Research
Vanadium (Vanadyl Sulfate)
25 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Systematic review of silver and vanadium-based antibiofilm agents: mechanisms and efficacy in oral biofilms.
Systematic review of the efficacy of silver and vanadium in disorganizing and eradicating oral biofilms. Silver nanoparticles showed efficacy against Gram-positive and Gram-negative oral bacteria, while vanadium compounds require further validation. The combination of silver and vanadium showed high biofilm eradicating effect.
Vanadium and biomarkers of inflammation and oxidative stress in diabetes: A systematic review of animal studies.
Systematic review of animal studies assessing the effect of vanadium supplementation on inflammation and oxidative stress biomarkers in diabetes-induced animals. The majority of studies confirmed the beneficial effects of vanadium on these biomarkers, with a minor risk of bias reported.
Vanadium and diabetic dyslipidemia: A systematic review of animal studies.
Systematic review of 48 animal studies evaluating the effect of vanadium on diabetic dyslipidemia. The majority of studies confirmed beneficial effects of vanadium compounds on lipid profile parameters, particularly triglycerides and total cholesterol.
Effect of Feeding and Withdrawal of Vanadium and Vitamin C on Egg Quality and Vanadium Residual Over Time in Laying Hens.
This experiment examined the effects of feeding and withdrawal of vanadium and vitamin C on egg quality and vanadium residuals in laying hens. Vanadium supplementation increased vanadium residuals in eggs and reduced albumen quality and shell color, with effects persisting up to 6 weeks after withdrawal. Vitamin C did not affect egg quality during storage or recovery.
Effect of dietary vanadium and vitamin C on egg quality and antioxidant status in laying hens.
This study assessed the effect of dietary vanadium and vitamin C on egg quality and antioxidant status in 360 laying hens. Vanadium decreased egg quality and caused oxidative stress, while 100 mg/kg vitamin C alleviated the reduction in egg quality and mitigated oxidative stress to some extent.
An evidence-based systematic review of vanadium by the Natural Standard Research Collaboration.
Systematic review by the Natural Standard Research Collaboration consolidating safety and efficacy data on vanadium. Includes analysis of clinical trials, expert opinion, history, pharmacology, interactions, adverse effects, and dosing.
Effect of vanadium on the subset and proliferation of peripheral blood T cells, and serum interleukin-2 content in broilers.
This 42-day study investigated the effects of dietary excess vanadium on immune function in 420 broilers. Vanadium reduced the percentages of peripheral blood T-cell subsets, proliferation function, and serum interleukin-2 contents, impairing cellular immune function in broilers.
Insulin Receptor Substrates Regulation and Clinical Responses Following Vanadium-Enriched Yeast Supplementation in Obese Type 2 Diabetic Patients: a Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
RCT of 44 obese T2DM patients comparing vanadium-enriched yeast (VEY) supplementation to placebo for 12 weeks. VEY significantly decreased anthropometric indices and glycemic parameters, increased insulin sensitivity, and affected gene expression levels of MAPK, PTP1B, and NFκB.
A systematic review of vanadium oral supplements for glycaemic control in type 2 diabetes mellitus.
Systematic review assessing the effectiveness of oral vanadium supplementation for glycaemic control in type 2 diabetes. No studies met the inclusion criteria, but five studies with less restrictive criteria showed significant effects with caution due to poor quality. Routine use of vanadium for glycaemic control is not recommended.
[Influence of treatment of vanadium electrophoresis on certainbio-chemical and immunological indicators in patients with prolonged cases of pneumonia].
RCT examining the effects of vanadium electrophoresis on patients with prolonged pneumonia. Treatment led to reduction of inflammatory processes in bronchi and lungs, strengthening of cellular immunity, and normalization of kidney cortex functions. Positive results were more significant in cases of nidal prolonged pneumonia.
Effects of vanadium supplementation on performance, some plasma metabolites and glucose metabolism in Mahabadi goat kids.
RCT investigating vanadium supplementation effects on performance, plasma metabolites, and glucose metabolism in Mahabadi goat kids. Vanadium improved feed efficiency and glucose utilization, with decreased plasma glucose concentrations and increased glucose clearance rate.
Coordination chemistry may explain pharmacokinetics and clinical response of vanadyl sulfate in type 2 diabetic patients.
The study investigated the pharmacokinetics of vanadyl sulfate in 16 type 2 diabetic patients over 6 weeks. Vanadium levels in serum, blood, and urine were measured, showing dose-dependent accumulation but no correlation with insulin-like response. The study highlights the importance of coordination chemistry in understanding vanadium's anti-diabetic effects.
Effect of vanadium on insulin sensitivity in patients with impaired glucose tolerance.
RCT of vanadyl sulfate (50 mg twice daily) in 14 overweight/obese patients with impaired glucose tolerance. Vanadium did not affect insulin sensitivity but increased triglyceride levels.
Effect of vanadium(IV) compounds in the treatment of diabetes: in vivo and in vitro studies with vanadyl sulfate and bis(maltolato)oxovandium(IV).
Vanadyl sulfate was administered orally to 16 subjects with type 2 diabetes mellitus for 6 weeks. No correlation was found between serum vanadium levels and clinical response, such as reduction in fasting blood glucose or increased insulin sensitivity. In diabetic rats, VO(malto)(2) treatment showed a tendency for low plasma glucose with high blood vanadium, unlike VOSO(4). The study also explored vanadium binding to serum proteins, suggesting that protein binding may affect the bioavailability of vanadium.
Metabolic effects of vanadyl sulfate in humans with non-insulin-dependent diabetes mellitus: in vivo and in vitro studies.
The study investigated the efficacy and mechanism of vanadyl sulfate as an oral hypoglycemic agent in 16 type 2 diabetic patients over 6 weeks. While fasting glucose and HbA1c decreased significantly in higher dose groups, there was no dramatic improvement in insulin sensitivity or glycemic control. Vanadyl sulfate modified proteins involved in early insulin signaling but was not additive with insulin in stimulating glycogen synthesis.
Vanadyl sulfate does not enhance insulin action in patients with type 1 diabetes.
The study investigates the effect of vanadyl sulfate on insulin action in patients with type 1 diabetes, finding no enhancement in insulin action.
Influence of vanadium on acclimatization of humans to high altitude.
The study investigated the effects of vanadyl sulphate on human acclimatization to high altitude at 3500 m. Plasma vanadium levels were maintained in the vanadium-treated group compared to controls, where levels decreased. The vanadium group drank more water and excreted less urine, with no diuretic effect observed.
Neurobehavioral effects of vanadium.
Study investigated the neurobehavioral effects of chronic vanadium exposure on cognitive abilities in 49 exposed subjects and 49 controls. Significant cognitive deficits were found in visuospatial abilities and attention, correlated with vanadium levels in urine and serum.
Oral vanadyl sulphate does not affect blood cells, viscosity or biochemistry in humans.
A 12-week double-blind, placebo-controlled trial investigated the effects of oral vanadyl sulphate (0.5 mg/kg/day) on haematological indices, blood viscosity, and biochemistry in 31 weight training athletes. The study found no significant effects of vanadyl sulphate treatment on these parameters, suggesting concerns about its adverse effects on blood are unsupported.
The effect of oral vanadyl sulfate on body composition and performance in weight-training athletes.
A 12-week double-blind, placebo-controlled trial investigated the effects of oral vanadyl sulfate on body composition and performance in weight-training athletes. No significant effects were found on anthropometric parameters and body composition, though a Treatment x Time interaction was noted in the 1 RM leg extension. The study concluded that vanadyl sulfate was ineffective in changing body composition, with any modest performance-enhancing effect requiring further investigation.
Oral vanadyl sulfate improves insulin sensitivity in NIDDM but not in obese nondiabetic subjects.
RCT comparing the effects of oral vanadyl sulfate (100 mg/day) in moderately obese NIDDM and nondiabetic subjects. Vanadyl sulfate improved insulin sensitivity in NIDDM subjects by enhancing insulin's inhibitory effect on lipolysis, but did not alter insulin sensitivity in nondiabetic subjects.
Effects of vanadyl sulfate on carbohydrate and lipid metabolism in patients with non-insulin-dependent diabetes mellitus.
Single-blind, placebo-controlled study of vanadyl sulfate (VS) in eight patients with non-insulin-dependent diabetes mellitus. VS administration was associated with a 20% decrease in fasting glucose concentration and a decrease in hepatic glucose output during hyperinsulinemia. VS was well tolerated after initial gastrointestinal side effects.
Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus.
RCT examining the effects of vanadyl sulfate (VS) in six NIDDM subjects. Treatment with VS improved glycemic control and insulin sensitivity, with increased glucose infusion rate and enhanced insulin-mediated glucose uptake. These effects were sustained for up to 2 weeks after discontinuation.
Vanadium: a possible aetiological factor in manic depressive illness.
The study assessed the effect of Vitamin C and vanadium intake on manic-depressive psychosis using a double-blind, placebo-controlled, crossover trial. Both manic and depressed patients showed significant improvement with a single 3 g dose of Vitamin C and with reduced vanadium intake compared to placebo and normal intake, respectively.
Vanadium levels in urine and cystine levels in fingernails and hair of exposed and normal persons.
The study measured vanadium levels in urine of workers exposed to vanadium-rich dust and compared them to control groups. Urinary vanadium levels were significantly higher in exposed workers compared to controls. No significant differences were found for cystine levels in fingernails and hair.