Research
Vitamin B5
32 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Serum Metabolomic Markers of Dairy Consumption: Results from the Atherosclerosis Risk in Communities Study and the Bogalusa Heart Study.
The study aimed to identify associations between dietary dairy intake and serum metabolites in two independent study populations. It found significant associations between dairy intake and serum metabolites, including myristate and pantothenate, suggesting these as candidate biomarkers of dairy consumption.
Effects of pantothenic acid on growth performance and carcass characteristics of growing-finishing pigs fed diets with or without ractopamine hydrochloride.
Two experiments evaluated the effects of added pantothenic acid on the growth performance and carcass characteristics of growing-finishing pigs. The study found that increasing dietary pantothenic acid did not improve growth performance or carcass composition, suggesting that the pantothenic acid in corn and soybean meal may be sufficient for pigs in this weight range.
Randomized-Controlled Trial Comparing Safety and Efficacy of Repairing Balm vs Topical Antimicrobial for Post-Procedural Wounds.
A multicenter, intra-individual, randomized control trial compared the safety and efficacy of a nonprescription repairing balm containing panthenol, madecassoside, and metal salts (CB5) versus a topical antibiotic (PSO) for post-procedural wound healing of actinic keratoses lesions. The study found no clinically significant differences in time to lesion healing, erythema, or oozing/crusting between the groups, and no adverse events related to the study products were reported.
Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study.
Double-blind RCT evaluating a panthenol-enriched mask with centella asiatica extract and bisabolol for skin barrier recovery after facial laser treatment. The mask group showed improved erythema index, hyperpigmentation index, sebum content, moisture content, and reduced transepidermal water loss compared to the control group.
Prebiotic and panthenol-containing dermocosmetic improves tolerance from artificial daylight photodynamic therapy: A randomized controlled trial in patients with actinic keratosis.
This randomized controlled trial investigated the effect of a prebiotic and panthenol-containing dermocosmetic cream on skin tolerance following artificial daylight photodynamic therapy in patients with actinic keratosis. The cream significantly improved post-treatment tolerance and accelerated healing time up to 14 days, without affecting the overall treatment efficacy.
Effects of a cream containing madecassoside, 5% panthenol, and copper-zinc-manganese on improving postlaser resurfacing wound healing: A split-face, randomized trial.
A split-face, randomized trial evaluating the effects of a cream containing madecassoside, 5% panthenol, and copper-zinc-manganese on postlaser resurfacing wound healing.
A new topical panthenol-containing emollient for maintenance treatment of childhood atopic dermatitis: results from a multicenter prospective study.
A multicenter prospective study evaluated the efficacy and safety of a new topical panthenol-containing emollient (NTP-CE) for maintenance treatment in infants and children with stabilized mild atopic dermatitis. The study involved 108 subjects randomized to receive NTP-CE or a reference emollient for approximately 3 months. Results showed a decrease in SCORAD scores and high success rates in preventing flares, indicating that NTP-CE is efficacious and safe for this purpose.
Skin moisturizing effects of panthenol-based formulations.
This study evaluated the skin moisturizing efficacy of formulations containing different concentrations of panthenol. Formulations with 1.0% and 5.0% panthenol significantly decreased transepidermal water loss (TEWL) after 30 days. Panthenol formulations also reduced TEWL two hours after application on skin washed with sodium laureth sulphate.
Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate-induced irritation.
RCT examining the effects of a dexpanthenol-containing cream on skin barrier repair, hydration, roughness, and inflammation after sodium lauryl sulphate-induced irritation. The dexpanthenol cream significantly enhanced skin barrier repair, increased hydration, reduced roughness, and decreased inflammation compared to placebo.
Vitamin B5 supports MYC oncogenic metabolism and tumor progression in breast cancer
The study investigates the role of vitamin B5 in MYC oncogenic metabolism and tumor progression in breast cancer. It finds that vitamin B5 associates with MYC-high areas in tumors, where its conversion to coenzyme A supports Krebs cycle activity. Dietary restriction of vitamin B5 reverses MYC-mediated metabolic changes and hampers tumor growth.
Vitamin B5 rewires Th17 cell metabolism via impeding PKM2 nuclear translocation.
The study investigates the role of vitamin B5 in Th17 cell metabolism and its potential therapeutic effects on autoimmune diseases. Vitamin B5 restrains Th17 cell differentiation and related autoimmune diseases by impeding PKM2 nuclear translocation, inhibiting glycolysis and STAT3 phosphorylation.
PI3K drives the de novo synthesis of coenzyme A from vitamin B5
The study investigates the role of PI3K signalling in the de novo synthesis of coenzyme A from vitamin B5. It identifies pantothenate kinase 2 (PANK2) and PANK4 as substrates of the PI3K effector kinase AKT, with PANK4 acting as a rate-limiting suppressor of CoA synthesis. The PI3K–PANK4 axis regulates coenzyme A synthesis and CoA-dependent processes such as lipid metabolism.
Immunostimulatory effects of vitamin B5 improve anticancer immunotherapy
The study reports that vitamin B5 and CoA promote the differentiation of CD8+ cytotoxic T cells into IL-22-producing Tc22 cells, enhancing mitochondrial metabolism. In melanoma patients, higher plasma levels of vitamin B5 correlate with better responses to PD-1-targeted immunotherapy. In mice, vitamin B5 supplementation increases the efficacy of PD-L1-targeted cancer immunotherapy, and CoA enhances T cell antitumor activity in vitro.
Efficacy and safety of moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese versus 0.02% triamcinolone acetonide cream in decreasing adverse reaction and downtime after ablative fractional carbon dioxide laser resurfacing: A split-face, double-blinded, randomized, controlled trial.
A split-face, double-blinded, randomized controlled trial comparing a moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese to 0.02% triamcinolone acetonide cream in 20 subjects post-ablative fractional carbon dioxide laser resurfacing. Both treatments significantly reduced post-laser downtime and adverse reactions, with comparable efficacy in wound healing improvement and lower postinflammatory hyperpigmentation.
Cerebral Vitamin B5 (D-Pantothenic Acid) Deficiency as a Potential Cause of Metabolic Perturbation and Neurodegeneration in Huntington’s Disease
Case-control study identifying pervasive lowering of vitamin B5 in HD-human brain, suggesting cerebral pantothenate deficiency as a metabolic defect in Huntington's disease. This deficiency could impair neuronal CoA biosynthesis and lead to neurodegeneration, potentially preventable by vitamin B5 treatment.
A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora.
Two randomized controlled studies evaluated a new topical panthenol-containing emollient (NTP-CE) for skin moisturization and barrier restoration. Study 1 showed significant improvements in transepidermal water loss, skin hydration, and intercellular lipid lamellae organization. Study 2 found no negative impact on skin microflora.
Comparative trial of 5% dexpanthenol in water-in-oil formulation with 1% hydrocortisone ointment in the treatment of childhood atopic dermatitis: a pilot study.
Pilot RCT comparing 5% dexpanthenol ointment to 1% hydrocortisone ointment in 30 children with atopic dermatitis. No statistically significant difference in SCORAD score reduction between the two treatments, suggesting dexpanthenol may be an alternative treatment for mild to moderate childhood AD.
Acute pantothenic acid and cysteine supplementation does not affect muscle coenzyme A content, fuel selection, or exercise performance in healthy humans.
RCT with 8 healthy male volunteers testing the effect of pantothenic acid and cysteine supplementation on muscle CoASH content, fuel metabolism, and exercise performance. Supplementation did not alter muscle CoASH content or impact muscle fuel metabolism or performance during exercise.
Evaluation of egg injection method of pantothenic acid in turkey eggs and effect of supplemental pantothenic acid on hatchability.
Two experiments were conducted with 120 Large White British United Turkeys to evaluate the effect of pantothenic acid egg injections and dietary supplementation on hatchability. Incremental dietary pantothenic acid levels increased its transfer to eggs but did not improve hatchability. Egg injections with pantothenic acid also did not enhance hatchability, suggesting pantothenic acid is not limiting for hatchability in commercial turkey diets with sufficient levels.
Does pantothenic acid accelerate the return of bowel motility in post-operative patients?
The study investigates whether pantothenic acid accelerates the return of bowel motility in post-operative patients. No abstract is available to provide further details.
Vitamin B5, a Coenzyme A precursor, rescues TANGO2 deficiency disease-associated defects in Drosophila and human cells
The study uses a Drosophila model and human cells to investigate the effects of vitamin B5 on TANGO2 deficiency disease. Vitamin B5 improved multiple defects associated with TANGO2 loss-of-function in Drosophila and rescued membrane trafficking defects in human cells, suggesting potential therapeutic benefits.
A novel treatment of intertrigo in athletes and overweight subjects.
Open-label prospective trial assessing a new barrier spray containing zinc gluconate-taurine complex, zinc oxide, panthenol, glycerin, and shea butter for mild-to-moderate intertrigo in athletes and overweight subjects. Significant reductions in erythema and pruritus were observed at 15 and 30 days, with no relevant side effects.
Substantively Lowered Levels of Pantothenic Acid (Vitamin B5) in Several Regions of the Human Brain in Parkinson’s Disease Dementia
The study investigated pantothenic acid levels in brain tissues from nine Parkinson’s disease dementia (PDD) cases and nine controls. Pantothenic acid was significantly decreased in the cerebellum, substantia nigra, and medulla of PDD cases, indicating a regionally selective disruption similar to that observed in Alzheimer's and Huntington's diseases.
Cerebral deficiency of vitamin B5 (d-pantothenic acid; pantothenate) as a potentially-reversible cause of neurodegeneration and dementia in sporadic Alzheimer's disease.
The study identified severe cerebral deficiency of vitamin B5 in Alzheimer's disease (AD) patients compared to controls, particularly in brain regions severely affected by AD. The deficiency may contribute to neurodegeneration and dementia, suggesting potential for prevention or reversal with vitamin B5 supplementation.
Calcium pantothenate in arthritic conditions. A report from the General Practitioner Research Group.
The paper reports on the use of calcium pantothenate in arthritic conditions, as studied by the General Practitioner Research Group. No abstract is available to provide further details.
Pantothenic acid in the treatment of osteoarthrosis.
RCT studying the effects of pantothenic acid in the treatment of osteoarthrosis.
Pantothenic acid (vitamin B5) supplementation in rheumatological diseases: a review
Narrative review of pantothenic acid (vitamin B5) supplementation in rheumatic diseases, including osteoarthritis, fibromyalgia, and systemic lupus erythematosus. Clinical improvement was reported, particularly in cutaneous lupus, fatigue in SLE, and pain reduction in OA and FM. Adverse events were rare and mild, but data are limited by small sample sizes and lack of standardized protocols.
The vitamin B5/coenzyme A axis: A target for immunomodulation?
This review discusses the role of Coenzyme A (CoA) and its precursor Vitamin B5/pantothenate in metabolic pathways and immune cell function. It highlights the potential of targeting CoA metabolism for therapeutic intervention in chronic diseases by modulating immune responses and inflammation.
Vitamin B5 Reduces Bacterial Growth via Regulating Innate Immunity and Adaptive Immunity in Mice Infected with Mycobacterium tuberculosis
The study examined the proinflammatory and antibacterial effects of vitamin B5 in macrophages infected with Mycobacterium tuberculosis and its therapeutic potential in mice. Vitamin B5 enhanced the phagocytosis and inflammatory response in infected macrophages and decreased bacterial burdens in the lungs of infected mice, suggesting it inhibits MTB growth by regulating immunity.
Plasmodium yoelii Vitamin B5 Pantothenate Transporter Candidate is Essential for Parasite Transmission to the Mosquito
The study investigates the role of a pantothenate (vitamin B5) transporter in Plasmodium yoelii, essential for parasite transmission to mosquitoes. Deletion of the transporter gene in parasites showed normal blood stage development but abolished progression to the oocyst stage and sporozoite formation, highlighting its potential as a target for malaria transmission intervention.
Dexpanthenol enemas in ulcerative colitis: a pilot study.
Open-label pilot study of dexpanthenol enemas in three patients with active left-sided ulcerative colitis. Despite increased urinary pantothenic acid, no significant changes were observed in colonic coenzyme A concentrations, fecal short-chain fatty acids, or clinical disease activity. Patients reported increased abdominal cramping.
Pantothenic acid deficiency as the pathogenesis of acne vulgaris.
The paper proposes a theory that pantothenic acid deficiency is a primary factor in the pathogenesis of acne vulgaris, suggesting that hormonal factors are secondary. It claims that liberal replacement therapy with pantothenic acid can completely cure the condition.