Research
Vitamin D
498 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Childhood malnutrition, rickets, and anemia: a systematic review and meta-analysis on global prevalence, determinants, and public health implications.
Systematic review and meta-analysis of 96 studies with 153,694 participants from various regions, examining the prevalence and determinants of childhood malnutrition, rickets, and anemia. The study found strong associations between low calcium and vitamin D intake and nutritional rickets, and demonstrated that supplementation programs effectively decrease rickets and malnutrition.
Effect of diet intervention on symptoms in autism spectrum disorder: An umbrella review.
Umbrella review of 15 meta-analyses covering 118 clinical studies with 5033 ASD patients, evaluating dietary interventions like GFCF diets, probiotics, Vitamin D, and PUFAs. Dietary interventions significantly improved overall symptoms, communication, social interaction, and hyperactivity in ASD, with Vitamin D showing the most significant effect on overall symptoms.
Comparative Efficacy of Medical Therapies in Reducing the Risk of Postoperative Recurrence in Crohn's Disease: A Systematic Review and Network Meta-Analysis.
Systematic review and network meta-analysis comparing the efficacy of medical treatments in preventing postoperative recurrence of Crohn's disease. Anti-tumor necrosis factor agents, adalimumab and infliximab, were most effective. Nonpharmacological interventions like curcumin, vitamin D, and probiotics did not demonstrate efficacy.
Pregnancy and Lactation Associated Osteoporosis of the Hip: A Systematic Review.
Systematic review of 64 studies totaling 149 cases of pregnancy and lactation associated osteoporosis (PLO) of the hip. Treatment included modified weight-bearing, vitamin D and/or calcitriol, and surgery. The review highlights the need for further research on metabolic disease workup in PLO cases.
Low Dose Versus High Dose Vitamin D for Treatment of Nutritional Rickets: A Systematic Review and Meta-analysis.
Systematic review and meta-analysis comparing low-dose versus high-dose vitamin D regimens for treating nutritional rickets in children. No statistically significant or clinically meaningful differences were found in serum 25(OH)D levels, radiological improvement, or other outcomes between the dosing regimens.
Vitamin D supplementation to prevent acute respiratory infections: systematic review and meta-analysis of stratified aggregate data.
This systematic review and meta-analysis examined the effect of vitamin D supplementation on the prevention of acute respiratory infections (ARIs) using data from 43 RCTs with 61,589 participants. The analysis found no statistically significant effect of vitamin D on overall ARI risk, with no evidence of effect modification by age, baseline vitamin D status, dosing frequency, or dose size.
Vitamin D in the Breast Cancer Continuum: A Systematic Review and Meta-Analysis of Primary Prevention, Patient Prognosis, and Adjunctive Treatment Response
Systematic review and meta-analysis of vitamin D's role in breast cancer prevention, prognosis, and treatment. Vitamin D supplementation showed no effect on primary prevention but was linked to better prognosis in cohort studies. Meta-analysis indicated improved pathological complete response rates during neoadjuvant chemotherapy, especially in hormone receptor-negative/triple-negative breast cancer patients.
Vitamin D supplementation vs. placebo and incident type 2 diabetes in an ancillary study of the randomized Vitamin D and Omega-3 Trial.
This study is an ancillary analysis of the VITAL trial, evaluating the effect of vitamin D supplementation (2000 IU/day) on the risk of type 2 diabetes (T2D) in older US adults. The study found no significant reduction in T2D incidence with vitamin D supplementation compared to placebo. A meta-analysis of four trials showed a modest reduction in T2D risk.
Is Vitamin D Fortification of Dairy Products Effective for Improving Vitamin D Status? A Systematic Review and Meta-Analysis of Randomised Controlled Trials
Systematic review and meta-analysis of 35 RCTs involving 4965 participants to assess the efficacy of vitamin D-fortified dairy products in improving serum 25-hydroxyvitamin D concentrations. Results showed significant increases in serum 25(OH)D levels with vitamin D3 and D2-fortified milk, milk powder, yoghurt, and yoghurt drinks, with mixed results for fortified cheese.
Effects of vitamin D supplements on bone metabolism in kidney transplant recipients: a systematic review and meta-analysis.
Systematic review and meta-analysis of 14 studies involving 985 kidney transplant recipients examining the effects of vitamin D supplementation on bone metabolism. Vitamin D significantly improved bone mineral density at the femoral neck, reduced serum PTH and BAP levels, and increased serum calcium levels, but also increased the risk of hypercalcemia. No significant effects were observed on lumbar spine BMD, fracture incidence, or acute graft rejection.
Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial
Post hoc analysis of the DO-HEALTH trial with 777 participants examining the effects of vitamin D, omega-3, and exercise on DNA methylation clocks of biological aging over 3 years. Omega-3 alone slowed several DNAm clocks, and all three treatments had additive benefits on PhenoAge, indicating a small protective effect on slowing biological aging.
The effect of pregnancy vitamin D supplementation on maternal blood pressure: real-world data analysis within the MAVIDOS randomised placebo-controlled trial.
The MAVIDOS randomised placebo-controlled trial studied the effect of 1000 IU/day vitamin D supplementation on maternal blood pressure and hypertensive disorders during pregnancy. The study found no significant differences in blood pressure or incidences of pregnancy-induced hypertension and preeclampsia between the vitamin D and placebo groups.
Dose–response effects of vitamin D supplementation on vitamin D status, glycosylated hemoglobin and total cholesterol in patients with diabetes mellitus: a systematic review and meta-analysis
Systematic review and meta-analysis of seven studies involving 468 diabetic patients examining the effects of vitamin D supplementation on vitamin D status, glycosylated hemoglobin (HbA1c), and total cholesterol (TC) levels. High-dose vitamin D supplementation significantly increased vitamin D levels and improved glycemic control, but did not significantly affect TC levels.
Can vitamin D supplementation affect cardiometabolic factors in children and adolescence with overweight and obesity? A grade-assessed systematic review and meta-analysis of randomized controlled trials
This meta-analysis assessed the effects of vitamin D supplementation on cardiometabolic risk factors in obese/overweight children and adolescents. It included nine studies with 440 participants and found that vitamin D supplementation did not significantly improve BMI, glycemic state, or lipid profile, except for a significant reduction in HDL-C levels. Vitamin D2 showed a greater reduction in HOMA-IR compared to vitamin D3.
The effect of nutraceutical interventions on reproductive health outcomes in women with polycystic ovary syndrome: A systematic review and meta-analysis.
Systematic review and meta-analysis of 78 studies evaluating nutraceutical interventions on reproductive and metabolic outcomes in women with PCOS. Nutraceuticals, including vitamin D, significantly reduced fasting insulin and luteinizing hormone, and increased sex-hormone-binding globulin. Vitamin D showed the strongest metabolic and hormonal improvements.
Effects of Vitamin D and E Supplementation on Prevention of Bronchopulmonary Dysplasia (BPD) in Premature Neonates: A Systematic Review and Meta-analysis.
Systematic review and meta-analysis examining the effects of vitamin D and E supplementation on the prevention of bronchopulmonary dysplasia (BPD) in preterm neonates. Vitamin D supplementation significantly reduced the risk of BPD, while vitamin E did not show a significant effect.
Systematic review of optimizing brain-targeted vitamin D delivery: Novel approaches to enhance mental illness therapeutics.
This systematic review evaluates strategies for optimizing brain-targeted vitamin D delivery, focusing on molecular, physiological, and technological approaches to enhance its efficacy in mental disorders. Strategies such as nanotechnology and transporter-mediated delivery show promise in enhancing vitamin D brain uptake.
Vitamin D Supplementation and Allergic Rhinitis: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of 5 RCTs examining vitamin D supplementation for allergic rhinitis. Vitamin D supplementation alleviated symptoms compared to placebo, though differences were not significant. Effects varied by sex and concomitant corticosteroid use.
Effect of Vitamin D Supplementation on Lipid Profile in Overweight or Obese Women: A Meta-analysis and Systematic Review of Randomized Controlled Trials.
Meta-analysis and systematic review of RCTs assessing the effect of vitamin D on lipid profile in overweight or obese women. Vitamin D supplementation resulted in significant reductions in triglycerides and total cholesterol, and an increase in HDL-C concentrations, but no significant effect on LDL-C.
Managing pediatric metabolic syndrome: a systematic review of current approaches.
Systematic review of 31 articles on managing pediatric metabolic syndrome (MetS) through lifestyle modifications, dietary changes, and pharmacological interventions. The Mediterranean and DASH diets improved MetS profiles, while vitamin D supplementation showed favorable effects. Omega-3 supplements had inconsistent effects, and natural products like fermented camel milk, grape juice, and pomegranate juice did not significantly improve MetS.
Micronutrients, Vitamin D, and Inflammatory Biomarkers in COVID-19: A Systematic Review and Meta-analysis of Causal Inference Studies.
Systematic review and meta-analysis of Mendelian randomization studies assessing the role of micronutrients, particularly vitamin D, in COVID-19 risk and outcomes. The analysis found no significant causal link between vitamin D/micronutrients and COVID-19 outcomes, though some studies reported associations with inflammatory markers.
Does Vitamin D Supplementation Impact Fibromyalgia-Related Pain? A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed the efficacy of vitamin D supplementation in reducing pain and improving quality of life in fibromyalgia patients. Results showed that vitamin D supplementation significantly reduced pain levels compared to the control group, with improvements observed using the NRS, VAS, and FIQ scales.
Association between vitamin D serum levels and thyroid cancer: a meta-analysis.
This meta-analysis evaluated the association between serum vitamin D levels and thyroid cancer (TC) risk. It included 23 studies and found that TC patients had significantly lower serum vitamin D levels and a higher prevalence of vitamin D deficiency compared to controls. Seasonal variation in vitamin D sampling was identified as a key source of heterogeneity.
Effect of vitamin D, calcium, or combined supplementation on fall prevention: a systematic review and updated network meta-analysis.
This systematic review and network meta-analysis assessed the efficacy of vitamin D, calcium, and combined supplementation in preventing falls in older adults. Vitamin D supplementation at 800-1000 IU/d was associated with a lower risk of falls compared to placebo or no treatment, while high-dose vitamin D (>1000 IU/day) increased the risk of falls. The analysis included 35 RCTs with 58,937 participants.
Optimal methods of vitamin D supplementation to prevent acute respiratory infections: a systematic review, dose-response and pairwise meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of 43 RCTs with 49320 participants examining vitamin D supplementation for preventing acute respiratory infections (ARIs). Overall, no significant preventive effects were found, but daily dosing of 400-1200 IU/day showed slight preventive effects in certain subgroups and seasons.
A systematic review and meta-analysis of the linkage between low vitamin D and the risk as well as the prognosis of stroke.
This systematic review and meta-analysis examined the connection between serum vitamin D levels and stroke risk and prognosis. It included 27 studies with 45,302 participants, finding that lower vitamin D levels are associated with a higher risk of ischemic stroke and a worse prognosis after stroke. No significant relationship was found between vitamin D levels and hemorrhagic stroke risk.
Effect of vitamin D status and vitamin D supplementation on immune function and prevention of acute respiratory tract infections in dark-skinned individuals: a systematic review and meta-analysis.
This systematic review and meta-analysis examined the relationship between vitamin D status and supplementation on immune function and prevention of acute respiratory tract infections in dark-skinned individuals. An inverse association was found between vitamin D status and inflammatory biomarkers in some studies, but no significant effect of vitamin D supplementation on ARTI incidence was observed.
Vitamin D Levels in Patients with Noninfectious Uveitis: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of 9 studies with 10,711 patients, examining the correlation between vitamin D levels and noninfectious uveitis. Patients with noninfectious uveitis showed higher rates of vitamin D deficiency compared to controls. Inactive uveitis patients had better vitamin D status than those with active uveitis.
Efficacy of vitamin D supplementation on the incidence of preeclampsia: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the impact of vitamin D supplementation on the incidence of preeclampsia and related maternal and neonatal outcomes. It included 33 RCTs with 10,613 participants, finding that vitamin D supplementation significantly reduced the risk of preeclampsia by 44.8% and preterm labor by 30%. Serum 25-hydroxyvitamin D levels increased significantly in the supplementation group, but no significant differences were observed in low birth weight or Apgar scores.
Association between vitamin D deficiency and benign paroxysmal positional vertigo (BPPV) incidence and recurrence: a systematic review and meta-analysis.
Systematic review and meta-analysis examining the relationship between serum vitamin D levels and the risk of developing benign paroxysmal positional vertigo (BPPV) incidence and recurrence. Lower serum vitamin D levels were associated with increased BPPV incidence, but the relationship with BPPV recurrence remained uncertain.
The association between vitamin D deficiency and multiple sclerosis: an updated systematic review and meta-analysis.
This updated systematic review and meta-analysis examined the association between vitamin D deficiency and multiple sclerosis (MS) across 14 case-control studies. Vitamin D deficiency was associated with a 54% higher risk of MS, with a stronger association in studies excluding participants taking vitamin D supplements.
The Association of Vitamin D with Uterine Fibroids in Premenopausal Patients: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of 3 RCTs and 23 observational studies examining the association between vitamin D and uterine fibroids in premenopausal patients. Vitamin D supplementation was associated with a significant reduction in fibroid size and lower serum vitamin D concentrations were linked to higher odds of fibroid presence.
High-dose oral vitamin D supplementation for prevention of infections in children aged 0 to 59 months: a systematic review and meta-analysis.
Systematic review and meta-analysis of seven trials with 5748 children evaluating high-dose vitamin D supplementation (>400 IU) for infection prevention. No significant effect on upper respiratory tract infections, but reduced incidence of influenza/cold, cough, and fever. Findings are based on limited trials and should be interpreted with caution.
Prevalence of Vitamin D Deficiency Among Adults in Kazakhstan: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis determined the mean prevalence of vitamin D deficiency among adults in Kazakhstan. The pooled mean prevalence of vitamin D deficiency was found to be 57% in the adult population, with 60% prevalence among those with chronic conditions and 55% among healthy adults.
Efficacy of vitamin D supplementation on glycaemic control in type 2 diabetes: An updated systematic review and meta-analysis of randomized controlled trials.
This meta-analysis of 39 randomized controlled trials involving 2982 subjects assessed the effects of vitamin D supplementation on glycaemic control in type 2 diabetes patients. Results showed significant reductions in fasting blood glucose, HbA1c, HOMA-IR, and fasting insulin levels, particularly with short-term, high-dose vitamin D in patients with deficiency or high baseline HbA1c.
The impact of vitamin D administration on mortality in COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of 19 randomized controlled trials with 2495 participants evaluating the impact of vitamin D supplementation on mortality in COVID-19 patients. The meta-analysis showed a significant reduction in all-cause mortality with vitamin D supplementation, especially in severe COVID-19 cases.
Vitamin D for the management of chronic obstructive pulmonary disease.
Meta-analysis of 10 double-blind, randomised, placebo-controlled trials involving 1372 adults with COPD, assessing the effects of vitamin D supplementation. The study found that vitamin D administration results in little to no effect on the rate of moderate or severe exacerbations, lung function, serious adverse events, mortality, or quality of life.
Ethnic Differences in Response to Oral Vitamin D Supplementation: A Systematic Review and Meta-analysis.
Systematic review and meta-analysis assessing the impact of ethnicity on response to oral vitamin D supplementation. Data from 18 studies with 1131 participants showed that Asian and White participants had a higher increase in dose and BMI-adjusted 25(OH)D3 blood levels compared to Arab and Black participants. Ethnicity was found to significantly affect vitamin D response.
Vitamin D Supplementation for Treating Atopic Dermatitis in Children and Adults: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of 11 RCTs with 686 participants assessing vitamin D supplementation for atopic dermatitis (AD) in children and adults. Vitamin D supplementation significantly reduced AD severity compared to control, with a standardized mean difference of -0.41.
Vitamin D status and neuromyelitis optica spectrum disease: A systematic review and meta-analysis.
Systematic review and meta-analysis assessing serum vitamin D levels in patients with neuromyelitis optica spectrum disorder (NMOSD) versus healthy controls. The analysis included 6 studies with 319 patients and 595 controls, finding significantly lower vitamin D levels in NMOSD patients.
Effect of vitamin D supplementation or fortification on bone turnover markers in women: a systematic review and meta-analysis.
This meta-analysis investigated the effects of vitamin D supplementation/fortification on bone turnover markers in women. It found that vitamin D significantly reduced bone resorption markers but showed inconsistent results for bone formation markers. Subgroup analysis indicated significant reductions in P1NP level with doses less than 600 μg/d and larger sample sizes.
Effect of vitamin D supplementation on lipid profile, and hormonal functions in polycystic ovary syndrome: An umbrella systematic review and meta-analysis.
Umbrella meta-analysis of RCTs assessing vitamin D supplementation in PCOS patients. Vitamin D significantly reduced TG, TC, LDL-c, DHEA, and TT levels, but had no significant effect on HDL-c, insulin, and BMI. It showed potential benefits for lipid profile and hormonal function in PCOS.
Vitamin D levels and the risk of overactive bladder: a systematic review and meta-analysis.
This systematic review and meta-analysis examined the association between vitamin D deficiency and overactive bladder or urinary incontinence. It found that vitamin D deficiency increases the risk of these conditions, while vitamin D supplementation reduces the risk of urinary incontinence.
The effect of vitamin D on the lipid profile in individuals with overweight or obesity: A meta-analysis and systematic review of randomized controlled trials.
Meta-analysis and systematic review of randomized controlled trials assessing the effect of vitamin D on the lipid profile in individuals with overweight or obesity. Vitamin D supplementation did not significantly alter LDL-C, HDL-C, and TC concentrations, but significantly decreased triglyceride levels in certain subgroups.
The relationship of vitamin D deficiency and childhood diarrhea: a systematic review and meta-analysis.
Systematic review and meta-analysis examining the relationship between vitamin D deficiency and childhood diarrhea. The meta-analysis found a statistically significant association between vitamin D deficiency and increased risk of diarrhea in children in developing countries.
The Effect of Vitamin D Supplementation on Glycemic Control and Cardiovascular Risk Factors in Type 2 Diabetes: An Updated Systematic Review and Meta-Analysis of Clinical Trials.
This meta-analysis investigated the effect of vitamin D supplementation on glycemic control and cardiovascular risk factors in patients with Type 2 diabetes. The findings revealed that vitamin D supplementation significantly decreased HbA1C, fasting blood sugar, systolic blood pressure, and LDL, while increasing HDL and vitamin D levels. The study suggests that vitamin D supplementation can significantly improve glycemic control and reduce the risk of complications associated with Type 2 diabetes, especially cardiovascular diseases.
Optimizing vitamin D status in polycystic ovary syndrome: a systematic review and dose-response meta-analysis.
Systematic review and dose-response meta-analysis of vitamin D supplementation in women with polycystic ovary syndrome (PCOS). The analysis found a dose-response relationship, with serum 25(OH)D levels increasing up to doses of approximately 3000 IU/day, after which the effect plateaued. The benefit of doses >3000 IU/day appears minimal, and further data is needed for doses >5000 IU/day.
Relationship between vitamin D levels and pediatric celiac disease: a systematic review and meta-analysis
Systematic review and meta-analysis examining the relationship between Vitamin D levels and pediatric celiac disease. Vitamin D levels were lower in CD patients compared to healthy controls, and deficiency was more prevalent in CD patients. 25(OH)D3 levels increased in CD patients after a gluten-free diet.
Association of vitamin D levels and oral lichen planus. Systematic review and meta-analysis.
Systematic review and meta-analysis assessing vitamin D levels in patients with oral lichen planus (OLP) compared to healthy individuals. The analysis found that patients with OLP have statistically lower vitamin D levels than healthy patients, suggesting a potential link between vitamin D deficiency and OLP.
Vitamin D and Risk of Incident Type 2 Diabetes in Older Adults: An Updated Systematic Review and Meta-Analysis.
This updated systematic review and meta-analysis examined the association between low serum 25OHD levels and incident type 2 diabetes in older adults. The study found that low vitamin D levels were associated with an increased risk of developing diabetes, even after adjusting for potential confounders, confirming previous findings.
The Association between Vitamin D Deficiency and the Risk of Mortality after Hip Fractures: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis exploring the association between low vitamin D levels and mortality in hip fracture patients. Found a strong connection between vitamin D deficiency (<20 ng/mL) and increased mortality risk, particularly in European studies. Insufficient and sufficient vitamin D levels did not significantly affect mortality outcomes.
The association between the triglyceride-glucose index and vitamin D status: a systematic review and meta-analysis.
This systematic review and meta-analysis explored the association between the triglyceride-glucose (TyG) index and vitamin D status. The analysis of nine studies found that patients with vitamin D deficiency had a significantly higher TyG index compared to those without deficiency. A negative correlation was observed between the TyG index and vitamin D levels, suggesting a potential role of vitamin D in metabolic health.
Preventive Vitamin D Supplementation and Risk for COVID-19 Infection: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis examining the protective role of preventive vitamin D supplementation against COVID-19 incidence, mortality, and ICU admission. Findings indicate vitamin D supplementation has a protective effect against COVID-19 incidence and ICU admission.
Association of Vitamin D Levels with Risk of Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis of Prospective Studies.
Systematic review and meta-analysis of prospective studies examining the association between vitamin D levels and risk of cognitive impairment and dementia. Vitamin D deficiency was associated with increased risks of dementia, Alzheimer's disease, and cognitive impairment. Nonlinear relationships suggest optimal 25(OH)D levels for reducing dementia risk.
Effects of vitamin D supplementation on metabolic syndrome parameters in patients with obesity or diabetes in Brazil, Europe, and the United States: A systematic review and meta-analysis.
Systematic review and meta-analysis of 12 RCTs on vitamin D supplementation effects on Metabolic Syndrome parameters in patients with obesity or type 2 diabetes. Vitamin D supplementation had no effect on most outcomes, but reduced fasting blood glucose and glycated hemoglobin in some subgroups, and reduced diastolic blood pressure in participants with vitamin D deficiency. Evidence quality varied from moderate to very low.
Prevalence of vitamin D deficiency in South America: a systematic review and meta-analysis.
Systematic review and meta-analysis estimating the prevalence of vitamin D deficiency in South American populations. The study included 96 studies with a total of 227,758 participants, finding an overall deficiency prevalence of 34.76%. Significant differences in prevalence were related to age, sex, country, latitude, season, and year of publication.
Association between vitamin D deficiency and lipid profiles in overweight and obese adults: a systematic review and meta-analysis.
Systematic review and meta-analysis of 21 articles involving 7952 overweight or obese adults. The study found that vitamin D deficiency is associated with impaired lipid profiles, including increased triglycerides, total cholesterol, and LDL levels, and reduced HDL levels.
Prevalence and associated factors of vitamin D deficiency after Roux-en-Y gastric bypass: a systematic review and meta-analysis
Systematic review and meta-analysis estimating the prevalence and associated factors of vitamin D deficiency (VDD) after Roux-en-Y gastric bypass (RYGB). The analysis included 72 studies with 7688 individuals, finding a 42% prevalence of VDD post-RYGB. VDD prevalence increased with longer follow-up times and was higher in populations with inadequate vitamin D supplementation, high presurgical VDD, noncompliance, and among black populations.
Effects of Vitamin D Supplementation on Cognitive Outcomes: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis of 24 randomized controlled trials investigated the effects of vitamin D supplementation on global cognitive function and specific cognitive domains in 7557 participants. The meta-analysis found that vitamin D significantly influenced global cognition, with a stronger effect in vulnerable populations and those with baseline vitamin D deficiency.
Vitamin D deficiency and non-infectious uveitis: A systematic review and Meta-analysis.
Systematic review and meta-analysis investigating the relationship between vitamin D deficiency and non-infectious uveitis (NIU). The analysis included 11 studies, with 5 meta-analyzed, showing that vitamin D deficiency is associated with a higher risk of developing NIU. The findings suggest vitamin D may play a role in NIU pathophysiology, and supplementation could be a potential therapeutic strategy.
Obstructive sleep apnea and vitamin D: an updated systematic review and meta-analysis.
Systematic review and meta-analysis of 18 observational studies involving 5592 individuals. Patients with obstructive sleep apnea (OSA) had significantly lower serum 25-OHD levels and higher prevalence of vitamin D deficiency compared to those without OSA. CPAP treatment did not significantly change serum 25-OHD levels.
Pharmacological agents for bone fracture healing: talking points from recent clinical trials.
Systematic review of 19 RCTs with 4067 patients on pharmacological agents for bone fracture healing. Vitamin D and calcium supplementation, among other agents, did not influence bony healing. Calcitonin could favor bone fracture healing, while the effect of parathormone remains controversial.
The Effect of Maternal Vitamin D Supplementation on Vitamin D Status of Exclusively Breastfeeding Mothers and Their Nursing Infants: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
Systematic review and meta-analysis of 19 clinical trials with 3337 breastfeeding mothers, examining the effect of maternal vitamin D supplementation on vitamin D status in mothers and their nursing infants. Maternal supplementation increased serum 25(OH)D concentrations in both mothers and infants, with a nonlinear response in mothers and a linear response in infants. High-dose supplementation (>6000 IU/d) effectively corrected vitamin D deficiency.
The effect of pregnancy vitamin D supplementation on offspring bone mineral density in childhood: a systematic review and meta-analysis.
Systematic review and meta-analysis of RCTs assessing the effect of moderate- to high-dose vitamin D supplementation during pregnancy on offspring bone mineral density (BMD) in childhood. The meta-analysis found a positive effect on offspring BMD at age 4-6 years, with a smaller effect on bone mineral content.
Vitamin D for the management of asthma.
This updated meta-analysis included 20 studies with 2225 participants to evaluate the effectiveness of vitamin D supplementation in reducing asthma exacerbations and improving asthma control. The analysis found no significant effect of vitamin D on reducing asthma exacerbations or improving asthma control, with high-quality evidence supporting these findings.
Association between vitamin D level and respiratory distress syndrome: A systematic review and meta-analysis.
This systematic review and meta-analysis explored the association between vitamin D levels and respiratory distress syndrome (RDS) in preterm infants. It included 15 studies with 2,051 preterm infants and found significant associations between vitamin D deficiency and increased risk of RDS development.
Vitamin D supplementation for improving bone density in vitamin D-deficient children and adolescents: systematic review and individual participant data meta-analysis of randomized controlled trials.
Systematic review and individual participant data meta-analysis of 11 RCTs on vitamin D supplementation in children and adolescents. The study found a small effect on total hip areal BMD but no significant effects on other bone density outcomes. The findings suggest that clinically important benefits for bone density from 1-year vitamin D supplementation are unlikely.
Vitamin D and gastric cancer - A systematic review and meta-analysis.
Systematic review and meta-analysis exploring the association between serum vitamin D levels and gastric cancer. Analyzed 10 trials with 1159 gastric cancer patients and 33,387 controls. Found that lower vitamin D levels were associated with higher occurrence and advanced pathological grades of gastric cancer, suggesting low vitamin D levels might predict poor prognosis.
Association between vitamin D deficiency and vasovagal syncope: A systematic review and meta-analysis.
Systematic review and meta-analysis investigating the association between vitamin D deficiency and vasovagal syncope (VVS). The analysis included six studies with 954 cases, showing that VVS patients had significantly lower vitamin D serum levels compared to controls, and VVS occurrence was higher in vitamin D-deficient individuals.
Vitamin D status and supplementation before and after Bariatric Surgery: Recommendations based on a systematic review and meta-analysis.
Systematic review and meta-analysis of vitamin D status and supplementation in bariatric surgery patients. Preoperative vitamin D insufficiency was prevalent, and postoperative high-dose vitamin D supplementation improved 25(OH)D levels and reduced insufficiency rates.
Bone mineral density, vitamin D and osseous metabolism indices in neurofibromatosis type 1: A systematic review and meta-analysis.
This systematic review and meta-analysis investigated the effects of neurofibromatosis type 1 (NF1) on bone mineral density (BMD) and osseous metabolic indices. The study found decreased BMD at the lumbar spine and femur in NF1 patients, with increased serum levels of PTH and CTX, while vitamin D, calcium, and other bone markers were not significantly altered.
Effect of Vitamin D Supplementation on Primary Dysmenorrhea: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Systematic review and meta-analysis of 8 RCTs involving 695 participants assessing vitamin D supplementation for primary dysmenorrhea. Results showed significantly lower pain levels in the vitamin D group compared to placebo, suggesting vitamin D as an alternative treatment for dysmenorrhea pain relief.
Vitamin D and Sjögren's Disease: Revealing the Connections-A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of 9 studies assessing vitamin D levels in Sjögren's disease (SD) patients compared to healthy controls. The analysis found a high prevalence of hypovitaminosis D in SD patients, suggesting lower levels of vitamin D in these patients.
Vitamin D in psoriatic arthritis - A systematic review and meta-analysis.
This systematic review and meta-analysis summarized evidence on vitamin D status in patients with psoriatic arthritis (PsA), focusing on disease activity. It included four studies with 264 PsA patients and 287 healthy controls, and five studies with 225 PsA patients and 391 psoriasis patients. Vitamin D levels were lower in PsA patients compared to healthy controls, but higher compared to psoriasis patients.
Myasthenia Gravis and Vitamin D Serum Levels: A Systematic Review and Meta-analysis.
Systematic review and meta-analysis assessing Vitamin D levels in Myasthenia Gravis (MG) patients compared to healthy controls. The analysis included five studies with a total of 450 individuals, showing significantly lower Vitamin D levels in MG patients, suggesting routine checking and possible correction.
Effects of vitamin D supplementation on maximal strength and power in athletes: a systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of 11 RCTs involving 436 athletes assessing the effects of vitamin D supplementation on muscle strength and power. Results showed no statistically significant effect of vitamin D on improving maximum strength and power, though further research is needed.
Effect of Vitamin D Supplementation on Serum 25-Hydroxyvitamin D and Homeostatic Model of Insulin Resistance Levels in Healthy Pregnancy: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the effect of vitamin D supplementation on serum 25-hydroxyvitamin D and insulin resistance levels in non-diabetic pregnant women. Vitamin D supplementation increased 25(OH)D levels and decreased HOMA-IR levels, with high doses further reducing HOMA-IR.
Effect of Vitamin D Supplementation on Fatigue in Multiple Sclerosis: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of RCTs assessing the effect of vitamin D supplementation on fatigue in multiple sclerosis patients. The analysis included five studies with 345 individuals and found a significant reduction in fatigue with vitamin D supplementation compared to control.
A nutritional supplement during preconception and pregnancy increases human milk vitamin D but not B-vitamin concentrations.
Double-blind RCT investigated the effects of maternal supplementation from preconception through pregnancy on human milk concentrations of vitamin D and B-vitamins. The intervention increased human milk vitamin D concentrations by 20% but had no effect on B-vitamin concentrations.
Vitamin D as adjuvant therapy for diabetic foot ulcers: Systematic review and meta-analysis approach.
Systematic review and meta-analysis assessing the effect of vitamin D supplementation on diabetic foot ulcer outcomes. The analysis included 4 papers with 197 participants, showing significant improvements in ulcer area, serum Vitamin D, Total Cholesterol, Fasting Plasma Glucose, Triglyceride, C-Reactive Protein, and HbA1c levels.
Impact of vitamin D supplementation on markers of bone turnover: Systematic review and meta-analysis of randomised controlled trials.
Systematic review and meta-analysis of 42 RCTs examining the impact of vitamin D supplementation on bone turnover markers in adults. Vitamin D administration decreased DPD, PINP, and ALP levels, indicating reduced bone turnover, but had no significant effect on CTX or OC levels.
Prevalence of Vitamin-D deficiency and insufficiency among prisoners across the globe: A systematic review and meta-analysis.
Systematic review and meta-analysis of vitamin D deficiency prevalence among prisoners worldwide. The pooled prevalence of vitamin D deficiency was found to be 55%, with 29.41% having insufficient levels.
Does vitamin D reduce the mortality rate of Plasmodium infection?: a systematic review and meta-analysis.
This systematic review and meta-analysis investigated the effect of vitamin D administration on the survival rate of Plasmodium-infected animals. The study found a statistically significant positive effect of vitamin D on survival rates in infected mice on days 6 and 10 post-infection, with subgroup analyses showing significant effects for cholecalciferol, higher doses, and oral administration.
Dietary interventions for perinatal depression and anxiety: a systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of dietary interventions for perinatal depression and anxiety. Polyunsaturated fatty acids and elemental metals were not effective, but vitamin D showed a small to medium effect size improvement in postpartum depression.
Association of vitamin D in individuals with periodontitis: an updated systematic review and meta-analysis.
This meta-analysis compared vitamin D levels in individuals with and without periodontitis and assessed the effects of vitamin D supplementation during scaling and root planing on periodontal clinical parameters. It found that periodontitis is associated with lower serum vitamin D levels and that vitamin D supplementation significantly improves periodontal clinical parameters when used alongside nonsurgical periodontal therapy.
Infections and Autoimmunity—The Immune System and Vitamin D: A Systematic Review
This systematic review examines the role of vitamin D in enhancing immunity and preventing autoimmunity. It suggests that maintaining serum 25(OH)D concentrations above 50 ng/mL reduces risks of infections, sepsis, and autoimmune disorders. The review highlights the cost-effectiveness of treating vitamin D deficiency and the high prevalence of deficiency worldwide.
RETRACTED: Protective Effect of Vitamin D Supplementation on COVID-19-Related Intensive Care Hospitalization and Mortality: Definitive Evidence from Meta-Analysis and Trial Sequential Analysis
Meta-analysis and trial sequential analysis of five RCTs assessing the protective role of vitamin D supplementation on COVID-19-related mortality and ICU admission. Results suggest vitamin D administration decreases the risk of death and ICU admission, though further studies are needed for conclusive evidence on mortality risk.
Effects of vitamin D supplementation in obese and overweight children and adolescents: A systematic review and meta-analysis.
Systematic review and meta-analysis evaluating the effect of vitamin D supplementation in overweight and obese children and adolescents. The meta-analysis showed a slight increase in 25(OH)D levels with vitamin D supplementation, but effects on metabolic and cardiovascular outcomes were controversial.
Using a Topical Formulation of Vitamin D for the Treatment of Vitiligo: A Systematic Review.
Systematic review of topical vitamin D formulations, including cholecalciferol, calcipotriol, and tacalcitol, for treating vitiligo. The review highlights vitamin D's role in stimulating melanin synthesis and its potential to enhance therapeutic outcomes when combined with other treatments like NB-UVB. Combining vitamin D analogues with corticosteroids shows superior efficacy in treating vitiligo.
Vitamin D and Risk for Type 2 Diabetes in People With Prediabetes : A Systematic Review and Meta-analysis of Individual Participant Data From 3 Randomized Clinical Trials.
Systematic review and meta-analysis of three randomized trials evaluating vitamin D supplementation in adults with prediabetes. Vitamin D reduced the risk for diabetes by 15% and increased the likelihood of regression to normal glucose regulation by 30%.
Comparison of the Effect of Daily Vitamin D2 and Vitamin D3 Supplementation on Serum 25-Hydroxyvitamin D Concentration (Total 25(OH)D, 25(OH)D2, and 25(OH)D3) and Importance of Body Mass Index: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis comparing the effects of vitamin D2 and vitamin D3 supplementation on serum 25-hydroxyvitamin D concentrations. Vitamin D3 was found to be superior to vitamin D2 in raising total 25(OH)D levels, although both had similar positive impacts on their respective hydroxylated forms. Body mass index was identified as a significant response modifier.
A systematic literature review and meta-analysis of the effectiveness of vitamin D supplementation for patients with Duchenne muscular dystrophy.
Systematic literature review and meta-analysis on vitamin D supplementation in Duchenne muscular dystrophy. Current dosing regimens prevent severe deficiency but do not maintain sufficient vitamin D levels. High variability and heterogeneity in response to supplementation were observed.
Association of food allergy in children with vitamin D insufficiency: a systematic review and meta-analysis.
Systematic review and meta-analysis investigating the association between vitamin D insufficiency and food allergy in children. Children with vitamin D insufficiency were found to have a higher probability of presenting food allergy episodes and sensitization, particularly in their second year of life.
Vitamin D Supplementation and Cardiovascular Disease Risks in More Than 134000 Individuals in 29 Randomized Clinical Trials and 157000 Individuals in 30 Prospective Cohort Studies: An Updated Systematic Review and Meta-analysis.
This systematic review and meta-analysis assessed the effect of vitamin D supplements on cardiovascular diseases (CVDs) using data from 29 randomized clinical trials and 30 prospective cohort studies. The analysis found no significant effect of vitamin D supplementation on CVD incidence or mortality in clinical trials, while cohort studies showed an association between vitamin D deficiency and increased CVD risk and mortality.
Prognostic and Therapeutic Role of Vitamin D in COVID-19: Systematic Review and Meta-analysis.
Systematic review and meta-analysis of 76 studies, including 72 observational studies with nearly 2 million adults, examining the role of vitamin D deficiency/insufficiency in COVID-19 susceptibility, severity, and mortality. Vitamin D deficiency/insufficiency was associated with increased odds of developing COVID-19, severe disease, and death, though the association with mortality was less robust. High risk of bias and heterogeneity were noted across analyses.
Vitamin D and SARS-CoV2 infection, severity and mortality: A systematic review and meta-analysis
Systematic review and meta-analysis of 38 studies assessing the relationship between vitamin D deficiency and supplementation with SARS-CoV2 infection, severity, and mortality. Vitamin D supplementation was associated with a significantly lower risk of severe Covid-19 disease and mortality, with greater benefits observed in older individuals and at higher latitudes.
The effect of vitamin D supplementation on depressive symptoms in adults: A systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis of 41 RCTs with a total of 53,235 participants investigated the efficacy of vitamin D supplementation in reducing depressive symptoms among adults. The analysis found a positive effect of vitamin D on depressive symptoms, although the certainty of evidence was very low due to high heterogeneity and concerning risk of bias in most studies.
Current opinion on the role of vitamin D supplementation in respiratory infections and asthma/COPD exacerbations: A need to establish publication guidelines for overcoming the unpublished data.
This systematic review and meta-analysis evaluated the effects of vitamin D supplementation on respiratory infections, including 65 RCTs with 50,554 participants. The analysis found that vitamin D significantly reduced the incidence of respiratory infections, although it had no effect on the duration or severity of upper respiratory tract infections. Subgroup analyses highlighted the protective effects of specific dosing regimens.
Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial
The VITAL randomized controlled trial investigated the effects of vitamin D and marine omega 3 fatty acids on autoimmune disease risk in 25,871 participants over a median of 5.3 years. Vitamin D supplementation reduced autoimmune disease incidence by 22%, while omega 3 fatty acids reduced it by 15%, though the latter was not statistically significant.
Effect of Vitamin D Supplementation on Overactive Bladder and Urinary Incontinence Symptoms in Older Men: Ancillary Findings From a Randomized Trial.
Ancillary study from the VITAL trial evaluating vitamin D supplementation for overactive bladder and urinary incontinence in men aged ≥55 years. Overall, vitamin D did not improve symptoms compared to placebo, but men with low baseline 25-hydroxyvitamin D levels showed inconsistent findings, with lower odds of overactive bladder but higher odds of urinary incontinence.