Research
Vitamin D3
401 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
P-1586. Safety and Efficacy of Vitamin D3 in the Management of COVID-19: A Systematic Review and Meta-Analysis
Systematic review and meta-analysis of 17 RCTs with 2,762 patients assessing vitamin D3's efficacy and safety in COVID-19 management. Vitamin D3 was associated with a significant reduction in ICU admissions but showed no significant effects on hospital stay, oxygen supplementation, mechanical ventilation, or inflammatory biomarkers.
Vitamin D Receptor Polymorphisms and the Effect of Vitamin D Supplementation on Diabetes Risk Among Adults With Prediabetes.
This genetic association study assessed the effect of 4000 IU/d of vitamin D3 supplementation on diabetes risk among adults with prediabetes, focusing on vitamin D receptor polymorphisms. Participants with ApaI AC and CC genotypes showed a 19% decrease in diabetes risk, while those with ApaI AA alleles exhibited no response.
Effect Modification by Serum Vitamin A Levels on the Association between Vitamin D and Relapse or Death in Patients with Digestive Tract Cancer.
Post hoc analysis of the AMATERASU RCT examined the effect of vitamin D3 supplementation on relapse or death in patients with digestive tract cancer, considering serum vitamin A levels as a modifier. Vitamin D supplementation reduced relapse and death risk in patients with middle-to-upper range serum vitamin A levels, but not in those with lower or higher levels.
Vitamin D supplementation during pregnancy and offspring bone microarchitecture: A post hoc analysis of the MAVIDOS randomised controlled trial.
Post hoc analysis of the MAVIDOS RCT examining the effect of 1000 IU/day cholecalciferol supplementation during pregnancy on offspring tibial bone microarchitecture at age 6-7 years. No significant differences in bone microarchitecture or interaction with genetic variants were observed.
Comparative Efficacy and Safety of Intralesional MMR Vaccine and Vitamin D3 in Managing Nongenital Warts: A Systematic Review and Meta‐Analysis
Systematic review and meta-analysis comparing the efficacy and safety of intralesional MMR vaccine and vitamin D3 in managing nongenital warts. The study evaluates these alternative treatments for cutaneous warts caused by human papillomavirus.
Impact of Vitamin D3 Supplementation on Androgens and Semen Parameters in Infertile Men: A Systematic Review and Meta-Analysis Based on Prospective Randomised Controlled Trials.
Systematic review and meta-analysis of six studies involving 945 infertile men, examining the effects of vitamin D3 supplementation on androgen levels and semen parameters. Vitamin D3 supplementation did not significantly affect androgen levels but improved total sperm count and percentage of motile sperm.
High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis: The D-Lay MS Randomized Clinical Trial.
The D-Lay MS trial was a double-blind, randomized placebo-controlled clinical trial evaluating high-dose cholecalciferol in patients with clinically isolated syndrome typical for MS. The study found that oral cholecalciferol significantly reduced disease activity compared to placebo, with longer median time to disease activity and fewer MRI-detected lesions.
Pregnancy vitamin D supplementation and bone mineral density of the mother: a post hoc analysis of the MAVIDOS randomised placebo-controlled trial.
Post hoc analysis of the MAVIDOS randomised placebo-controlled trial assessing the effect of 1000 IU/day cholecalciferol supplementation during pregnancy on maternal bone mineral density (BMD) immediately after delivery and 4 years later. The study found no significant difference in BMD between the cholecalciferol and placebo groups at either time point.
Vitamin D Supplementation During Neoadjuvant Chemotherapy for Breast Cancer Improves Pathological Complete Response: A Prospective Randomized Clinical Trial.
Prospective randomized clinical trial investigating the effect of oral vitamin D3 supplementation during neoadjuvant systemic therapy on pathological complete response (pCR) in breast cancer patients. Vitamin D intake significantly improved pCR rates, with an odds ratio of 2.33 in multivariate analysis.
Impact of vitamin D supplementation in the prognosis of patients with SARS-CoV2 pneumonia admitted to the intensive care unit - a randomized controlled trial.
RCT evaluating the impact of cholecalciferol supplementation in ICU patients with severe SARS-CoV-2 pneumonia. Lower vitamin D levels on admission were associated with more organ failures, and high-dose cholecalciferol supplementation was related to fewer organ failures.
Vitamin D and its Analogs in Treatment of Mild to Moderate Alopecia Areata: Systematic Review and Meta-Analysis
Systematic review and meta-analysis evaluating the efficacy and safety of topical/intralesional vitamin D3 and its analogs for treating mild-to-moderate alopecia areata. The study found a success rate of about 53.75% for vitamin D3 treatments, with both intralesional and topical applications being effective. Vitamin D3 analogs showed synergistic effects when combined with other treatments.
The effect of vitamin D supplementation on depression: a systematic review and dose–response meta-analysis of randomized controlled trials
Systematic review and dose-response meta-analysis of 31 RCTs with 24189 participants evaluating vitamin D3 supplementation on depressive and anxiety symptoms. Vitamin D3 supplementation slightly reduced depressive symptoms, especially in those with depression, but had no significant effects on anxiety symptoms.
Preventive Medications in Pediatric Migraine: A Network Meta-Analysis.
Network meta-analysis of 45 trials with 3771 participants evaluating pharmacological treatments for pediatric migraine prophylaxis. Topiramate with vitamin D3 and riboflavin were associated with a reduction in migraine frequency, but no treatments improved quality of life or attack duration. Adverse events were higher with some drugs, highlighting the need for further research.
Effect of cholecalciferol versus calcifediol on serum 25(OH)D concentrations: a systematic review with meta-analysis.
Systematic review and meta-analysis comparing the effects of cholecalciferol (vitamin D3) and calcifediol (25OHD3) on serum 25(OH)D levels. Calcifediol was found to be more effective in raising serum 25(OH)D concentrations compared to cholecalciferol.
Vitamin D supplementation decrease asthma exacerbations in children: a systematic review and meta-analysis of randomized controlled trials
Systematic review and meta-analysis of randomized controlled trials assessing the effect of vitamin D supplementation on asthma exacerbations in children. The analysis included 10 studies with 1243 asthmatic children and found that vitamin D supplementation significantly reduced the total number of asthma exacerbations.
Effects of Supplemental Vitamin D3, Omega-3 Fatty Acids on Physical Performance Measures in the VITamin D and OmegA-3 TriaL.
The VITamin D and OmegA-3 TriaL (VITAL) was a double-blinded, placebo-controlled randomized trial assessing the effects of supplemental vitamin D3 and omega-3 fatty acids on physical performance measures in 1054 older adults. After 2 years, there were no significant differences in physical performance measures between the supplement and placebo groups, with all groups showing worsening walking speeds and TUG.
Effects of Vitamin D-3 Supplementation During Pregnancy and Lactation on Maternal and Infant Biomarkers of Environmental Enteric Dysfunction, Systemic Inflammation, and Growth: A Secondary Analysis of a Randomized Controlled Trial.
This study conducted a secondary analysis of a randomized controlled trial to examine the effects of maternal vitamin D-3 supplementation during pregnancy and lactation on biomarkers of environmental enteric dysfunction, systemic inflammation, and growth in women living with HIV and their infants. Vitamin D-3 supplementation reduced selected EED and systemic inflammation biomarkers among mothers, but effects on infants were limited to growth factors.
Efficacy of weekly versus daily cholecalciferol for repleting serum vitamin D (25(OH)D) deficiency: A systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of RCTs comparing weekly versus daily cholecalciferol dosing in 542 patients with hypovitaminosis D. No significant difference was found in correcting vitamin D deficiency between the two dosing regimens, though weekly dosing reduces pill burden.
Pregnancy vitamin D supplementation and offspring bone mineral density in childhood follow-up of a randomized controlled trial.
The MAVIDOS randomized controlled trial investigated the effect of gestational cholecalciferol supplementation on offspring bone mineral density (BMD) at ages 6-7 years. The study found that supplementation with 1000 IU/d cholecalciferol during pregnancy resulted in higher BMD, bone mineral content, and lean mass in offspring compared to placebo, suggesting potential benefits for bone health.
Effects of vitamin D3 supplementation on strength of lower and upper extremities in athletes: an updated systematic review and meta-analysis of randomized controlled trials
This updated systematic review and meta-analysis examined the effects of vitamin D3 supplementation on muscle strength in athletes. It included 10 RCTs with 318 athletes, showing a significant increase in serum 25(OH)D levels with supplementation. While overall muscle strength improvements were not significant, there was a significant increase in quadriceps contraction.
High-dose vitamin D3 supplementation shows no beneficial effects on white blood cell counts, acute phase reactants, or frequency of respiratory infections
A double-blinded, randomized, placebo-controlled trial of 307 infertile men investigated the effects of high-dose vitamin D3 supplementation on white blood cell counts, acute phase reactants, and respiratory infections. No differences were found in WBC counts or APRs between the vitamin D3 and placebo groups, but a higher prevalence of self-reported respiratory infections was observed in the vitamin D3 group.
Has a High Dose of Vitamin D3 Impacted Health Conditions in Older Adults?—A Systematic Review and Meta-Analysis Focusing on Dose 100,000 IU
Systematic review and meta-analysis of 13 studies on the effects of a single high dose of 100,000 IU vitamin D3 in older adults. The meta-analysis showed a significant increase in 25(OH)D blood levels, with mixed evidence for health benefits such as improved lung and cardiovascular function, skin cancer progression, and immune response.
Influence of vitamin D in orthodontic tooth movement-a systematic review and meta-analysis of randomized controlled trials in humans.
Systematic review and meta-analysis of RCTs examining the impact of vitamin D on orthodontic tooth movement (OTM). The analysis found that vitamin D enhances the rate of tooth movement, but data on its effect on root resorption is inconclusive.
A systematic review to evaluate the efficacy and safety of high-dose vitamin D supplementation in adults with cystic fibrosis
This systematic review evaluated the efficacy and safety of high-dose cholecalciferol (vitamin D3) supplementation in adults with cystic fibrosis. The meta-analysis of five RCTs showed that high-dose cholecalciferol effectively increased serum 25(OH)D concentrations, with minimal adverse effects reported. The review suggests high-dose cholecalciferol is a safe method to improve bone health outcomes in this population.
Effects of intermittent overload doses of oral vitamin D3 on serum 25(OH)D concentrations and the incidence rates of fractures, falls, and mortality in elderly individuals: A systematic review and meta-analysis
This systematic review and meta-analysis assessed the impact of high-dose intermittent oral administration of vitamin D3 on serum 25(OH)D levels, fractures, falls, and mortality among elderly individuals. The analysis included 14 RCTs and found that while vitamin D3 significantly raised serum 25(OH)D levels, it did not significantly reduce the risks of falls and fractures or affect all-cause mortality.
Pharmacotherapy for Reducing RBC Transfusion for Patients in the ICU: A Systematic Review and Network Meta-Analysis
Systematic review and network meta-analysis of 75 studies with 15,091 patients comparing therapies to reduce RBC transfusion in ICU patients. Combination therapy with iron and Epo reduces transfusion requirement. Evidence for vitamin D3 and HIF-PHI remains uncertain.
Role of vitamin D in the prevention of acute respiratory infections: a systematic review and meta-analysis
This systematic review and meta-analysis evaluated the preventive efficacy of vitamin D3 (cholecalciferol) against acute respiratory infections (ARIs) among adults using data from randomized clinical trials. The analysis found that vitamin D3 intake was effective in preventing ARIs compared to placebo, with an odds ratio of 0.82. Daily intake of D3 at a dose of ≥ 2000 IU/day was identified as the most effective strategy.
Impact of Common Vitamin D-Binding Protein Isoforms on Supplemental Vitamin D3 and/or Calcium Effects on Colorectal Adenoma Recurrence Risk: A Secondary Analysis of a Randomized Clinical Trial.
Secondary analysis of a randomized, double-blind, placebo-controlled clinical trial with 2259 participants to assess the impact of vitamin D3 and/or calcium supplementation on colorectal adenoma recurrence, considering common vitamin D-binding protein isoforms. Results suggest that individuals with the DBP2 isoform may benefit more from supplementation for adenoma prevention.
Does antenatal cholecalciferol supplementation affect the mode or timing of delivery? Post hoc analyses of the MAVIDOS randomized controlled trial.
The MAVIDOS randomized controlled trial assessed the effect of antenatal cholecalciferol supplementation on delivery outcomes in 965 women. Cholecalciferol did not significantly alter the timing of birth or prevalence of preterm birth but was associated with a higher likelihood of spontaneous vaginal delivery and a lower incidence of post-partum haemorrhage.
Prevention of relapse in drug sensitive pulmonary tuberculosis patients with and without vitamin D3 supplementation: A double blinded randomized control clinical trial
This double-blind randomized controlled trial investigated the effect of vitamin D3 supplementation on relapse prevention and sputum conversion in pulmonary tuberculosis patients in India. The study found no significant difference in relapse rates or time to sputum smear and culture conversion between the vitamin D3 and placebo groups.
Apolipoprotein E and its association with cognitive change and modification of treatment effects of vitamin D3 and omega-3s on cognitive change: results from the in-clinic subset of a randomized clinical trial.
This study examined the effects of vitamin D3 and omega-3 supplementation on cognitive change in older adults, considering the influence of the APOE-ε4 allele. APOE-ε4 carriers showed worse cognitive outcomes, but the allele did not significantly modify the effects of the supplements on cognition over 2 years.
Effects of Vitamin D3 and Marine Omega-3 Fatty Acids Supplementation on Indicated and Selective Prevention of Depression in Older Adults: Results From the Clinical Center Sub-Cohort of the VITamin D and OmegA-3 TriaL (VITAL).
The VITamin D and OmegA-3 TriaL (VITAL) tested vitamin D3 and omega-3 fatty acids for depression prevention in older adults. The study found no significant benefits of either supplement for indicated and selective prevention of late-life depression, with no significant differences in PHQ-9 score change compared to placebo.
Long-Term Treatment and Effect of Discontinuation of Calcifediol in Postmenopausal Women with Vitamin D Deficiency: A Randomized Trial.
A 1-year, phase III-IV, double-blind, randomized, controlled trial assessed the efficacy and safety of monthly calcifediol versus cholecalciferol in postmenopausal women with vitamin D deficiency. Calcifediol showed a faster onset of action and maintained stable 25(OH)D levels, while withdrawal led to a decrease in levels. No safety issues were reported.
Effect of Vitamin D Supplementation on (25(OH)D) Status in Children 12-30 Months of Age: A Randomized Clinical Trial.
RCT assessing the effect of vitamin D supplementation at different doses on serum 25(OH)D concentrations in 222 preschool children. Vitamin D3 at 1000 IU/day showed the highest efficacy in increasing serum 25(OH)D levels and reducing vitamin D deficiency over three months.
Systematic review and meta-analysis of preoperative interventions to support the maturation of arteriovenous fistulae in patients with advanced kidney disease.
Systematic review and meta-analysis of preoperative interventions to support arteriovenous fistula maturation in advanced kidney disease patients. Interventions included hand exercise, cholecalciferol supplementation, and pneumatic compression. Hand exercise showed a positive effect on vein calibre, while cholecalciferol was one of the interventions studied.
Vitamin D and Acute Diarrhea in Children: A Meta-Analysis
Meta-analysis of ten studies examining the association between vitamin D3 levels and acute diarrhea in children. The analysis found a significant relationship between vitamin D3 deficiency and increased risk of acute diarrhea, suggesting a potential role for vitamin D3 in mitigating this risk.
Effect of supplemental vitamin D3 on bone mineral density: a systematic review and meta-analysis.
Systematic review and meta-analysis evaluating the effects of vitamin D3 supplementation on bone mineral density (BMD) and markers of bone turnover. Vitamin D3 showed a beneficial effect on BMD at the lumbar spine and femoral neck, but decreased BMD at the forearm. A linear dose-response relationship was found for BMD at various sites.
Effect of Vitamin D3 and Omega-3 Fatty Acid Supplementation on Risk of Frailty
Ancillary study of a randomized clinical trial with 25,871 individuals aged 50 years or older, examining the effect of vitamin D3 and omega-3 fatty acid supplementation on frailty risk. Neither supplementation significantly affected change in frailty score during 5 years of treatment.
What is the impact of daily oral supplementation of vitamin D3 (cholecalciferol) plus calcium on the incidence of hip fracture in older people? A systematic review and meta-analysis.
This systematic review and meta-analysis assessed the impact of daily oral supplementation of vitamin D3 plus calcium on hip fracture incidence in people over 65 years. The meta-analysis of seven RCTs found that supplementation with 800 IU of vitamin D3 plus 1200 mg of calcium was more effective in reducing hip fractures compared to lower calcium doses. The study concluded that this supplementation reduces hip and non-vertebral fractures in older people, though it had no effect on femoral neck bone mineral density.
Cholecalciferol Supplementation Does Not Affect the Risk of HIV Progression, Viral Suppression, Comorbidities, Weight Loss, and Depression among Tanzanian Adults Initiating Antiretroviral Therapy: Secondary Outcomes of a Randomized Trial.
RCT of 4000 HIV-infected adults in Tanzania assessing vitamin D3 supplementation effects on HIV progression, viral suppression, comorbidities, weight change, and depression. Vitamin D3 supplementation showed no significant effect on these outcomes compared to placebo.
Vitamin D3 supplementation during pregnancy and lactation for women living with HIV in Tanzania: A randomized controlled trial
RCT of vitamin D3 supplementation in 2,300 pregnant and lactating women living with HIV in Tanzania. The study found no significant effect of vitamin D3 on maternal HIV progression, small-for-gestational-age births, or infant stunting at 1 year of age compared to placebo.
Combined Vitamin D, Omega-3 Fatty Acids, and a Simple Home Exercise Program May Reduce Cancer Risk Among Active Adults Aged 70 and Older: A Randomized Clinical Trial
The DO-HEALTH trial tested the individual and combined effects of vitamin D3, omega-3 fatty acids, and a home strength exercise program on cancer risk in adults aged 70 and older. Over a median follow-up of 2.99 years, the combination of vitamin D3 and omega-3s, with or without exercise, showed a reduction in cancer risk.
Effects of Vitamin D, Omega-3 Fatty Acids and a Home Exercise Program on Prevention of Pre-Frailty in Older Adults: The DO-HEALTH Randomized Clinical Trial
The DO-HEALTH trial tested the effects of vitamin D3, omega-3 fatty acids, and a home exercise program on pre-frailty and frailty in older adults over 36 months. While individual treatments did not significantly reduce pre-frailty odds, the combination of all three significantly decreased the odds of becoming pre-frail.
Effects of Vitamin D3 and Marine Omega-3 Fatty Acids Supplementation on Biomarkers of Systemic Inflammation: 4-Year Findings from the VITAL Randomized Trial
The VITAL randomized trial investigated the effects of vitamin D3 and marine omega-3 fatty acids on systemic inflammatory biomarkers over 4 years. Vitamin D3 supplementation decreased serum hs-CRP levels by 19% at 2-year follow-up, but not at 4-year follow-up. Marine omega-3 fatty acids did not significantly affect inflammatory markers at either time point.
Impact of Vitamin D3 Versus Placebo on Cardiac Structure and Function: A Randomized Clinical Trial
The VITAL trial examined the effects of vitamin D3 (2000 IU/d) and n−3 fatty acids on cardiac structure and function in 1025 participants aged ≥50 years. After 2 years, there were no significant differences in changes in left ventricular mass or function between the vitamin D and placebo groups.
Maternal antenatal vitamin D supplementation and offspring risk of atopic eczema in the first 4 years of life: evidence from a randomized controlled trial.
RCT within the UK Maternal Vitamin D Osteoporosis Study examined the effect of maternal cholecalciferol supplementation during pregnancy on offspring's risk of atopic eczema. Results showed a reduced risk of atopic eczema at 12 months in the intervention group, particularly in infants breastfed for ≥ 1 month, but the effect was not significant at 24 or 48 months.
A single-oral bolus of 100,000 IU of cholecalciferol at hospital admission did not improve outcomes in the COVID-19 disease: the COVID-VIT-D-a randomised multicentre international clinical trial.
The COVID-VIT-D trial investigated the effect of a single oral bolus of 100,000 IU cholecalciferol at hospital admission on outcomes in patients with moderate-severe COVID-19. The trial found no significant differences in length of hospitalisation, ICU admission, or mortality between the cholecalciferol and control groups. However, higher baseline serum calcidiol levels were associated with better outcomes.
Vitamin D3 Supplementation at 5000 IU Daily for the Prevention of Influenza-Like Illness in Healthcare Workers: A Randomized Clinical Trial
Randomized clinical trial assessing the effect of 5000 IU daily vitamin D3 supplementation on influenza-like illness (ILI) in healthcare workers. The study found that vitamin D3 supplementation was associated with a lower risk of ILI and a lower incidence rate for non-COVID-19 ILI, but not for COVID-19 ILI.
Vitamin D3 Supplementation at 5000 IU Daily for the Prevention of Influenza-like Illness in Healthcare Workers: A Pragmatic Randomized Clinical Trial
Pragmatic randomized clinical trial assessing vitamin D3 supplementation at 5000 IU daily for nine months in healthcare workers. The study found that vitamin D3 supplementation was associated with a lower risk of influenza-like illness, particularly non-COVID-19 ILI, but not significantly different for COVID-19 ILI.
High-dose versus standard-dose vitamin D supplementation in older adults with COVID-19 (COVIT-TRIAL): A multicenter, open-label, randomized controlled superiority trial.
This multicenter, open-label RCT tested high-dose versus standard-dose vitamin D3 supplementation in older adults with COVID-19. The high-dose group showed improved 14-day overall survival compared to the standard-dose group, but the effect was not sustained at 28 days. No increase in adverse effects was observed with high-dose vitamin D3.
Relative Efficacy of Vitamin D2 and Vitamin D3 in Improving Vitamin D Status: Systematic Review and Meta-Analysis
Systematic review and meta-analysis comparing the efficacy of vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol) in improving vitamin D status. Cholecalciferol was found to be more effective than ergocalciferol in raising serum 25(OH)D levels and reducing PTH levels across various participant demographics and dosages.
Effects of Vitamin D3 Supplementation on Body Composition in the VITamin D and OmegA-3 TriaL (VITAL)
The VITamin D and OmegA-3 TriaL (VITAL) was a double-blinded, placebo-controlled RCT involving 771 US adults to assess the effects of vitamin D3 supplementation on body composition. The study found no significant effects of vitamin D3 on weight, BMI, or measures of adiposity and lean tissue, although there was a slight improvement in body fat percentage in participants with normal BMI at baseline.
Vitamin D3 to Treat COVID-19: Different Disease, Same Answer.
RCT of 240 hospitalized patients with moderate to severe COVID-19 in Brazil, testing a single dose of vitamin D3 (200,000 IU) vs placebo. The study found no significant difference in hospital length of stay or secondary outcomes, including in-hospital mortality, between the vitamin D3 and placebo groups.
Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial.
A multicenter, double-blind, randomized, placebo-controlled trial in Sao Paulo, Brazil, with 240 hospitalized COVID-19 patients. A single high dose of vitamin D3 did not significantly reduce hospital length of stay compared to placebo. No significant differences were found in secondary outcomes such as in-hospital mortality, ICU admission, or mechanical ventilation need.
Vitamin D3 Dose Requirement That Raises 25-Hydroxyvitamin D to Desirable Level in Overweight and Obese Elderly
This post hoc analysis of a 12-month, double-blind, randomized control trial investigated the impact of two vitamin D3 doses on vitamin D nutritional status in elderly individuals. Participants received either 600 IU or 3750 IU of vitamin D3 daily. The study found that the higher dose was more effective in raising serum 25-hydroxyvitamin D levels to desirable levels, with 99% of participants reaching ≥ 20 ng/mL compared to 86% in the low dose group.
Vitamin d supplementation and bone health in children with nephrotic syndrome: A systematic review and meta-analysis
Systematic review and meta-analysis of 4 trials (164 subjects) assessing vitamin D3 supplementation in children with nephrotic syndrome on steroid therapy. The vitamin D group showed a more positive change in bone mineral content, but evidence was insufficient to recommend supplementation due to low-quality data and risk of hypercalciuria.
Efficacy of vitamin D3 supplementation on cancer mortality in the general population and the prognosis of patients with cancer: protocol of a systematic review and individual patient data meta-analysis of randomised controlled trials
This paper outlines a protocol for a systematic review and individual patient data meta-analysis of randomised controlled trials on vitamin D3 supplementation. It aims to update the systematic review on vitamin D supplementation and cancer mortality in the general population and conduct meta-analyses on cancer-specific and overall survival of patients with cancer.
COVID-19 Mortality Risk Correlates Inversely with Vitamin D3 Status, and a Mortality Rate Close to Zero Could Theoretically Be Achieved at 50 ng/mL 25(OH)D3: Results of a Systematic Review and Meta-Analysis
Systematic review and meta-analysis examining the correlation between vitamin D3 levels and COVID-19 mortality risk. The study found a negative correlation between D3 levels and mortality risk, suggesting that higher D3 levels may reduce mortality risk. The authors recommend maintaining serum 25(OH)D levels above 50 ng/ml to prevent or mitigate new outbreaks.
Vitamin D for Autism Spectrum Disorders:a Protocol for Systematic Review and Meta-analysis
This paper outlines a protocol for a systematic review and meta-analysis on the effects of vitamin D3 supplementation in autism spectrum disorder (ASD). It aims to update the latest systematic review on vitamin D supplementation and ASD, and conduct subgroup analyses based on individual patient data from randomized controlled trials.
Effect of Vitamin D3 Supplements on Development of Advanced Cancer
Secondary analysis of a randomized clinical trial with 25,871 patients examining the effect of vitamin D3 supplementation on the risk of developing advanced cancer. Vitamin D3 reduced the incidence of advanced cancer in the overall cohort, with the strongest risk reduction in individuals with normal weight and no reduction among those with overweight or obesity.
Effect of Vitamin D and ω-3 Fatty Acid Supplementation on Risk of Age-Related Macular Degeneration: An Ancillary Study of the VITAL Randomized Clinical Trial.
This ancillary study of the VITAL randomized clinical trial evaluated whether daily supplementation with vitamin D3 and marine ω-3 fatty acids prevents the development or progression of age-related macular degeneration (AMD) in 25,871 participants. The study found no significant overall effect of either supplement on AMD incidence or progression.
Effect of Long-term Vitamin D3 Supplementation vs Placebo on Risk of Depression or Clinically Relevant Depressive Symptoms and on Change in Mood Scores: A Randomized Clinical Trial.
RCT of 18,353 adults aged 50 or older testing vitamin D3 supplementation (2000 IU/d) versus placebo on depression risk and mood scores over a median of 5.3 years. No significant differences were found in depression incidence, recurrence, or mood score changes between the vitamin D3 and placebo groups.
Effect of monthly high-dose vitamin D supplementation on acute respiratory infections in older adults: A randomized controlled trial.
RCT of 5,110 adults aged 50-84 years testing monthly high-dose vitamin D3 supplementation versus placebo for prevention of acute respiratory infections (ARI). The study found no significant difference in ARI incidence between the vitamin D and placebo groups.
Effect of Vitamin D Supplementation, Omega-3 Fatty Acid Supplementation, or a Strength-Training Exercise Program on Clinical Outcomes in Older Adults: The DO-HEALTH Randomized Clinical Trial.
Double-blind, placebo-controlled RCT among 2157 older adults testing vitamin D3, omega-3s, and exercise on 6 health outcomes. No statistically significant benefits were found for blood pressure, physical performance, cognitive function, infection rates, or nonvertebral fractures over 3 years.
The effect of calcium and vitamin D compounds on bone mineral density in patients undergoing glucocorticoid therapies: a network meta-analysis.
Network meta-analysis of 16 RCTs with 1073 patients undergoing glucocorticoid therapy, examining the effect of vitamin D and calcium compounds on bone mineral density. Alfacalcidol+calcium showed the greatest increase in lumbar spine BMD, and calcitriol+calcium showed the greatest increase in femoral neck BMD.
The Effects of Vitamin D-Enriched Mushrooms and Vitamin D3 on Cognitive Performance and Mood in Healthy Elderly Adults: A Randomised, Double-Blinded, Placebo-Controlled Trial
This 6-month randomized, double-blinded, placebo-controlled trial studied the effects of vitamin D3, enhanced vitamin D2 in a mushroom matrix, standard mushroom, and placebo on cognition and mood in 436 healthy elderly adults. The study found that vitamin D3 supplementation maintained serum vitamin D levels but did not significantly affect cognitive function or mood.
Adverse Effects of High‐Dose Vitamin D Supplementation on Volumetric Bone Density Are Greater in Females than Males
RCT of 311 healthy vitamin D–sufficient individuals aged 55 to 70 years, examining the effects of high-dose vitamin D supplementation (400 IU, 4000 IU, 10,000 IU) on bone density and strength over three years. The study found a negative dose-response relationship for bone density, with greater losses in females compared to males, particularly at higher doses.
Effect of daily 2000 IU versus 800 IU vitamin D on blood pressure among adults age 60 years and older: a randomized clinical trial.
This randomized, double-blind trial compared the effects of daily 2000 IU versus 800 IU vitamin D3 supplementation on blood pressure control among adults aged 60 and older. While both doses reduced mean systolic blood pressure to a small extent, 2000 IU significantly reduced systolic blood pressure variability compared to 800 IU. The study lacked a placebo control group.
Vitamin D3 supplementation improves glycemic control in type 2 diabetic patients: Results from an Italian clinical trial.
RCT of 239 type 2 diabetic patients with Vitamin D deficiency, comparing Vitamin D3 supplementation to placebo over 6 months. The Vitamin D3 group showed significant reductions in fasting and post-prandial glucose, HbA1c levels, and required lower doses of hypoglycemic agents and insulin compared to placebo.
Effect of vitamin D3 supplementation on vascular and metabolic health of vitamin D-deficient overweight and obese children: a randomized clinical trial.
Randomized clinical trial in 225 vitamin D-deficient overweight and obese children comparing vitamin D3 supplementation at doses of 1000 or 2000 IU/d versus 600 IU/d. The study found no differences in arterial endothelial function, arterial stiffness, systemic inflammation, or lipid profile, but noted reductions in blood pressure and fasting glucose concentration and improvements in insulin sensitivity with higher doses.
The effects of vitamin D3 supplementation on insulin resistance and glycaemic control in individuals at high risk of type 2 diabetes: a systematic review and meta–analysis
This systematic review and meta-analysis examined the effect of vitamin D3 supplementation on insulin resistance and glycaemic control in individuals with prediabetes. The meta-analysis of ten studies showed a modest reduction in fasting plasma glucose after vitamin D3 supplementation, but no effect on other primary outcomes. The inclusion of calcium supplements showed a significant reduction in HbA1c.
Vitamin D3 Supplementation: An Option Associated with The Treatment of Multiple Sclerosis:
Systematic review and meta-analysis of observational studies and RCTs on Vitamin D3 supplementation in multiple sclerosis patients. The analysis suggests Vitamin D3 is effective in treatment and offers protective effects against remission outbreaks, with doses of 50,000 IU/week improving neuroimmunological parameters over 12 weeks.
Women's Health Initiative clinical trials: potential interactive effect of calcium and vitamin D supplementation with hormonal therapy on cardiovascular disease.
This study explored the interaction between calcium and vitamin D supplementation and menopausal hormone therapy on cardiovascular disease events in postmenopausal women. Calcium and vitamin D supplementation mitigated the increased risk of stroke associated with conjugated equine estrogens therapy, but did not influence the risk of stroke with CEE + MPA therapy or other cardiovascular endpoints.
Monthly high-dose vitamin D supplementation does not increase kidney stone risk or serum calcium: results from a randomized controlled trial.
The ViDA study was a randomized, double-blind, placebo-controlled trial in 5110 participants in Auckland, New Zealand, investigating the impact of monthly 100,000 IU vitamin D3 supplementation on kidney stone events and hypercalcemia. Over a median follow-up of 3.3 years, vitamin D3 supplementation did not increase the incidence of kidney stone events or hypercalcemia compared to placebo.
Early High-Dose Vitamin D3 for Critically Ill, Vitamin D-Deficient Patients.
A randomized, double-blind, placebo-controlled trial of early high-dose vitamin D3 supplementation in 1360 critically ill, vitamin D-deficient patients. The study found no significant difference in 90-day mortality or other outcomes between the vitamin D3 and placebo groups.
Effect of Vitamin D and Omega-3 Fatty Acid Supplementation on Kidney Function in Patients With Type 2 Diabetes: A Randomized Clinical Trial.
Randomized clinical trial with 1312 adults with type 2 diabetes testing vitamin D3 and omega-3 fatty acids supplementation for 5 years. No significant difference in change in eGFR was found between supplementation and placebo groups, indicating no effect on kidney function preservation.
Impact of three different daily doses of vitamin D3 supplementation in healthy schoolchildren and adolescents from North India: a single-blind prospective randomised clinical trial.
A single-blind prospective randomized clinical trial in North India evaluated the efficacy of different doses of vitamin D3 supplementation in 1008 vitamin D-deficient children aged 6-16 years. The study found that daily supplementation with 2000 IU of vitamin D3 resulted in the highest increase in serum 25(OH)D levels, achieving sufficiency in 92.9% of participants, compared to lower doses. Secondary hyperparathyroidism decreased significantly post-supplementation.
Monthly High-Dose Vitamin D Supplementation and Cancer Risk: A Post Hoc Analysis of the Vitamin D Assessment Randomized Clinical Trial
Post hoc analysis of the Vitamin D Assessment (ViDA) study, a randomized, double-blind, placebo-controlled trial with 5108 participants aged 50 to 84 years. The study examined the effect of high-dose monthly vitamin D3 supplementation on cancer incidence and mortality, finding no significant difference between the vitamin D and placebo groups.
Efficacy of vitamin D3 supplementation in reducing incidence of pulmonary tuberculosis and mortality among HIV-infected Tanzanian adults initiating antiretroviral therapy: study protocol for a randomized controlled trial
The Trial of Vitamins-4 (ToV4) is a randomized, double-blind, placebo-controlled trial of vitamin D3 supplementation among 4000 HIV-infected adults with low vitamin D levels initiating ART in Tanzania. The trial aims to determine the effect of vitamin D3 on mortality and pulmonary TB incidence, with secondary outcomes including CD4 T cell reconstitution and bone health.
Effect of maternal vitamin D3 supplementation on maternal health, birth outcomes, and infant growth among HIV-infected Tanzanian pregnant women: study protocol for a randomized controlled trial
The Trial of Vitamins-5 (ToV5) is a randomized, double-blind, placebo-controlled trial studying the effects of maternal vitamin D3 supplementation on HIV-infected pregnant women in Tanzania. The trial aims to assess the impact on maternal HIV disease progression, risk of small-for-gestational age births, and infant stunting at 1 year of age. The study involves 2300 participants and follows them from pregnancy through 12 months postpartum.
SNP rs11185644 of RXRA gene is identified for dose-response variability to vitamin D3 supplementation: a randomized clinical trial
This randomized clinical trial investigated the genetic factors affecting vitamin D3 supplementation response in 2,207 postmenopausal Caucasian women. The study identified SNP rs11185644 near the RXRA gene as significantly associated with 25(OH)D dose-response, suggesting genetic variation influences vitamin D status and response.
The effect of combined resistance exercise training and vitamin D3 supplementation on musculoskeletal health and function in older adults: a systematic review and meta-analysis
This systematic review and meta-analysis evaluated the effectiveness of combined resistance exercise training and vitamin D3 supplementation on musculoskeletal health in older adults. Seven studies with a total of 792 participants were included. The meta-analysis found significant improvements in muscle strength of the lower limb with the intervention, while other outcomes showed small but non-significant positive effects.
Effect of Vitamin D3 Supplementation on Respiratory Tract Infections in Healthy Individuals: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Systematic review and meta-analysis of 15 randomized controlled trials with 7053 individuals assessing the effect of vitamin D3 supplementation on respiratory tract infections. Found a 6% risk reduction in clinical RTIs with vitamin D3, but the result was not statistically significant. Heterogeneity was large and overall study quality was low.
Effect of cholecalciferol supplementation on arterial stiffness: a systematic review and meta-analysis.
Systematic review and meta-analysis of RCTs investigating the impact of cholecalciferol supplementation on arterial stiffness in adults. Analysis of seven RCTs with 547 participants found no significant improvement in markers of arterial stiffness (PWV and AIx) with vitamin D supplementation.
Evaluation of responses to vitamin D3 (cholecalciferol) in patients on dialysis: a systematic review and meta-analysis.
Systematic review and meta-analysis of 9 studies with 368 patients on dialysis for ESRD, evaluating vitamin D3 supplementation. Results showed increased levels of 25(OH)D and 1,25(OH)2D in the treatment group without significant changes in serum calcium or PTH levels, but with increased phosphorus levels.
Maternal vitamin D supplementation during pregnancy and lactation to promote infant growth in Dhaka, Bangladesh (MDIG trial): study protocol for a randomized controlled trial
The Maternal Vitamin D for Infant Growth study is a randomized, placebo-controlled, dose-ranging trial in Dhaka, Bangladesh, assessing the effect of maternal vitamin D3 supplementation during pregnancy and lactation on infant length at 1 year of age. The trial involves 1300 pregnant women and aims to provide insights into the effects of improving maternal-infant vitamin D status in a low-income setting.
Vitamin D supplementation for prevention of mortality in adults.
This systematic review and meta-analysis assessed the effects of vitamin D supplementation on mortality in adults. It included 56 randomized trials with 95,286 participants, mostly elderly women. Vitamin D3 was found to decrease mortality, while vitamin D2, alfacalcidol, and calcitriol did not significantly affect mortality. Vitamin D3 combined with calcium increased the risk of nephrolithiasis, and alfacalcidol and calcitriol increased the risk of hypercalcaemia.
Cardiovascular disease and vitamin D supplementation: trial analysis, systematic review, and meta-analysis.
This study analyzed the effects of vitamin D supplementation on cardiovascular events through the RECORD RCT and a systematic review/meta-analysis. The trial analysis showed vitamin D might protect against cardiac failure but not myocardial infarction or stroke. The systematic review included 21 studies with similar findings.
Vitamin D₃supplementation and childhood diarrhea: a randomized controlled trial.
This double-blind placebo-controlled trial investigated the effect of vitamin D3 supplementation on the incidence and risk of diarrheal illnesses among 3046 high-risk infants in Kabul, Afghanistan. The study found no significant difference in the time to first diarrheal illness or the risk for recurrent diarrheal disease between the vitamin D3 and placebo groups.
Vitamin D supplementation for prevention of mortality in adults.
Meta-analysis of 50 randomized trials with 94,148 participants, primarily elderly women, assessing vitamin D supplementation for mortality prevention. Vitamin D3 decreased mortality, while vitamin D2, alfacalcidol, and calcitriol did not. Vitamin D3 combined with calcium increased nephrolithiasis risk, and alfacalcidol and calcitriol increased hypercalcaemia risk.
The impact of vitamin D supplementation on sudden sensorineural hearing loss in vitamin D deficient patients: A double-blind, placebo-controlled trial: A pilot study.
This double-blind, placebo-controlled trial evaluated the impact of vitamin D3 supplementation on sudden sensorineural hearing loss (SSNHL) in vitamin D deficient patients. The study found that vitamin D supplementation led to significantly greater improvements in hearing at 2000 Hz and 4000 Hz frequencies, which are critical for speech perception, compared to the control group.
The D-FISH Trial: A Randomized, Double-Blind, Non-Inferiority Trial Comparing Fish Processing By-Product-Derived Versus Synthetic Vitamin D3 Supplementation in Adults with Suboptimal 25-Hydroxyvitamin D
The D-FISH trial is a randomized, double-blind, non-inferiority trial comparing fish processing by-product-derived vitamin D3 with synthetic vitamin D3 in adults with suboptimal 25-hydroxyvitamin D levels. The primary endpoint is the change in plasma 25(OH)D levels over 12 weeks, with secondary endpoints including markers of mineral metabolism and tolerability.
COMPARATIVE EFFICACY OF CRYOTHERAPY AND INTRALESIONAL VITAMIN D3 IN PATIENTS WITH PLANTAR WARTS
RCT comparing cryotherapy and intralesional vitamin D3 for plantar warts in 194 patients. Cryotherapy showed a significantly higher clearance rate of 66.0% compared to 45.4% with intralesional vitamin D3.
COMPARISON OF THE EFFICACY OF INTRALESIONAL VITAMIN D3 AND INTRALESIONAL 5 FLUOROURACIL IN TREATMENT OF CUTANEOUS WARTS
RCT comparing intralesional vitamin D3 and 5-FU in 192 patients with cutaneous warts. The 5-FU group showed a higher efficacy rate (82%) compared to the vitamin D3 group (64%), suggesting 5-FU may be preferred for treating cutaneous warts.
The effect of calcitriol and cholecalciferol on inflammatory markers in periprocedural myocardial injury: A randomized controlled trial.
RCT evaluating the impact of calcitriol and cholecalciferol on inflammatory biomarkers in patients undergoing elective PCI. Calcitriol administration was associated with significantly lower levels of hs-CRP, a main cardiac inflammatory marker, compared to control.
Randomized Comparative Study Assessing the Efficacy of Intralesional Measles, Mumps, and Rubella (MMR) Vaccine and Vitamin D3 in Treating Warts
Randomized comparative study assessing the efficacy of intralesional vitamin D3 and MMR vaccine in treating warts. The study found that the MMR vaccine showed a better response than vitamin D3, with 60% clearance in the MMR group compared to 32.5% in the vitamin D3 group.
Impact of high‑dose vitamin D3 supplementation on hematological, hepatic and immune biomarkers, and viral load in patients infected with human immunodeficiency virus: A randomized, double‑blind, multicenter controlled trial
A multicenter, double-blind, randomized, placebo-controlled trial evaluated the impact of high-dose vitamin D3 supplementation on hematological, immunological, and hepatic biomarkers, and viral load in 95 HIV-infected patients on antiretroviral therapy. Vitamin D3 supplementation significantly improved circulating vitamin D concentration, CD4 cell count, leukocytes, lymphocytes, platelets, neutrophil percentage, hemoglobin concentration, and hematocrit values, but did not affect liver enzyme levels or HIV viral load.
Daily Vitamin D3 Versus Stoss Vitamin D3 for Correction of 25OHD Deficiency in Children with Inflammatory Bowel Disease, a Randomised Controlled Trial
RCT comparing daily 2000 IU vitamin D3 supplementation to stoss protocol in children with Paediatric Inflammatory Bowel Disease and 25OHD deficiency. Both methods significantly increased 25OHD levels, with no difference in biochemical, stool, or clinical markers between groups. Stoss protocol was non-inferior to daily supplementation in raising 25OHD levels.
The efficacy of Sarcomeal® oral supplementation plus vitamin D3 on muscle parameters, metabolic factors, and quality of life in diabetic sarcopenia: a randomized controlled clinical trial
RCT investigating the efficacy of Sarcomeal® sachet plus vitamin D3 on muscle parameters, metabolic factors, and quality of life in diabetic sarcopenia. The intervention group showed significant improvements in lean mass and lean mass index, and maintained weight compared to the control group. No significant changes in blood parameters were observed.
Effects of Vitamin D3 Treatment on Polycystic Ovary Symptoms: A Prospective Double-Blind Two-Phase Randomized Controlled Clinical Trial
Prospective, double-blind, two-phase RCT investigating the effects of vitamin D3 supplementation in women with PCOS. The study found improvements in ovarian morphology, menstrual cycle regularity, and ovulation rate, along with a reduction in testosterone levels in certain patients.