Research
Trikatu (Ayurvedic Triple Pepper)
17 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Efficacy and safety of topical Trikatu preparation in, relieving mosquito bite reactions: a randomized controlled trial.
A double-blind, within-person randomized controlled trial with 30 healthy volunteers tested the efficacy and safety of topical Trikatu on mosquito bite reactions. Trikatu did not show additional effects for relieving mosquito bite reactions compared to a reference product containing camphor, menthol, and eucalyptus.
Effect of trikatu pretreatment on the pharmacokinetics of pefloxacin administered orally in mountain Gaddi goats.
The study evaluated the bio-enhancing effect of trikatu on the pharmacokinetics of orally administered pefloxacin in mountain Gaddi goats. Trikatu pretreatment resulted in altered plasma concentrations of pefloxacin, with higher concentrations during the elimination phase and improved pharmacokinetic parameters such as bioavailability and drug penetration.
Deciphering the impact and mechanism of Trikatu, a spices-based formulation on alcoholic liver disease employing network pharmacology analysis andvalidation.
The study evaluated the hepatoprotective effects of Trikatu, a spices-based formulation, on ethanol-induced alcoholic liver disease (ALD) using network pharmacology and animal studies. Trikatu demonstrated significant hepatoprotective effects by improving various liver function markers and morphology, and its bioactive components were identified to regulate signaling processes related to inflammation, oxidation, and apoptosis.
Spice-infused palmyra palm syrup improved cell-mediated immunity in Wistar Albino rats.
The study formulated a 'Trikatu syrup' using ginger, black pepper, and long pepper, and tested its immunomodulatory potential in Wistar Albino rats. The syrup showed a dose-dependent increase in cell-mediated immunity, as indicated by increased footpad thickness in treated rats.
Role of Pradhamana Nasya and Trayodashanga Kwatha in the management of Dushta Pratishyaya with special reference to chronic sinusitis.
Clinical study on 37 patients with chronic sinusitis, divided into three groups. Group A received Trayodashanga Kwatha with Madhu orally, Group B received Pradhamana Nasya with Trikatu + Triphala Churna, and Group C received both treatments. Group C showed better results in symptom relief compared to Groups A and B.
Is Trikatu an ayurvedic formulation effective for the management of flu-like illness? A narrative review.
Narrative review summarizing studies on Trikatu, an ayurvedic formulation, highlighting its anti-inflammatory, anti-dyslipidaemia, and immune-modulatory properties. The review suggests potential use in managing flu-like illnesses and COVID-19, but calls for rigorous RCTs for validation.
Trikatu, an herbal compound ameliorates rheumatoid arthritis by the suppression of inflammatory immune responses in rats with adjuvant-induced arthritis and on cultured fibroblast like synoviocytes via the inhibition of the NFκB signaling pathway.
The study investigates the therapeutic effect of trikatu on rheumatoid arthritis in rats with adjuvant-induced arthritis. Trikatu administration suppressed pro-inflammatory cytokines and downregulated inflammatory mediators and transcription factors, suggesting its potential as a treatment for rheumatoid arthritis.
Cytochrome P450 inhibitory potential and RP-HPLC standardization of trikatu--a Rasayana from Indian Ayurveda.
The study investigated the effect of trikatu and its individual components (Piper longum, Piper nigrum, Zingiber officinale) on drug metabolizing enzymes CYP3A4 and CYP2D6 using rat liver microsomes. The RP-HPLC method was developed to quantify piperine and 6-gingerol in trikatu. The formulations showed inhibitory potential against CYP450 enzymes, indicating less interaction potential with drug metabolizing enzymes.
Trikatu, a herbal compound mitigates the biochemical and immunological complications in adjuvant-induced arthritic rats.
The study investigated the anti-arthritic efficacy of trikatu, a herbal compound, on biochemical and immunological complications in adjuvant-induced arthritic rats. Trikatu treatment significantly reverted biochemical and immunological parameters to near normal levels in arthritic rats, suggesting its potential as an alternative treatment for rheumatoid arthritis.
Trikatu, a herbal compound that suppresses monosodium urate crystal-induced inflammation in rats, an experimental model for acute gouty arthritis.
The study investigated the anti-inflammatory effect of trikatu, a herbal compound, in monosodium urate crystal-induced inflammation in rats, an experimental model for acute gouty arthritis. Trikatu administration reverted biochemical changes to near normal levels and exhibited significant analgesic and anti-pyretic effects without causing gastric damage.
Trikatu, an herbal compound as immunomodulatory and anti-inflammatory agent in the treatment of rheumatoid arthritis--an experimental study.
Experimental study evaluating trikatu for its immunomodulatory and anti-inflammatory properties in rats. Trikatu showed significant immunosuppressive and anti-inflammatory effects, suggesting potential as a treatment for autoimmune inflammatory disorders like rheumatoid arthritis.
Safety evaluation of Trikatu, a generic Ayurvedic medicine in Charles Foster rats.
Chemical characterization and toxicity study of Trikatu, an Ayurvedic herbal formulation, was conducted in Charles Foster rats. Acute toxicity at 2,000 mg/kg was well tolerated with no significant changes in various health parameters. Sub-acute toxicity at 5, 50, and 300 mg/kg for 28 days showed non-significant changes except for increased LDL cholesterol, decreased HDL cholesterol, increased SGPT activity, and decreased WBC count at higher doses.
Pharmacokinetic and pharmacodynamic studies on interaction of "Trikatu" with diclofenac sodium.
The study investigated the interaction of Trikatu, an Ayurvedic formulation, with diclofenac sodium in rabbits and rats. Trikatu significantly decreased the serum levels of diclofenac sodium and reduced its anti-inflammatory efficacy in a carragenin-induced rat paw edema model.
Effect of an indigenous herbal compound preparation 'Trikatu' on the lipid profiles of atherogenic diet and standard diet fed Rattus norvegicus.
The study investigated the effects of the herbal preparation 'Trikatu' on lipid profiles in normal and cholesterol-fed male Rattus norvegicus. 'Trikatu' reduced triglycerides and LDL cholesterol while increasing HDL cholesterol, suggesting its potential as a hypolipidaemic agent to reduce hyperlipidaemia and atherosclerosis risk.
Efficacy of Nasya (nasal medication) in coma: A case study.
Case study of a 61-year-old female patient with a history of hypertension and coma treated with Ayurvedic Nasya using Trikaṭu cūrṇa for seven days, followed by dhūmapāna with consciousness restorative drugs. The treatment resulted in positive changes in the Glasgow Coma Scale from 3 to 11.
EFFECT OF TRIKATU, AN AYURVEDIC PRESCRIPTION ON THE PHARMACOKINETIC PROFILE OF CARBAMAZEPINE IN RABBITS.
The study investigated the effect of Trikatu on the pharmacokinetics of carbamazepine in rabbits. Single and multiple doses of Trikatu were administered with carbamazepine, showing a significant decrease in T(max) with a single dose, but not with multiple doses. The changes in plasma levels of carbamazepine due to Trikatu did not provide a significant advantage.
Effect of trikatu, an Ayurvedic prescription, on the pharmacokinetic profile of rifampicin in rabbits.
The study investigated the effect of trikatu, an Ayurvedic herbal preparation, on the pharmacokinetics of rifampicin in rabbits. Trikatu administration reduced the peak plasma concentration (Cmax) of rifampicin, suggesting it may reduce the efficacy of rifampicin therapy by affecting its rate of bioavailability.