Research
Zinc
340 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Clinical Use of Zinc in Treatment of Human Papillomavirus Cervical Infection and Viral Warts: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of 33 clinical trials on 2728 patients assessing zinc and nitric-zinc complex solution for viral warts and cervical HPV infection. Zinc showed significant efficacy for clearance of cervical HPV infection and viral warts, but not as adjuvant therapy with cryotherapy.
Zinc status following different bariatric procedures: systematic review and meta-analysis.
This systematic review and meta-analysis evaluated changes in serum zinc levels following different bariatric procedures. It found that serum zinc levels significantly decline during the first postoperative year, particularly after Roux-en-Y gastric bypass and mini-gastric bypass, while sleeve gastrectomy shows minimal impact. Routine zinc monitoring and individualized supplementation are recommended within the first year after surgery to prevent deficiency-related complications.
Prenatal and preschool micronutrient supplementation and behavioral outcomes in school-aged children in Nepal-a cohort study.
Cohort study in Nepal examining the effect of prenatal and preschool micronutrient supplementation on behavioral outcomes in school-aged children. Prenatal iron-folic acid supplementation resulted in lower oppositionality/hyperactivity and inattention scores. Iron-folic acid with zinc reversed the positive effect. Multiple micronutrient supplementation also showed benefits in reducing oppositionality/hyperactivity scores.
Effect of zinc supplementation on premenstrual symptoms: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the efficacy of zinc supplementation for alleviating premenstrual symptoms in women of reproductive age. Zinc supplementation reduced total PMS scores and emotional symptoms with moderate certainty of evidence, while physical symptoms were supported by low certainty of evidence. Meta-analyses showed significant reductions in total PMS scores, emotional symptoms, and physical symptoms, favoring zinc supplementation.
A systematic review and meta-analysis examining the role of zinc supplementation in ameliorating physical and psychological manifestations of premenstrual syndrome in young females.
This meta-analysis of randomized clinical trials assessed the efficacy of zinc supplements in alleviating physical and psychological symptoms of premenstrual syndrome (PMS) in young females. Zinc supplementation showed significant improvements in physical health, mood, cognitive function, and sleep-related symptoms compared to placebo.
Oral zinc sulphate reduces the recurrence rate and provides significant therapeutic effects for viral warts: A systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of RCTs evaluating oral zinc sulphate for treating viral warts. Findings show higher clearance rates of warts and reduced recurrence when combined with traditional treatments, especially in individuals with low initial plasma zinc levels. Common side effects included nausea and vomiting.
Influencing factors of neural tube malformation: a systematic review and meta-analysis.
Systematic review and meta-analysis of 49 case-control studies on factors influencing neural tube malformation. Folic acid and zinc supplementation were found to reduce the risk of neural tube defects, while factors like fever, obesity, passive smoking, antiepileptic drugs, and mercury exposure increased the risk.
Zinc deficiency and zinc/copper ratio imbalance in autism spectrum disorder: a reanalysis of six multinational studies.
This study reanalyzes six multinational investigations on zinc and copper homeostasis in autism spectrum disorder (ASD), including a meta-analysis of three case-control studies. It finds significantly lower circulating zinc levels in ASD and altered zinc/copper ratios. An Egyptian trial showed that oral elemental zinc supplementation reduced serum copper and increased metallothionein protein, with improvements in motor scores.
Zinc Status and Occurrence of Thyroid Cancer: Systematic Review and Meta-Analysis.
Systematic review and meta-analysis investigating the association between low serum zinc concentrations and the occurrence of thyroid cancer. The analysis included 10 studies (7 case-control and 3 cross-sectional) with sample sizes ranging from 44 to 294 individuals. Results indicated that serum zinc levels were not significantly lower in patients with thyroid cancer compared to healthy controls.
The association between zinc and prostate cancer development: A systematic review and meta-analysis.
Systematic review and meta-analysis of 52 studies examining the association between zinc levels or intake and prostate cancer development. Findings suggest that higher zinc levels in serum, hair, and prostatic fluid or tissue are associated with a protective role against prostate cancer, while no significant differences were found in nail zinc levels and zinc intake.
Zinc for prevention and treatment of the common cold.
Systematic review of 34 RCTs involving 8526 participants assessing zinc for prevention and treatment of the common cold. Zinc may have little or no effect on cold prevention but may reduce the duration of colds, with an increase in non-serious adverse events.
Effect of Zinc Supplementation on Lipid Profile and Body Composition in Patients with Type 2 Diabetes Mellitus: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis.
This systematic review and meta-analysis of 19 RCTs with 1357 participants assessed the effects of zinc supplementation on lipid profile and body composition in patients with type 2 diabetes mellitus. Zinc supplementation significantly reduced triglycerides, total cholesterol, LDL-C, and BMI, and increased HDL-C, suggesting it may improve lipid profile and body composition in this population.
Zinc as a potential prophylactic adjuvant therapy for prolonged hospitalization: A systematic review and meta-analysis of an umbrella of randomized controlled trials.
Systematic review and meta-analysis of randomized controlled trials evaluating oral zinc supplementation on hospital length of stay. The analysis included 1267 patients and found that zinc supplementation was associated with a slightly reduced duration of hospital stay.
Efficacy of Zinc Supplementation in the Management of Primary Dysmenorrhea: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed the efficacy and safety of zinc supplementation in reducing pain severity among women with primary dysmenorrhea. Six RCTs with 739 participants showed that zinc significantly reduced pain severity compared to placebo, with longer treatment durations enhancing efficacy. Zinc was well-tolerated, with no significant difference in adverse event rates compared to placebo.
Zinc supplementation for acute and persistent watery diarrhoea in children: A systematic review and meta-analysis.
Systematic review and meta-analysis of 38 RCTs assessing zinc supplementation for acute and persistent diarrhoea in children under 10. Zinc supplementation improved recovery rates and reduced diarrhoea duration, but increased vomiting incidents. Recommendations suggest continued use with adjusted dosing.
A systematic review of the association between zinc and anxiety.
Systematic review of nine human studies examining the relationship between zinc and anxiety. The review found that patients with anxiety have lower serum zinc levels and that zinc consumption is inversely associated with anxiety, suggesting a positive role for zinc in anxiety treatment.
The effect of zinc supplementation on anthropometric measurements in healthy children over two years: a systematic review and meta-analysis.
Systematic review and meta-analysis of eight studies with 1586 participants assessing the effect of zinc supplementation on anthropometric parameters in healthy children over two years. Zinc supplementation significantly increased height, weight, and height for age (HAZ).
Early neurological deterioration in Wilson's disease: a systematic literature review and meta-analysis.
Systematic review and meta-analysis of early neurological deterioration in Wilson's disease patients after anti-copper treatment initiation. Among 1512 patients, 217 cases of deterioration were reported, most commonly in those treated with d-penicillamine, trientine, or zinc salts. The study highlights the need for further research to distinguish natural disease progression from treatment-related effects.
Effect of zinc supplementation in the management of type 2 diabetes: A grading of recommendations assessment, development, and evaluation-assessed, dose-response meta-analysis of randomized controlled trials.
This meta-analysis assessed the effectiveness of oral zinc supplementation in improving cardio-metabolic risk markers in people with type 2 diabetes mellitus. It included 22 RCTs with 1442 participants and found that zinc supplementation significantly reduced glycemic indices, improved lipid profiles, and had favorable effects on blood pressure, weight, CRP, and serum zinc levels. The findings suggest a potential beneficial effect of zinc supplementation on type 2 diabetic patients.
The Effect of Zinc Supplementation on Lipid Profiles in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Dose-Response Meta-Analysis of Randomized Clinical Trials.
This systematic review and meta-analysis evaluated the effects of zinc supplementation on lipid profiles in patients with type 2 diabetes mellitus. Fourteen randomized clinical trials with 1067 patients were analyzed, showing significant improvements in total cholesterol, LDL, triglycerides, and HDL levels following zinc supplementation. The study suggests zinc supplementation may positively impact lipid profiles in T2DM patients, particularly those who are zinc-deficient.
Serum Zinc Level and Efficacy of Zinc Therapy in Cutaneous Leishmaniasis: a Systematic Review and Meta-analysis.
Systematic review and meta-analysis evaluating serum zinc levels and the efficacy of zinc therapy in cutaneous leishmaniasis. Serum zinc levels were significantly lower in patients compared to controls, but zinc therapy did not show significant clinical improvement over standard treatment.
Effect of zinc supplement on patients with trauma: A systematic review and meta-analysis.
Systematic review and meta-analysis assessing zinc supplementation in patients with acute trauma. Zinc supplementation was associated with a lower risk of pneumonia but did not affect mortality rate or length of hospital stay.
Treatment for osteoporosis in people with beta-thalassaemia.
Systematic review of treatments for osteoporosis in people with beta-thalassaemia, including bisphosphonates, zinc supplementation, denosumab, and strontium ranelate. Zinc supplementation probably increases BMD at the lumbar spine and hip after 12 months. Bisphosphonates may increase BMD at the femoral neck, lumbar spine, and forearm compared to placebo after two years.
Zinc supplementation and cardiovascular disease risk factors: A GRADE-assessed systematic review and dose-response meta-analysis.
Systematic review and meta-analysis of 75 RCTs assessing zinc supplementation's effects on cardiovascular disease risk factors. Zinc significantly lowered triglycerides, total cholesterol, fasting blood glucose, HbA1C, HOMA-IR, CRP, IL-6, TNF-α, nitric oxide, malondialdehyde, total antioxidant capacity, and glutathione, with no effects on LDL, HDL, insulin, blood pressure, AST, and ALT.
Toward revising dietary zinc recommendations for children aged 0 to 3 years: a systematic review and meta-analysis of zinc absorption, excretion, and requirements for growth.
Systematic review and meta-analysis of zinc absorption, excretion, and requirements for growth in children aged 0 to 3 years. The study synthesizes data on zinc needs for growth, losses, absorption, and bioavailability, revealing differences in zinc absorption associated with dietary transitions in early childhood.
Effects of Daily Zinc Alone or in Combination with Other Nutrient Supplements on the Risk of Malaria Parasitaemia: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.
This systematic review and meta-analysis evaluated the effects of daily zinc supplementation, alone or in combination with other nutrients, on the risk of malaria parasitaemia. The analysis found that zinc alone did not significantly affect malaria risk, while zinc combined with other micronutrients showed a borderline significant effect. Further research is needed to explore multi-nutrient supplementation effects.
Organic or Inorganic Zinc for Laying Hens? A Systematic Review and Meta-analysis of the Effects of Zinc Sources on Laying Performance, Egg Quality, and Zinc Excretion.
This systematic review and meta-analysis evaluated the effects of replacing inorganic zinc with organic zinc in the diet of laying hens. The analysis included 18 primary studies and found that organic zinc improved egg production, eggshell thickness, and eggshell resistance. Positive effects on egg weight and zinc excretion were observed under specific conditions, particularly when organic zinc was supplemented alone.
Enteral Zinc Supplementation in Preterm or Low Birth Weight Infants: A Systematic Review and Meta-analysis.
Systematic review and meta-analysis of 14 trials with 9940 preterm or low birth weight infants assessing enteral zinc supplementation. Zinc supplementation showed little or no effect on mortality but increased weight, length, head growth, and decreased diarrhea. No effect on acute respiratory infections, bacterial sepsis, and psychomotor development scores. Evidence quality was moderate to low due to bias and heterogeneity.
Serum Zinc Levels in Chronic Kidney Disease Patients, Hemodialysis Patients, and Healthy Controls: Systematic Review and Meta-Analysis.
This meta-analysis assessed serum zinc levels in chronic kidney disease (CKD) and hemodialysis (HD) patients compared to healthy controls. It included 42 studies with 4,161 participants. Both CKD and HD patients showed lower serum zinc levels compared to healthy controls. Pre-HD serum zinc levels were significantly lower than post-HD levels.
Prevalence of Zinc Deficiency in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of zinc deficiency prevalence in inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC). Zinc deficiency was more prevalent in CD (54%) than in UC (41%), with an overall prevalence of 50% across studies. High heterogeneity was noted, and no publication bias was detected.
Effects of zinc and vitamin A supplementation on prognostic markers and treatment outcomes of adults with pulmonary tuberculosis: a systematic review and meta-analysis.
Systematic review and meta-analysis of nine RCTs with 1375 participants assessing zinc and vitamin A supplementation in adults with pulmonary TB. Zinc and vitamin A supplementation increased early sputum smear conversion and serum levels of zinc, retinol, and haemoglobin, but was not associated with TB treatment success.
Daily preventive zinc supplementation increases the antibody response against pathogenic Escherichia coli in children with zinc insufficiency: a randomised controlled trial.
This randomized controlled trial investigated the impact of different zinc supplementation regimens on antibody production against pathogenic Escherichia coli in Laotian children aged 6-23 months. Zinc supplementation significantly increased plasma anti-E. coli IgG levels, particularly in children with zinc deficiency, suggesting that preventive zinc supplementation may enhance both the quantity and quality of antibody responses.
FADS1 and FADS2 as biomarkers of Zn status - a systematic review and meta-analysis.
This systematic review and meta-analysis assessed studies examining changes in fatty acid desaturase 1 (FADS1) and fatty acid desaturase 2 (FADS2) activities in relation to dietary zinc intake. The review included 21 studies, both animal and human trials. No significant correlation was found between delta 6 desaturase and zinc status, and the magnitude of variation in desaturase activities in response to zinc intake was inconsistent among studies.
Adverse Effects of Excessive Zinc Intake in Infants and Children Aged 0-3 Years: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis examined the adverse effects of excessive zinc intake in infants and children aged 0-3 years. It found that zinc supplementation had adverse effects on several biochemical markers, including serum ferritin and plasma/serum copper concentration, but improved the lactulose:mannitol ratio. The certainty of evidence was very low to moderate, and the clinical importance of these findings is unclear.
Effect of zinc supplementation on mortality in under 5-year children: a systematic review and meta-analysis of randomized clinical trials.
This systematic review and meta-analysis of 28 RCTs with 237,068 participants found that zinc supplementation significantly reduced the risk of all-cause mortality by 16% in children under 5 years. Notable reductions were observed with doses of 10 mg/d or more, supplementation durations of less than 11 months, and in low birth weight infants. Zinc also reduced mortality from pneumonia, infection, diarrhea, and sepsis.
Zinc supplementation for improving pregnancy and infant outcome.
Meta-analysis of 25 RCTs involving over 18,000 women and their babies assessing zinc supplementation during pregnancy. The evidence suggests zinc supplementation may result in little or no difference in reducing preterm births, stillbirths, perinatal deaths, neonatal death, mean birthweight, low birthweight, and small-for-gestational age babies.
Zinc for the prevention or treatment of acute viral respiratory tract infections in adults: a rapid systematic review and meta-analysis of randomised controlled trials
This rapid systematic review and meta-analysis evaluated the benefits and risks of zinc formulations for preventing or treating acute viral respiratory tract infections in adults. The analysis included 28 RCTs with 5446 participants, finding that zinc may prevent some RTIs and shorten symptom duration, though non-serious adverse events were more common. The evidence quality was limited by bias and heterogeneity.
Effects of zinc supplementation on inflammatory biomarkers and oxidative stress in adults: A systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of 25 clinical trials with 1428 participants assessing zinc supplementation's effects on inflammatory biomarkers and oxidative stress. Zinc supplementation significantly reduced C-reactive protein, interleukin-6, and malondialdehyde levels, and increased total antioxidant capacity, suggesting beneficial anti-inflammatory and anti-oxidative effects.
Zinc status in attention-deficit/hyperactivity disorder: a systematic review and meta-analysis of observational studies.
This meta-analysis examined the association between zinc levels and ADHD by analyzing 22 articles with 1280 subjects with ADHD and 1200 controls. The pooled effect size indicated no significant difference in serum/plasma zinc levels between ADHD subjects and controls, but excluding one study showed lower zinc levels in ADHD subjects. Hair zinc levels were not significantly different. The study suggests that individuals with ADHD may have lower zinc levels, warranting further investigation.
Zinc as a complementary treatment for cancer patients: a systematic review.
Systematic review of 23 studies with 1230 cancer patients examining zinc supplementation during cancer treatment. Zinc showed a positive impact on mucositis after radiotherapy but not after chemotherapy. There was a trend towards reduced loss of taste, less dry mouth, and oral pain with zinc. No significant effects on weight, quality of life, fatigue, or survival were observed. Zinc may help prevent oral toxicities during irradiation with a relatively small risk of side effects.
Effects of Dose and Duration of Zinc Interventions on Risk Factors for Type 2 Diabetes and Cardiovascular Disease: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis examining the effects of zinc supplementation on risk factors for type 2 diabetes and cardiovascular disease. Low-dose zinc supplementation significantly benefited fasting blood glucose, insulin resistance, triglycerides, total cholesterol, and LDL cholesterol. High-dose zinc benefited glycated hemoglobin and insulin resistance. Short-duration interventions benefited fasting blood glucose, insulin resistance, and triglycerides, while long-duration studies benefited fasting blood glucose, triglycerides, and total and LDL cholesterol.
The effect of zinc-biofortified rice on zinc status of Bangladeshi preschool children: a randomized, double-masked, household-based, controlled trial
A 9-month randomized controlled trial tested the efficacy of zinc-biofortified rice in improving zinc status among 520 zinc-deficient Bangladeshi preschool children. The study found no significant effect on plasma zinc concentration or zinc deficiency prevalence, but a positive effect on height-for-age z-scores was observed in the zinc-biofortified rice group.
Enteral zinc supplementation for prevention of morbidity and mortality in preterm neonates.
Meta-analysis of five trials with 482 preterm infants assessing enteral zinc supplementation versus no supplementation. Zinc supplementation may decrease all-cause mortality and probably improves short-term weight gain and linear growth, but may have little or no effect on common morbidities of prematurity.
Zinc Supplementation for Prevention of Febrile Seizures Recurrences in Children: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of randomized and quasi-randomized controlled trials on zinc supplementation for preventing febrile seizure recurrences in children under 60 months. Four trials with 350 children showed no statistically significant difference in seizure recurrence between zinc and placebo groups.
Zinc supplementation in prediabetes mellitus.
Systematic review and meta-analysis of zinc supplementation in prediabetic individuals, including 265 participants. Zinc supplementation significantly reduced fasting blood glucose and 2hr-OGTT blood glucose levels, improved HbA1c and CRP, and enhanced zinc status. It showed beneficial effects on glycemic and lipid parameters, potentially reducing prediabetes prevalence and associated morbidity.
Zinc supplementation combined with antidepressant drugs for treatment of patients with depression: a systematic review and meta-analysis.
Systematic review and meta-analysis evaluating the effect of zinc supplementation combined with antidepressant drugs on depressive symptoms. The analysis found that zinc supplementation may reduce depressive symptoms, particularly in individuals aged 40 years and older.
Zinc-biofortified staple food crops to improve zinc status in humans: a systematic review.
Systematic review of studies on zinc biofortified foods and their effects on zinc status in humans. Of nine articles included, five observed increased zinc absorption, suggesting that zinc biofortification can improve zinc status by reducing the phytate:zinc molar ratio.
Effects of Foods Fortified with Zinc, Alone or Cofortified with Multiple Micronutrients, on Health and Functional Outcomes: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of zinc fortification in foods, alone or with multiple micronutrients, assessing health outcomes. Zinc fortification increased plasma zinc concentrations, reduced zinc deficiency prevalence, improved child weight, short-term auditory memory, and decreased incidence of diarrhea and fever. Effects cannot be solely attributed to zinc.
Maternal Serum Zinc Level and Pre-eclampsia Risk in African Women: a Systematic Review and Meta-analysis.
Systematic review and meta-analysis of 12 observational studies assessing the association between maternal serum zinc levels and pre-eclampsia in African women. The study found that serum zinc levels were significantly lower in pre-eclamptic women compared to normotensive pregnant women, suggesting zinc's involvement in the etio-pathogenesis of pre-eclampsia.
Zinc supplementation for the promotion of growth and prevention of infections in infants less than six months of age.
Meta-analysis of eight studies with 85,629 infants assessing zinc supplementation for growth and infection prevention. Zinc supplementation positively affected growth outcomes (WAZ and WLZ) but had no effect on mortality or incidence of diarrhoea and respiratory infections. Zinc plus riboflavin reduced wasting but increased stunting incidence.
Does zinc with and without iron co-supplementation have effect on motor and mental development of children? A systematic review and meta-analysis.
Systematic review and meta-analysis of 25 studies with 11,559 participants assessing the effects of zinc supplementation with and without iron on mental and motor development in children aged 0-5 years. The analysis concluded that zinc alone and zinc with iron co-supplementation do not have beneficial or adverse effects on child mental and motor development at 6 and 12 months of age, with low to moderate quality of evidence.
Effects of therapeutic zinc supplementation for diarrhea and two preventive zinc supplementation regimens on the incidence and duration of diarrhea and acute respiratory tract infections in rural Laotian children: A randomized controlled trial
This randomized controlled trial evaluated the effects of different zinc supplementation regimens on diarrhea and respiratory tract infections in 3407 rural Laotian children aged 6-23 months. Therapeutic zinc supplementation reduced diarrhea incidence and duration in children over 18 months, but there was no overall impact on diarrhea, ALRI, or AURI across all age groups.
Effect of Folic Acid and Zinc Supplementation in Men on Semen Quality and Live Birth Among Couples Undergoing Infertility Treatment: A Randomized Clinical Trial.
A multicenter randomized clinical trial with 2370 men assessed the effect of daily folic acid and zinc supplementation on semen quality and live birth among couples undergoing infertility treatment. The study found no significant improvement in semen quality or live birth rates with supplementation, though a significant increase in DNA fragmentation was observed.
Zinc supplementation and immune factors in adults: a systematic review and meta-analysis of randomized clinical trials.
This systematic review and meta-analysis of 35 RCTs with 1995 participants investigated the effect of zinc supplementation on immune factors. Zinc supplementation significantly reduced circulating CRP, hs-CRP, and neutrophil levels, and increased CD4 levels. No significant effects were found on WBC, lymphocyte, monocyte levels, or CD3.
Zinc Supplementation and Body Weight: A Systematic Review and Dose-Response Meta-analysis of Randomized Controlled Trials.
Systematic review and dose-response meta-analysis of 27 RCTs with 1438 participants examining zinc supplementation's effect on anthropometric measures. Zinc increased body weight in hemodialysis patients and decreased it in overweight/obese individuals, though the latter effect disappeared after normalization for study duration.
Effect of zinc and vitamin A supplementation on immune responses in Indonesian pre-schoolers.
RCT of 826 Indonesian pre-schoolers assessing zinc and vitamin A supplementation effects on immune responses. Zinc increased ex-vivo IFN-γ production, especially in boys, younger, normal weight, and low baseline retinol children. Vitamin A increased IFN-γ in low baseline retinol children, with no effect on serum IgG and salivary IgA. Zinc modified vitamin A's effect on salivary IgA in younger and underweight children.
Daily Preventive Zinc Supplementation Decreases Lymphocyte and Eosinophil Concentrations in Rural Laotian Children from Communities with a High Prevalence of Zinc Deficiency: Results of a Randomized Controlled Trial.
RCT of 512 Laotian children aged 6-23 months receiving daily zinc supplementation or placebo for 9 months. Zinc supplementation decreased lymphocyte and eosinophil concentrations but had no effect on cytokines or T-cell concentrations.
Effects of zinc supplementation on lipid profile in patients with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of 9 RCTs with 424 patients with type 2 diabetes mellitus. Zinc supplementation significantly lowered serum triglycerides and total cholesterol, and increased HDL-C concentrations in most subgroups.
Antibiotic adjuvant therapy for pulmonary infection in cystic fibrosis.
Meta-analysis of 42 trials, including eight trials with 350 participants, examining antibiotic adjuvant therapies for pulmonary infection in cystic fibrosis. The included trials assessed β-carotene, garlic, KB001-A, nitric oxide, and zinc supplementation. Zinc probably makes no difference to pulmonary exacerbations, and the evidence for other substances is of low quality.
Clinical effectiveness of zinc supplementation on the biomarkers of oxidative stress: A systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis evaluated the effects of zinc supplementation on oxidative stress biomarkers across ten RCTs. Zinc supplementation significantly reduced MDA levels and increased serum TAC and GSH levels, but did not significantly change NO levels. The study supports zinc supplementation for oxidative stress-related diseases.
The effects of zinc on radiation-induced dysgeusia: a systematic review and meta-analysis.
Systematic review and meta-analysis assessing zinc's effect on radiation-induced dysgeusia (RID) in head and neck cancer patients. Zinc reduces the incidence of RID compared to placebo but does not significantly improve taste acuity following radiation therapy.
Zinc deficiency and febrile seizure: a systematic review and meta-analysis.
Meta-analysis evaluating serum zinc levels in febrile children aged 6-72 months with or without seizures. The analysis found that zinc levels are lower in children with febrile seizures compared to those without, suggesting a potential role of zinc deficiency in seizure occurrences.
Is Zinc an Important Trace Element on Bone-Related Diseases and Complications? A Meta-analysis and Systematic Review from Serum Level, Dietary Intake, and Supplementation Aspects.
This meta-analysis evaluates the effects of zinc supplementation or dietary zinc intake on serum zinc levels and bone turnover markers. It finds that zinc supplementation improves bone mineral density at the femoral neck and lumbar spine, and correlates with serum osteocalcin levels, suggesting a role in preventing osteoporosis.
Efficacy of zinc as adjunctive pneumonia treatment in children aged 2 to 60 months in low-income and middle-income countries: a systematic review and meta-analysis.
Systematic review and meta-analysis of RCTs assessing zinc as adjunctive treatment for pneumonia in children aged 2 to 60 months in LMICs. The analysis found no significant difference in treatment failure, mortality, or time to recovery between zinc and placebo groups.
Serum zinc levels and efficacy of zinc treatment in acne vulgaris: A systematic review and meta-analysis.
Systematic review and meta-analysis assessing serum zinc levels and the efficacy of zinc treatment in acne vulgaris. Acne patients had significantly lower serum zinc levels compared to controls. Zinc treatment significantly improved inflammatory papule count in acne patients, with no significant difference in side effects compared to comparators.
Zinc Therapy Is a Reasonable Choice for Patients With Pressure Injuries: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of zinc supplementation efficacy in patients with pressure injuries. The intervention group showed significantly improved healing rates, PI area reduction, and PUSH score improvement compared to control. Zinc therapy is suggested to promote wound healing in pressure injury treatment.
Taste disorder's management: a systematic review.
Systematic review assessing interventions for taste disorder recovery, including zinc supplementation and other treatments. Zinc may prevent and alleviate taste disorder in patients undergoing head and neck radiotherapy. The quality of evidence ranged from poor to high.
Prevalence and associated factors of zinc deficiency among pregnant women and children in Ethiopia: a systematic review and meta-analysis.
Systematic review and meta-analysis estimating the prevalence and associated factors of zinc deficiency among pregnant women and children in Ethiopia. The pooled prevalence of zinc deficiency was 59.9% among pregnant women and 38.4% among children. Factors associated with zinc deficiency included coffee intake, low intake of animal source foods, and inadequate diet diversity.
Comparative effectiveness of common therapies for Wilson disease: A systematic review and meta-analysis of controlled studies.
Systematic review and meta-analysis comparing the effectiveness and safety of treatments for Wilson disease, including D-penicillamine, zinc salts, trientine, and tetrathiomolybdate. Zinc was found to be safer than D-penicillamine while similarly effective in preventing or reducing hepatic or neurological symptoms of Wilson disease. Study quality was low, warranting cautious interpretation.
Zinc supplementation improves glycemic control for diabetes prevention and management: a systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis of 32 placebo-controlled interventions from 36 publications assessed the effects of zinc supplementation on glycemic control in 1700 participants across 14 countries. Zinc supplementation significantly reduced fasting glucose, 2-hour postprandial glucose, fasting insulin, insulin resistance, glycated hemoglobin, and high-sensitivity C-reactive protein concentrations, particularly in subjects with diabetes and those receiving inorganic zinc supplements.
A meta-analysis of zinc levels in breast cancer.
Meta-analysis of 36 studies evaluating zinc levels in breast cancer patients compared to controls. Zinc concentrations were typically decreased in blood and hair samples of patients with breast cancer, while elevated in tumor tissues. Significant relationship found between lowered serum zinc concentrations and breast cancer risk, though high heterogeneity suggests need for further studies.
Effectiveness of zinc supplementation on diarrhea and average daily gain in pre-weaned dairy calves: A double-blind, block-randomized, placebo-controlled clinical trial
This double-blind, block-randomized, placebo-controlled clinical trial evaluated zinc supplementation's effect on diarrhea and average daily weight gain in pre-weaned dairy calves. Zinc methionine-treated bull calves showed increased weight gain compared to placebo, while zinc supplementation reduced the hazard of diarrhea and expedited recovery in calves.
Effects of Zinc Supplementation on Cardiometabolic Risk Factors: a Systematic Review and Meta-analysis of Randomized Controlled Trials.
Systematic review and meta-analysis of 20 studies with 1141 participants evaluating zinc supplementation on cardiometabolic risk factors. Zinc supplementation significantly decreased triglycerides, very-low-density lipoprotein, total cholesterol, fasting blood glucose, and HbA1c, but had no significant effect on blood pressure or anthropometric indices.
Zinc status and polycystic ovarian syndrome: A systematic review and meta-analysis.
Systematic review and meta-analysis of serum zinc levels in women with polycystic ovarian syndrome (PCOS) compared to healthy controls. Initial analysis showed no significant difference, but exclusion of one study revealed significantly lower zinc levels in women with PCOS. Large scale studies are needed to clarify the relationship between zinc status and PCOS etiology.
Zinc supplementation in patients with cirrhosis and hepatic encephalopathy: a systematic review and meta-analysis.
Systematic review and meta-analysis of zinc supplementation in patients with cirrhosis and hepatic encephalopathy. Zinc supplementation combined with lactulose improved performance in the number connection test but showed no significant difference in the digit symbol test or serum ammonia levels compared to lactulose alone.
Comparative effectiveness and safety of interventions for acute diarrhea and gastroenteritis in children: A systematic review and network meta-analysis.
Systematic review and network meta-analysis of 174 studies involving 32,430 children to compare the effectiveness and safety of various interventions for acute diarrhea and gastroenteritis. Zinc, Saccharomyces boulardii, and smectite combinations were among the most effective, particularly in low- and middle-income countries, while loperamide had more side effects.
Efficacy of high zinc biofortified wheat in improvement of micronutrient status, and prevention of morbidity among preschool children and women - a double masked, randomized, controlled trial
Double-masked RCT evaluating the efficacy of zinc biofortified wheat flour on zinc status and morbidity among preschool children and women in Delhi, India. No significant difference in zinc levels was observed between high and low zinc groups, but a positive impact on self-reported morbidity was noted, with reductions in days with pneumonia, vomiting, and fever.
Effects of Daily Zinc, Daily Multiple Micronutrient Powder, or Therapeutic Zinc Supplementation for Diarrhea Prevention on Physical Growth, Anemia, and Micronutrient Status in Rural Laotian Children: A Randomized Controlled Trial.
RCT involving 3407 Laotian children aged 6-23 months, comparing daily preventive zinc tablets, high-zinc micronutrient powder, therapeutic zinc supplementation for diarrhea, and placebo over ~9 months. Preventive zinc and micronutrient powder improved zinc status but had no impact on growth. Micronutrient powder improved iron status and tended to reduce anemia among previously anemic children.
Comparison of two forms of daily preventive zinc supplementation versus therapeutic zinc supplementation for diarrhea on young children’s physical growth and risk of infection: study design and rationale for a randomized controlled trial
This study is a community-based randomized controlled trial in the Lao PDR, involving 3400 children aged 6-23 months. It compares daily preventive zinc supplementation, multiple micronutrient powder, and therapeutic zinc supplementation for diarrhea against a placebo. The primary outcomes include physical growth, diarrhea incidence, hemoglobin and micronutrient status, and immune function.
Does zinc with and without iron co-supplementation have effect on motor and mental development of children? A systematic review and meta-analysis
Systematic review and meta-analysis of 25 studies with 11,559 participants assessing the effects of zinc supplementation with and without iron on mental and motor development in children aged 0-5 years. The analysis concluded that zinc alone and zinc with iron co-supplementation do not have beneficial or adverse effects on child mental and motor development at 6 and 12 months of age, with no long-term effects observed in preschool and school-age children.
Vitamin A and Zinc Supplementation Among Pregnant Women to Prevent Placental Malaria: A Randomized, Double-Blind, Placebo-Controlled Trial in Tanzania.
RCT among 2,500 pregnant women in Tanzania to assess the effect of vitamin A and zinc supplementation on placental malaria and adverse pregnancy outcomes. Zinc supplementation reduced the risk of histopathology-positive placental malaria, but neither nutrient affected PCR-positive malaria, small for gestational age births, or prematurity.
Efficacy of zinc given as an adjunct to the treatment of severe pneumonia: A meta-analysis of randomized, double-blind and placebo-controlled trials.
Meta-analysis of six randomized, double-blind, placebo-controlled trials with 2216 patients evaluating zinc as an adjunct therapy for severe pneumonia. Zinc significantly reduced mortality but had no significant effect on treatment failure or change of antibiotic therapy.
Efficacy of zinc supplementation for neonatal sepsis: a systematic review and meta-analysis.
Systematic review and meta-analysis of four RCTs involving 986 patients assessing zinc supplementation for neonatal sepsis. Zinc supplementation significantly reduced mortality rate and improved serum zinc levels, but had no substantial influence on hospital stay or the number of expired patients.
Interventions for managing taste disturbances.
This Cochrane Review assessed interventions for managing taste disturbances, focusing on zinc supplements and acupuncture. Nine trials with 544 participants compared zinc supplements to placebo, showing very low-quality evidence for improvement in taste acuity. Adverse events were reported in some zinc trials. One trial tested acupuncture with very low-quality evidence for taste discrimination improvement. The review found insufficient evidence to conclude the effectiveness of zinc or acupuncture for taste disorders.
Oral zinc for treating diarrhoea in children.
Meta-analysis of 33 trials with 10,841 children evaluating oral zinc supplementation for treating acute or persistent diarrhoea. Zinc supplementation may shorten diarrhoea duration in children older than six months, especially in malnourished children, but may have no effect in children younger than six months. Zinc increased the risk of vomiting in both age groups.
Zinc levels in seminal plasma and their correlation with male infertility: A systematic review and meta-analysis.
Systematic review and meta-analysis of 20 studies with 2,600 cases and 867 controls examining the relationship between seminal plasma zinc and male infertility. Results indicated that infertile males had significantly lower seminal plasma zinc levels compared to controls. Zinc supplementation significantly improved semen volume, sperm motility, and normal sperm morphology in infertile males.
Fortification of staple foods with zinc for improving zinc status and other health outcomes in the general population.
Meta-analysis of eight trials with 709 participants evaluating the fortification of staple foods with zinc. Zinc fortification increased serum or plasma zinc levels compared to unfortified foods, but had similar effects on underweight and stunting. The addition of zinc to foods with other micronutrients showed little difference in zinc status.
Zinc supplementation for improving pregnancy and infant outcome.
Meta-analysis of 21 RCTs involving over 17,000 women assessing zinc supplementation in pregnancy. Zinc supplementation resulted in a small reduction in preterm birth but no significant effect on low birthweight or other maternal and neonatal outcomes. The evidence quality was moderate for preterm birth and low for other outcomes.
The effect of chronic prostatitis on zinc concentration of prostatic fluid and seminal plasma: a systematic review and meta-analysis.
Systematic review and meta-analysis assessing the effect of chronic prostatitis on zinc concentration in prostatic fluid and seminal plasma. Zinc concentrations were significantly lower in chronic prostatitis patients compared to normal controls.
Serum trace element differences between Schizophrenia patients and controls in the Han Chinese population.
The study quantified levels of 35 elements in the sera of 111 Schizophrenia patients and 110 healthy participants, finding significantly reduced concentrations of cesium, zinc, and selenium in patients. A meta-analysis including 522 cases and 360 controls confirmed that zinc was significantly associated with Schizophrenia, suggesting element profile differences between patients and controls.
Zinc Absorption Is Not Related to Dietary Phytate Intake in Infants and Young Children Based on Modeling Combined Data from Multiple Studies.
Meta-analysis of zinc absorption in 236 children aged 8 to 50 months, using data from stable-isotope studies. The study found that dietary phytate had a very small and statistically insignificant effect on zinc absorption, while absorption varied with age, weight, and height.
Preventive zinc supplementation for children, and the effect of additional iron: a systematic review and meta-analysis.
Systematic review and meta-analysis of 80 randomized trials with 205,401 participants on preventive zinc supplementation in children aged 6 months to 12 years. Zinc supplementation showed a small, non-significant effect on all-cause mortality and may reduce the incidence of all-cause diarrhea. There was no significant effect on respiratory infections or malaria, and a small effect on linear growth. Zinc supplementation increased vomiting risk. Effects of zinc with and without iron co-supplementation varied.
Zinc supplements for preventing otitis media.
Meta-analysis of 12 trials with 6820 participants evaluating zinc supplements for preventing otitis media. Results are mixed; some trials show no significant difference, while others indicate a lower incidence rate of otitis media in zinc-supplemented groups. Evidence suggests potential benefit in children with severe malnutrition, but findings should be treated with caution.
Association between zinc intake and risk of digestive tract cancers: a systematic review and meta-analysis.
Systematic review and meta-analysis of 19 studies with approximately 400,000 participants examining the association between zinc intake and digestive tract cancer risk. Higher zinc intake was significantly associated with reduced colorectal cancer risk, but not with gastric or esophageal cancer risk overall. Subgroup analyses indicated significant associations in Asia for esophageal and gastric cancer risk.
Oral zinc supplementation for the treatment of acute diarrhea in children: a systematic review and meta-analysis.
Systematic review and meta-analysis of 89 Chinese and 15 non-Chinese studies on zinc supplementation for acute diarrhea in children under five. Zinc treatment reduced the relative risk of diarrhea lasting beyond three days by 26%. Supports WHO recommendation for zinc treatment in low- and middle-income countries.
Zinc supplementation for treating diarrhea in children: a systematic review and meta-analysis.
Systematic review and meta-analysis of 18 randomized clinical trials assessing zinc supplementation in children with acute diarrhea. Zinc significantly reduced diarrhea duration, especially in malnourished children, and decreased diarrhea prevalence on days 3, 5, and 7. However, zinc increased the incidence of vomiting compared to controls.
Zinc for the common cold.
Meta-analysis of 16 therapeutic and 2 preventive trials with 1781 participants assessing zinc's efficacy in reducing common cold symptoms. Zinc intake was associated with a significant reduction in the duration of cold symptoms but not severity. Adverse events like bad taste and nausea were higher in the zinc group. High heterogeneity suggests caution in interpreting results.
Zinc in depression: a meta-analysis.
Meta-analysis of 17 studies comparing peripheral blood zinc concentrations between 1643 depressed and 804 control subjects. Zinc concentrations were significantly lower in depressed subjects, with greater depression severity associated with greater zinc deficiency. The study suggests a potential link between zinc status and depression.
Zinc supplements for treating thalassaemia and sickle cell disease.
Meta-analysis of nine trials assessing zinc supplementation in thalassaemia and sickle cell disease. Zinc increased height velocity in thalassaemia patients and reduced sickle cell crises and infections in sickle cell patients, though no significant changes in serum zinc levels or haemoglobin were observed.
Zinc supplements for preventing otitis media.
Meta-analysis of 12 trials with 6820 participants evaluating zinc supplements for preventing otitis media (OM). Results are mixed: some trials showed no significant difference, while others indicated a lower incidence of OM in zinc-supplemented groups, particularly in children with severe malnutrition. Zinc supplements were generally well-tolerated.