Research
Valerian Root
78 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Does valerian work for insomnia? An umbrella review of the evidence.
Umbrella review of systematic reviews on the efficacy of valerian for sleep disturbances, focusing on insomnia. The review found no evidence of efficacy for insomnia treatment, though valerian may improve subjective sleep quality. Further high-quality RCTs are recommended due to the heterogeneity and low quality of existing studies.
Valerian Root in Treating Sleep Problems and Associated Disorders-A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of 60 studies (n=6,894) evaluating valerian's effectiveness for sleep problems and associated disorders. Meta-analyses showed valerian improved subjective sleep quality and reduced anxiety. Inconsistent outcomes were attributed to variable quality of herbal extracts. Valerian was found to be safe with no severe adverse events.
Effect of the fixed combination of valerian, lemon balm, passionflower, and butterbur extracts (Ze 185) on the prescription pattern of benzodiazepines in hospitalized psychiatric patients—A retrospective case‐control investigation
Retrospective case-control study of 3,252 psychiatric in-house patients comparing the prescription pattern of benzodiazepines with and without the herbal extract combination Ze 185 (valerian, lemon balm, passionflower, butterbur). The Ze 185 group had significantly fewer benzodiazepine prescriptions, suggesting it as a potential alternative for stress management.
Valerian for sleep: a systematic review and meta-analysis.
Systematic review and meta-analysis of 16 randomized, placebo-controlled trials examining valerian for improving sleep quality in 1093 patients. The review found a statistically significant benefit in sleep quality with valerian, though methodological issues and publication bias were noted.
Standardized Extract of Valeriana officinalis Improves Overall Sleep Quality in Human Subjects with Sleep Complaints: A Randomized, Double-Blind, Placebo-Controlled, Clinical Study
RCT of 80 adults with sleep complaints comparing Valeriana officinalis extract to placebo for 8 weeks. The valerian group showed significant improvements in sleep quality, sleep latency, sleep efficiency, and total sleep time, as well as decreased anxiety and daytime sleepiness.
Efficacy of Valerian Extract on Sleep Quality after Coronary Artery bypass Graft Surgery: A Triple-Blind Randomized Controlled Trial.
Triple-blind RCT assessing the effect of 530 mg valerian root extract on sleep quality in patients after coronary artery bypass graft surgery. Valerian significantly improved total sleep quality, sleep latency, sleep duration, sleep efficiency, and daytime dysfunction compared to placebo over 30 nights.
Addition of Valerian and Lemon Balm Extract to Quetiapine Reduces Agitation in Critically Ill Patients with Delirium: A Pilot Randomized Clinical Trial
A randomized, double-blind, placebo-controlled study evaluated the addition of valerian and lemon balm (Neurogol syrup) to quetiapine in 53 ICU patients with delirium. The treatment group showed a significant reduction in agitation and ICU stay length compared to placebo, with no adverse effects.
The use of Valeriana officinalis (Valerian) in improving sleep in patients who are undergoing treatment for cancer: a phase III randomized, placebo-controlled, double-blind study (NCCTG Trial, N01C5).
Phase III RCT evaluating 450 mg valerian supplementation for sleep improvement in cancer patients undergoing treatment. The primary outcome showed no significant improvement in sleep quality as measured by PSQI. However, exploratory analyses indicated improvements in fatigue and some secondary outcomes.
Effectiveness of Valerian on insomnia: a meta-analysis of randomized placebo-controlled trials.
Meta-analysis of 18 RCTs evaluating the effectiveness of Valerian on insomnia. Valerian showed a relative risk of sleep-quality improvement of 1.37 compared to placebo, but no significant differences in latency time or standardized mean differences. The study suggests subjective improvement but not demonstrated with quantitative measures.
A televised, web-based randomised trial of an herbal remedy (valerian) for insomnia.
RCT conducted via television and the Internet in Norway, involving 405 participants with insomnia. Valerian was compared to placebo over two weeks. The valerian group showed modest improvements in sleep quality, night awakenings, and sleep duration, but differences were not statistically significant. Valerian appears safe with modest beneficial effects on insomnia.
A systematic review of valerian as a sleep aid: safe but not effective.
Systematic review of 37 studies on valerian as a sleep aid. Most studies found no significant differences between valerian and placebo for sleep improvement. Valerian is considered safe but not effective for insomnia.
Efficacy and tolerability of valerian extract LI 156 compared with oxazepam in the treatment of non-organic insomnia--a randomized, double-blind, comparative clinical study.
RCT comparing 600 mg/die valerian extract LI 156 to 10 mg/die oxazepam in 202 patients with non-organic insomnia over 6 weeks. Valerian was at least as efficacious as oxazepam in improving sleep quality, with both treatments showing significant improvements from baseline.
Effects of a Valerian-Hops Extract Combination (Ze 91019) on Sleep Duration and Daytime Cognitive and Psychological Parameters in Occasional Insomnia: A Randomized Controlled Feasibility Trial.
RCT evaluating the effect of a valerian and hops-based herbal medication (Ze 91019) on sleep duration and daytime cognitive and psychological parameters in individuals with occasional insomnia. Ze 91019 significantly increased sleep duration without affecting cognitive or psychological outcomes.
Comparison the effect of valerian and gabapentin on RLS and sleep quality in hemodialysis patients: A randomized clinical trial.
Randomized clinical trial comparing the effects of valerian and gabapentin on restless legs syndrome (RLS) and sleep quality in 40 hemodialysis patients. Gabapentin was more effective than valerian in improving RLS, but both were equally effective in improving sleep quality.
The Effect of Valerian Root Extract on Reducing Dysmenorrhea Pain Levels and Endorphin Hormone Levels in Women of Childbearing Age
This study used a pretest posttest randomized control group design to analyze the effect of valerian root extract on dysmenorrhea pain levels and endorphin levels in women of childbearing age. The intervention group received 100 mg of valerian root extract and showed a significant reduction in dysmenorrhea pain and an increase in endorphin levels compared to the control group.
The chronic effects of a combination of herbal extracts (Euphytose) on psychological mood state and response to a laboratory stressor: A randomised, placebo-controlled, double blind study in healthy humans.
This randomized, placebo-controlled, double-blind study assessed the effects of a multi-herb extract preparation (Euphytose) containing valerian, passionflower, hawthorn, and ballota on psychological state and stress responses in 31 healthy participants. The herbal combination reduced subjective anxiety and lowered physiological stress markers such as salivary α-amylase and galvanic skin response compared to placebo.
The Effects of Valerian on Sleep Quality, Depression, and State Anxiety in Hemodialysis Patients: A Randomized, Double-blind, Crossover Clinical Trial
This randomized, double-blind, placebo-controlled, crossover clinical trial studied the effects of valerian on sleep quality, depression, and state anxiety in 39 hemodialysis patients. Valerian significantly improved sleep quality, and reduced symptoms of state anxiety and depression compared to placebo.
Valerian extract alters functional brain connectivity: A randomized double-blind placebo-controlled trial.
This 4-week, double-blinded, randomized, placebo-controlled trial investigated the effects of valerian root extract (VRE) on functional brain connectivity and anxiety in 64 nonclinical volunteers with psychological stress. While both VRE and placebo groups showed improvements on clinical scales, the VRE group exhibited significantly greater changes in EEG coherence, suggesting altered brain connectivity related to anxiety.
Effects of a fixed herbal drug combination (Ze 185) to an experimental acute stress setting in healthy men - An explorative randomized placebo-controlled double-blind study.
This randomized, placebo-controlled, double-blind study examined the effects of Ze 185, a combination of valerian, passion flower, lemon balm, and butterbur extracts, on stress responses in 72 healthy men. Ze 185 significantly reduced self-reported anxiety responses to acute psychosocial stress without affecting salivary cortisol levels.
The effect of Valerian on the severity and frequency of hot flashes: A triple-blind randomized clinical trial.
This triple-blind, randomized clinical trial studied the effect of Valerian on hot flashes in 60 postmenopausal women. Valerian significantly reduced the severity and frequency of hot flashes compared to placebo over a two-month period.
Effect of Valerian in Preventing Neuropsychiatric Adverse Effects of Efavirenz in HIV-Positive Patients: A Pilot Randomized, Placebo-Controlled Clinical Trial.
Pilot randomized, placebo-controlled clinical trial evaluating valerian's efficacy in preventing neuropsychiatric adverse effects of efavirenz in 51 HIV-positive patients. Valerian significantly improved sleep and anxiety compared to placebo over 4 weeks.
Effects of valerian on subjective sedation, field sobriety testing and driving simulator performance.
Randomized, placebo-controlled, double-blind, cross-over trial assessing the effects of a one-time valerian 1600mg dose on subjective sedation, field sobriety testing, and driving simulator performance. No significant differences were found between placebo and valerian in reaction tests, sleepiness scales, sobriety test failure rates, or driving simulator performance.
Valerian Root and Lemon Balm Extracts: A Phytomedicine Compound Improves Symptoms of Hyperactivity, Attention Deficits, and Impulsivity in Children.
RCT studying the effects of a phytomedicine compound containing valerian root and lemon balm extracts on symptoms of hyperactivity, attention deficits, and impulsivity in children. The compound improved these symptoms.
Can Valeriana officinalis root extract prevent early postoperative cognitive dysfunction after CABG surgery? A randomized, double-blind, placebo-controlled trial.
RCT evaluating the effect of Valeriana officinalis root extract on preventing early postoperative cognitive dysfunction in CABG surgery patients. The valerian group showed better cognitive function compared to placebo, suggesting valerian may prevent cognitive dysfunction post-surgery.
Valerian/lemon balm use for sleep disorders during menopause.
RCT of 100 menopausal women with sleep disorders comparing valerian/lemon balm supplementation to placebo. The valerian/lemon balm group showed significant improvements in sleep quality as measured by the Pittsburgh Sleep Quality Index.
The Effects of Valerian Root on Hot Flashes in Menopausal Women
Double-blind clinical trial of 68 menopausal women comparing 255 mg Valerian capsules to placebo for 8 weeks. Valerian significantly reduced the severity and frequency of hot flashes compared to placebo, suggesting it as an effective treatment for menopausal hot flashes.
The effectiveness of valerian acupressure on the sleep of ICU patients: a randomized clinical trial.
RCT exploring the effectiveness of valerian acupressure on sleep in ICU patients. Valerian acupressure increased sleeping hours, reduced wake frequency, and improved sleep quality as measured by the Stanford Sleepiness Scale. Heart rate variability data indicated a relaxation response.
Effect of valerian on sleep quality in postmenopausal women: a randomized placebo-controlled clinical trial.
RCT of 100 postmenopausal women with insomnia comparing 530 mg valerian extract to placebo twice a day for 4 weeks. Valerian significantly improved sleep quality compared to placebo, with 30% of the intervention group showing improvement.
Effects of valerian on the severity and systemic manifestations of dysmenorrhea.
Double-blind, randomized, placebo-controlled trial with 100 students to evaluate the impact of valerian on dysmenorrhea. Valerian significantly reduced pain severity compared to placebo, suggesting its effectiveness due to antispasmodic effects.
A randomized, double blind, placebo-controlled, prospective clinical study to demonstrate clinical efficacy of a fixed valerian hops extract combination (Ze 91019) in patients suffering from non-organic sleep disorder.
This randomized, double-blind, placebo-controlled study evaluated the efficacy of a fixed valerian hops extract combination (Ze 91019) in patients with non-organic insomnia. The study found that the extract combination significantly reduced sleep latency compared to placebo, while single valerian extract did not show superiority over placebo.
Valerian for anxiety disorders.
Systematic review investigating the effectiveness and safety of valerian for treating anxiety disorders. One RCT with 36 patients showed no significant differences between valerian and placebo or diazepam in anxiety scores, indicating insufficient evidence for valerian's efficacy or safety in anxiety disorders.
Valerian-hops combination and diphenhydramine for treating insomnia: a randomized placebo-controlled clinical trial.
Multicenter RCT evaluating valerian-hops combination and diphenhydramine for mild insomnia in 184 adults. Valerian-hops showed modest improvements in subjective sleep parameters and quality of life, with no significant adverse effects or rebound insomnia. Diphenhydramine improved sleep efficiency initially but had no significant long-term effects.
FORMULATION AND EVALUATION OF MICROEMULSION-BASED SUBLINGUAL LIQUID CONTAINING VALERIAN ROOT EXTRACT
The study focused on the formulation and evaluation of a microemulsion-based sublingual liquid containing valerian root extract. The microemulsion was optimized and evaluated for various parameters, suggesting it may offer a natural solution for the treatment of insomnia.
The Toxicological Risk Assessment of Cu, Mn, and Zn as Essential Elemental Impurities in Herbal Medicinal Products with Valerian Root (Valeriana officinalis L., radix) Available in Polish Pharmacies
The paper conducts a toxicological risk assessment of elemental impurities (Cu, Mn, and Zn) in herbal medicinal products containing valerian root available in Polish pharmacies. The study finds that these impurities are present at very low levels, confirming the safety of the products from a regulatory toxicology perspective.
Study toward possible sources of polycyclic aromatic hydrocarbons in dried valerian root
The study investigates the sources of polycyclic aromatic hydrocarbons (PAHs) in dried valerian root to comply with EU limits. It aims to identify the origin of PAHs and possible measures to reduce their concentration in valerian root.
An Unsuccessful Attempt to Confirm the Occurrence of 4′-O-β- d-Glucosyl-9-O-(6″-deoxysaccharosyl)olivil in Valerian Root
The study attempted to confirm the presence of the lignan 4′-O-β- d-glucosyl-9-O-(6″-deoxysaccharosyl)olivil in valerian root using LCMS. The compound was not detected in any of the six investigated batches, suggesting it does not occur regularly in valerian root.
Assessment of Valeriana officinalis l. (Valerian) for Conscious Sedation of Patients During the Extraction of Impacted Mandibular Third Molars: A Randomized, Split-Mouth, Double-Blind, Crossover Study.
RCT comparing valerian 100 mg to midazolam 15 mg for anxiety control during mandibular third molar extraction in 20 patients. Valerian provided comfort and relaxation with less somnolence than midazolam, though midazolam was more effective in reducing physiological parameters.
Effect of valerian on cognitive disorders and electroencephalography in hemodialysis patients: a randomized, cross over, double-blind clinical trial.
This crossover, double-blind clinical trial studied the effect of Valerian on cognitive disorders and electroencephalography in 39 hemodialysis patients. Valerian significantly improved cognitive scores, but no significant changes were observed in electroencephalography.
Valeriana officinalis Root Extract Modulates Cortical Excitatory Circuits in Humans.
Double-blind, randomized, cross-over, placebo-controlled study with 15 healthy volunteers investigating the effects of a single dose of Valeriana officinalis extract on cortical excitability using transcranial magnetic stimulation. The study found a significant reduction in intracortical facilitation, which returned to baseline 6 hours after intake.
Extract of valerian root (Valeriana officinalis L.) vs. placebo in treatment of obsessive-compulsive disorder: a randomized double-blind study.
An 8-week double-blind randomized trial comparing valerian root extract to placebo in 31 adults with OCD. The valerian group showed significant improvement in OCD symptoms compared to placebo, with somnolence as the only significant side effect.
Early effect of NEURAPAS® balance on current source density (CSD) of human EEG.
RCT using EEG to assess the effect of NEURAPAS® balance, a combination of valerian, passion flower, and St. John's wort, on brain electric activity in 16 healthy volunteers. Under mental load, the supplement showed statistically significant lower spectral power in certain frequency ranges, indicating calming and anti-depressive effects similar to fluoxetine.
Effectiveness of the homeopathic preparation Neurexan compared with that of commonly used valerian-based preparations for the treatment of nervousness/restlessness - an observational study.
Observational study comparing the effectiveness of Neurexan and valerian-based preparations for treating nervousness/restlessness in 826 subjects. Neurexan showed a greater reduction in nervousness/restlessness scores compared to valerian, with both treatments being well tolerated.
Does valerian improve sleepiness and symptom severity in people with restless legs syndrome?
A prospective, triple-blinded, randomized, placebo-controlled trial comparing 800 mg of valerian to placebo in 37 participants with restless legs syndrome (RLS) over 8 weeks. Valerian improved sleep quality and reduced RLS symptom severity and daytime sleepiness, suggesting it may be an effective alternative treatment for RLS.
The homeopathic preparation Neurexan vs. valerian for the treatment of insomnia: an observational study.
Observational study comparing the homeopathic preparation Neurexan to valerian for insomnia treatment in 409 subjects. Both groups showed improved sleep latency and duration, with Neurexan showing a significant advantage in sleep duration improvement at certain time points. Neurexan also resulted in less daytime fatigue compared to valerian.
Sleep improving effects of a single dose administration of a valerian/hops fluid extract - a double blind, randomized, placebo-controlled sleep-EEG study in a parallel design using electrohypnograms.
Double-blind, randomized, placebo-controlled study testing a single dose of valerian/hops fluid extract on sleep quality in poor sleepers. The valerian/hops group showed significantly higher time spent in sleep and deeper sleep compared to placebo, indicating its effectiveness as a sleep aid.
A randomized clinical trial of valerian fails to improve self-reported, polysomnographic, and actigraphic sleep in older women with insomnia.
RCT of 16 older women with insomnia testing 300 mg valerian extract vs placebo for 2 weeks. Valerian did not improve sleep latency, wake after sleep onset, sleep efficiency, or self-rated sleep quality compared to placebo. WASO increased significantly after valerian treatment.
A feasibility study of valerian extract for sleep disturbance in person with arthritis.
Pilot RCT of 15 persons with arthritis and mild sleep disturbance, randomized to receive 600 mg valerian or placebo for five nights. Protocol adherence was high, but nonsignificant differences were found between groups on sleep outcomes. Efficacy outcomes were inconclusive due to small sample size.
A combination of valerian and lemon balm is effective in the treatment of restlessness and dyssomnia in children.
Open, multicentre study of a combined valerian/lemon balm preparation in 918 children under 12 with restlessness and dyssomnia. The study found a distinct reduction in symptom severity, with 80.9% of dyssomnia patients and 70.4% of restlessness patients showing improvement. The preparation was well tolerated with no medication-related adverse events.
The fixed combination of valerian and hops (Ze91019) acts via a central adenosine mechanism.
RCT investigating the interaction between caffeine and a fixed valerian/hop extract combination (Ze91019) in healthy volunteers. The valerian/hop extract reduced or inhibited caffeine-induced arousal, suggesting its action via a central adenosine mechanism and potential sleep-inducing and -maintaining activity.
A double-blind, placebo-controlled investigation of the effects of two doses of a valerian preparation on the sleep, cognitive and psychomotor function of sleep-disturbed older adults.
A placebo-controlled three way crossover clinical trial with 16 sleep-disturbed older adults tested the effects of valerian 300 mg and 600 mg on sleep and cognitive function. Results showed no significant effect of valerian on EEG sleep parameters or psychometric measures, suggesting valerian at these doses is ineffective as an acute treatment for sleep problems.
Multiple night-time doses of valerian (Valeriana officinalis) had minimal effects on CYP3A4 activity and no effect on CYP2D6 activity in healthy volunteers.
This study assessed the influence of valerian extract on the activity of CYP2D6 and CYP3A4 enzymes in 12 healthy volunteers. Valerian had minimal effects on CYP3A4 activity and no effect on CYP2D6 activity, with a modest increase in alprazolam Cmax observed.
Assessing subjective and psychomotor effects of the herbal medication valerian in healthy volunteers.
RCT assessing the subjective and psychomotor effects of valerian extract in 10 young healthy volunteers. Valerian extract had no significant effects on mood or psychomotor/cognitive performance, while diazepam showed subjective effects and impaired performance.
Valerian does not appear to reduce symptoms for patients with chronic insomnia in general practice using a series of randomised n-of-1 trials.
Series of n-of-1 trials in Queensland, Australia, comparing valerian to placebo for chronic insomnia management. Valerian showed no significant improvement over placebo in promoting sleep or sleep-related factors, though it had a fair response for energy levels.
Acute pharmacological effects of temazepam, diphenhydramine, and valerian in healthy elderly subjects.
A double-blind, randomized, crossover, placebo-controlled study assessed the pharmacodynamics of temazepam, diphenhydramine, and valerian in 14 healthy elderly volunteers. Valerian showed no significant difference from placebo on measures of psychomotor performance or sedation.
Comparative cognitive and psychomotor effects of single doses of Valeriana officianalis and triazolam in healthy volunteers.
Double-blind, placebo-controlled, four-way crossover study comparing cognitive and psychomotor effects of valerian and triazolam in 9 healthy volunteers. Valerian showed no effect on cognitive or psychomotor performance, while triazolam had detrimental effects.
Can valerian improve the sleep of insomniacs after benzodiazepine withdrawal?
RCT studying the effect of valerian on sleep in 19 insomniacs after benzodiazepine withdrawal. Valerian subjects reported better subjective sleep quality and decreased wake time after sleep onset compared to placebo, despite some side effects and longer sleep latency.
Effect of valerian, Valeriana edulis, on sleep difficulties in children with intellectual deficits: randomised trial.
Randomised trial of valerian in five children with intellectual deficits and sleep problems. Valerian treatment led to significant reductions in sleep latencies, nocturnal time awake, and improved sleep quality compared to placebo.
Critical evaluation of the effect of valerian extract on sleep structure and sleep quality.
Randomised, double-blind, placebo-controlled, cross-over study assessed the effects of valerian extract on sleep in 16 patients with psychophysiological insomnia. Long-term valerian treatment improved sleep efficiency, reduced slow-wave sleep latency, and increased slow-wave sleep percentage compared to placebo. Few adverse events were reported during valerian treatment.
Pharmacodynamic effects of valerian and hops extract combination (Ze 91019) on the quantitative-topographical EEG in healthy volunteers.
The study investigated the pharmacodynamic effects of a valerian and hops extract combination (Ze 91019) on the quantitative topographical EEG in 12 healthy volunteers. Two dosages were tested in a single-blind, cross-over design. The high dosage led to power increases in delta, decreases in alpha, and a weak decrease in beta-power, indicating slight but clear effects on the CNS.
The influence of valerian treatment on "reaction time, alertness and concentration" in volunteers.
A randomized, controlled, double-blind trial on 102 volunteers examined the effects of valerian root extract (600 mg) on reaction time, alertness, and concentration. The study found no significant impairment in these cognitive functions after single or repeated evening administrations of valerian compared to placebo.
[Acute sedative effect of a herbal relaxation tablet as compared to that of bromazepam].
Double-blind RCT comparing the sedative effects of Valverde relaxation dragées (containing valerian, balm, passion-flower, and pestilence wort) to 3 mg bromazepam and placebo in 60 healthy male volunteers. The study found no significant sedative effects or side effects for either Valverde or bromazepam compared to placebo.
Double blind study of a valerian preparation.
Double blind study of a valerian preparation (VALERINA NATT) containing primarily sesquiterpenes. Compared to placebo, it showed a significant positive effect on poor sleep, with 44% reporting perfect sleep and 89% reporting improved sleep. No side effects were observed.
Aqueous extract of valerian root (Valeriana officinalis L.) improves sleep quality in man.
RCT studying the effect of an aqueous extract of valerian root on sleep measures in 128 people. Valerian significantly decreased sleep latency scores and improved sleep quality, especially in poor sleepers, smokers, and those with long sleep latencies. Night awakenings, dream recall, and morning somnolence were unaffected.
Physiological impacts of valerian extract and lemon balm on some neurobiomarkers in broilers
Study on the effects of valerian and lemon balm extracts on neurobiomarkers in broilers. Valerian and lemon balm increased GABA and serotonin levels, with valerian showing moderate neurotransmitter expression and lemon balm showing weak GABA expression. Both extracts improved hematological indicators and performance in broilers.
The Toxicological Risk Assessment of Lead and Cadmium in Valeriana officinalis L., radix (Valerian root) as Herbal Medicinal Product for the Relief of Mild Nervous Tension and Sleep Disorders Available in Polish Pharmacies
The study assessed the toxicological risk of lead and cadmium impurities in Valeriana officinalis L., radix (Valerian root) as a herbal medicinal product for mild nervous tension and sleep disorders. The results confirmed the safety of Valerian root available in Polish pharmacies according to ICH guideline Q3D.
The Toxicological Risk Assessment of Lead and Cadmium in Valeriana officinalis L., radix (Valerian root) as Herbal Medicinal Product for the Relief of Mild Nervous Tension and Sleep Disorders Available in Polish Pharmacies
The study assessed the toxicological risk of lead and cadmium impurities in Valeriana officinalis L., radix (Valerian root) as a herbal medicinal product for mild nervous tension and sleep disorders. The results confirmed the safety of Valerian root available in Polish pharmacies according to ICH guideline Q3D.
Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications
In vitro study investigating the effects of valerian root extract and valeric acid on breast cancer cells. The study found that valerian extract and valeric acid reduced breast cancer cell growth, proliferation, migration, and colony formation, potentially through epigenetic modifications such as HDAC inhibition and DNA hypomethylation.
Hyperactivity, concentration difficulties and impulsiveness improve during seven weeks' treatment with valerian root and lemon balm extracts in primary school children.
Observational study of 169 primary school children treated with valerian root and lemon balm extracts for hyperactivity and concentration difficulties. Significant improvements were observed in focus, hyperactivity, impulsiveness, social behavior, and sleep. Mild transient adverse reactions were noted in two children.
The effect of valerian extract on sleep polygraphy in poor sleepers: a pilot study.
Pilot study on the effect of valerian extract on sleep in 14 elderly poor sleepers. Valerian increased slow-wave sleep and decreased sleep stage 1, with no effect on sleep onset time or REM sleep. Self-rated sleep quality was unchanged.
The effects of valerian, propranolol, and their combination on activation, performance, and mood of healthy volunteers under social stress conditions.
The study investigates the effects of valerian, propranolol, and their combination on activation, performance, and mood in healthy volunteers under social stress conditions. The specific outcomes are not detailed due to the lack of an abstract.
Effect of valerian on human sleep.
RCT studying the effect of aqueous valerian root extract on sleep in healthy young subjects. Valerian reduced perceived sleep latency and wake time after sleep onset at home, with dose-dependent effects. No significant differences from placebo were observed in the sleep laboratory, but trends were consistent with home findings.
An Alternative Cause of Encephalopathy: Valerian Root Overdose
Case report of encephalopathy due to overdose of Valerian root, a plant with sedating properties, combined with a natural GABA supplement. Highlights the need for awareness of alternative therapies and their potential interactions.
Delirium After Withdrawal From Valerian Root: A Case Report.
Case report of a patient who developed delirium secondary to withdrawal from valerian root, an herbal supplement with anxiolytic and sedative properties. The report highlights the importance of considering herbal supplement withdrawal as a potential cause of delirium.
Analgesic Effect of Valerian Root and Turnip Extracts
Animal study comparing the analgesic effects of valerian root and turnip extracts in female Wistar rats. Valerian root extract significantly decreased pain scores in the acute phase, while the combination of valerian root and turnip extracts reduced pain scores in both acute and chronic phases compared to the control group.
Reversal of pentylenetetrazole-altered swimming and neural activity-regulated gene expression in zebrafish larvae by valproic acid and valerian extract
The study used zebrafish larvae to establish a screening method for psychoactive efficacy of plant extracts. Valerian extract and valproic acid reversed PTZ-altered swimming behaviors and affected neural activity-regulated gene expression, demonstrating the psychoactivity of valerian.
Valerian: No Evidence for Clinically Relevant Interactions
A review was conducted on the interaction potential of valerian root preparations with anticancer drugs. The review included seven in vitro studies and clinical studies, which did not support the prediction of clinically relevant interactions. The interaction potential of valerian preparations appears to be low and without clinical relevance, suggesting safety in cancer patients.
Safety and Efficacy of Herbal Sedatives in Cancer Care
Narrative review discussing the use of herbal sedatives in cancer care, highlighting valerian and kava. Valerian shows moderate evidence for safety and efficacy, while kava has toxicity concerns. Other herbs like German chamomile, lavender, hops, lemon balm, passionflower, and St. John's wort are mentioned for their potential anxiolytic effects.
Valerian as a hypnotic for Hispanic patients.
Case study of 23 Hispanic patients with insomnia using valerian root supplement. 16 patients reported at least moderate improvement in sleep by Week 1, with further improvement by Week 2, suggesting valerian may help improve insomnia.