Research
Vitamin E
244 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Vitamin E in the management of oral mucositis: Systematic review with meta-analysis of randomized clinical trials.
Systematic review and meta-analysis of 14 randomized clinical trials evaluating the efficacy of vitamin E in the treatment of oral mucositis in cancer patients. The meta-analysis showed a significant reduction in the incidence of severe mucositis in the vitamin E group compared to controls, with consistent effects in both pediatric and non-pediatric populations.
Vitamin E and cognitive function: A systematic review of clinical evidence.
Systematic review of 43 clinical studies involving 80,488 participants evaluating the role of vitamin E in cognitive function. The review suggests that vitamin E, particularly as a dietary component or in multivitamin supplements, is associated with a protective effect against cognitive impairment.
Efficacy of vitamin E from dietary, circulation system, and supplementation on chronic obstructive pulmonary disease (COPD): a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the association between vitamin E consumption and chronic obstructive pulmonary disease (COPD) across 10 studies with 65,425 participants. The results indicated a significant protective effect of vitamin E intake against the onset risk of COPD, though no significant correlation was found with the risk of death from COPD. Subgroup analysis showed that different subtypes and sources of vitamin E were inversely associated with COPD.
The addition of vitamin E could reduce femoral head penetration of the polyethylene liners.
This meta-analysis investigated the effect of vitamin E-diffused highly cross-linked polyethylene liners in total hip arthroplasty. The pooled results from 23 studies with 54,920 participants showed a significant decrease in femoral head penetration at the last follow-up, mainly due to decreased wear in proximal directions. However, no significant improvements in clinical functions or complications were identified.
Comparison of pharmacological therapies in metabolic dysfunction-associated steatohepatitis for fibrosis regression and MASH resolution: Systematic review and network meta-analysis.
Systematic review and network meta-analysis of 29 RCTs (n=9324) comparing pharmacological therapies for metabolic dysfunction-associated steatohepatitis (MASH). Pegozafermin, cilofexor + firsocostat, and other agents were effective for fibrosis regression and MASH resolution. Vitamin E + pioglitazone was among the interventions significantly better than placebo for MASH resolution.
Comparative efficacy of multiple drugs for non-alcoholic fatty liver disease: a Bayesian network meta-analysis.
This Bayesian network meta-analysis compared the efficacy of several hypoglycemic drugs and vitamin E in treating NAFLD. Vitamin E was found to improve liver enzyme levels and histological features, suggesting it may be a suitable option for nondiabetic patients with NAFLD.
The effect of co-administration of vitamin E and C supplements on plasma oxidative stress biomarkers and antioxidant capacity: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials with meta-regression.
This meta-analysis of 17 randomized controlled trials with a total sample size of 965 investigated the effect of co-administration of vitamins E and C on plasma oxidative stress biomarkers and antioxidant capacity. The study found significant beneficial effects on MDA, LP, TAC, and GPx, but not on SOD. Subgroup analyses showed significant effects in unhealthy participants and those receiving a placebo.
Effects of vitamin supplementation on related symptoms in women with endometriosis: a systematic review and meta-analysis
Systematic review and meta-analysis of 9 studies involving 562 patients evaluating the effects of vitamin supplementation on endometriosis symptoms. Vitamin E significantly alleviated pelvic pain, but no significant effects were observed for vitamin D or vitamin C combined with vitamin E on dysmenorrhea and dyspareunia.
Effect of Vitamin E on Serum Adiponectin and Leptin in Adults: A Systematic Review and Meta-analysis.
This systematic review and meta-analysis evaluated the impact of vitamin E oral supplementation on serum adiponectin and leptin levels in adults. The pooled analysis of 10 RCTs showed no significant overall effect of vitamin E on adiponectin and leptin levels. However, long-term supplementation significantly increased adiponectin and reduced leptin levels in patients with nonalcoholic fatty liver disease (NAFLD).
Effects of vitamin E supplementation on sow gestation: a meta-analysis.
Meta-analysis of 21 articles evaluating vitamin E supplementation in pregnant sows. Vitamin E increased α-tocopherol levels in sow serum during gestation and in piglet serum on the first day after birth, but did not significantly affect other reproductive parameters.
Effect of tocotrienol-rich fraction (TRF) on lipid profile in hyperlipidemic experimental animal model: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the effects of tocotrienol-rich fraction (TRF) on lipid profiles in hyperlipidemic experimental animal models. TRF significantly reduced total cholesterol, LDL, and triglycerides, while increasing HDL, particularly in rats and mice. The study highlights the need for standardized protocols and physiologically relevant models for better assessment of TRF's therapeutic potential in CVD management.
The effect of vitamin E supplementation on serum low-density lipoprotein oxidization: A systematic review and meta-analysis of clinical trials.
Systematic review and meta-analysis of clinical trials evaluating the impact of vitamin E supplementation on LDL oxidation. The analysis showed that vitamin E significantly reduced LDL oxidation and increased the lag time of LDL oxidation, indicating a positive effect on heart health.
Rate of revision and wear penetration in different polyethylene liner compositions in total hip arthroplasty: a Bayesian network meta-analysis.
Bayesian network meta-analysis comparing different polyethylene liners in total hip arthroplasty, including Vitamin E infused highly cross-linked polyethylene. XLPE and HXLPE liners showed the lowest wear penetration and revision rates over approximately 7 years of follow-up.
Efficacy and acceptability of pharmacological interventions for tardive dyskinesia in people with schizophrenia or mood disorders: a systematic review and network meta-analysis.
Systematic review and network meta-analysis of 46 trials (n=2844) evaluating pharmacological interventions for tardive dyskinesia in adults with schizophrenia or mood disorders. Valbenazine and vitamin E were found to be superior to placebo in reducing TD symptoms, with vitamin E showing a standardized mean difference of -0.49. Confidence in findings was low for most treatments.
Vitamin E for people with non-alcoholic fatty liver disease.
Meta-analysis of 16 RCTs involving 1066 participants with NAFLD, evaluating vitamin E alone or with vitamin C versus placebo or no intervention. Vitamin E likely reduces ALT and AST levels slightly, but effects on mortality, quality of life, and adverse events are uncertain due to very low certainty evidence.
Impact of Vitamin E Supplementation on High-Density Lipoprotein in Patients With Haptoglobin Genotype-Stratified Diabetes: A Systematic Review of Randomized Controlled Trials.
Systematic review of randomized controlled trials evaluating the effect of vitamin E supplementation on HDL levels and function in individuals with diabetes stratified by haptoglobin genotype. Vitamin E did not affect HDL levels but improved cholesterol efflux and HDL lipid peroxides in individuals with Hp2-2 diabetes, indicating a pharmacogenetic interaction.
Vitamin E Does not Favor Recovery After Exercises: Systematic Review and Meta-analysis.
Systematic review and meta-analysis of 20 studies with 298 participants evaluating the effects of vitamin E supplementation on recovery after exercise. Vitamin E showed no significant effects on oxidative stress, inflammatory response, muscle damage, soreness, or strength compared to placebo.
The effect of vitamin E and docosahexaenoic acid ethyl ester on Metabolic Dysfunction-Associated steatotic Liver Disease (MASLD)-A randomised, double-blind, placebo-controlled, parallel-group clinical trial (PUVENAFLD).
RCT evaluating the efficacy of vitamin E and DHA, alone or in combination, versus placebo in reducing liver fat content in adults with MASLD over 6 months. The study found no significant effect on hepatic steatosis or aminotransferase levels for any intervention group compared to placebo.
Vitamin E improves serum markers and histology in adults with metabolic dysfunction-associated steatotic liver disease: Systematic review and meta-analysis.
Systematic review and meta-analysis of randomized controlled trials assessing the effect of vitamin E on metabolic dysfunction-associated steatotic liver disease (MASLD). Vitamin E significantly reduced serum ALT and AST levels, steatosis, lobular inflammation, and hepatocyte ballooning, and increased MASH resolution, but did not reduce fibrosis.
Vitamin E supplementation (alone or with other antioxidants) and stroke: a meta-analysis.
Meta-analysis of 16 randomized controlled trials evaluating the effect of vitamin E supplementation on stroke. Vitamin E alone did not reduce stroke incidence, while vitamin E with other antioxidants reduced ischemic stroke but increased hemorrhagic stroke risk, negating overall benefit.
The effectiveness of interventions to prevent intraventricular haemorrhage in premature infants: A systematic review and network meta-analysis.
Systematic review and network meta-analysis of interventions to prevent intraventricular haemorrhage (IVH) in preterm infants. Vitamin E and indomethacin were identified as having the highest probability of being effective, but results are difficult to interpret due to study limitations.
Effect of vitamin E intake on glycemic control and insulin resistance in diabetic patients: an updated systematic review and meta-analysis of randomized controlled trials.
Updated systematic review and meta-analysis of 38 RCTs with 2171 diabetic patients evaluating the effect of vitamin E on glycemic control and insulin resistance. Vitamin E intake significantly lowered HbA1c, fasting insulin, and HOMA-IR, but not fasting blood glucose overall. Short-term interventions showed reduced fasting blood glucose.
Comparative efficacy of glucagon-like peptide 1 (GLP-1) receptor agonists, pioglitazone and vitamin E for liver histology among patients with nonalcoholic fatty liver disease: systematic review and pilot network meta-analysis of randomized controlled trials.
Systematic review and pilot network meta-analysis comparing the efficacy of GLP-1 receptor agonists, pioglitazone, and vitamin E in patients with nonalcoholic fatty liver disease (NAFLD). GLP-1 receptor agonists ranked first in improving liver histology, including steatosis and ballooning necrosis, and were as effective as pioglitazone and vitamin E.
The Effect of Vitamin E Supplementation on Serum Aminotransferases in Non-Alcoholic Fatty Liver Disease (NAFLD): A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of 12 randomized trials with 794 patients examining the effect of vitamin E supplementation on serum aminotransferase levels in NAFLD patients. Vitamin E supplementation at 400 IU/day and above reduced alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels compared to placebo or no intervention.
Vitamin E Treatment Improves the Antioxidant Capacity of Patients Receiving Dialysis: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of 24 studies involving 512 dialysis patients. Vitamin E-coated dialyzer membranes and oral vitamin E intake improve antioxidant markers in hemodialysis patients, including SOD, GPX, and CAT levels. No significant effect observed in peritoneal dialysis patients.
Selenium and Vitamin E for Prevention of Non-Muscle-Invasive Bladder Cancer Recurrence and Progression: A Randomized Clinical Trial.
This randomized clinical trial investigated the effects of selenium and vitamin E on the recurrence and progression of non-muscle-invasive bladder cancer (NMIBC) in 270 patients. Selenium supplementation did not reduce recurrence risk, while vitamin E was associated with an increased risk of recurrence. Neither supplement affected progression or overall survival.
Vitamin C, vitamin E, β-carotene and risk of Parkinson's disease: a systematic review and dose-response meta-analysis of observational studies.
Systematic review and meta-analysis of observational studies examining the relationship between vitamin C, vitamin E, and beta-carotene intake and Parkinson's disease risk. High-dose vitamin E intake was associated with a reduced risk of Parkinson's disease, while vitamin C showed no significant association, and beta-carotene had a borderline non-significant effect.
Effect of Malaria on Blood Levels of Vitamin E: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis examining blood levels of vitamin E in malaria patients compared to uninfected individuals. Results show a significant reduction in vitamin E levels in malaria patients, especially in severe cases, suggesting a potential role of vitamin E in malaria pathogenesis.
Consumption and supplementation of vitamin E in breast cancer risk, treatment, and outcomes: A systematic review with meta-analysis.
Systematic review with meta-analysis assessing the effects of vitamin E consumption and supplementation on breast cancer risk, treatment, and outcomes. No significant association was found between vitamin E consumption and breast cancer risk, but an inverse association was observed with breast cancer recurrence. No impact on breast cancer mortality was noted.
Vitamin E supplementation in the treatment on nonalcoholic fatty liver disease (NAFLD): Evidence from an umbrella review of meta-analysis on randomized controlled trials.
Umbrella review of meta-analyses on RCTs assessing vitamin E supplementation in NAFLD patients. Vitamin E significantly decreased ALT, AST, fibrosis, and steatosis, but had no effect on GGT. Fibrosis scores notably decreased with dosages >600 IU/day and treatment duration ≥12 months.
Vitamin E and Pioglitazone: A Comprehensive Systematic Review of Their Efficacy in Non-alcoholic Fatty Liver Disease
Systematic review comparing the efficacy of vitamin E, pioglitazone, and their combination in treating NAFLD/NASH. The review found that both substances are effective in reducing steatosis, inflammation, and liver markers, with conflicting data on fibrosis resolution. Pioglitazone may have superior efficacy in fibrosis reduction, and the combination may be more effective for NASH resolution.
Effect of vitamin E supplementation in rheumatoid arthritis: a systematic review and meta-analysis.
Systematic review and meta-analysis of randomized controlled trials evaluating vitamin E supplementation in rheumatoid arthritis patients. Vitamin E was found to be more effective in reducing sensitive and swollen joints, and may improve gastrointestinal health, potentially aiding in the prevention and treatment of rheumatoid arthritis.
Efficacy of Off-Label Therapy for Non-alcoholic Fatty Liver Disease in Improving Non-invasive and Invasive Biomarkers: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.
Systematic review and network meta-analysis of 27 RCTs with 3,416 patients evaluating vitamin E, pioglitazone, SGLT2 inhibitors, and GLP-1 receptor agonists for NAFLD. Vitamin E (δ-tocotrienol) was superior to placebo in decreasing GGT levels and improving NASH resolution.
Change in plasma α-tocopherol associations with attenuated pulmonary function decline and with CYP4F2 missense variation.
The study investigated the association between changes in plasma vitamin E levels and pulmonary function decline in 1144 men from the SELECT trial. Higher changes in vitamin E were linked to attenuated decline in FEV1, with genetic factors such as the CYP4F2 variant influencing the response to supplementation.
The effect of oral vitamin E and omega-3 alone and in combination on menopausal hot flushes: A systematic review and meta-analysis.
Systematic review and meta-analysis of 10 papers with 1100 participants on the effects of vitamin E and omega-3 on menopausal hot flushes. Combination of vitamin E and omega-3 significantly reduced the intensity of hot flushes compared to placebo, while omega-3 alone showed no significant effect. No serious adverse effects were reported.
The effects of vitamin E on the intensity of primary dysmenorrhea: A systematic review and meta-analysis.
This systematic review and meta-analysis examined the effects of oral vitamin E supplementation on primary dysmenorrhea (PD) intensity. The analysis included eight articles with a total sample size of 1002 people, showing that vitamin E significantly reduced PD intensity in the first and second months compared to placebo. No serious side effects were reported.
A meta-analysis of effects of vitamin E supplementation alone and in combination with omega-3 or magnesium on polycystic ovary syndrome.
This meta-analysis of 10 RCTs with 504 participants evaluated the effects of vitamin E supplementation, alone or in combination with omega-3 or magnesium, on polycystic ovary syndrome (PCOS). Vitamin E significantly reduced serum levels of TG, VLDL, LDL-c, TC, TC/HDL-c ratio, hs-CRP, and hirsutism score, and increased nitric oxide levels, highlighting its potential anti-hyperlipidemic, anti-oxidant, and anti-inflammatory properties in PCOS patients.
Vitamin E, Alpha-Tocopherol, and Its Effects on Depression and Anxiety: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of vitamin E supplementation effects on depression and anxiety. Meta-analysis of 354 participants showed a standardized mean difference favoring vitamin E for depression and anxiety, but results were inconclusive. Future studies should consider larger sample sizes and exclude other constituents like omega-3 fatty acids.
Chemopreventive and anti-tumor potential of vitamin E in preclinical breast cancer studies: A systematic review.
This systematic review evaluated the antitumor and chemopreventive activity of different vitamin E isoforms (tocopherols and tocotrienols) in preclinical breast cancer studies. The review included in vitro and animal studies, finding that vitamin E delayed tumor development, reduced tumor size, and affected gene expression related to apoptosis and immune response. Conflicting results were noted on oxidative stress markers and antioxidant activity.
Effect of vitamin E supplementation on cardiometabolic risk factors, inflammatory and oxidative markers and hormonal functions in PCOS (polycystic ovary syndrome): a systematic review and meta-analysis.
This systematic review and meta-analysis assessed the effects of vitamin E supplementation on cardiometabolic risk factors, inflammatory and oxidative markers, and hormonal functions in women with PCOS. Vitamin E supplementation improved lipid profiles, decreased insulin and HOMA-IR levels, and positively affected hormonal parameters such as LH, testosterone, FSH, and progesterone concentrations.
Vitamin E supplementation improves testosterone, glucose- and lipid-related metabolism in women with polycystic ovary syndrome: a meta-analysis of randomized clinical trials.
This meta-analysis assessed the effect of vitamin E supplementation on various health markers in women with polycystic ovary syndrome (PCOS). Vitamin E supplementation improved glucose, lipid, and androgenic-related biomarkers, but had no impact on female sex hormones, HDL-cholesterol, BMI, and hirsutism. The certainty of the evidence was very low to moderate.
Vitamin E concentration in breast milk in different periods of lactation: Meta-analysis.
Meta-analysis of vitamin E concentration in breast milk during different stages of lactation. The study found that vitamin E concentration decreases from colostrum to mature milk, with colostrum in Asian countries having lower vitamin E levels compared to Western countries.
Vitamin E Intake and Risk of Prostate Cancer: A Meta-Analysis.
Meta-analysis of observational and interventional studies examining the association between vitamin E intake and prostate cancer risk. Overall, vitamin E intake showed no significant effect on prostate cancer risk, but supplemental vitamin E was associated with reduced risk in European studies.
The Vitamin E Isoform α-Tocopherol is Not Effective as a Complementary Treatment in Cancer Treatment: A Systematic Review.
Systematic review of 20 studies with 1941 cancer patients assessing the impact of alpha-tocopherol on cancer treatment outcomes. Results were heterogeneous, with some studies showing improvement in mucositis and CIPN, but overall, alpha-tocopherol is discouraged due to potential negative influence on survival rates.
A systematic review and meta-analysis on the impact of oral vitamin E supplementation on apolipoproteins A1 and B100.
This systematic review and meta-analysis evaluated the impact of oral vitamin E supplementation on apolipoproteins A1 and B100 levels. Seven studies with 1284 participants were included. The analysis found no significant effect of vitamin E on ApoA1 and ApoB levels.
Beneficial Effects of Vitamin E Supplementation on Endothelial Dysfunction, Inflammation, and Oxidative Stress Biomarkers in Patients Receiving Hemodialysis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Systematic review and meta-analysis of 11 RCTs with 491 patients receiving hemodialysis, assessing vitamin E supplementation effects. Vitamin E significantly decreased biomarkers of endothelial dysfunction, inflammation, and oxidative stress, suggesting potential benefits for cardiovascular health in this population.
Protective Effects of Vitamin E on Chemotherapy-Induced Peripheral Neuropathy: A Meta-Analysis of Randomized Controlled Trials.
Meta-analysis of 8 RCTs involving 488 patients examining the effect of vitamin E supplementation on chemotherapy-induced peripheral neuropathy (CIPN). Vitamin E supplementation of 600 mg/day was associated with a lower incidence of CIPN and improved neurotoxicity scores compared to placebo.
Vitamin E for the Prevention of Chemotherapy-Induced Peripheral Neuropathy: A meta-Analysis
Meta-analysis of 9 RCTs with 486 patients comparing vitamin E to control for preventing chemotherapy-induced peripheral neuropathy (CIPN). Vitamin E significantly reduced the incidence of all-grade CIPN and total neuropathy scores, but not severe CIPN. Subgroup analysis of double-blind RCTs showed no significant effect on all-grade CIPN.
Interventional study with vitamin E in cardiovascular disease and meta-analysis.
This meta-analysis reviews the impact of vitamin E on the atherothrombotic process in cardiovascular disease. It describes experimental and clinical studies, noting that while observational studies show an inverse association between vitamin E levels and CVD, interventional trials with vitamin E supplements have provided negative results.
Can vitamin E supplementation affect obesity indices? A systematic review and meta-analysis of twenty-four randomized controlled trials.
Systematic review and meta-analysis of 24 RCTs assessing the effect of vitamin E supplementation on obesity indices. No significant effect was found on weight, BMI, or waist circumference overall, but subgroup analysis suggested an increase in BMI among participants with normal BMI.
Vitamin E-Enhanced Liners in Primary Total Hip Arthroplasty: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis evaluating the use of vitamin E-enhanced liners in total hip arthroplasty. The study found that vitamin E-enhanced liners reduced the all-cause revision rate and femoral head penetration compared to liners without vitamin E, but did not improve clinical function.
Serum vitamin E levels and chronic inflammatory skin diseases: A systematic review and meta-analysis.
Systematic review and meta-analysis evaluating the association between serum vitamin E levels and chronic inflammatory skin diseases. The analysis found lower vitamin E levels in patients with vitiligo, psoriasis, atopic dermatitis, and acne compared to controls.
Systematic review and meta-analyses of vitamin E (alpha-tocopherol) supplementation and blood lipid parameters in patients with diabetes mellitus.
Systematic review and meta-analysis evaluating the efficacy of alpha-tocopherol supplementation on lipid parameters in diabetes mellitus patients. The results showed no significant effects on lipid profiles except when used for 12 weeks or more.
Effects of vitamin E on stroke: a systematic review with meta-analysis and trial sequential analysis.
Systematic review and meta-analysis of 18 studies with 148,016 participants evaluating vitamin E supplementation versus placebo/no vitamin E on stroke risk. No significant difference was found in total, fatal, and non-fatal stroke prevention, but vitamin E showed a significant risk reduction in ischaemic stroke. More studies are needed to control random errors.
The effect of vitamin E supplementation on selected inflammatory biomarkers in adults: a systematic review and meta-analysis of randomized clinical trials.
Systematic review and meta-analysis of 33 RCTs with 2102 individuals examining the effect of vitamin E supplementation on inflammatory biomarkers. Vitamin E, particularly alpha-tocopherol, significantly reduced serum CRP and TNF-α concentrations, with a notable effect at dosages ≥700 mg/day. The effect on IL-6 was significant in specific subgroups.
Serum Metabolomic Response to Low- and High-Dose Vitamin E Supplementation in Two Randomized Controlled Trials.
Two RCTs examined serum metabolomic responses to low- and high-dose vitamin E supplementation in men. Significant alterations in serum alpha-carboxyethyl hydrochroman sulfate, alpha-tocopherol, and beta/gamma-tocopherol were observed. High-dose vitamin E in VEAPS significantly decreased Clactone sulfate, correlated with changes in androgenic steroid metabolites.
Vitamin E supplementation in people with cystic fibrosis.
This meta-analysis reviewed the effects of vitamin E supplementation in people with cystic fibrosis, including four studies with 141 participants. The studies used different formulations and doses of vitamin E. Results indicated that vitamin E supplementation may improve serum vitamin E levels, although the evidence quality was low. No significant data on other outcomes like lung function or quality of life were available.
Systematic review with meta-analysis: The effect of vitamin E supplementation in adult patients with non-alcoholic fatty liver disease.
Systematic review and meta-analysis of randomized clinical trials examining vitamin E supplementation in adults with non-alcoholic fatty liver disease (NAFLD). Vitamin E reduced liver enzyme levels and improved liver pathology, low-density lipoprotein cholesterol, fasting blood glucose, and serum leptin values, suggesting it could be a promising treatment option for NAFLD.
Pharmacologic Treatment of Tardive Dyskinesia: A Meta-Analysis and Systematic Review.
Meta-analysis and systematic review examining pharmacologic treatments for tardive dyskinesia. Vitamin E and vitamin B6 were associated with significant reduction in TD symptoms compared to placebo. Evidence of publication bias and a negative association of dose and duration with efficacy suggest benefits of vitamin E may be overstated.
Pentoxifylline and tocopherol protocol to treat medication-related osteonecrosis of the jaw: A systematic literature review.
Systematic literature review on the effectiveness of pentoxifylline and tocopherol (PENTO protocol) for medication-related osteonecrosis of the jaw (MRONJ). The PENTO protocol was reported to relieve painful symptoms and promote significant new bone formation, suggesting potential usefulness in non-surgical management of MRONJ.
A meta-analysis and meta-regression of the effects of vitamin E supplementation on serum enrichment, udder health, milk yield, and reproductive performance of transition cows.
Meta-analysis of 53 trials evaluating vitamin E supplementation in transition cows. Vitamin E improved reproductive performance, reduced days open, and decreased services per conception, but did not affect somatic cell counts or colostrum quality. Serum vitamin E levels increased, and effects were modulated by selenium supplementation.
Effects of vitamin E supplementation on the risk and progression of AD: a systematic review and meta-analysis.
Systematic review and meta-analysis evaluating the effects of vitamin E supplementation on the risk and progression of Alzheimer's disease (AD). The study included five cohort studies and three RCTs with a total of 14,262 participants. The pooled relative risk for vitamin E supplementation and AD risk was 0.81, but no unified outcome measure was available for AD progression. The study concluded that there is insufficient evidence to determine the association between vitamin E and AD.
Association of vitamin E on the risk of ovarian cancer: a meta-analysis.
Meta-analysis of 14 observational studies with 4597 patients assessing the association of vitamin E intake on ovarian cancer risk. The analysis found no significant effect of high vitamin E intake from food or supplements on ovarian cancer risk.
Vitamin E for antipsychotic-induced tardive dyskinesia.
Meta-analysis of 13 randomized trials with 478 participants with antipsychotic-induced tardive dyskinesia. Vitamin E showed no clear improvement in TD symptoms compared to placebo, but may protect against symptom deterioration. Evidence quality was low, and further research is needed.
Management of osteoradionecrosis of the jaws with pentoxifylline-tocopherol: a systematic review of the literature and meta-analysis.
Systematic review and meta-analysis evaluating the use of pentoxifylline and tocopherol (PENTO) in the treatment of osteoradionecrosis (ORN) of the jaws. Out of 211 patients treated, 126 recovered fully or improved significantly, while 60 remained the same, 10 were lost to follow-up, and the disease progressed in 15. The literature supports the use of PENTO for ORN treatment.
Could Vitamin E Prevent Contrast-Induced Acute Kidney Injury? A Systematic Review and Meta-Analysis.
A systematic review and meta-analysis of four RCTs with 623 participants assessed the effects of vitamin E on contrast-induced acute kidney injury (CIAKI). Vitamin E significantly reduced the risk of CIAKI by 62% and decreased serum creatinine increase after contrast administration, though changes in glomerular filtration rate were not significant.
Vitamin E for Alzheimer's dementia and mild cognitive impairment.
This meta-analysis assessed the efficacy of vitamin E in treating mild cognitive impairment (MCI) and Alzheimer's disease (AD). The review found no evidence that vitamin E prevents progression to dementia or improves cognitive function in MCI or AD. However, it may slow functional decline in AD. Vitamin E was not associated with an increased risk of serious adverse events or mortality.
Comparative efficacy of interventions on nonalcoholic fatty liver disease (NAFLD): A PRISMA-compliant systematic review and network meta-analysis.
Systematic review and network meta-analysis of 44 studies with 3802 participants comparing interventions for NAFLD. Vitamin E, along with OCA and TZD, significantly improved histological outcomes in NAFLD, including resolution of NASH and improvements in NAS, steatosis, ballooning, and inflammation.
Vitamin E supplementation in pregnancy.
Meta-analysis of 21 trials involving 22,129 pregnant women assessing vitamin E supplementation, often in combination with vitamin C and other agents. No clear difference was found for stillbirth, neonatal death, pre-eclampsia, preterm birth, or intrauterine growth restriction. Vitamin E was associated with decreased risk of placental abruption but increased risk of abdominal pain and term prelabour rupture of membranes.
Comparative effectiveness of pharmacological interventions for nonalcoholic steatohepatitis: A systematic review and network meta-analysis.
Bayesian network meta-analysis of nine RCTs with 964 patients with NASH comparing vitamin E, TZDs, pentoxifylline, and obeticholic acid. Vitamin E, TZDs, and obeticholic acid showed high-quality evidence for improving ballooning degeneration. Pentoxifylline and obeticholic acid improved fibrosis with moderate-quality evidence.
Blood α-tocopherol, γ-tocopherol levels and risk of prostate cancer: a meta-analysis of prospective studies.
Meta-analysis of nine nested case-control studies involving approximately 370,000 participants examined the association of blood alpha-tocopherol and gamma-tocopherol levels with prostate cancer risk. Blood alpha-tocopherol levels were inversely associated with prostate cancer risk, while gamma-tocopherol levels showed no significant association.
Vitamin E serum levels and controlled supplementation and risk of amyotrophic lateral sclerosis.
The study investigated the relationship between serum alpha-tocopherol (vitamin E) levels and the risk of amyotrophic lateral sclerosis (ALS) in 29,127 Finnish male smokers. It was part of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study, a prospective cohort and randomized controlled trial. Results suggested a potential protective effect of higher serum alpha-tocopherol levels on ALS risk, though further pooled analyses are needed.
Vitamin E for Alzheimer's dementia and mild cognitive impairment.
Meta-analysis assessing the efficacy of vitamin E in the treatment of Alzheimer's dementia (AD) and prevention of progression of mild cognitive impairment (MCI) to dementia. Three studies were included, with mixed results: some benefit was noted in one AD study, but no significant effects were found in another AD study and the MCI study. Overall, no convincing evidence was found for vitamin E's benefit in AD or MCI treatment.
Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT).
The Selenium and Vitamin E Cancer Prevention Trial (SELECT) involved 34,887 men randomized to receive selenium, vitamin E, both, or placebo. The study found that vitamin E supplementation significantly increased the risk of prostate cancer compared to placebo.
Genome-wide association study identifies common variants associated with circulating vitamin E levels.
Genome-wide association study identified common genetic variants associated with circulating alpha- and gamma-tocopherol concentrations in two adult cohorts of 5006 men of European descent. Three loci were associated with alpha-tocopherol levels, with two novel SNPs and one previously reported locus confirmed. These SNPs are linked to lipid metabolism and regulation.
Vitamin E for neuroleptic-induced tardive dyskinesia.
Meta-analysis of 11 randomized trials with 427 participants assessing vitamin E for neuroleptic-induced tardive dyskinesia. No clear difference was found between vitamin E and placebo for clinically relevant improvement in TD, but vitamin E may protect against symptom deterioration.
Systematic review on "vitamin E and prevention of colorectal cancer".
Systematic review and meta-analysis of four trials with 94069 participants assessing vitamin E for primary prevention of colorectal cancer. The review found no sufficient evidence that vitamin E decreases the risk of colorectal cancer incidence.
Associations between alpha-tocopherol, beta-carotene, and retinol and prostate cancer survival.
The study investigated the effects of serum alpha-tocopherol, beta-carotene, and retinol concentrations on prostate cancer survival in men from the alpha-Tocopherol, beta-Carotene Cancer Prevention Study. Higher serum alpha-tocopherol was associated with improved prostate cancer survival, while beta-carotene and retinol showed no apparent effects.
Vitamin E for Alzheimer's disease and mild cognitive impairment.
Meta-analysis assessing the efficacy of Vitamin E in the treatment of Alzheimer's disease and prevention of progression of Mild Cognitive Impairment to Alzheimer's disease. The analysis found no significant evidence of efficacy for Vitamin E in preventing or treating cognitive impairment, though some benefit was noted in fewer participants reaching certain endpoints in Alzheimer's disease. More participants taking Vitamin E suffered falls.
Vitamin E and age-related cataract in a randomized trial of women.
RCT of 39,876 healthy female health professionals aged 45 or older, receiving 600 IU natural-source vitamin E or placebo every other day for an average of 9.7 years. The study found no significant difference in the incidence of age-related cataract or its subtypes between the vitamin E and placebo groups.
Vitamin E supplementation in pregnancy.
Meta-analysis of four trials involving 566 women at high risk of pre-eclampsia or with established pre-eclampsia, assessing vitamin E supplementation in combination with other supplements. No significant differences were found for stillbirth, neonatal death, perinatal death, preterm birth, intrauterine growth restriction, or birthweight. A decreased risk of clinical pre-eclampsia was observed with fixed-effect models but not with random-effects models.
Is all-rac-alpha-tocopherol different from RRR-alpha-tocopherol regarding cardiovascular efficacy? A meta-analysis of clinical trials.
Meta-analysis of 14 clinical studies with 83,800 subjects comparing RRR- and all-rac-alpha-tocopherol for cardiovascular efficacy. No significant differences were found between the vitamin E forms, supporting the safety of vitamin E supplements up to 800 mg/d for up to 6.5 years.
Vitamin E and beta-carotene supplementation and hospital-treated pneumonia incidence in male smokers.
The ATBC study, a randomized, double-blind, placebo-controlled trial, examined the effects of vitamin E and beta-carotene supplementation on pneumonia incidence in 29,133 male smokers. Overall, neither supplement affected pneumonia risk, but vitamin E reduced risk in those who started smoking later, while beta-carotene increased it.
Vitamin E supplementation and cataract: randomized controlled trial.
RCT of 1193 subjects aged 55 to 80 years assessing the effect of 500 IU daily vitamin E supplementation on age-related cataract incidence and progression over 4 years. The study found no significant difference in cataract incidence or progression between the vitamin E and placebo groups.
Physical activity and the common cold in men administered vitamin E and beta-carotene.
Cohort study from the ATBC Study examining the effect of vitamin E and beta-carotene on common cold risk in 14,401 middle-aged male smokers. Physical activity had no association with cold risk, but vitamin E and beta-carotene increased the risk of colds in subjects engaging in heavy exercise at leisure.
Vitamin E supplementation and macular degeneration: randomised controlled trial.
RCT of 1193 healthy volunteers aged 55-80 years testing vitamin E 500 IU daily versus placebo for four years. The study found no significant effect of vitamin E supplementation on the incidence or progression of early or late age-related macular degeneration.
A randomized trial of vitamin E supplementation and cognitive function in women.
The Women's Health Study, a randomized, double-blind, placebo-controlled trial, examined the effects of vitamin E supplementation on cognitive function in 6377 women aged 65 years or older. Over 9.6 years, no significant cognitive benefits were observed in the vitamin E group compared to placebo.
Immunomodulatory and Anti-Inflammatory Effects of Ketotifen Versus Vitamin E in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Pilot Study.
Randomized pilot study comparing ketotifen and vitamin E in 60 individuals with NAFLD over six months. Ketotifen showed superior improvements in hepatic steatosis, fibrosis severity, glycemic outcomes, and inflammatory markers compared to vitamin E. Ketotifen was well tolerated, with drowsiness as the most common adverse event.
Vitamin E TPGS-enhanced riboflavin accelerated transepithelial cross-linking versus accelerated epithelium-off protocol in progressive keratoconus: a prospective randomized trial.
Prospective randomized trial comparing accelerated transepithelial corneal collagen cross-linking using Vitamin E TPGS-enhanced riboflavin with accelerated epithelium-off protocol in progressive keratoconus. Both groups showed significant improvement in visual acuity and keratometric parameters at 12 months, with differences in corneal thickness behavior and demarcation line depth.
The Effect of Maternal Antioxidant Vitamin Supplementation on Maternal and Cord Blood Adiponectin Concentrations.
Secondary analysis of an RCT investigating prenatal vitamin C and E supplementation on adiponectin concentrations in pregnant participants and their newborns. Adiponectin concentrations at delivery were higher in the vitamin group compared to placebo, with significant interactions based on baseline adiponectin levels. Vitamin supplementation was associated with higher adiponectin at delivery for those with high baseline levels, but lower cord blood adiponectin for those with low baseline levels.
Oxidative stress markers and tissue iron overload after 12-months vitamin E supplementation for children with transfusion-dependent β-thalassemia on different iron chelators: A randomized placebo-controlled trial.
This randomized controlled trial investigated the efficacy and safety of vitamin E supplementation as an adjuvant therapy to iron chelators in 180 pediatric patients with transfusion-dependent β-thalassemia. Vitamin E supplementation led to significant decreases in transfusion index, serum ferritin, and liver iron content, while improving hemoglobin levels and oxidative stress markers compared to baseline and placebo.
Combination therapy with vitamin E and ertugliflozin in patients with non-alcoholic fatty liver disease and type 2 diabetes mellitus: a randomized clinical trial.
A 24-week, double-blind, randomized controlled trial on 173 patients with NAFLD and T2DM evaluated the effects of vitamin E and ertugliflozin, individually and in combination, alongside pioglitazone therapy. The combination of vitamin E and ertugliflozin showed the highest decrease in liver fat content and significant improvements in glycemic control, HbA1c, triglycerides, and liver enzymes.
Vitamin E (300 mg) in the treatment of MASH: A multi-center, randomized, double-blind, placebo-controlled study.
This multi-center, randomized, double-blind, placebo-controlled study evaluated the efficacy and safety of vitamin E 300 mg for treating metabolic dysfunction-associated steatohepatitis (MASH) in 124 non-diabetic participants. The vitamin E group showed significant improvements in hepatic histology, steatosis, lobular inflammation, and fibrosis stages compared to placebo.
Comparison of 2 Paclitaxel-Coated Balloons with Different Excipients for the Treatment of Femoropopliteal Artery Disease: A Randomized Prospective Trial.
This randomized prospective trial compared the effectiveness and safety of a novel drug-coated balloon (DCB) using shellac plus vitamin E as an excipient with a reference DCB using urea in patients with femoropopliteal arterial disease. The study found that the new DCB was noninferior in terms of late lumen loss at 6 months compared to the reference DCB, with no significant differences in clinically-driven target lesion revascularization, major amputation, and all-cause mortality.
Effects of meat-based, meat-based with α-tocopherol, and pesco-vegetarian diets on biomarkers associated with colorectal cancer risk: a randomized behavioral intervention trial.
This 12-week randomized, open-label study evaluated the impact of three diets on colorectal cancer risk markers: a meat-based diet, a meat-based diet with alpha-tocopherol supplementation, and a pesco-vegetarian diet. The study found that the meat-based diet increased several biomarkers associated with colorectal cancer risk, while alpha-tocopherol supplementation attenuated some adverse effects. The pesco-vegetarian diet was associated with a more favorable biochemical and inflammatory profile.
Vitamin E ameliorates blood cholesterol level and alters gut microbiota composition: A randomized controlled trial.
RCT with 90 healthy individuals assessing the impact of vitamin E on blood cholesterol levels and gut microbiota. Vitamin E reduced LDL-C levels and increased the abundance of SCFA-producing bacteria and bile acid metabolizers.
The impact of vitamin E supplementation on sperm analysis in varicocelectomy patients: a triple-blind randomized controlled trial.
Triple-blind RCT evaluating the impact of vitamin E supplementation on sperm analysis in 90 varicocelectomy patients. The vitamin E group showed significantly higher improvements in sperm motility compared to placebo, suggesting potential benefits for male infertility related to varicocele.
New Approach Combination-Dosed Therapy for Nonalcoholic Steatohepatitis Versus Vitamin E: A Randomized Controlled Trial.
This randomized controlled trial compared the efficacy of N-acetyl cysteine (NAC) and rosuvastatin (RSV) with conventional vitamin E in patients with nonalcoholic steatohepatitis (NASH). Group 2, treated with NAC/RSV, showed significant improvements in liver steatosis, fibrosis, metabolic parameters, and health-related quality of life compared to the vitamin E group.
Effect of vitamin E supplementation on recovery and recurrence prevention in women with lower urinary tract infections: A triple-blind randomized clinical trial.
Triple-blind randomized clinical trial evaluating the effect of vitamin E supplementation on recovery and recurrence prevention in women with lower urinary tract infections. The intervention group receiving vitamin E showed significant improvements in urinary frequency and dysuria, faster recovery time, and lower UTI recurrence rates compared to the control group.
Measures of cellular oxidative damage following vitamin E supplementation in young patients with transfusion-dependent thalassemia: a double-blind randomized controlled trial.
Double-blind RCT of 74 transfusion-dependent thalassemia patients aged 10-25 years, comparing vitamin E 400 IU/day to placebo for 6 months. Vitamin E significantly reduced oxidative damage markers in β-Thal-NS patients, improving RBC pathology without affecting Hb levels or platelet pathology.