Research
Vitamin C
328 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Effects of Vitamin C and/or E Supplementation on Glycemic Control and Cardiovascular Risk Factors in Type 2 Diabetes: A Systematic Review and Subgroup Meta-analysis.
This systematic review and meta-analysis evaluated the effects of vitamin C, vitamin E, and their combination on glycemic control and cardiovascular risk factors in individuals with type 2 diabetes. The study found that vitamin C and combined vitamin C + E supplementation significantly reduced systolic blood pressure, while combined supplementation increased HDL levels. Effects on glycemic control and other blood lipids were comparable across the supplements.
Clinical benefits and risks of high-dose intravenous vitamin C: a systematic review.
Systematic review of high-dose intravenous vitamin C (IVC) as an adjunct in sepsis, oncology, and symptom management. Evidence shows potential benefits through antioxidant effects and immune modulation, but risks include oxalate nephropathy and hemolysis in certain patients. The role of IVC in oncology is supportive and exploratory, with caution advised due to potential risks.
Therapeutic Role of HAT Therapy in Sepsis: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the effects of HAT therapy (hydrocortisone, vitamin C, and thiamine) on sepsis and septic shock. The analysis included nine clinical trials and nine cohorts, showing significant improvements in SOFA score, vasopressor duration, and procalcitonin clearance. HAT therapy was effective in reducing ICU mortality, but no significant differences were found in hospital mortality or other outcomes.
Causal effects of dietary antioxidants on epigenetic age: A two-sample Mendelian randomization study.
A two-sample Mendelian randomization study explored the causal associations between dietary antioxidants and epigenetic age using data from 34,710 European participants. Genetically predicted dietary vitamin C was associated with decreased HannumAge, suggesting potential benefits for longevity. No significant effects were found for vitamin A, vitamin E, and carotene on epigenetic age measures.
Efficacy of vitamin C supplementation during pregnancy in the prevention of preterm birth: a systematic review and meta-analysis.
Systematic review and meta-analysis of 17 RCTs with 21,567 patients assessing vitamin C supplementation during pregnancy for preventing preterm birth. Vitamin C, alone or with vitamin E, showed no significant effect on preterm birth or related neonatal outcomes.
Efficacy of vitamin C in COVID-19 management: a systematic review and meta-analysis.
Systematic review and meta-analysis evaluating the impact of vitamin C supplementation on COVID-19 patients. The study included 13 studies with a total sample size of 12,062. Results indicated no significant improvement in short-term mortality, in-hospital mortality, or other secondary clinical outcomes with vitamin C supplementation.
Pharmacologic Interventions for Endometriosis-Related Pain: A Systematic Review and Meta-analysis.
Systematic review and meta-analysis of 31 RCTs involving 8,665 patients evaluating pharmacologic interventions for endometriosis-related pain. Vitamins C and E were identified as effective interventions for dysmenorrhea and dyspareunia.
Effects of Vitamin C Supplements on Clinical Outcomes and Hospitalization Duration for Patients with Coronavirus Disease 2019 (COVID-19): A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of 22 studies with 3429 patients assessing vitamin C supplementation in COVID-19 patients. Vitamin C showed significant effects on alleviating clinical outcomes, reducing mortality risk, and decreasing severity, but did not shorten hospitalization duration.
Overall and Progression-Free Survival of Patients With Malignant Neoplasm Following Intravenous Vitamin C: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of 8 studies with 2722 adult participants assessing intravenous vitamin C in patients with malignant neoplasm. Intravenous vitamin C was associated with significantly longer median overall survival and a trend towards improved progression-free survival.
Sepsis subtypes and differential treatment response to vitamin C: biological sub-study of the LOVIT trial.
The study investigated the differential response to intravenous vitamin C treatment among sepsis subtypes in the LOVIT trial. Three sepsis subtypes were identified based on inflammatory response profiles. Vitamin C treatment did not show discernible anti-inflammatory effects across subtypes, with no subtype benefiting from the treatment.
Early administration of vitamin C in patients with sepsis or septic shock in emergency departments: a multicenter, double-blind, randomized controlled trial: the C-EASIE trial.
This multicenter, double-blind, randomized controlled trial investigated the effect of early administration of vitamin C in patients with sepsis or septic shock. The primary outcome, average post-baseline SOFA score, was 8.7% lower in the vitamin C group but not significantly. A subgroup analysis showed a significant reduction in SOFA score for patients with a baseline score of 6 or above. No significant differences were found in secondary outcomes, except for a lower probability of renal replacement therapy in the vitamin C group.
Intravaginal vitamin C supplementation in bacterial vaginosis: a systematic review
Systematic review assessing the efficacy of intravaginal vitamin C in treating and reducing symptoms of Bacterial Vaginosis (BV). The review included five randomized studies and found that intravaginal vitamin C improved BV cure rates and reduced symptoms compared to placebo, with a decrease in BV recurrence when used prophylactically.
Effects of water-soluble vitamins on glycemic control and insulin resistance in adult type 2 diabetes: an umbrella review of meta-analyses.
Umbrella review of meta-analyses examining the effects of water-soluble vitamins on glycemic control and insulin resistance in type 2 diabetes. Vitamin C supplementation improved glycemic control, while folic acid improved insulin resistance.
Association between dietary vitamin C intake/blood level and risk of digestive system cancer: a systematic review and meta-analysis of prospective studies.
Systematic review and meta-analysis of 32 prospective studies with 1,664,498 participants examining the relationship between dietary vitamin C intake/plasma concentration and digestive system cancer risk. Vitamin C intake significantly reduced the risk of digestive system cancers, including oral, pharyngeal, esophageal, gastric, and colon cancers. Plasma vitamin C concentration was inversely associated with gastric cancer risk.
Does Vitamin C Supplementation Provide a Protective Effect in Periodontal Health? A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis evaluating the effectiveness of vitamin C supplementation in preventing and treating periodontal diseases. The analysis included 16 studies with 17,853 participants, finding that higher vitamin C intake was associated with a reduction in periodontal disease risk. The study highlights the potential protective effects of vitamin C on periodontal health, though variability among studies suggests the need for personalized nutritional guidance.
The effects of vitamin C supplementation in the critically ill patients outcomes: A systematic review and meta-analysis of randomized controlled trials.
This meta-analysis of 19 RCTs with 2047 critically ill patients evaluated the effects of intravenous vitamin C supplementation. The study found that vitamin C reduced the duration of vasopressor use and mechanical ventilation but had no significant effect on 28-day mortality, overall mortality, fluid intake, urine output, ICU days, hospital stay, or pneumonia.
Oral vitamin C supplementation decreased low-density lipoprotein in adults on hemodialysis: A systematic review and meta-analysis.
Systematic review and meta-analysis of 12 studies (8 RCTs, 4 NRS) involving 549 hemodialysis patients, examining the effects of oral vitamin C supplementation on lipid profiles. The meta-analysis showed a reduction in low-density lipoprotein with vitamin C supplementation, though inflammation and oxidative stress could not be evaluated due to variable differences.
Efficacy and safety of mesotherapy with tranexamic acid versus vitamin C in the treatment of melasma: A meta-analysis and systemic review.
Meta-analysis and systematic review comparing mesotherapy with tranexamic acid (TXA) versus vitamin C for treating melasma. Five studies with 127 patients were included. No significant difference in melasma area and severity index (MASI) score change between TXA and vitamin C groups. Both treatments are safe and effective for melasma.
The association between vitamin C and breast cancer, prostate cancer and colorectal cancer: A systematic review and meta-analysis.
This meta-analysis evaluated the association between vitamin C and breast, prostate, and colorectal cancers. It found an inverse significant relationship between dietary vitamin C and breast cancer in case-control studies, and a decrease in prostate and colorectal cancers with dietary vitamin C.
Vitamin C Levels in Pregnant Women and the Efficacy of Vitamin C Supplements in Preventing Premature Rupture of Membranes: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of 25 studies assessing vitamin C levels and supplementation in preventing premature rupture of membranes (PROM). Women with PROM, especially preterm, had significantly lower vitamin C levels. Vitamin C supplementation reduced the risk of preterm or term PROM, particularly preterm PROM.
Efficacy and safety of vitamin C supplementation in the treatment of community-acquired pneumonia: a systematic review and meta-analysis with trial sequential analysis.
This systematic review and meta-analysis evaluated the efficacy and safety of vitamin C supplementation in adults with community-acquired pneumonia (CAP). Analysis of six RCTs showed a non-significant trend towards reduced mortality in the vitamin C group. Secondary outcomes like hospital and ICU length-of-stay showed mixed results. Minimal adverse effects were reported, but findings are inconclusive due to methodological limitations.
Vitamin C and E antioxidant supplementation may significantly reduce pain symptoms in endometriosis: A systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of RCTs assessing the efficacy of vitamin C and E antioxidant supplementation in managing pain associated with endometriosis. The analysis found that supplementation was associated with reduced chronic pelvic pain, alleviations of dysmenorrhea, and dyspareunia compared to placebo.
A comprehensive meta-analysis on the association between vitamin C intake and gestational diabetes mellitus: Insights and novel perspectives.
Meta-analysis of 15 studies with 10,131 subjects, including 1304 GDM cases, examining the association between Vitamin C intake and gestational diabetes mellitus (GDM). The analysis found that low Vitamin C exposure during pregnancy is associated with higher odds of developing GDM.
Effect of intravenous vitamin C on adult septic patients: a systematic review and meta-analysis.
Systematic review and meta-analysis of 22 studies with 3,570 adult septic patients evaluating the efficacy of intravenous vitamin C. IVVC treatment did not improve 28-day mortality overall but showed a trend to decrease mortality in sepsis patients, not septic shock. IVVC monotherapy decreased mortality, whereas combination therapy did not. IVVC reduced vasopressor use duration but did not affect AKI incidence, ICU stay, or mechanical ventilation duration.
The outcome of IV vitamin C therapy in patients with sepsis or septic shock: a meta-analysis of randomized controlled trials.
Meta-analysis of 18 RCTs with 3364 patients assessing IV vitamin C therapy in sepsis or septic shock. IVVC significantly improved delta SOFA score and reduced vasopressor use duration, but did not improve short-term mortality and was associated with higher adverse events.
Intravenous vitamin C monotherapy in critically ill patients: a systematic review and meta-analysis of randomized controlled trials with trial sequential analysis
Systematic review and meta-analysis of 16 RCTs with 2130 critically ill patients evaluating intravenous vitamin C monotherapy. The analysis found a significant reduction in overall mortality with IVVC, though the certainty of evidence was rated low due to bias and inconsistency. Further studies are needed to optimize treatment parameters.
Impact of intravenous vitamin C as a monotherapy on mortality risk in critically ill patients: A meta-analysis of randomized controlled trials with trial sequential analysis
Meta-analysis of 12 RCTs with 1,712 critically ill patients assessing the impact of intravenous vitamin C on mortality risk. Results showed a lower risk of mortality with IVVC treatment, particularly at low dosages, and reduced durations of vasopressor use and mechanical ventilation. Further research is needed to confirm findings and determine optimal dosage.
Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis.
Systematic review and meta-analysis of 8 RCTs with 1,572 patients evaluating hydrocortisone combined with vitamin C and thiamine (HVT) for sepsis/septic shock. The HVT regimen did not reduce mortality or improve outcomes such as organ failure, ICU stay, or ventilator-free days. More trials are needed to confirm these results.
The effects of vitamin C supplementation on glycemic control in patients with type 2 diabetes: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the effect of vitamin C supplementation on glycemic control in patients with type 2 diabetes mellitus. The analysis included 22 RCTs with 1447 patients and found that vitamin C supplementation significantly decreased serum HbA1c, fasting insulin, and fasting blood glucose levels. High-dose vitamin C (≥1000 mg/d) was particularly effective in reducing serum HOMA-IR levels.
Treatment efficacy of vitamin C or ascorbate given as co-intervention with iron for anemia - A systematic review and meta-analysis of experimental studies.
Systematic review and meta-analysis of experimental studies assessing the efficacy of oral vitamin C or ascorbate as a co-intervention with iron for anemia. The pooled estimates for hemoglobin and serum ferritin were not statistically significant, indicating no significant benefit of adding vitamin C to iron supplementation for anemia treatment.
Vitamin C supplementation showed greater effects on systolic blood pressure in hypertensive and diabetic patients: an updated systematic review and meta-analysis of randomised clinical trials.
This systematic review and meta-analysis evaluated the effects of vitamin C supplementation on blood pressure, including 20 RCTs with 890 participants. Vitamin C supplementation reduced systolic blood pressure by -3.0 mmHg overall, with more pronounced effects in hypertensive and diabetic patients.
IV Vitamin C in Adults With Sepsis: A Bayesian Reanalysis of a Randomized Controlled Trial.
Bayesian reanalysis of a randomized placebo-controlled trial in 35 ICUs with 872 patients. Vitamin C administration in adults with sepsis showed a higher risk of death or persistent organ dysfunction at 28 days, indicating a high probability of harm.
Association of Vitamin C, Thiamine, and Hydrocortisone Infusion With Long-term Cognitive, Psychological, and Functional Outcomes in Sepsis Survivors: A Secondary Analysis of the Vitamin C, Thiamine, and Steroids in Sepsis Randomized Clinical Trial.
Secondary analysis of the VICTAS randomized clinical trial assessing long-term cognitive, psychological, and functional outcomes in sepsis survivors treated with vitamin C, thiamine, and hydrocortisone. The intervention group showed lower immediate memory scores, higher odds of PTSD, and lower odds of receiving mental health care compared to placebo, with no other significant differences found.
The association between vitamin C dietary intake and its serum levels with anthropometric indices: A systematic review and meta-analysis.
This systematic review and meta-analysis examined the relationship between dietary and serum vitamin C levels with anthropometric indices such as BMI and waist circumference. The study found an inverse significant correlation between serum vitamin C levels and both BMI and waist circumference, suggesting higher vitamin C consumption is associated with lower BMI.
The effect of vitamin C on the risk of mortality in patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of RCTs assessing vitamin C's effect on all-cause mortality in COVID-19 patients. The analysis of eleven trials showed a significant reduction in mortality risk with vitamin C administration, especially in severe cases.
Efficacy of Ascorbic Acid, Thiamine, and Hydrocortisone Combination Therapy: Meta-analysis of Randomized Controlled Trials.
Meta-analysis of RCTs assessing HAT therapy (ascorbic acid, thiamine, hydrocortisone) in sepsis or septic shock. HAT therapy did not improve mortality, SOFA score, renal injury, or ICU-LOS, but significantly shortened vasopressor use duration.
IV Vitamin C in Sepsis: A Latest Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the efficacy and safety of intravenous vitamin C in the treatment of sepsis. The analysis included 24 RCTs and found that IV vitamin C might improve short-term and overall mortality in sepsis patients, as well as significantly improve the SOFA score after 72 hours of treatment. The evidence was of moderate quality, and further high-quality RCTs are recommended.
Parenteral Vitamin C in Patients with Severe Infection: A Systematic Review.
Systematic review and meta-analysis of 41 RCTs involving 4915 patients assessing parenteral vitamin C in severe infection. Low-certainty evidence suggested potential reduction in mortality, but effects were attenuated in sensitivity analyses. Moderate-certainty evidence suggested an increased risk of hypoglycemia. Overall, no survival benefit was established.
The impact of vitamin C-containing treatment on the mortality of patients with sepsis: A systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of 16 RCTs involving 2985 patients with sepsis, comparing vitamin C-containing therapy to placebo or alternative treatments. No significant difference in 28-day mortality, ICU mortality, in-hospital mortality, or 90-day mortality was observed between the groups.
Efficacy and safety of perioperative vitamin C in patients undergoing noncardiac surgery: a systematic review and meta-analysis of randomised trials.
Systematic review and meta-analysis of 37 RCTs with 2747 patients undergoing noncardiac surgery, comparing perioperative vitamin C administration to placebo or no treatment. Vitamin C was associated with no difference in hospital length of stay, but a reduction in postoperative pain score and cumulative morphine consumption. The incidence of complex regional pain syndrome was lower in orthopaedic patients receiving vitamin C. Adverse events were rare but not systematically assessed.
The Role and Efficacy of Vitamin C in Sepsis: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of 23 RCTs with a total of 2712 patients evaluating the role of vitamin C in sepsis. Vitamin C treatment was associated with reduced mortality, SOFA score, and vasopressor requirement, but no significant difference in hospital or ICU length of stay.
IV Vitamin C in Critically Ill Patients: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of 15 studies involving 2,490 critically ill patients evaluating IV vitamin C. High-dose IV vitamin C monotherapy was associated with a significant reduction in overall mortality, while low-dose had no effect. No increase in adverse events was reported.
Vitamin C-based regimens for sepsis and septic shock: Systematic review and meta-analysis of randomized clinical trials.
Systematic review and meta-analysis of 20 RCTs assessing vitamin C-based regimens for sepsis or septic shock in adults. Evidence suggests vitamin C may reduce all-cause mortality up to 28 days, but results are of low to very low certainty. Further high-quality RCTs are needed.
Clinical efficacy and safety of vitamin C in the treatment of septic shock patients: systematic review and meta-analysis.
Systematic review and meta-analysis of 13 studies, including 6 cohort studies and 7 RCTs, with a total of 1,423 patients. The analysis found no significant effect of intravenous vitamin C on reducing in-hospital mortality, ICU mortality, ICU stay, total stay, or improving the 72-h SOFA score in sepsis patients.
Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit.
RCT of 872 adults with sepsis in the ICU receiving vasopressor therapy, comparing intravenous vitamin C to placebo. The vitamin C group had a higher risk of death or persistent organ dysfunction at 28 days compared to placebo.
Efficacy of Vitamin C Supplementation on Chronic Obstructive Pulmonary Disease (COPD): A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of 10 RCTs with 487 participants assessing vitamin C supplementation in COPD patients. Vitamin C supplementation (≥400 mg/day) significantly improved lung function (FEV1% and FEV1/FVC) and increased serum antioxidant levels (vitamin C and GSH), but showed no significant effect on BMI, FFMI, vitamin E, and SOD levels.
Early administration of hydrocortisone, vitamin C, and thiamine in adult patients with septic shock: a randomized controlled clinical trial.
This RCT evaluated the efficacy and safety of early combination therapy with hydrocortisone, vitamin C, and thiamine in adult patients with septic shock. Among 408 patients analyzed, there was no significant difference in 90-day mortality or other secondary outcomes between the intervention and placebo groups.
Comparison of optimal bowel cleansing effects of 1L polyethylene glycol with ascorbic acid versus sodium picosulfate with magnesium citrate: A randomized controlled study.
This randomized controlled study compared the bowel cleansing effectiveness of 1 L polyethylene glycol (PEG) with ascorbic acid versus sodium picosulfate with magnesium citrate in 254 participants. The study found no significant difference in overall bowel cleansing success between the two groups, with high-quality cleansing achieved in 87% of the PEG with ascorbic acid group. Patient satisfaction was higher with PICO with magnesium citrate, but compliance and side effects were similar.
Effect of Vitamin C Supplementation for Pregnant Smokers on Offspring Airway Function and Wheeze at Age 5 Years: Follow-up of a Randomized Clinical Trial.
This follow-up study of the VCSIP trial assessed the effects of vitamin C supplementation (500 mg/d) in pregnant smokers on their offspring's airway function and wheeze at age 5 years. Offspring of mothers who received vitamin C showed significantly improved airway function and reduced occurrence of wheeze compared to placebo.
Effect of Vitamin C Supplements on Respiratory Tract Infections: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of placebo-controlled trials assessing vitamin C supplementation on respiratory tract infections. The study found that vitamin C supplementation lowers the occurrence of illness, though the effect was statistically insignificant. Vitamin C significantly reduced the duration of respiratory infections but had no consistent effect on severity.
Intravenous vitamin C use and risk of severity and mortality in COVID-19: A systematic review and meta-analysis.
Systematic review and meta-analysis of intravenous vitamin C (IV-VC) use in COVID-19 patients. The analysis included seven studies and found that IV-VC treatment did not significantly affect disease severity or mortality compared to placebo or usual care.
The Use of Hydrocortisone, Ascorbic Acid and Thiamine in Patients with Sepsis and Septic Shock - A Systematic Review.
Systematic review of HAT therapy (hydrocortisone, ascorbic acid, and thiamine) in sepsis and septic shock. Among 11 studies, 3 reported mortality benefit, 1 reported higher mortality in the HAT group, and others showed no significant mortality difference. Secondary outcomes showed inconsistent improvements.
Homeopathic Medicines Used as Prophylaxis in Kolkata during the COVID-19 Pandemic: A Community-Based, Cluster-Randomized Trial.
Cluster-randomized trial in Kolkata comparing three homeopathic medicines and placebo for COVID-19 prevention, with all participants receiving vitamin C. No new confirmed COVID-19 cases were diagnosed, making the trial inconclusive. Unconfirmed COVID-19 cases were significantly less in one group compared to placebo.
Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis.
Systematic review and network meta-analysis comparing the effects of vitamin C, glucocorticoids, vitamin B1, and their combinations on longer-term mortality in adults with sepsis or septic shock. No significant differences in longer-term mortality were found between treatments and placebo/usual care. Glucocorticoid addition shortened vasopressor therapy duration and ICU stay.
Steroid, ascorbic acid, and thiamine in adults with sepsis and septic shock: a systematic review and component network meta-analysis.
Systematic review and component network meta-analysis of 33 RCTs with 9898 patients assessing the effects of steroid, ascorbic acid, and thiamine in adults with sepsis and septic shock. Ascorbic acid alone was associated with lower short-term mortality, but not with improved long-term outcomes. The combination of glucocorticoid and fludrocortisone improved both short-term and long-term mortality.
Mortality in septic patients treated with vitamin C: a systematic meta-analysis.
Meta-analysis of 17 studies with 3133 septic patients evaluating the effect of intravenous vitamin C on mortality. Pooled analysis showed no overall mortality reduction, but subgroup analysis indicated improved survival with 3-4 days of treatment and reduced short-term mortality (<30 days). Further research is needed to identify benefiting subgroups.
Effect of IV High-Dose Vitamin C on Mortality in Patients With Sepsis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Systematic review and meta-analysis of 11 randomized controlled trials with 1,737 patients to assess the effect of IV high-dose vitamin C on short-term mortality in sepsis patients. High-dose vitamin C was not associated with significantly lower short-term mortality but was linked to a shorter duration of vasopressor use and a greater decline in the Sequential Organ Failure Assessment score.
Effects of Vitamin C Supplementation on Glycemic Control and Cardiovascular Risk Factors in People With Type 2 Diabetes: A GRADE-Assessed Systematic Review and Meta-analysis of Randomized Controlled Trials.
Systematic review and meta-analysis of 28 RCTs with 1,574 participants assessing vitamin C supplementation in type 2 diabetes. Vitamin C showed statistically significant improvements in systolic and diastolic blood pressure and HbA1c levels, though evidence certainty varied. Larger, long-term trials are needed to confirm these findings.
Effect of Combined Hydrocortisone, Ascorbic Acid and Thiamine for Patients with Sepsis and Septic Shock: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of HAT therapy (hydrocortisone, ascorbic acid, and thiamine) in patients with sepsis and septic shock. HAT therapy was associated with significant reductions in vasopressor use duration and organ dysfunction at 72 hours in RCTs, and lower hospital mortality and higher PCT clearance in observational studies.
A meta-analysis of randomized clinical trials on the impact of oral vitamin C supplementation on first-year outcomes in orthopedic patients.
This meta-analysis of seven randomized controlled trials with 1,361 participants investigated the impact of oral vitamin C supplementation on orthopedic patients. It found no significant difference in functional outcomes or pain severity but showed that vitamin C reduced the risk of complex regional pain syndrome type I.
Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis.
Meta-analysis of randomized controlled trials assessing the effects of a combination of thiamine, ascorbic acid, and hydrocortisone in septic ICU patients. The intervention improved the Sequential Organ Failure Assessment score within 72 hours, but the clinical relevance is questionable. No significant impact on renal failure or mortality was observed.
Does vitamin C supplementation exert profitable effects on serum lipid profile in patients with type 2 diabetes? A systematic review and dose-response meta-analysis.
Systematic review and meta-analysis of 15 studies with 872 participants evaluating the effects of vitamin C supplementation on lipid profile in patients with type 2 diabetes. Vitamin C significantly decreased triglycerides and total cholesterol but did not improve LDL and HDL levels. Long-term supplementation showed more benefits.
Thiamine combined with vitamin C in sepsis or septic shock: a systematic review and meta-analysis.
Systematic review and meta-analysis of seven randomized controlled trials with 868 patients to evaluate the efficacy of thiamine combined with vitamin C in sepsis or septic shock. The study found no statistical difference in in-hospital mortality but noted improvements in SOFA score and duration of vasopressor use.
Vitamin C, Thiamine, and Hydrocortisone in the Treatment of Sepsis: A Meta-Analysis and Trial Sequential Analysis of Randomized Controlled Trials.
Meta-analysis of RCTs evaluating vitamin C, thiamine, and hydrocortisone in sepsis treatment. No significant reduction in mortality, AKI incidence, or hospital/ICU stay was found, but a significant reduction in SOFA score on day 3 was observed. Results are inconclusive for mortality benefit.
The effect of vitamin C supplementation on mood status in adults: a systematic review and meta-analysis of randomized controlled clinical trials.
Systematic review and meta-analysis of 10 RCTs with 836 participants assessing the effect of vitamin C supplementation on mood. Overall, no significant improvement in mood status was found, but subgroup analysis suggested mood-elevating effects in subclinical depression patients not on antidepressants.
[Therapeutic effect of hydrocortisone combined with vitamin C and vitamin B1 on patients with sepsis: a Meta-analysis].
Meta-analysis of 6 articles involving 816 patients with sepsis or septic shock, evaluating the effect of hydrocortisone combined with vitamin C and vitamin B1. The combination shortened the duration of vasoactive drugs but did not significantly affect SOFA score, mortality, new AKI patients, or length of ICU and hospital stay.
Vitamin C and COVID-19 treatment: A systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of 6 RCTs with 572 patients investigating vitamin C supplementation in COVID-19. Vitamin C treatment did not significantly reduce mortality, ICU length of stay, hospital length of stay, or need for invasive mechanical ventilation. No significant benefits were observed in sub-group analyses.
Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial.
RCT of 501 critically ill patients with sepsis comparing intravenous vitamin C, thiamine, and hydrocortisone to placebo. The intervention did not significantly increase ventilator- and vasopressor-free days within 30 days. The trial was terminated early for administrative reasons and may have been underpowered.
Early high-dose vitamin C in post-cardiac arrest syndrome (VITaCCA): study protocol for a randomized, double-blind, multi-center, placebo-controlled trial
This is a study protocol for a randomized, double-blind, multi-center, placebo-controlled trial investigating the effects of high-dose intravenous vitamin C on organ failure in post-cardiac arrest patients. A total of 270 patients will be assigned to receive either a placebo, a supplementation dose of 3 g, or a pharmacological dose of 10 g of vitamin C per day for 96 hours. The primary endpoint is organ failure as measured by the delta R-SOFA score.
Effect of Perioperative Vitamin C on the Incidence of Complex Regional Pain Syndrome: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis assessing the role of vitamin C on complex regional pain syndrome type 1 (CRPS-I) and functional outcomes after limb extremity surgeries. Vitamin C was associated with a decreased rate of CRPS-I compared to placebo, but no significant differences were found in complications, functional outcomes, and pain scores.
Targeted Therapies for Hereditary Peripheral Neuropathies: Systematic Review and Steps Towards a 'treatabolome'.
Systematic review of pharmacological and gene-based treatments for hereditary peripheral neuropathies. Ascorbic acid showed no therapeutic benefit in CMT1A, while other treatments like PXT3003 and L-serine showed some efficacy in specific neuropathies.
Vasoplegic syndrome after cardiovascular surgery: A review of pathophysiology and outcome-oriented therapeutic management.
This systematic review examines vasoplegic syndrome (VPS) after cardiac surgery, focusing on pathophysiology and therapeutic management. It discusses the use of vasopressors like norepinephrine and vasopressin, and adjuvant therapies including vitamin C, thiamine, and hydrocortisone, which reduce vasopressor requirements and improve outcomes.
Vitamin C in Critically Ill Patients: An Updated Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the efficacy of intravenous vitamin C in critically ill patients. The analysis included 48 studies and found a 19% reduction in odds of mortality and a significant reduction in ICU stay length for patients receiving vitamin C, with no significant difference in adverse renal events.
Benefits of combination therapy of hydrocortisone, ascorbic acid and thiamine in sepsis and septic shock: A systematic review.
Systematic review of combination therapy with hydrocortisone, ascorbic acid, and thiamine (HAT) in sepsis and septic shock. The review included 11 trials and found inconsistent results regarding the benefits of HAT therapy on mortality and other clinical outcomes in sepsis and septic shock.
Association about dietary vitamin C intake on the risk of ovarian cancer: a meta-analysis.
A meta-analysis of 16 studies, including 5 cohort and 11 case-control studies with 4553 cases and 439,741 participants, evaluated the association between dietary vitamin C intake and ovarian cancer risk. The pooled results showed no significant association between vitamin C intake and the risk of ovarian cancer.
Vitamin C supplementation reduces the odds of developing a common cold in Republic of Korea Army recruits: randomised controlled trial.
RCT of 1444 Republic of Korea Army recruits comparing vitamin C supplementation (6000 mg/day) to placebo for 30 days. The vitamin C group had a 0.80-fold lower risk of developing a common cold compared to the placebo group, with stronger effects in certain subgroups.
Lessening Organ dysfunction with VITamin C (LOVIT): protocol for a randomized controlled trial
The LOVIT trial is a multicenter, blinded RCT designed to assess the effect of high-dose intravenous vitamin C on the composite endpoint of death or persistent organ dysfunction at 28 days in patients with sepsis. The study aims to provide evidence on the impact of vitamin C on patient-important outcomes, including mortality and health-related quality of life.
The effects of surgery on plasma/serum vitamin C concentrations: a systematic review and meta-analysis.
Systematic review and meta-analysis assessing plasma vitamin C levels post-surgery compared with pre-surgery. Pooled data revealed a mean depletion of plasma vitamin C concentration by 39% during the first postoperative week and 21% 2-3 months postoperatively. High heterogeneity was observed among trials assessing concentration change during the first postoperative week.
Effects of vitamin C supplementation on essential hypertension: A systematic review and meta-analysis.
Systematic review and meta-analysis of 8 RCTs involving 614 participants to assess the effect of vitamin C supplementation on blood pressure in patients with essential hypertension. Vitamin C supplementation resulted in a significant reduction in both systolic and diastolic blood pressure.
The Efficacy and Safety of Vitamin C for Iron Supplementation in Adult Patients With Iron Deficiency Anemia: A Randomized Clinical Trial.
This randomized clinical trial compared the efficacy and safety of oral iron supplements plus vitamin C versus oral iron supplements alone in 440 adult patients with iron deficiency anemia. The study found that vitamin C supplementation did not significantly enhance hemoglobin recovery or iron absorption compared to iron supplements alone, suggesting that vitamin C is not essential for patients with IDA.
Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock: The VITAMINS Randomized Clinical Trial.
Multicenter RCT comparing intravenous vitamin C, hydrocortisone, and thiamine to hydrocortisone alone in 216 patients with septic shock. The combination did not significantly improve the duration of time alive and free of vasopressor administration over 7 days compared to hydrocortisone alone.
Dietary Supplementation of Citrus limon L. (Lemon) and Evaluation of Its Role to Prevent and Cure of Vitamin C Deficiency Diseases
RCT of 200 people assessing the effects of lemon supplementation on vitamin C deficiency symptoms. The lemon group showed significant improvement in symptoms like gum bleeding, poor wound healing, hyperkeratosis, tiredness, joint pain, and edema compared to the non-supplementation group.
Effect of vitamins C and E on recovery of motor function after spinal cord injury: systematic review and meta-analysis of animal studies.
Meta-analysis of animal studies evaluating the effects of vitamin C and vitamin E on recovery of motor function after spinal cord injury. Both vitamins significantly improved motor function recovery, with vitamin C being effective only when administered intraperitoneally. Concurrent supplementation did not show better efficacy than individual treatments.
Association between Serum Vitamin C and the Blood Pressure: A Systematic Review and Meta-Analysis of Observational Studies.
Systematic review and meta-analysis of 18 observational studies examining the relationship between serum vitamin C and blood pressure. Findings indicate that hypertensive subjects have lower serum vitamin C levels, and vitamin C is inversely associated with both systolic and diastolic blood pressure.
The neuropsychiatric effects of vitamin C deficiency: a systematic review
Systematic review of nine studies examining the neuropsychiatric effects of vitamin C deficiency. Vitamin C deficiency is linked to depression and cognitive impairment, but not to affective or non-affective psychosis. The review highlights the need for awareness of vitamin C deficiency in patients with depression or cognitive impairment.
The Effect of Perioperative Vitamin C on Postoperative Analgesic Consumption: A Meta-Analysis of Randomized Controlled Trials.
Meta-analysis of seven randomized controlled trials assessing the effect of perioperative vitamin C on postoperative pain and analgesic consumption. Results showed significant reductions in pain scores and morphine consumption up to 24 hours post-surgery in patients receiving intravenous vitamin C.
The Effect of Vitamin C on Clinical Outcome in Critically Ill Patients: A Systematic Review With Meta-Analysis of Randomized Controlled Trials.
Systematic review and meta-analysis of 44 randomized controlled trials on vitamin C administration in critically ill patients. In ICU patients, vitamin C showed no significant effect on mortality or length of stay. In cardiac surgery patients, vitamin C was associated with reduced postoperative atrial fibrillation and shorter ICU and hospital stays, though evidence quality is insufficient for firm conclusions.
Effects of Helicobacter pylori treatment and vitamin and garlic supplementation on gastric cancer incidence and mortality: follow-up of a randomized intervention trial
Blinded randomized placebo-controlled trial in Linqu County, China, assessing the effects of H pylori treatment, vitamin supplementation (C, E, selenium), and garlic supplementation on gastric cancer incidence and mortality. H pylori treatment and vitamin supplementation significantly reduced gastric cancer incidence and mortality, while garlic supplementation reduced mortality but not incidence.
Effects of Vitamin C on Organ Function in Cardiac Surgery Patients: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis included 19 RCTs with 2008 cardiac surgery patients, examining the effects of perioperative vitamin C administration. Vitamin C significantly decreased the incidence of atrial fibrillation, ventilation time, ICU length-of-stay, and hospital length-of-stay, but had no significant effects on in-hospital mortality or stroke incidence.
Efficacy of vitamin C in patients with sepsis: An updated meta-analysis.
Meta-analysis of 10 studies (4 RCTs and 6 retrospective) involving 1671 patients with sepsis, comparing vitamin C treatment to control. Overall, vitamin C did not reduce 28-day, ICU, or in-hospital mortality, nor did it affect vasopressor usage or length of stay. Subgroup analysis of RCTs suggested reduced 28-day mortality, but this was not observed in retrospective studies.
Efficacy of vitamin C for the prevention and treatment of upper respiratory tract infection. A meta-analysis in children.
Meta-analysis of 8 RCTs involving 3135 children assessing vitamin C for prevention and treatment of upper respiratory tract infections (URTI). Vitamin C did not prevent URTI but reduced its duration by 1.6 days. More effective in children under 6 years when combined with echinacea.
Vitamin C Administration to the Critically Ill: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of RCTs assessing vitamin C administration in ICU patients. Vitamin C was not associated with reduced mortality, infections, ICU or hospital length of stay, or duration of mechanical ventilation. A tendency towards mortality reduction was observed with high-dose intravenous vitamin C monotherapy, but current evidence does not support supplementation.
Vitamin C for preventing atrial fibrillation in high risk patients: a systematic review and meta-analysis.
Systematic review and meta-analysis of 15 trials with 2050 subjects on vitamin C for preventing atrial fibrillation (AF) in high-risk patients. Vitamin C decreased the incidence of post-operative AF in non-US trials and reduced hospital and ICU stay durations, but showed no effect in US trials. No adverse effects were reported.
Effects of vitamin C supplementation on glycaemic control: a systematic review and meta-analysis of randomised controlled trials.
Systematic review and meta-analysis of RCTs testing vitamin C's effect on glucose, HbA1c, and insulin concentrations in adults. Overall, vitamin C did not modify these biomarkers, but subgroup analyses showed significant glucose reduction in type 2 diabetes patients and longer interventions. Age, baseline BMI, and plasma glucose levels were modifiers of vitamin C's effect.
Efficacy of vitamin C in preventing complex regional pain syndrome after wrist fracture: A systematic review and meta-analysis.
Systematic review and meta-analysis of randomized placebo-controlled trials assessing the efficacy of vitamin C in preventing complex regional pain syndrome type I (CRPS-I) after wrist fractures. Daily supplementation with 500mg of vitamin C for 50 days significantly decreased the risk of developing CRPS-I.
Comparative Effectiveness of 12 Treatment Strategies for Preventing Contrast-Induced Acute Kidney Injury: A Systematic Review and Bayesian Network Meta-analysis.
Systematic review and Bayesian network meta-analysis of 150 RCTs with 31,631 participants evaluating pharmacologic strategies for preventing contrast-induced acute kidney injury (AKI). High-dose statins plus NAC or high-dose statin alone were most effective in reducing AKI risk compared to hydration alone.
Vitamin C supplementation in pregnancy.
Meta-analysis of 29 trials involving 24,300 pregnant women evaluating vitamin C supplementation. No clear differences were found in the risk of stillbirth, neonatal death, or preterm birth. Vitamin C supplementation was associated with a decreased risk of placental abruption and preterm PROM, but increased risk of term PROM when combined with vitamin E.
Is there a role for oral or intravenous ascorbate (vitamin C) in treating patients with cancer? A systematic review.
Systematic review evaluating the antitumor effects and toxicity of ascorbate (vitamin C) treatment in cancer patients. No RCTs reported statistically significant improvements in survival or reduced toxicity with ascorbate. Evidence for antitumor effects was limited to case reports and observational studies.
Vitamin C for asthma and exercise-induced bronchoconstriction.
Meta-analysis of 11 trials with 419 participants examining the effects of vitamin C supplementation on asthma and exercise-induced bronchoconstriction. The evidence was low quality, with no significant difference in health-related quality of life or exacerbations between vitamin C and placebo. Some improvement in lung function was suggested for exercise-induced bronchoconstriction, but findings were inconclusive due to small study sizes.
Vitamin C supplementation for asthma.
Meta-analysis of nine randomised controlled trials evaluating vitamin C supplementation for asthma treatment, involving 330 participants. The review found insufficient evidence to recommend vitamin C for asthma, highlighting the need for more robust trials.