Research
Theacrine (TeaCrine)
9 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Assessing the impact of high theacrine doses on hemodynamic measures, cognitive performance, and physiological stress.
This randomized, double-blind, crossover-design study investigated the effects of high doses of theacrine on heart rate, blood pressure, subjective feelings of energy, cognitive performance, salivary cortisol, and alpha-amylase in 19 healthy participants. Theacrine increased salivary cortisol levels but had no significant impact on heart rate, blood pressure, subjective feelings of energy, alpha-amylase, or cognitive performance.
Theacrine as a novel ergogenic aid: impact on canoe sprint performance.
RCT with 20 elite canoe sprint athletes assessing the effects of theacrine, caffeine, and their combination on performance. Caffeine significantly improved performance metrics, while theacrine alone did not show significant improvements. The combination of caffeine and theacrine produced additional improvements compared to placebo.
A caffeine and theacrine combination improves cognitive performance in tactical personnel under physically fatiguing conditions.
RCT with 20 tactically trained participants comparing caffeine, caffeine + theacrine, and placebo on cognitive and physical performance. The caffeine + theacrine combination improved cognitive performance and reaction times more than caffeine alone, suggesting additional cognitive benefits.
Different doses of theacrine do not improve 4 km cycling time trial performance.
RCT testing the effects of different doses of anhydrous theacrine on 4 km cycling time trial performance in 19 cyclists. No significant differences in performance were observed between placebo and theacrine conditions, but theacrine increased blood pressure and caused side effects.
Effects of Theacrine as a Pre-Workout Supplement.
This randomized controlled trial investigated the effects of theacrine supplementation on physical performance in 22 male amateur flag-football athletes. The study found no significant differences in physical performance tests between the theacrine and placebo groups.
Safety of TeaCrine®, a non-habituating, naturally-occurring purine alkaloid over eight weeks of continuous use.
RCT examining the safety and non-habituating effects of TeaCrine (theacrine) in 60 healthy men and women over 8 weeks. Clinical safety markers remained within normal limits, and no habituation was observed for energy, focus, concentration, anxiety, and motivation to exercise.
The effects of TeaCrine® and caffeine on endurance and cognitive performance during a simulated match in high-level soccer players.
RCT with 24 high-level soccer players comparing the effects of TeaCrine (theacrine) and caffeine on cognitive performance and endurance during a simulated match. TeaCrine and its combination with caffeine improved time-to-exhaustion and cognitive performance, suggesting enhanced endurance and cognitive benefits.
The effects of a caffeine-like supplement, TeaCrine®, on muscular strength, endurance and power performance in resistance-trained men.
RCT with 12 resistance-trained men testing the effects of TeaCrine® (theacrine) on muscular strength, endurance, and power performance. No significant improvements were found for TeaCrine® compared to placebo. Only caffeine improved measures of focus, energy, and motivation to exercise.
Cognitive Performance and Mood Following Ingestion of a Theacrine-Containing Dietary Supplement, Caffeine, or Placebo by Young Men and Women.
RCT comparing the effects of a theacrine-containing dietary supplement, caffeine, and placebo on energy, mood, cognitive performance, heart rate, and blood pressure in 10 healthy men and 10 healthy women. TheaTrim improved subjective feelings of energy and mood compared to placebo and caffeine, but did not significantly enhance cognitive performance.