Research
Vitamin B6
116 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
The effectiveness of vitamin B6 in reducing mastalgia: a systematic review and meta-analysis.
This meta-analysis evaluated the effect of vitamin B6 on mastalgia severity in women. The analysis included three studies with a total of 951 participants and found no significant difference between vitamin B6 and placebo in reducing pain intensity. The evidence was limited by low methodological quality and high heterogeneity.
Effect of Nutritional Supplements for Reducing Homocysteine Levels in Healthy Adults: A Systematic Review and Network Meta-Analysis of Randomized Trials.
Systematic review and network meta-analysis of 16 randomized trials evaluating the efficacy of nutritional supplements in reducing homocysteine levels in healthy adults. The combination of 1mg folic acid, 7.2mg vitamin B6, and 20µg vitamin B12 was found to be the most effective in reducing homocysteine levels.
Off-label use of sodium cantharidinate and vitamin B6 injection in cancer: a protocol for a systematic review and meta-analysis
This systematic review and meta-analysis aims to consolidate evidence regarding the efficacy and safety of off-label use of sodium cantharidinate/vitamin B6 injection in oncology. It will include both randomized controlled trials and cohort studies to assess the add-on effect of SC/VB6 to conventional cancer treatments.
Drug Efficacy in the Treatment of Antipsychotic-Induced Akathisia: A Systematic Review and Network Meta-Analysis.
Systematic review and network meta-analysis comparing the efficacy of treatments for antipsychotic-induced akathisia (AIA) in 492 participants across 15 trials. Mirtazapine, biperiden, and vitamin B6 showed the greatest efficacy, with vitamin B6 having the best efficacy and tolerance profile. Trazodone, mianserin, and propranolol were also effective alternatives.
High-dose Vitamin-B6 reduces sensory over-responsivity.
RCT of 300 adults examining the effects of high-dose Vitamin-B6 supplementation on sensory over-responsivity (SOR). Vitamin-B6 reduced SOR and postural disorder in individuals with high baseline SOR scores compared to placebo and Vitamin-B12.
The potential hazards of high doses of vitamin B6 in treating nausea and vomiting in pregnancy: A systematic review.
This systematic review investigates the effects of high doses of vitamin B6 on pregnant women experiencing nausea and vomiting. It highlights the potential neurological hazards and adverse pregnancy outcomes associated with excessive vitamin B6 intake, including miscarriage and congenital abnormalities.
Epilepsy Phenotypes of Vitamin B6-Dependent Diseases: An Updated Systematic Review
Systematic review of 497 pediatric cases with vitamin B6-dependent epilepsy, focusing on seizure semiology, EEG patterns, and treatment outcomes. Pyridoxine was administered to most patients, achieving complete seizure freedom in 160 cases. The review highlights the variability in epilepsy phenotypes and treatment responses.
Can vitamin B6 alleviate the adverse reactions of quadruple anti-Helicobacter pylori regimen? : randomized controlled trial.
RCT of 280 patients with H. pylori infection comparing conventional treatment to vitamin B6 supplementation. Vitamin B6 significantly reduced the incidence and severity of adverse reactions from the quadruple anti-H. pylori regimen containing minocycline and metronidazole.
Current evidence for adjunct pyridoxine (vitamin B6) for the treatment of behavioral adverse effects associated with levetiracetam: A systematic review.
Systematic review of studies on pyridoxine (vitamin B6) supplementation for treating neuropsychiatric adverse events associated with levetiracetam. The review includes seven additional studies, with mixed results on the effectiveness of pyridoxine in improving behavioral adverse events. The quality of evidence remains poor, and further well-designed trials are needed.
A systematic review of the potential consequences of abnormal serum levels of vitamin B6 in people living with Parkinson's disease.
Systematic review examining the potential consequences of abnormal serum levels of vitamin B6 in people with Parkinson's disease (PwPD). The review highlights associations between abnormal B6 levels and conditions like polyneuropathy and epilepsy in PwPD, with a focus on interactions with levodopa treatment.
The Role of Vitamin B6 in Peripheral Neuropathy: A Systematic Review.
Systematic review examining the role of vitamin B6 in peripheral neuropathy (PN). High levels of vitamin B6, often from supplements, may lead to sensory neuropathy, while low levels are not directly linked to PN. B6 supplementation shows subjective improvement in PN symptoms, but its therapeutic role as monotherapy is unconfirmed.
Pharmacological treatment strategies for antipsychotic-induced hyperprolactinemia: a systematic review and network meta-analysis.
Systematic review and network meta-analysis of pharmacological treatments for antipsychotic-induced hyperprolactinemia. Adjunctive vitamin B6 and aripiprazole were associated with significant decreases in prolactin levels in patients with levels over 50 ng/ml.
High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression.
Double-blind RCT investigating high-dose Vitamin B6 or B12 supplementation effects on anxiety and visual processing in 478 young adults. Vitamin B6 reduced self-reported anxiety and increased visual surround suppression, suggesting enhanced inhibitory neural influences.
Safety and Efficacy of High-Dose Vitamin B6 as an Adjunctive Treatment for Antipsychotic-Induced Hyperprolactinemia in Male Patients With Treatment-Resistant Schizophrenia
This randomized double-blinded controlled study investigated high-dose vitamin B6 as an adjunct treatment for antipsychotic-induced hyperprolactinemia in male patients with treatment-resistant schizophrenia. The vitamin B6 group showed a 68.1% reduction in serum prolactin levels and better alleviation of psychotic symptoms and cognitive impairment compared to the aripiprazole group. No serious adverse secondary effects were observed.
Vitamin B6, vitamin B12 and methionine and risk of pancreatic cancer: a meta-analysis.
Meta-analysis examining the association between pancreatic cancer risk and intake or blood levels of vitamins B6, B12, and methionine. High intake of vitamin B6 and high blood PLP levels were associated with a reduced risk of pancreatic cancer, while no significant association was found for vitamin B12 and methionine.
MTHFR 677C → T genotype modulates the effect of a 5-year supplementation with B-vitamins on homocysteine concentration: The SU.FOL.OM3 randomized controlled trial
RCT of 2381 patients with cardiovascular disease history, examining the effect of B-vitamin supplementation on homocysteine levels across different MTHFR genotypes. B-vitamin concentrations increased and homocysteine levels decreased initially, with genotype influencing the long-term effect.
Decreased serum pyridoxal levels in schizophrenia: meta-analysis and Mendelian randomization analysis.
Meta-analysis and Mendelian randomization analysis of serum pyridoxal levels in schizophrenia. Serum pyridoxal levels were significantly lower in patients with schizophrenia, but no causal relationship was found between pyridoxal levels and schizophrenia risk.
Efficacy and safety of sodium cantharidinate and vitamin B6 injection for the treatment of digestive system neoplasms: a meta-analysis of randomized controlled trials.
Meta-analysis of 24 trials with 1,825 advanced digestive system neoplasm patients. The combination of sodium cantharidinate and vitamin B6 with conventional medical treatment significantly improved overall response rate, disease control rate, and quality of life, while alleviating adverse effects of chemotherapy.
Vitamin B6 and Cancer Risk: A Field Synopsis and Meta-Analysis.
This meta-analysis reviewed 121 observational studies and nine RCTs to assess the relationship between vitamin B6 intake or PLP levels and cancer risk. High dietary intake of vitamin B6 and high PLP levels were associated with a lower risk of all cancers, particularly gastrointestinal tumors. However, RCTs did not support a protective effect, and total intake findings were inconsistent.
Interventions for treating hyperemesis gravidarum.
This meta-analysis reviewed 25 trials involving 2052 women to assess the effectiveness and safety of various interventions for hyperemesis gravidarum. The interventions included acupressure/acupuncture, intravenous fluids, and pharmaceutical interventions like vitamin B6. The evidence was generally of low quality, with no clear evidence supporting any one intervention.
Effect of long-term supplementation with folic acid and B vitamins on risk of depression in older women.
RCT of 4331 women testing long-term supplementation with folic acid, vitamin B6, and vitamin B12 on depression risk. No significant difference in depression risk between supplement and placebo groups, despite reduced homocysteine levels.
Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes.
Meta-analysis of four trials with 1646 women evaluating vitamin B6 supplementation during pregnancy and/or labour. The study found decreased risk of dental decay with vitamin B6, but no significant differences in pre-eclampsia, eclampsia, or Apgar scores. The evidence quality was low, and the risk of bias was unclear.
Folic acid supplementation with and without vitamin B6 and revascularization risk: a meta-analysis of randomized controlled trials.
Meta-analysis of randomized trials examining the effect of folic acid supplementation with and without vitamin B6 on revascularization risk. Folic acid alone had no significant effect on coronary revascularization, CABG, PCI, coronary restenosis, or total revascularization. A combination of folic acid and moderate vitamin B6 showed a beneficial effect on reducing coronary revascularization risk.
Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: a randomized trial.
RCT of 5442 high-risk women testing a combination pill of folic acid, vitamin B6, and vitamin B12 for 7.3 years. The study found no significant reduction in total cardiovascular events despite significant homocysteine lowering.
Homocysteine lowering with folic acid and B vitamins in vascular disease.
RCT of 5522 patients with vascular disease or diabetes assessing the effect of folic acid, vitamin B6, and B12 supplementation on major cardiovascular events. The supplementation did not significantly reduce the risk of major cardiovascular events, though it did reduce stroke risk but increased hospitalization for unstable angina.
Pyridoxine (vitamin B6) supplementation in pregnancy.
Meta-analysis of five trials with 1646 women evaluating vitamin B6 supplementation during pregnancy and/or labour. The study found decreased risk of dental decay with vitamin B6 supplementation but no significant differences in birthweights, eclampsia, pre-eclampsia, or Apgar scores. The trials had unclear methodology and inadequate follow-up.
The effect of vitamin B6 on cognition.
Systematic review assessing the efficacy of vitamin B6 supplementation on cognitive function in older adults. No evidence was found for short-term benefits on mood or cognition, though vitamin B6 supplementation improved biochemical indices of vitamin B6 status.
RENAL PROTECTIVE EFFECT AND CLINICAL ANALYSIS OF VITAMIN B 6 IN PATIENTS WITH SEPSIS.
RCT of 128 sepsis patients comparing intravenous vitamin B6 therapy to sodium chloride. Vitamin B6 reduced inflammatory markers and improved oxidative stress indicators, leading to better renal function. ICU stay and hospitalization costs were lower in the vitamin B6 group.
Assessing pyridoxine adjuvant therapy effects on blood glucose levels in type 2 diabetes: A randomized clinical trial.
This randomized clinical trial assessed the effects of pyridoxine adjuvant therapy on blood glucose levels in patients with type 2 diabetes mellitus. Patients were divided into three groups: control, Metformin only, and Metformin plus vitamin B6. The study found that adding pyridoxine to Metformin significantly improved fasting plasma glucose, glycated hemoglobin, fasting serum insulin, and insulin resistance compared to the control group after 4 weeks.
Efficacy of vitamins B1 and B6 as an adjunctive therapy to lithium in bipolar-I disorder: A double-blind, randomized, placebo-controlled, clinical trial.
This double-blind, randomized, placebo-controlled clinical trial evaluated the effect of vitamins B1 and B6 as adjunctive therapy to lithium in 66 hospitalized patients with bipolar disorder in manic episodes. Vitamin B6 significantly improved mood and sleep quality compared to placebo, while vitamin B1 significantly improved sleep quality but not mood.
Effect of vitamin B6 on pain, disease severity, and psychological profile of fibromyalgia patients; a randomized, double-blinded clinical trial.
This randomized, double-blinded, placebo-controlled trial evaluated the effect of an 80-mg daily dose of vitamin B6 on pain, disease severity, and psychological symptoms in fibromyalgia patients. The study found no statistically significant difference between the vitamin B6 and placebo groups in terms of primary outcomes, including FIQR, pain-VAS, and HADS-anxiety scores.
Vitamin B6 Status among Vegetarians: Findings from a Population-Based Survey
The study assessed vitamin B6 status among vegetarians, pescatarians, flexitarians, and meat-eaters using NHANES data. No significant differences in vitamin B6 biomarkers were found across dietary groups, and vitamin B6 supplements were the strongest predictor of vitamin B6 status.
Prospective Randomized Evaluation of Idiopathic Hyperoxaluria Treatments.
RCT comparing low oxalate diet, vitamin B6 and magnesium oxide supplementation, and combination therapy in patients with idiopathic hyperoxaluria. The low oxalate diet was more effective than supplementation in reducing urinary oxalate levels. Combination therapy did not offer additional benefits over monotherapy.
The efficacy of vitamin B6 as an adjunctive therapy to lithium in improving the symptoms of acute mania in patients with bipolar disorder, type 1; a double‐blind, randomized, placebo‐controlled, clinical trial
Double-blind, randomized, placebo-controlled clinical trial investigating the effect of vitamin B6 as an adjunctive therapy to lithium in improving symptoms of acute mania in patients with bipolar disorder, type 1.
A Pilot Randomized Treatment-Controlled Trial Comparing Vitamin B6 with Broad-Spectrum Micronutrients for Premenstrual Syndrome
This double-blind, randomized, treatment-controlled trial compared the efficacy of a broad-spectrum micronutrient formula to vitamin B6 (80 mg/day) for treating premenstrual syndrome (PMS) in 72 women. Both treatments reduced PMS symptoms with medium effect sizes, but the micronutrient group showed greater improvement in health-related quality of life. The study suggests potential clinical benefits of micronutrients for premenstrual dysphoric disorder (PMDD).
Effect of Combined Treatment With Folic Acid, Vitamin B6, and Vitamin B12 on Plasma Biomarkers of Inflammation and Endothelial Dysfunction in Women
RCT of 300 women at increased risk of cardiovascular disease testing combined treatment with folic acid, vitamin B6, and vitamin B12. The treatment reduced homocysteine concentrations by 18% but did not alter major biomarkers of vascular inflammation or endothelial dysfunction.
The effect of 1 mg folic acid supplementation on clinical outcomes in female migraine with aura patients
This 6-month randomized, double-blind, placebo-controlled trial studied the effect of daily supplementation with 1 mg folic acid, 25 mg Vitamin B6, and Vitamin B12 on homocysteine levels and migraine occurrence in 300 female patients with migraine with aura. The supplementation did not significantly decrease homocysteine levels or reduce migraine disability, severity, or frequency.
Pyridoxal 5 phosphate for neuroleptic-induced tardive dyskinesia.
Meta-analysis of three RCTs involving 80 inpatients with schizophrenia, assessing pyridoxal 5 phosphate for neuroleptic-induced tardive dyskinesia. Pyridoxal 5 phosphate showed significant improvement in tardive dyskinesia symptoms compared to placebo, but the quality of evidence is low due to small sample sizes and short follow-up periods.
Studying the antiemetic effect of vitamin B6 for morning sickness: pyridoxine and pyridoxal are prodrugs.
This study was a substudy of a randomized, placebo-controlled trial comparing the antiemetic effect of the doxylamine-vitamin B6 combination (Diclectin) to placebo in women with nausea and vomiting of pregnancy. Serum concentrations of pyridoxine, pyridoxal, and pyridoxal 5' phosphate (PLP) were measured, with PLP showing a correlation with reduced morning sickness symptoms, suggesting it may be the active antiemetic form of vitamin B6.
Is vitamin B(6) deficiency an under-recognized risk in patients receiving haemodialysis? A systematic review: 2000-2010.
Systematic review assessing vitamin B6 deficiency in haemodialysis patients from 2000 to 2010. Vitamin B6 deficiency was found to be between 24% and 56%, with dialysis reducing plasma levels by 28-48%. Advances in renal medicine may contribute to increased deficiency levels.
Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial.
RCT of high-dose folic acid, vitamins B6 and B12 in 271 individuals over 70 years old with mild cognitive impairment. The study found that B vitamin supplementation slowed the rate of brain atrophy compared to placebo, particularly in those with higher baseline homocysteine levels.
WITHDRAWN: Interventions for nausea and vomiting in early pregnancy.
Systematic review of 28 trials assessing treatments for nausea and vomiting in early pregnancy. Vitamin B6 (pyridoxine) appears effective in reducing nausea severity. Ginger and other treatments were also evaluated, but results were mixed.
Vitamin B6 and risk of colorectal cancer: a meta-analysis of prospective studies.
Meta-analysis of prospective studies assessing the association of vitamin B6 intake or blood PLP levels with colorectal cancer risk. The analysis found an inverse association, with higher vitamin B6 intake and blood PLP levels linked to reduced colorectal cancer risk.
Homocysteine lowering with folic acid and B vitamins in people with chronic kidney disease--results of the renal Hope-2 study.
RCT of 619 participants with CKD comparing folic acid, vitamin B6, and vitamin B12 supplementation to placebo over 5 years. The treatment lowered homocysteine levels but did not reduce cardiovascular risk. More participants in the treatment group were hospitalized for heart failure and unstable angina.
Dietary folate, vitamin B12, and vitamin B6 and the risk of Parkinson disease.
The Rotterdam Study, a prospective cohort study, evaluated the association between dietary intake of folate, vitamin B12, and vitamin B6 and the risk of Parkinson's disease (PD) among 5,289 participants. After a mean follow-up of 9.7 years, higher dietary intake of vitamin B6 was associated with a significantly decreased risk of PD, particularly among smokers. No association was observed for dietary folate and vitamin B12.
Interventions for nausea and vomiting in early pregnancy.
Systematic review assessing treatments for nausea and vomiting in early pregnancy, including anti-histamines, vitamin B6 (pyridoxine), Debendox, P6 acupressure, ginger root extract, corticosteroids, ACTH, and diazepam. Vitamin B6 appears effective in reducing nausea severity, while other treatments show variable results.
Combined vitamin B6-magnesium treatment in autism spectrum disorder.
Meta-analysis reviewing the efficacy of vitamin B6 and magnesium for treating social, communication, and behavioral responses in individuals with autism. Two trials were included, with one providing insufficient data and the other showing no significant differences between treatment and placebo groups.
Vitamin B6 Supplementation Reduces Symptoms of Depression in College Women Taking Oral Contraceptives: A Randomized, Double-Blind Crossover Trial.
A randomized, double-blind crossover trial in college women using oral contraceptives examined the effects of 100mg daily vitamin B6 supplementation on depression symptoms. Vitamin B6 supplementation reduced BDI-II scores by 20% compared to an 11% increase with placebo, while POMS scores were not significantly affected.
Quantification of the B6 vitamers in human plasma and urine in a study with pyridoxamine as an oral supplement; pyridoxamine as an alternative for pyridoxine.
This study assessed the metabolization of oral pyridoxamine (PM) supplements in five healthy volunteers. After a single oral dose of 200 mg PM, plasma PM increased significantly, with PLP levels also rising and reaching a plateau. The study suggests PM as a promising supplement for inhibiting harmful processes in metabolic diseases and treating vitamin B6 deficiency.
Effectiveness of misoprostol administration for cervical ripening in women before operative hysteroscopy: a randomized, double-blinded controlled trial
RCT comparing the effectiveness of misoprostol and vitamin B6 for cervical ripening in women before operative hysteroscopy. Misoprostol was more effective than the control for preoperative cervical priming, with a shorter duration required for cervical priming and a higher effect on cervical dilation in premenopausal participants.
Nutraceutical approaches to homocysteine lowering in hypertensive subjects at low cardiovascular risk: a multicenter, randomized clinical trial.
A multicenter randomized clinical trial comparing the efficacy of a nutraceutical (Normocis) versus high-dose folic acid in lowering homocysteine levels in hypertensive subjects at low cardiovascular risk. Normocis significantly reduced homocysteine levels more than the control, with 55.8% of subjects reaching ideal levels. No side effects were observed.
Intravenous Vitamin B6 Increases Resistance to Erythropoiesis-Stimulating Agents in Hemodialysis Patients: A Randomized Controlled Trial.
RCT of 56 hemodialysis patients examining the effects of intravenous vitamin B6 on ESA resistance and bone turnover markers. Vitamin B6 increased ESA resistance and blunted bone response to parathyroid hormone.
Vitamin B6 supplementation increases immune responses in critically ill patients.
A single-blind intervention study at Taichung Veterans General Hospital investigated the effects of vitamin B6 supplementation on immune responses in critically ill patients. Fifty-one subjects were randomly assigned to control, 50 mg, or 100 mg vitamin B6 groups for 14 days. The study found significant increases in immune response markers in the vitamin B6 groups compared to the control.
Combined vitamin B6-magnesium treatment in autism spectrum disorder.
Systematic review of studies on vitamin B6 and magnesium treatment in autism spectrum disorder. Three studies were included with a total sample size of 33. One study found a statistically significant benefit for IQ in a subgroup of children with pervasive developmental disorders, but overall, no recommendation can be made due to small sample sizes and methodological limitations.
Homocysteine-lowering treatment with folic acid plus vitamin B6 lowers urinary albumin excretion but not plasma markers of endothelial function or C-reactive protein: further analysis of secondary end-points of a randomized clinical trial.
A 2-year placebo-controlled RCT among 158 healthy siblings of patients with premature atherosclerotic disease studied the effect of folic acid plus vitamin B6 on markers of endothelial function and inflammation. The treatment decreased the urinary albumin-to-creatinine ratio but had no effect on other markers of endothelial dysfunction or plasma C-reactive protein.
Plasma vitamin B6 vitamers before and after oral vitamin B6 treatment: a randomized placebo-controlled study.
RCT examining plasma B6 vitamers before and after vitamin B6 supplementation in patients undergoing coronary angiography. Vitamin B6 treatment significantly increased concentrations of B6 vitamers in plasma, with changes remaining stable during prolonged treatment.
Vitamin B6 metabolism and homocysteine in end-stage renal disease and chronic renal insufficiency.
The study evaluated vitamin B6 metabolism and homocysteine levels in patients with chronic renal insufficiency and those on hemodialysis, compared to healthy controls. High-dose vitamin B6 and folic acid supplementation was administered, revealing vitamin B6 deficiency and high homocysteine levels in patients. The response to supplementation varied, with partial resistance observed, suggesting nonvitamin factors or toxic pyridoxic acid levels may affect metabolism during renal insufficiency.
Association of the B-vitamins pyridoxal 5'-phosphate (B(6)), B(12), and folate with lung cancer risk in older men.
A nested case-control study within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study cohort tested associations between B-vitamins and lung cancer risk in older men. Higher serum vitamin B6 levels were associated with a significantly lower risk of lung cancer, while no significant associations were found for folate, vitamin B12, or homocysteine.
Vitamin Intervention for Stroke Prevention (VISP) trial: rationale and design.
The Vitamin Intervention for Stroke Prevention (VISP) trial is a double-masked, randomized, multicenter clinical trial designed to determine if high-dose folic acid, vitamin B6, and vitamin B12 supplements will reduce recurrent stroke compared to lower doses. The study targets patients with a nondisabling ischemic stroke and elevated plasma homocyst(e)ine levels.
Vitamin B6 Competition in the Tumor Microenvironment Hampers Antitumor Functions of NK Cells
The study investigates how pancreatic cancer cells deplete vitamin B6 in the tumor microenvironment, affecting NK cell antitumor functions. Supplementation of vitamin B6 or blocking VB6-dependent metabolism enhances NK cell immunity and inhibits tumor growth in pancreatic cancer models.
Vitamin B6 Is Under a Tight Balance During Disease Development by Rhizoctonia solani on Different Cultivars of Potato and on Arabidopsis thaliana Mutants
The study explores the role of vitamin B6 during disease progression in potato cultivars with different susceptibility levels to Rhizoctonia solani. It finds that vitamin B6 levels and gene expression patterns differ between susceptible and tolerant cultivars, with implications for disease tolerance and oxidative stress response.
Simultaneous determination of vitamin B6 and catechins in dietary supplements by ZIC-HILIC chromatography and their antioxidant interactions
The study used ZIC-HILIC chromatography to simultaneously determine vitamin B6 and catechins in dietary supplements. It evaluated the antioxidant interactions between green tea extract and vitamin B6, finding that mixtures of GTE and vitamin B6 acted synergistically, particularly with pyridoxal, in DPPH radical bleaching.
Treatment of mid-late stage NSCLC using sodium cantharidinate/vitamin B6/GP regimen in clinic.
RCT of 86 NSCLC patients comparing sodium cantharidinate/vitamin B6/GP regimen to regular GP regimen over four 21-day cycles. The treatment group showed a higher effectiveness rate, better life quality, and lower occurrence of toxic/adverse effects compared to the control group.
Effects of exercise and B vitamins on homocysteine and glutathione in Parkinson's disease: a randomized trial.
RCT with 36 subjects with Parkinson's disease testing effects of B vitamin supplementation and exercise on homocysteine and glutathione levels. B vitamin supplementation lowered homocysteine levels, while exercise increased glutathione levels, strength, and aerobic capacity. No greater changes were observed with combined interventions.
B vitamin supplementation reduces excretion of urinary dicarboxylic acids in autistic children.
RCT of 30 autistic children receiving magnesium, vitamin B6, and vitamin B2 supplementation for 3 months. The study found a reduction in urinary dicarboxylic acids, suggesting improved metabolic profiles.
Vitamin B(6) supplementation improves pro-inflammatory responses in patients with rheumatoid arthritis.
Single-blind co-intervention study of vitamin B6 supplementation in rheumatoid arthritis patients. Vitamin B6 group showed significant decreases in plasma IL-6 and TNF-alpha levels after 12 weeks, indicating suppressed pro-inflammatory cytokines.
Vitamin B6 supplementation can improve peripheral polyneuropathy in patients with chronic renal failure on high-flux haemodialysis and human recombinant erythropoietin.
RCT of vitamin B6 supplementation (60 mg/day) in 26 chronic HD patients with peripheral polyneuropathy (PPN). Vitamin B6 significantly increased predialysis P5P levels and improved PPN symptoms compared to vitamin B12 supplementation, which showed no improvement.
Effect of isoniazid prophylaxis on incidence of active tuberculosis and progression of HIV infection.
RCT in Port-au-Prince, Haiti, comparing isoniazid plus vitamin B6 to vitamin B6 alone in 118 HIV-infected individuals to prevent active tuberculosis. Isoniazid significantly reduced tuberculosis incidence and delayed progression to HIV disease, AIDS, and death.
Effects of seven low-dose combined contraceptives on vitamin B6 status.
The study investigated the effect of seven low-dose oral contraceptive preparations on vitamin B6 status in 55 women. After six months, EGOT activity increased, but plasma PLP levels returned to normal, indicating no adverse effects on vitamin B6 status.
The biochemistry of vitamin B6 is basic to the cause of the Chinese restaurant syndrome.
The study investigated the role of vitamin B6 deficiency in the Chinese Restaurant Syndrome using a differential assay of aspartate transaminase in 155 students. 27 students with low transaminase activity were challenged with glutamate and placebo. 12 showed symptoms of the syndrome, and after treatment with pyridoxine, 8 of 9 did not respond to glutamate, suggesting vitamin B6's role in the syndrome.
Gut dysbiosis-induced vitamin B6 metabolic disorder contributes to chronic stress-related abnormal behaviors in a cortisol-independent manner
The study used a repeated restraint stress rat model to investigate the role of gut dysbiosis-induced vitamin B6 metabolic disorder in chronic stress-related abnormal behaviors. Vitamin B6 supplementation alleviated weight loss, abnormal behaviors, and inflammation in stressed rats, suggesting its potential as a therapeutic strategy for chronic stress-related disorders.
Human-derived fecal microbiota transplantation alleviates social deficits of the BTBR mouse model of autism through a potential mechanism involving vitamin B6 metabolism
The study evaluated the effects of human-derived fecal microbiota transplantation (FMT) on the BTBR mouse model of autism spectrum disorder (ASD). FMT alleviated social deficits and normalized plasma metabolic profiles, linking these changes to vitamin B6 metabolism. Vitamin B6 supplementation improved social behaviors in BTBR mice, suggesting a potential mechanism involving vitamin B6 metabolism.
High-Dose Vitamin B6 (Pyridoxine) Displays Strong Anti-Inflammatory Properties in Lipopolysaccharide-Stimulated Monocytes
In vitro study examining the effects of high-dose vitamin B6 on LPS-stimulated monocyte/macrophage cells. High-dose vitamin B6 demonstrated a global anti-inflammatory effect by downregulating various inflammatory mediators, suggesting its potential as a broad-spectrum anti-inflammatory agent.
Fusarium-produced vitamin B6 promotes the evasion of soybean resistance by Phytophthora sojae.
The study investigates the interaction between Fusarium spp. and Phytophthora sojae in soybean roots, revealing that Fusarium-produced vitamin B6 promotes the evasion of soybean resistance by P. sojae. Vitamin B6 suppresses expression of soybean disease resistance-related genes, facilitating infection.
Drosophila carrying epilepsy-associated variants in the vitamin B6 metabolism gene PNPO display allele- and diet-dependent phenotypes
The study used Drosophila melanogaster as a model to investigate the effects of epilepsy-associated variants in the vitamin B6 metabolism gene PNPO. It examined developmental, behavioral, electrophysiological, and fitness effects of mutant alleles under different dietary conditions, showing allele- and diet-dependent phenotypes.
Vitamin B6 Inhibits High Glucose-Induced Islet β Cell Apoptosis by Upregulating Autophagy
The study investigated the effect of vitamin B6 on high glucose-induced apoptosis in RIN-m5F cells. Vitamin B6 reduced apoptosis rates and increased autophagy, suggesting a protective mechanism via the mTOR-dependent pathway. The hydrothermal process decreased vitamin B6 content in eggs but did not affect its cytoprotective function.
Pyridoxamine and Aminoguanidine Attenuate the Abnormal Aggregation of β-Tubulin and Suppression of Neurite Outgrowth by Glyceraldehyde-Derived Toxic Advanced Glycation End-Products
The study investigated the effects of aminoguanidine and pyridoxamine on glyceraldehyde-derived toxic advanced glycation end-products (TAGE) in human neuroblastoma SH-SY5Y cells. Both substances inhibited TAGE-β-tubulin aggregation, mitigated suppression of neurite outgrowth, and reduced tau phosphorylation, suggesting potential to prevent diabetes-associated Alzheimer's disease progression.
Vitamin B6 efficacy in the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, single-center trial.
Open-label, single-arm, single-center trial examining the effect of vitamin B6 supplementation (90 mg/day) for 12 weeks in 22 patients with nonalcoholic fatty liver disease. While serum alanine aminotransferase levels did not change significantly, hepatic lipid accumulation was significantly reduced, suggesting vitamin B6 may ameliorate hepatic fat accumulation.
Vitamin B6 deficiency disrupts serotonin signaling in pancreatic islets and induces gestational diabetes in mice
The study investigates the impact of vitamin B6 deficiency on islet β-cell proliferation during pregnancy in mice. It finds that gestational vitamin B6 deficiency decreases serotonin levels in pancreatic islets and reduces β-cell proliferation, leading to glucose intolerance and insulin resistance.
Vitamin B6 deficiency hyperactivates the noradrenergic system, leading to social deficits and cognitive impairment
The study investigates the effects of vitamin B6 deficiency in mice, showing that VB6-deficient mice exhibit social deficits and cognitive impairment. The deficiency leads to enhanced noradrenaline metabolism, which is linked to the observed behavioral deficits. Supplementation with VB6 and treatment with guanfacine ameliorated these deficits.
Vitamin B6 Alleviates Lipopolysaccharide-induced Myocardial Injury by Ferroptosis and Apoptosis Regulation
The study demonstrated that Vitamin B6 can improve lipopolysaccharide-induced myocardial injury by suppressing oxidative stress and lipid peroxidation, which lead to ferroptosis and apoptosis. Vitamin B6 regulated iron homeostasis and the expression of antioxidant enzymes, improving survival rates in mice challenged with high LPS doses.
Effect of vitamin B6 on brain damage in valproic acid induced toxicity
Animal study investigating the protective effect of vitamin B6 on valproic acid-induced brain injury in male Sprague–Dawley rats. Vitamin B6 administration reversed oxidative stress markers and enzyme activity changes caused by valproic acid, indicating a protective effect on brain damage.
Rice Bran and Vitamin B6 Suppress Pathological Neovascularization in a Murine Model of Age-Related Macular Degeneration as Novel HIF Inhibitors
The study investigated the effects of rice bran and vitamin B6 as novel HIF inhibitors in a murine model of age-related macular degeneration. Both substances showed inhibitory effects on HIF activation and suppressed VEGF mRNA induction, leading to a significant suppression of retinal neovascularization.
Clinical Evaluation of Sequential Transdermal Delivery of Vitamin B6, Compound Glycyrrhizin, Metronidazole, and Hyaluronic Acid Using Needle-Free Liquid Jet in Facial Seborrheic Dermatitis
The study evaluated the use of needle-free transdermal jet injection (NTJI) for delivering vitamin B6, glycyrrhizin compound, metronidazole, and hyaluronic acid in treating facial seborrheic dermatitis. Erythema was significantly reduced, and stratum corneum hydration increased after treatment, with no significant improvement in superficial lipid level until week 6 and no improvement in skin roughness.
The gut microbiota regulates autism-like behavior by mediating vitamin B6 homeostasis in EphB6-deficient mice
The study investigates the role of gut microbiota in regulating autism-like behavior in EphB6-deficient mice by mediating vitamin B6 homeostasis. It finds that disturbed gut microbiota leads to vitamin B6 and dopamine defects, affecting the excitation/inhibition balance in the medial prefrontal cortex, which is linked to autism-like behavior.
Vitamin B6 prevents excessive inflammation by reducing accumulation of sphingosine‐1‐phosphate in a sphingosine‐1‐phosphate lyase–dependent manner
The study investigates the anti-inflammatory mechanism of vitamin B6, showing it reduces sphingosine-1-phosphate accumulation in macrophages via sphingosine-1-phosphate lyase. Vitamin B6 supplementation decreased pro-inflammatory cytokines and protected mice from lethal endotoxic shock and autoimmune encephalomyelitis.
Genotype-Specific Changes in Vitamin B6 Content and the PDX Family in Potato
The study investigates the interactions and expression profiles of PDX genes for vitamin B6 biosynthesis in potato, highlighting genotype-specific variations in vitamin B6 content. The findings suggest that potato is a valuable resource for vitamin B6 and has potential for fortifying vitamin B6 nutrition in potato-based foods.
Kinetics of homocysteine metabolism after moderate alcohol consumption.
RCT with 19 participants examining the effects of moderate alcohol consumption on plasma homocysteine concentrations and vitamin B status. Moderate alcohol consumption increased plasma vitamin B6 and decreased serum vitamin B12, but did not affect plasma homocysteine concentrations or S-adenosyl methionine/S-adenosyl homocysteine ratio.
A benfotiamine-vitamin B combination in treatment of diabetic polyneuropathy.
Double-blind, randomized controlled study of benfotiamine plus vitamin B6/B12 combination in 24 diabetic patients with polyneuropathy over 12 weeks. Significant improvement in nerve conduction velocity and a trend toward improved vibration perception threshold were observed. Long-term observation of 9 patients over 9 months supported these results.
Theophylline increases pyridoxal kinase activity independently from vitamin B6 nutritional status.
A cross-over, placebo-controlled study on 15 healthy volunteers investigated the mechanism by which theophylline induces pyridoxal kinase activity. Vitamin B6 supplementation resulted in a four-fold increase in circulating pyridoxal 5'-phosphate levels, while placebo had no effect. Theophylline therapy increased erythrocyte pyridoxal kinase activities significantly, independent of vitamin B6 supplementation.
Pyridoxine (vitamin B6) and the premenstrual syndrome: a randomized crossover trial.
A randomized double-blind crossover trial studied the effects of pyridoxine (vitamin B6) at 50 mg per day on premenstrual syndrome symptoms in 63 women. Thirty-two women completed the study, showing a significant beneficial effect of pyridoxine on emotional symptoms like depression, irritability, and tiredness.
Effect of oral vitamin B6 supplementation on in vitro platelet aggregation.
A randomized, double-blind study with 12 healthy adult males examined the effects of oral pyridoxine supplementation on in vitro platelet aggregation. Plasma PLP concentrations increased significantly in the vitamin B6 group, but there was no significant effect on collagen-stimulated platelet aggregation and only a slight effect on ADP-stimulated aggregation.
Vitamin B6 requirements of women using oral contraceptives.
RCT involving 15 women using oral contraceptives and 9 control women on a vitamin B6-deficient diet followed by supplementation with pyridoxine hydrochloride. The study measured various indices of vitamin B6 nutrition, finding altered tryptophan metabolism in contraceptive users despite normal other indices, suggesting a specific effect on tryptophan metabolism unrelated to vitamin B6 deficiency.
Relationship of Low Vitamin B6 Status with Sarcopenia, Frailty, and Mortality: A Narrative Review
Narrative review assessing the relationship between vitamin B6 status and age-related conditions such as sarcopenia, frailty, and mortality. Among 31 studies reviewed, 25 showed a significant association of B6 status with these conditions, while 6 showed no association. The review discusses potential mechanisms involving signaling pathways and metabolic processes.
Scientific opinion on the tolerable upper intake level for vitamin B6
The EFSA Panel on Nutrition, Novel Foods and Food Allergens delivered a scientific opinion on the tolerable upper intake level (UL) for vitamin B6. The relationship between excess vitamin B6 intakes and peripheral neuropathy is well established. A UL of 12 mg/day for adults is established, with lower ULs for infants and children. EU populations are unlikely to exceed ULs, except for regular users of high-dose vitamin B6 supplements.
Non-enzymatic hydrogen sulfide production from cysteine in blood is catalyzed by iron and vitamin B6
The study investigates non-enzymatic hydrogen sulfide production from cysteine in blood, catalyzed by iron and Vitamin B6. It highlights the chemical mechanism and potential pathophysiological implications in hemolytic, iron overload, and hemorrhagic disorders.
Anti-diabetic study of vitamin B6 on hyperglycaemia induced protein carbonylation, DNA damage and ROS production in alloxan induced diabetic rats.
The study examines the effects of pyridoxamine (vitamin B6) supplementation in alloxan-induced diabetic rats. Pyridoxamine treatment showed dose-dependent recovery in oxidative stress parameters, reduced ROS production, and improved fasting blood glucose levels. Histological studies indicated recovery in liver and kidney tissues, and cellular DNA damage was notably reduced.
Understanding the effect of vitamin B6 and PEG functionalization on improving the performance of carbon nanotubes in temozolomide anticancer drug transportation
The study uses density functional theory and molecular dynamics simulation to explore the efficiency of functionalized carbon nanotubes with polyethylene glycol in temozolomide delivery. It finds that vitamin B6 can improve the adsorption behavior of the temozolomide drug molecule on the nanocarrier surface.
Determination and evaluation of in vitro bioaccessibility of the pyridoxal, pyridoxine, and pyridoxamine forms of vitamin B6 in cereal-based baby foods.
The study evaluated the bioaccessibility of pyridoxal, pyridoxine, and pyridoxamine forms of vitamin B6 in cereal-based baby foods using an in vitro digestive system. The bioaccessibility of these forms was found to be lower at both gastric pH 1.5 and 4.
Vitamin B6 is essential for serine de novo biosynthesis
The study investigates the role of vitamin B6 in serine de novo biosynthesis using vitamin B6-deprived Neuro-2a cells. It finds that vitamin B6 is essential for serine biosynthesis, with deficiencies leading to reduced serine and glycine levels, which may contribute to vitamin B6 responsive epilepsy.