Research
Willow Bark (Salix)
5 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Willow Bark (Salix spp.) Used for Pain Relief in Arthritis: A Meta-Analysis of Randomized Controlled Trials
Meta-analysis of six RCTs with 329 arthritis patients assessing willow bark's analgesic effects and safety. Significant pain relief and physical improvement were observed with willow bark treatment compared to placebo, with no significant differences in adverse events. Further RCTs are needed due to potential bias.
A systematic review on the effectiveness of willow bark for musculoskeletal pain.
Systematic review of clinical trials on willow bark for musculoskeletal pain. Evidence suggests a dose-dependent analgesic effect in low back pain, comparable to rofecoxib. Conflicting results in osteoarthritis and no significant effect in rheumatoid arthritis, though the latter study was underpowered. Minor adverse events reported.
Effect of salicis cortex extract on human platelet aggregation.
RCT investigating the effect of Salicis cortex extract on platelet aggregation in 51 patients. The study found that Salicis cortex extract with 240 mg salicin/day affects platelet aggregation to a lesser extent than acetylsalicylate, with significant differences in maximal platelet aggregation induced by arachidonic acid and ADP compared to placebo.
Drug-Drug Interaction Potential, Cytotoxicity, and Reactive Oxygen Species Production of Salix Cortex Extracts Using Human Hepatocyte-Like HepaRG Cells
The study evaluated the effects of two Salix cortex extracts on human hepatocyte-like HepaRG cells, focusing on CYP450 enzyme activity modulation, cytotoxicity, and ROS production. Both extracts showed no significant cytotoxicity or ROS increase but reduced CYP1A2 and CYP3A4 enzyme activity, indicating potential drug interaction at higher concentrations.
Botanical Extracts from Rosehip (Rosa canina), Willow Bark (Salix alba), and Nettle Leaf (Urtica dioica) Suppress IL-1β-Induced NF-κB Activation in Canine Articular Chondrocytes
In vitro study of botanical extracts from rosehip, willow bark, and nettle leaf on canine articular chondrocytes. The extracts suppressed IL-1β-induced NF-κB activation and reversed downregulation of cartilage-related proteins, suggesting anti-inflammatory and anabolic effects.