severity grades and lesion counts in the erythromycin-zinc group compared to the vehicle. After crossover, the vehicle-treated group showed similar improvements.
Failure of effervescent zinc acetate lozenges to alter the course of upper respiratory tract infections in Australian adults.
Double-blind randomized trial evaluating effervescent zinc acetate lozenges as a treatment for upper respiratory tract infections in Australian adults. No benefit was observed among zinc users, with a mean symptom duration of 12.1 days compared to 7.7 days for placebo users. Some zinc users reported nausea and unpleasant taste.
Acne treatment with topical erythromycin and zinc: effect of Propionibacterium acnes and free fatty acid composition.
Double-blind RCT examining the effect of topical 4% erythromycin/1.2% zinc acetate solution on P. acnes and free fatty acids in acne treatment. The erythromycin/zinc group showed a significant reduction in P. acnes counts and inflammatory lesions, and a reduction in free fatty acids compared to the control group.
Topical erythromycin with zinc in acne. A double-blind controlled study.
This double-blind controlled study compared the effectiveness of 4% topical erythromycin with 1.2% zinc acetate and 1.2% zinc octoate against oral tetracycline and placebo in acne treatment. The erythromycin/zinc formulations were significantly better than placebo and as effective as oral tetracycline in reducing acne severity and papule count.
Evaluation of the effect of zinc acetate on the stratum corneum penetration kinetics of erythromycin in healthy male volunteers.
RCT investigating the effect of zinc acetate on the stratum corneum penetration kinetics of erythromycin in 12 healthy male volunteers. Zinc acetate increased the amount of erythromycin remaining on the skin and reduced its penetration into the stratum corneum, suggesting prolonged residence time on the skin.
Enteric protein loss and intestinal permeability changes in children during acute shigellosis and after recovery: effect of zinc supplementation.
RCT studying the effect of zinc supplementation on intestinal permeability and protein loss in 32 children with acute shigellosis. Zinc supplementation improved intestinal permeability and nitrogen absorption, suggesting a resolution of small bowel mucosal damage, but did not influence enteric protein loss.
Zinc deficiency and hyperprolactinaemia are not reversible causes of sexual dysfunction in uraemia.
Double-blind study of male dialysis patients with sexual dysfunction comparing oral zinc acetate with placebo. Serum zinc concentrations increased in the zinc-treated group, but there were no significant changes in sexual function or related hormonal measures compared to placebo.
Stimulation of specific immune response to varicella antigens in the elderly with varicella vaccine.
Double-blind RCT assessing the immune response to varicella-zoster virus vaccination in elderly subjects pretreated with zinc acetate or placebo. Zinc acetate increased tuberculin delayed reactions, but the effects on varicella-specific responses were masked by repeated skin testing. The study suggests that the speed of immune response, rather than potential, is decreased in the elderly.
Zinc deficiency: a reversible complication of uremia.
Double-blind RCT in hemodialysis patients comparing zinc acetate supplementation to placebo. Zinc supplementation significantly increased plasma, leucocyte, and hair zinc levels, and decreased plasma ammonia and ribonuclease activity. Improvements in taste and sexual function were observed in the zinc group, suggesting zinc deficiency in uremia can be corrected by supplementation.