Research
Vitamin B12 (Cyanocobalamin)
4 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Hydroxocobalamin, thiamine, and pyridoxine as an adjunct to standard treatment in chronic low back pain: a randomized clinical trial.
RCT evaluating the efficacy and safety of a combined injectable formulation of hydroxocobalamin (B12), thiamine hydrochloride (B1), and pyridoxine hydrochloride (B6) as an adjunct treatment for chronic low back pain. 84% of the treatment group achieved ≥30% reduction in pain score compared to 64% in the control group, with significant improvements in patient assessments.
High-Dose IV Hydroxocobalamin (Vitamin B12) in Septic Shock: A Double-Blind, Allocation-Concealed, Placebo-Controlled Single-Center Pilot Randomized Controlled Trial (The Intravenous Hydroxocobalamin in Septic Shock Trial).
This pilot RCT tested high-dose IV hydroxocobalamin versus placebo in 20 critically ill adults with septic shock. The study found a greater reduction in vasopressor dose and plasma hydrogen sulfide levels in the hydroxocobalamin group compared to placebo, with no serious adverse events, establishing feasibility for this intervention.
Homocysteine-reducing strategies improve symptoms in chronic schizophrenic patients with hyperhomocysteinemia.
RCT with 42 schizophrenic patients with elevated homocysteine levels, using a crossover design to compare vitamin therapy (folic acid, B-12, pyridoxine) to placebo. Vitamin therapy reduced homocysteine levels and improved clinical symptoms and neuropsychological test results.
Guidelines for diagnosis and management of the cobalamin-related remethylation disorders cblC, cblD, cblE, cblF, cblG, cblJ and MTHFR deficiency
The paper provides guidelines for the diagnosis and management of cobalamin-related remethylation disorders, recommending plasma total homocysteine measurement and treatment with parenteral hydroxocobalamin and betaine to improve outcomes.