Research
Vitamin B1
90 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Thiamine as a putative natural modulator of PPARγ: exploring a nutrient-based approach for type 2 diabetes
The study explores thiamine (vitamin B1) as a potential natural modulator of PPARγ for type 2 diabetes. Molecular docking and dynamics simulations show thiamine's stable interaction with PPARγ. In 3T3-L1 adipocytes, thiamine induced adipogenesis and PPARγ-response element binding. A meta-analysis of RCTs indicates high-dose benfotiamine improves neuropathic and vascular outcomes in T2D patients.
Diagnosis and treatment of Wernicke's encephalopathy: A systematic literature review.
Systematic review of 27 studies on IV thiamine treatment in Wernicke's encephalopathy (WE), including case reports and trials. IV thiamine was found to alleviate neurological symptoms and cognitive dysfunction in WE, though evidence and diagnostic standards need improvement.
Effect of vitamin B1 supplementation on blood creatinine and lactate levels and clinical outcomes in patients in intensive care units: a systematic review and meta-analysis of randomized controlled trials.
This meta-analysis evaluated the effect of thiamine supplementation on clinical and biochemical outcomes in ICU patients. Thiamine supplementation reduced serum creatinine levels but did not significantly affect lactate levels, mortality, need for renal replacement therapy, or length of ICU stay.
Prevalence of thiamine deficiency in anorexia nervosa: a systematic review and narrative synthesis.
Systematic review of the prevalence of thiamine deficiency in individuals with anorexia nervosa. Prevalence rates varied widely, with self-reporting showing 5.9% to 100% and objective measurements showing 0% to 56.7%. The review found limited evidence associating supplement use and higher energy intake with reduced deficiency risk.
When time is brain: a systematic review about Wernicke encephalopathy as a dramatic consequence of thiamin deficiency in hyperemesis gravidarum.
Systematic review of 82 cases of Wernicke encephalopathy (WE) due to thiamin deficiency in women with hyperemesis gravidarum (HG). The review highlights the clinical presentation, maternal and perinatal outcomes, and treatment of WE, emphasizing the importance of early diagnosis and thiamin administration to prevent severe neurological sequelae.
Association between diabetes and thiamine status - A systematic review and meta-analysis.
Systematic review and meta-analysis examining thiamine status in individuals with diabetes compared to those with normal glucose metabolism. Results indicate lower concentrations of thiamine and its analytes in individuals with diabetes, suggesting higher thiamine requirements.
Wernicke's Encephalopathy in Acute and Chronic Kidney Disease: A Systematic Review.
Systematic review of Wernicke's encephalopathy (WE) in patients with kidney disease, focusing on thiamine (vitamin B1) deficiency. The review included 46 cases from 37 reports, highlighting clinical characteristics and treatment outcomes. High doses of parenteral thiamine often led to full recovery, while low doses were associated with Korsakoff's syndrome.
Interventions to prevent or treat heavy menstrual bleeding or pain associated with intrauterine-device use.
Systematic review of 21 RCTs involving 3689 women evaluating interventions for heavy menstrual bleeding or pain associated with IUD use. Vitamin B1 and mefenamic acid showed potential benefits for treating heavy menstruation with Cu IUD, while tolfenamic acid may prevent heavy menstruation. Evidence is low to very low certainty, indicating a need for further research.
B1 Vitamin Deficiency After Bariatric Surgery, Prevalence, and Symptoms: a Systematic Review and Meta-analysis.
Systematic review and meta-analysis of 11 studies examining 1494 patients, focusing on the prevalence and symptoms of vitamin B1 deficiency after bariatric surgery. Twenty-seven percent of patients experienced vitamin B1 deficiency, highlighting the need for lifelong thiamine supplementation and dietary monitoring post-surgery.
Wernicke Encephalopathy Presenting with Dysphagia: A Case Report and Systematic Literature Review.
The paper reports a case of Wernicke encephalopathy (WE) presenting with dysphagia and conducts a systematic review of literature on this rare presentation. It highlights that thiamine deficiency should be suspected in patients with dysphagia of unknown cause, even without alcohol abuse, and suggests varying susceptibilities to clinical manifestations of thiamine deficiency.
Maternal Thiamine Supplementation Promotes Infants’ Language Processing at 24 Weeks
This double-blind, randomized controlled trial studied the effect of maternal thiamine supplementation on infants' language processing at 24 weeks. 335 lactating mothers received varying doses of thiamine, and infants' attentional enhancement to infant-directed speech was measured. Only infants whose mothers received the 10 mg daily supplement showed significant attentional enhancement, suggesting a positive link between thiamine and language processing.
The Dichotomous Effect of Thiamine Supplementation on Tumorigenesis: A Systematic Review.
This systematic review examines the effects of thiamine (vitamin B1) on tumorigenesis, highlighting its dichotomous role. Low doses of thiamine may stimulate tumor growth, while correcting vitamin B1 deficiency has shown evidence of tumor regression. The review suggests further research to explore thiamine's influence on cancer cell metabolism.
Wernicke Encephalopathy in schizophrenia: a systematic review.
Systematic review of Wernicke's Encephalopathy (WE) in schizophrenia patients, highlighting the importance of thiamine deficiency as a cause. The review found that 12 out of 15 schizophrenia cases presented the full triad of WE symptoms. Prophylactic thiamine checks and treatment are recommended for schizophrenia patients to prevent WE.
Beriberi, a severe complication after metabolic surgery - review of the literature.
Systematic review of literature on bariatric beriberi, a complication after metabolic surgery due to thiamine deficiency. The review highlights the increased risk of thiamine deficiency and Wernicke-Korsakoff syndrome post-surgery, particularly in women and older patients. Prompt parenteral thiamine substitution is recommended to prevent severe consequences.
Effectiveness of acupoint injection combined with specific electromagnetic spectrum irradiation and acupuncture on peripheral facial paralysis.
RCT of 85 patients with peripheral facial paralysis comparing prednisone acetate, acupuncture with electromagnetic spectrum irradiation, and acupuncture with vitamin B1 and B12 acupoint injection. The acupoint injection group showed higher effectiveness scores, shorter cure times, and lower serum inflammatory factors compared to other groups.
The association between dietary vitamin B1 intake and constipation: a population-based study
This population-based study examined the association between dietary vitamin B1 intake and chronic constipation using NHANES data from 2005 to 2010. The study found that higher dietary intake of vitamin B1 was significantly associated with a reduced risk of constipation, particularly among men, non-hypertensive, and non-diabetic individuals.
Association between dietary vitamin B1 intake and cognitive function among older adults: a cross-sectional study
Cross-sectional study using NHANES data from 2011-2014 to investigate the relationship between dietary vitamin B1 intake and cognitive function in older adults. Higher vitamin B1 intake was associated with better scores on cognitive function tests, including processing speed and executive function, as well as a global cognition z score.
Efficacy of Thiamine (Vitamin B1) on Post-Acute COVID-19 Syndrome: An Open-Label, Randomized, Controlled Trial
Open-label, randomized, controlled trial of 66 recovered COVID-19 patients with post-acute syndrome. Vitamin B1 administration significantly shortened symptom improvement duration compared to control, with effects observed within two weeks. Symptoms like myalgia, anosmia, ageusia, fatigue, and sleep disturbances improved after five weeks of supplementation.
The Effects of Thiamine Supplementation on General Health and Infertility Treatment Outcomes in Women with Polycystic Ovary Syndrome: A Triple-Blinded Randomized Placebo-Controlled Clinical Trial
Triple-blinded, randomized, placebo-controlled clinical trial on 64 infertile women with PCOS to evaluate the effects of thiamine (vitamin B1) on general health and infertility treatment outcomes. Thiamine supplementation improved general health scores and increased positive pregnancy tests, but did not change the number of fetuses.
Association of vitamin B1 with cardiovascular diseases, all-cause and cardiovascular mortality in US adults
This study analyzed NHANES data from 1999 to 2018 to examine the correlation between dietary vitamin B1 intake and cardiovascular diseases, as well as all-cause and cardiovascular mortality. It found that higher vitamin B1 intake was significantly associated with reduced risk of hypertension, heart failure, and cardiovascular mortality, particularly in elderly men, overweight individuals, smokers, drinkers, and those with dyslipidemia.
Thiamine for Renal Protection in Septic Shock (TRPSS): A Randomized, Placebo-controlled, Clinical Trial.
The TRPSS trial was a multicenter, randomized, placebo-controlled trial assessing thiamine supplementation for renal protection in septic shock. No significant difference was found in serum creatinine levels between thiamine and placebo groups at 72 hours. Thiamine recipients had more ICU-free days, but no differences in other secondary outcomes.
B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
This study analyzed plasma samples from a randomized clinical trial to compare levels of vitamins B1, B2, B3, and B6 in patients with quiescent inflammatory bowel disease and chronic fatigue. High doses of oral thiamine improved clinical fatigue scores, with a significant association between FMN and riboflavin levels and chronic fatigue.
The Utility of Oral Vitamin B1 and Mecobalamin to Improve Corneal Nerves in Dry Eye Disease: An In Vivo Confocal Microscopy Study.
This randomized double-blind controlled trial studied the effects of oral vitamin B1 and mecobalamin on corneal nerve parameters and symptoms in dry eye disease patients. The treatment group showed significant improvements in corneal nerve length, width, and neuromas, as well as symptoms like dryness, pain, photophobia, and blurred vision at 1 and 3 months post-treatment.
A multicenter randomized clinical trial of pharmacological vitamin B1 administration to critically ill patients who develop hypophosphatemia during enteral nutrition (The THIAMINE 4 HYPOPHOSPHATEMIA trial).
This multicenter randomized clinical trial investigated the effects of intravenous thiamine on blood lactate and clinical outcomes in 90 critically ill patients with hypophosphatemia during enteral nutrition. The study found no significant differences in blood lactate levels or clinical outcomes between the thiamine and control groups.
Effects of Oral Vitamin B1 and Mecobalamin on Dry Eye Disease
RCT assessing the effects of oral vitamin B1 and mecobalamin on dry eye disease (DED) in 76 patients. Group 3, receiving vitamin B1 and mecobalamin, showed significant improvements in dryness, foreign body sensation, burning, and tear film breakup time, as well as increased patient satisfaction. Improvements in corneal nerve fiber density were also observed.
Wernicke's encephalopathy in hyperemesis gravidarum: A systematic review.
Systematic review of 146 case studies on Wernicke's Encephalopathy (WE) in hyperemesis gravidarum (HG) patients. Thiamine depletion was common, leading to WE with symptoms like nausea, vomiting, and vision issues. Subtherapeutic thiamine treatment was frequent, and WE was exacerbated by intravenous glucose. Chronic cognitive disorders, pregnancy loss, and maternal death were reported. Adequate thiamine supplementation is necessary to prevent WE in HG.
The role of thiamine dependent enzymes in obesity and obesity related chronic disease states: A systematic review.
This systematic review examines the role of thiamine dependent enzymes in obesity and obesity-related chronic disease states. It discusses the potential under-recognition of thiamine and magnesium deficiencies in obesity, which may impact glucose metabolism and contribute to the progression of obesity and related diseases.
Preventing Wernicke's encephalopathy in anorexia nervosa: A systematic review.
Systematic review of Wernicke's encephalopathy (WE) in anorexia nervosa (AN) patients, highlighting the importance of prophylactic thiamine checks and treatment. The review suggests that WE is a rare but serious complication in AN, characterized by a complex triad of symptoms including mental status change, ocular signs, and ataxia.
Thiamine supplementation for the treatment of heart failure: a review of the literature.
Systematic review of 20 articles on thiamine supplementation in heart failure patients. Evidence suggests thiamine supplementation may improve left ventricular ejection fraction, cardiac function, urine output, weight loss, and signs and symptoms of heart failure.
Wernicke encephalopathy after bariatric surgery: a systematic review.
Systematic review of 84 cases of Wernicke encephalopathy (WE) after bariatric surgery. Frequent vomiting and intravenous glucose administration without thiamine were identified as risk factors. Incomplete recovery with memory deficits and gait difficulties was observed in 49% of cases.
Thiamine for Alzheimer's disease.
Systematic review evaluating the efficacy of thiamine for Alzheimer's disease. Three included studies showed no significant effect of thiamine compared to placebo on cognitive measures, and no significant side-effects were reported. The review concludes that the results are inadequate to draw conclusions.
Thiamine for Alzheimer's disease.
Systematic review evaluating the effect of thiamine on Alzheimer's disease. The review found no evidence that thiamine is a useful treatment for Alzheimer's symptoms, with data suggesting no significant effect compared to placebo.
Impact of Vitamin B1 and Vitamin B2 Supplementation on Anxiety, Stress, and Sleep Quality: A Randomized, Double-Blind, Placebo-Controlled Trial.
RCT of 43 participants comparing 100 mg of vitamin B1 and B2 supplementation to placebo over four weeks. The supplement group showed significant reductions in stress and improvements in sleep quality and sleepiness, but no significant effect on anxiety.
Relationship of blood thiamine pyrophosphate to plasma phosphate and the response to enteral nutrition plus co-administration of intravenous thiamine during critical illness.
This study evaluated whether plasma phosphate concentrations predict hypovitamin B1 and the effects of enteral nutrition and intravenous thiamine supplementation in critically ill patients. Intravenous thiamine achieved supraphysiological concentrations, while enteral nutrition alone prevented new cases of hypovitamin B1.
A functional evaluation of anti-fatigue and exercise performance improvement following vitamin B complex supplementation in healthy humans, a randomized double-blind trial.
A randomized double-blind crossover trial evaluated the effects of 28-day vitamin B complex supplementation on exercise performance and fatigue in 32 healthy adults. The study found significant improvements in exercise endurance and reductions in blood lactate and ammonia levels compared to placebo.
Effectiveness of Acupuncture Treatment on Chemotherapy-Induced Peripheral Neuropathy: A Pilot, Randomized, Assessor-Blinded, Controlled Trial
Pilot RCT comparing acupuncture to vitamin B1 and gabapentin for chemotherapy-induced peripheral neuropathy (CIPN) in 40 participants. Acupuncture showed significantly greater reduction in CIPN symptom severity and higher patient satisfaction compared to vitamin B1 and gabapentin.
Addition of Vitamin B Complex to Prime Solution in Cobalamin-Deficient Patients to Prevent Postoperative Delirium.
RCT investigating the addition of vitamin B complex to prime solution for CPB in cobalamin-deficient patients undergoing CABG. The study found that vitamin B complex decreased the incidence and severity of postoperative delirium compared to the control group.
Comparable Performance Characteristics of Plasma Thiamine and Erythrocyte Thiamine Diphosphate in Response to Thiamine Fortification in Rural Cambodian Women.
The study evaluated plasma concentrations of thiamine and thiamine monophosphate as measures of vitamin B1 status in response to thiamine fortification in 196 healthy Cambodian women. Plasma thiamine showed the strongest response to fortification, increasing by 266%, while plasma TMP and eThDP increased by 60% and 53%, respectively.
Perinatal Consumption of Thiamine-Fortified Fish Sauce in Rural Cambodia: A Randomized Clinical Trial.
This randomized clinical trial in rural Cambodia studied the effects of thiamine-fortified fish sauce on erythrocyte thiamine diphosphate concentrations in lactating women and their infants. Women consuming thiamine-fortified fish sauce had higher eTDP and breast milk thiamine concentrations, with more pronounced effects in the high-concentration group, suggesting potential to prevent infantile beriberi.
The effects of vitamin B1 on ameliorating the premenstrual syndrome symptoms.
Double-blind placebo-controlled clinical trial with 80 students with PMS at Jahrom University. Vitamin B1 significantly reduced mean mental (35.08%) and physical (21.2%) symptoms of PMS compared to placebo.
[Sleep disorder treated mainly with flying needling therapy: a clinical randomized controlled research].
RCT comparing flying needling therapy, estazolam, and non-acupoint acupuncture in 315 patients with sleep disorder. Flying needling therapy, which included vitamin B1 administration, showed superior efficacy in improving sleep quality compared to estazolam and non-acupoint acupuncture.
Double-blind, randomized placebo-controlled clinical trial of benfotiamine for severe alcohol dependence.
A double-blind, randomized placebo-controlled trial of 120 alcohol dependent men and women examined the effects of 600 mg benfotiamine supplementation on alcohol consumption over 24 weeks. The study found that benfotiamine was well-tolerated and significantly reduced alcohol consumption among women compared to placebo.
Plasma AGE-peptides and C-peptide in early-stage diabetic nephropathy patients on thiamine and pyridoxine therapy.
RCT evaluating the effects of thiamine (vitamin B1) and pyridoxine (vitamin B6) therapy on circulatory AGE-peptide levels in diabetic nephropathy patients. AGE-peptides were higher in the diabetic group with nephropathy than without. B1+B6 or B6 treatment prevented further increase in AGE-peptides and increased C-peptide levels.
Effects of vitamin B1 (thiamine) deficiency in lake trout alevins and preventive treatments.
The study examined the effects of thiamine immersion on lake trout alevins from a population affected by early mortality syndrome (EMS). Progeny were divided into groups based on thiamine concentration and treated with thiamine solution at hatching or swim-up stage. Low thiamine-treated groups showed significantly higher survival rates compared to controls, while high thiamine-treated groups showed no difference. Thiamine treatment at swim-up enhanced survival of EMS-affected lake trout.
Wernicke encephalopathy after obesity surgery: a systematic review.
Systematic review of 32 cases of Wernicke encephalopathy after bariatric surgery, highlighting clinical features, risk factors, and radiographic findings. Vomiting was a common risk factor, and the condition often occurred between 4 and 12 weeks postoperatively, especially in young women. The review suggests the need for prospective studies on thiamine supplementation for prevention.
Curative treatment of primary (spasmodic) dysmenorrhoea.
A randomized, double-blind, placebo-controlled study on 556 girls aged 12-21 years with primary dysmenorrhoea tested the efficacy of oral vitamin B1 (thiamine hydrochloride) at 100 mg daily for 90 days. Results showed 87% were completely cured, 8% relieved, and 5% showed no effect. The treatment was curative, free from side effects, and results persisted two months post-treatment.
Structure‐based discovery of thiamine uptake inhibitors
The paper discusses the discovery of inhibitors for thiamine (vitamin B1) uptake, focusing on the structural analysis of the SLC19A2 and A3 transporters. It hypothesizes that the binding site of SLC19A3 is promiscuous, allowing different small molecules to potentially inhibit this transporter.
Long-Term Maintenance of Normal Serum Vitamin B1 Levels Is Associated with Better Outcomes in Patients with Heart Failure.
Observational study of 88 heart failure patients assessing the impact of long-term maintenance of normal serum vitamin B1 levels on outcomes. The long-term maintenance group showed better outcomes compared to short-term supplementation and control groups, suggesting that maintaining normal vitamin B1 levels may improve heart failure prognosis.
Effect of alcohol-dependence on cognitive performance in middle-aged men: Preliminary results
Cross-sectional pilot study comparing cognitive performance and serum thiamine levels in 82 middle-aged men with and without alcohol dependence. Alcohol-dependent men had significantly lower MoCA and MMSE scores and lower serum thiamine levels. Thiamine levels positively correlated with cognitive scores, suggesting its potential as a screening tool for cognitive impairment in alcohol dependence.
Exchange of Vitamin B1 and Its Biosynthesis Intermediates Shapes the Composition of Synthetic Microbial Cocultures and Reveals Complexities of Nutrient Sharing
The study investigates the exchange of vitamin B1 (thiamin) and its intermediates between microbes within synthetic cocultures of Escherichia coli and Vibrio anguillarum. It reveals specific patterns for thiamin metabolism and exchange among these microbes, highlighting the importance of nutrient sharing in microbial community composition.
Metabolic engineering of rice endosperm towards higher vitamin B1 accumulation
The study focuses on metabolic engineering of rice endosperm to enhance thiamin (vitamin B1) levels. By employing tissue-specific promoters and biosynthesis genes, engineered rice lines showed up to a threefold increase in thiamin content compared to wild type, stable upon cooking.
Vitamin B1 Intake in Multiple Sclerosis Patients and its Impact on Depression Presence: A Pilot Study
Cross-sectional observational study analyzing dietary habits and vitamin B1 consumption in 51 Spanish MS patients. A significant negative correlation between depression and the intake of thiamine and total carbohydrates was observed, suggesting an influence of eating habits on depression levels.
Effect of pentoxifylline on diabetic distal polyneuropathy in type 2 diabetic patients: A randomized trial
Randomized double-blinded placebo-controlled trial with 60 patients with diabetic peripheral neuropathy. The intervention group received Vitamin B1 and pentoxifylline, showing significant improvement in symptoms of peripheral neuropathy compared to placebo.
Effect of Mannitol plus Vitamins B in the management of patients with piriformis syndrome.
RCT investigating the effectiveness of Mannitol plus Vitamins B in managing piriformis syndrome in 22 patients. Significant reductions in clinical test scores and pain levels were observed, indicating the treatment's effectiveness.
Physiological changes and reproductive performance of Sterlet sturgeon Acipenser ruthenus injected with thiamine.
RCT evaluating the effects of thiamine injection on physiological changes and reproductive performance in Sterlet sturgeon. Thiamine injection increased hematocrit and testosterone levels, and improved reproductive performance, while reducing negative impacts of anti-thiamine on offspring.
Ondansetron combined with ST36 (Zusanli) acupuncture point injection for postoperative vomiting.
RCT evaluating the effects of ondansetron and ST36 acupuncture point injection with vitamin B1 on postoperative vomiting after laparoscopic surgery. The combination of ondansetron and acupuncture showed the lowest incidence of POV at 6%, compared to 33% in the placebo group. All intervention groups had significantly better outcomes than placebo.
[Clinical observation on common peroneal nerve palsy treated with comprehensive therapy].
RCT comparing comprehensive therapy (electroacupuncture, moxibustion, moving cupping) to western medication (vitamin B1 and mecobalamine) in 90 cases of common peroneal nerve palsy. The comprehensive therapy group showed a higher total effective rate and improved motor and sensory nerve function compared to the western medication group.
[Clinical observation on acupuncture for treatment of paralytic strabismus].
RCT comparing acupuncture at local points of the eye to oral administration of Methycobal and Vitamin B1 for treating paralytic strabismus. The acupuncture group showed a higher total effective rate and better therapeutic effects on oculomotor and abducent nerves compared to the medication group.
[Observation on the therapeutic effect of electroacupuncture of Jiaji (EX-B 2) plus regional encircled needling for herpes zoster].
RCT comparing electroacupuncture (EA) and medication (valaciclovir hydrochloride and vitamin B1) for herpes zoster treatment. EA showed superior effects in facilitating crust formation and pain relief compared to medication. VAS scores and crust formation time were significantly better in the EA group.
[Clinical observation on effect of auricular point injection combined with superficial anesthesia for nasal endoscopy surgery].
RCT comparing combined auricular point injection with Vitamin B1 and superficial anesthesia to simple superficial anesthesia in 40 patients undergoing nasal endoscopy surgery. The combined approach showed a higher effective rate and reduced use of analgesics and vasoactive substances.
Thiamine (vitamin B1) improves endothelium-dependent vasodilatation in the presence of hyperglycemia.
The study evaluated the effect of thiamine on brachial artery vasoactivity (BAVA) in the presence of hyperglycemia. Thiamine improved endothelium-dependent vasodilatation (EDV) in healthy subjects and patients with impaired glucose tolerance and non-insulin-dependent diabetes mellitus, suggesting potential benefits for endothelial function and atherosclerosis prevention.
Effect of intravenous infusions of thiamine on the disposition kinetics of thiamine and its pyrophosphate.
RCT investigating the effect of different intravenous infusion rates of thiamine on blood concentrations and renal excretion in 12 healthy subjects. The study found that slower infusion rates resulted in increased tissue uptake and decreased urinary excretion of thiamine compared to rapid infusion.
The Aulhorn flicker test: possibilities and limits. Its use in optic neuritis for diagnosis, differential diagnosis, monitoring the course of the disease, and assessing the effect of oral prednisolone.
The study used the Aulhorn flicker test to assess the effect of oral prednisolone versus vitamin B1 in patients with optic neuritis. Although a trend toward faster recovery with prednisolone was noted, no long-term benefit was observed after 1 year.
Thiamin and pyridoxine requirements during intravenous hyperalimentation.
The study evaluated the appropriate dosages of vitamin B1 (thiamin) and B6 (pyridoxine) during long-term intravenous hyperalimentation. It compared standard vitamin combinations with new formulations to prevent overdose, finding that 5 mg/day for thiamin HCl and 3 mg/day for pyridoxine HCl were sufficient and safe.
Effect of vitamin B1 supplementation on bone turnover markers in adults: an exploratory single-arm pilot study.
This single-arm pilot study investigated the effects of vitamin B1 supplementation on bone turnover markers in middle-aged and older adults in Japan. Participants received 28.0 mg of vitamin B1 per day for 1 month. The study found a significant reduction in serum TRACP 5b levels, a bone resorption marker, but no change in P1NP levels, a bone formation marker. Serum calcium increased, while vitamin D decreased.
Maternal vitamin B1 is a determinant for the fate of primordial follicle formation in offspring
The study investigates the impact of maternal vitamin B1 on the formation of primordial follicles in offspring. In mice, a high-fat maternal diet impaired ovarian follicle preservation in female offspring, linked to mitochondrial dysfunction. Vitamin B1 supplementation restored these defects by promoting acetyl-CoA metabolism, enhancing mitochondrial function, and improving granulosa cell proliferation.
Dietary Vitamin B1 Intake Influences Gut Microbial Community and the Consequent Production of Short-Chain Fatty Acids
The study examined the impact of dietary vitamin B1 on gut microbiota and short-chain fatty acid production. It found that vitamin B1 significantly affects the survival and competition of gut bacteria, particularly influencing the abundance of Ruminococcaceae and the production of butyrate and acetate.
Pharmacokinetics of thiamine (vitamin B1) in adult horses after administration of three single intravenous doses.
Pharmacokinetic study of thiamine (vitamin B1) in 9 healthy horses after administration of three single intravenous doses. The study found that thiamine follows non-linear elimination kinetics in horses, with supraphysiologic plasma concentrations and a short half-life, without adverse effects.
High-dose vitamin B1 therapy prevents the development of experimental fatty liver driven by overnutrition
Animal study using overnourished sheep on a high-calorie diet to test the effects of thiamine (vitamin B1) on hepatic steatosis. Thiamine treatment prevented the development of fatty liver, decreased hyperglycemia, and increased liver glycogen content, though it did not improve insulin sensitivity.
Modeling vitamin B1 transfer to consumers in the aquatic food web
The paper presents a model identifying conditions that constrain the flow of vitamin B1 from unicellular organisms to planktivorous fishes in aquatic ecosystems. It highlights the impact of anthropogenic pressures and ecological factors on vitamin B1 transfer, which is crucial for preventing mass death and reproductive failure in top aquatic consumers.
An Electrocatalytic Screen-Printed Amperometric Sensor for the Selective Measurement of Thiamine (Vitamin B1) in Food Supplements
The paper investigates an electrocatalytic screen-printed sensor for measuring vitamin B1 (thiamine) in food supplements. The sensor uses cobalt phthalocyanine to improve selectivity and detection limits, showing promise for quality control in supplements. It demonstrated a linear response suitable for quantifying vitamin B1 in commercial products.
Free-thiamine is a potential biomarker of thiamine transporter-2 deficiency: a treatable cause of Leigh syndrome.
The study analyzed thiamine derivatives in blood and cerebrospinal fluid samples from patients with Leigh syndrome and other neurological disorders. It found a deficiency of free-thiamine in patients with thiamine transporter-2 deficiency, which improved with thiamine supplementation.
Alteration of thiamine pharmacokinetics by end-stage renal disease (ESRD).
Comparative study of thiamine pharmacokinetics in 20 ESRD patients using 100 mg benfotiamin or thiamine mononitrate. Benfotiamin showed higher pharmacokinetic parameters and increased thiamine diphosphate concentration, suggesting its therapeutic application in ESRD.
Effects of thiamine supplementation on exercise-induced fatigue.
RCT of high-dose thiamine (vitamin B1) supplementation (100 mg/day) in 16 male athletes to assess effects on exercise-induced fatigue. Thiamine supplementation increased blood thiamine levels and significantly suppressed blood glucose increase and decreased subjective fatigue complaints after exercise.
Thiamine (vitamin B1) supplementation does not reduce fasting blood homocysteine concentration in most homozygotes for homocystinuria.
RCT studying the effect of thiamine supplementation on fasting blood homocysteine concentration in nine homozygote CS deficient patients. Methionine levels decreased in 6 out of 9 patients, but plasma homocysteine levels remained unchanged in 8 out of 9 patients. Thiamine was not effective as a homocysteine-lowering treatment in most patients.
Improved left ventricular function after thiamine supplementation in patients with congestive heart failure receiving long-term furosemide therapy.
RCT assessing thiamine repletion in 30 patients with CHF on long-term furosemide therapy. Thiamine improved left ventricular ejection fraction and biochemical evidence of thiamine deficiency.
Alcohol-related cardiomyopathy in the Seychelles.
The study investigated alcohol-related cardiomyopathy in the Seychelles through surveys and clinical data. It found high alcohol consumption rates and a significant prevalence of alcohol-related cardiomyopathy. Hospitalized patients were treated with vitamin B1, showing marked diuresis in young patients.
Thiamine (Vitamin B1)—An Essential Health Regulator
This narrative review highlights the essential role of thiamine (vitamin B1) in maintaining cellular health and energy metabolism. Thiamine is crucial for enzyme function in glucose metabolism and has antioxidant properties that help reduce oxidative stress, supporting DNA integrity and overall cellular health.
Pharmacological thiamine (Vitamin B1) as a treatment for alzheimer’s disease
The paper discusses the role of thiamine (vitamin B1) deficiency in Alzheimer's disease (AD) and its correlation with cognitive deficits. It highlights that thiamine deficiency in animals causes AD-like changes, and increasing thiamine levels with benfotiamine reduces these changes.
The importance of thiamine (vitamin B1) in humans
The paper reviews the biological functions of thiamine (vitamin B1), its role as a coenzyme in metabolism, and its importance in energy production and nervous system function. It discusses the effects of thiamine deficiency, including neurological and cardiovascular complications, and highlights alcohol abuse as a common risk factor for deficiency.
Prolonged Emesis as Prodromal Symptom and Exacerbating Factor of Non-alcoholic Wernicke-Korsakoff Syndrome: a Costly Diagnostic Delay
Case report of a 72-year-old woman with a history of gastrointestinal resection presenting with recurrent emesis and worsening neurological signs, leading to a diagnosis of non-alcoholic Wernicke-Korsakoff syndrome due to thiamine deficiency. The report emphasizes the importance of early diagnosis and treatment with intravenous vitamin supplementation to prevent severe outcomes.
Thiamine deficiency disorders: a clinical perspective
The paper discusses thiamine deficiency disorders (TDDs), highlighting the broad clinical spectrum affecting multiple systems and the challenges in diagnosis and treatment. It emphasizes the importance of early therapeutic thiamine administration and the need for research to improve identification and dosing regimens for thiamine-responsive disorders.
Thiamine (vitamin B1) in septic shock: a targeted therapy.
This narrative review discusses the role of thiamine (vitamin B1) in septic shock, highlighting its importance in metabolic processes and potential benefits in specific sepsis phenotypes. The review suggests that early identification and supplementation of thiamine in septic shock patients may be beneficial.
Exploring Vitamin B1 Cycling and Its Connections to the Microbial Community in the North Atlantic Ocean
The paper explores the cycling of vitamin B1 (thiamin) and its related compounds in the North Atlantic Ocean, focusing on their influence on plankton community structure and productivity. It reports measurements of various thiamin-related compounds and suggests that microbial community shifts during blooms may affect the balance of thiamin production and consumption.
Vitamin B1 as a Scavenger of Reactive Oxygen Species Photogenerated by Vitamin B2
The study investigates the kinetics and mechanism of photoprocesses involving riboflavin (vitamin B2) and thiamine (vitamin B1) under visible light irradiation. Vitamin B1 acts as a scavenger of reactive oxygen species generated by vitamin B2, suggesting its potential as a photoprotector against oxidative damage.
Thiamine deficiency and unexplained encephalopathy in hemodialysis and peritoneal dialysis patients.
Prospective study of 30 dialysis patients with altered mental status to assess thiamine deficiency as a cause of unexplained encephalopathy. Thiamine deficiency was confirmed in 10 patients, who showed marked improvement with thiamine supplementation. The study concludes that thiamine deficiency is a significant cause of encephalopathy in dialysis patients.
Neurological, Psychiatric, and Biochemical Aspects of Thiamine Deficiency in Children and Adults
This review discusses the neurological, psychiatric, and biochemical aspects of thiamine deficiency in children and adults. It highlights the role of thiamine in energy metabolism and its deficiency's impact on neurological and psychiatric disorders, with a focus on the potential benefits of thiamine supplementation in autism spectrum disorder and other neurological conditions.
Stem Cell Transplant-Associated Wernicke Encephalopathy in a Patient with High-Risk Neuroblastoma.
Case report of a 5-year-old patient with high-risk neuroblastoma who developed symptoms of Wernicke encephalopathy due to thiamine deficiency during stem cell transplantation. Vitamin B1 administration rapidly reversed symptoms, highlighting the need for micronutrient monitoring in pediatric cancer patients.
The effects of thiamine and oxythiamine on the survival of cultured brain neurons.
The study investigated the effects of thiamine and oxythiamine on the survival of cultured brain neurons. Thiamine promoted the survival of hippocampal neurons in high cell density culture, but not in low cell density culture. The survival-promoting activity of thiamine was decreased by oxythiamine, which alone had no effect.
Thiamine response in maple syrup urine disease.
The study measured the biochemical response of four patients with maple syrup urine disease to pharmacologic doses of thiamine. Three children responded to thiamine therapy with a reduction in plasma and urinary branched-chain amino and ketoacids, suggesting a positive nutritional effect.