Research
Zeolite (Clinoptilolite)
15 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Clinoptilolite in the drug refractory chronic diarrhoea.
RCT assessing the safety and effectiveness of a specific zeolite powder (Xeoderm) in 100 patients with chronic or recurrent diarrhoea. The treatment improved stool consistency and quality of life, reducing diarrhoea symptoms and discomfort.
Effect of clay supplementation on growth performance of broiler chickens: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed the effect of dietary clay supplementation on broiler growth performance. It included 33 studies and found that clay supplementation significantly improved broiler daily gain and feed conversion ratio, with zeolite and kaolin clays showing notable effects. The analysis highlighted the importance of clay supplemental level and broiler sex in influencing growth outcomes.
Treatment of osteoporosis with a modified zeolite shows beneficial effects in an osteoporotic rat model and a human clinical trial.
The study investigates the effects of PMA-zeolite-clinoptilolite on osteoporosis in an ovariectomized rat model and a human clinical trial. Treatment with PMA-zeolite-clinoptilolite improved bone histomorphometric parameters in rats and increased bone mineral density, reduced pain, and improved quality of life in humans, suggesting it as a potential adjuvant therapy for osteoporosis.
Effects of dietary clays on performance and intestinal mucus barrier of broiler chicks challenged with Salmonella enterica serovar Typhimurium and on goblet cell function in vitro.
In vivo and in vitro experiments tested dietary clays on broiler chicks challenged with Salmonella enterica. Dietary clays, particularly smectite A, restored growth rates and affected goblet cell function, indicating potential gut health benefits.
A field study on the effect of in-feed inclusion of a natural zeolite (clinoptilolite) on health status and performance of sows/gilts and their litters.
RCT evaluating the long-term dietary use of natural zeolite (clinoptilolite) on health status and reproductive performance of sows/gilts and their litters. The study found improved reproductive performance with the inclusion of clinoptilolite and chlortetracycline, and no adverse effects were noted. The beneficial effect of clinoptilolite may also ameliorate zearalenone exposure consequences.
Preventive efficacy of clinoptilolite in broilers during chronic aflatoxin (50 and 100 ppb) exposure.
This study evaluated the protective efficacy of clinoptilolite (CLI) in preventing toxic effects of aflatoxin (AF) in broiler chicks. 576 chicks were divided into six treatment groups, including control, CLI, 50 ppb AF, 50 ppb AF plus CLI, 100 ppb AF, and 100 ppb AF plus CLI. CLI addition to the 100 ppb AF diet moderately reduced adverse effects on chick performance, suggesting CLI's potential benefit in protecting against AF toxicity.
Activated and Micronized Zeolite in the Modulation of Cellular Oxidative Stress in Mexican Smokers: A Randomized Clinical Trial.
Randomized clinical trial evaluating activated and micronized zeolites as modulators of cellular oxidative stress in Mexican smokers. Zeolites showed equivalent antioxidant activities to vitamin E, suggesting potential as a modulator of oxidative stress.
Effects of zeolite supplementation on parameters of intestinal barrier integrity, inflammation, redoxbiology and performance in aerobically trained subjects.
RCT of 52 endurance trained men and women receiving 1.85g of zeolite per day for 12 weeks. Zeolite supplementation decreased stool zonulin concentrations, indicating improved intestinal wall integrity, and showed mild anti-inflammatory effects. No significant changes were observed in other measured parameters.
[Use of zeolite-containing biologically active food supplement in patients with burn trauma].
RCT assessing the effects of zeolite-containing supplement 'Lytovit' in burn trauma patients. The supplement promoted earlier normalization of trace elements, improved neutrophil function, and accelerated clinical recovery compared to standard therapy alone.
A pilot study on the ability of clinoptilolite to absorb ethanol in vivo in healthy drinkers: effect of gender.
Pilot study evaluating clinoptilolite's ability to absorb ethanol in vivo in 12 healthy drinkers. A dose of 5 g clinoptilolite significantly reduced blood ethanol levels at 30, 60, 90, and 120 minutes after ethanol consumption, with a more significant effect observed in males.
Effect of pre-calving zeolite, magnesium and phosphorus supplementation on periparturient serum mineral concentrations.
RCT testing the effect of supplementing dry cow rations with phosphorus and magnesium on the beneficial effect of zeolite supplementation on periparturient blood calcium concentration in dairy cattle. Group B, receiving zeolite without magnesium phosphate, showed less variable serum calcium concentrations and no cases of milk fever, while groups A and C experienced hypocalcaemia and milk fever cases.
Aspects of physiological effects of sodium zeolite A supplementation in dry, non-pregnant dairy cows fed grass silage.
A prospective longitudinal study on the effects of sodium zeolite A supplementation in non-pregnant, non-lactating dairy cows. The study observed significant influences on calcium, phosphate, and magnesium homeostasis, with changes in serum and urine biochemical parameters during and after supplementation.
Effect of in-feed inclusion of a natural zeolite (clinoptilolite) on certain vitamin, macro and trace element concentrations in the blood, liver and kidney tissues of sows.
The study evaluated the effect of long-term dietary use of clinoptilolite (CLI) and antibacterials (chlortetracycline, CTC) on vitamin and mineral concentrations in blood and body tissues of sows. CLI and CTC supplementation had no significant effect on the uptake and distribution of vitamins and minerals in the body.
Clinoptilolite for Treatment of Dyslipidemia: Preliminary Efficacy Study.
A phase I/IIa prospective, open-label, uncontrolled study on 41 subjects with dyslipidemia, testing different doses and granule sizes of tribomechanically activated clinoptilolite. All lipid fractions significantly improved after 8 weeks of treatment, with effects reversing after withdrawal. No side effects were reported.
Natural zeolite clinoptilolite: new adjuvant in anticancer therapy.
Study on the use of finely ground clinoptilolite as an adjuvant in anticancer therapy. Treatment in mice and dogs led to improved health status, prolonged life-span, and decreased tumor size. In vitro studies showed inhibition of protein kinase B and induction of tumor suppressor proteins, suggesting potential anticancer effects.