Research
Terminalia Chebula (Haritaki)
15 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Terminalia bellirica (Gaertn.) roxb. (Bahera) in health and disease: A systematic and comprehensive review.
Systematic review of Terminalia bellirica, highlighting its traditional medicinal use and pharmacological activities such as antioxidant, anti-inflammatory, immunomodulatory, antimicrobial, hepatoprotective, renoprotective, antidiabetic, anti-hyperlipidemic, and anticancer effects. The review emphasizes the need for further in vivo studies and clinical trials.
Effectiveness of final cavity disinfectant terminalia chebula, malachite, and indocyanine green, against E. Faecalis and on the bond interface of fiber post to radicular dentin.
The study evaluated the antimicrobial efficacy of Terminalia chebula, Malachite green, and Indocyanine green against E. faecalis and their effect on the push-out bond strength of glass fiber post to root dentin. Terminalia chebula showed promising results in improving canal sterility and bond strength compared to conventional irrigation methods.
Evaluating the effect of black myrobalan on cognitive, positive, and negative symptoms in patients with chronic schizophrenia: A randomized, double-blind, placebo-controlled trial.
RCT evaluating black myrobalan's impact on cognitive impairments and symptoms in chronic schizophrenia. Significant improvements in cognitive impairments, negative symptoms, and excitement/activity were observed in the black myrobalan group compared to placebo after 4 weeks.
Effect of an aqueous extract of Terminalia chebula on endothelial dysfunction, systemic inflammation, and lipid profile in type 2 diabetes mellitus: A randomized double-blind, placebo-controlled clinical study.
A randomized, double-blind, placebo-controlled clinical study evaluated the effects of an aqueous extract of Terminalia chebula on endothelial dysfunction and cardiovascular risk factors in type 2 diabetic patients. Treatment with T. chebula significantly improved endothelial function and other cardiovascular risk indicators compared to placebo, with the 500 mg dose showing the most pronounced effects.
A Placebo-Controlled Double-Blind Study Demonstrates the Clinical Efficacy of a Novel Herbal Formulation for Relieving Joint Discomfort in Human Subjects with Osteoarthritis of Knee.
A 90-day randomized, placebo-controlled double-blind study evaluated the clinical efficacy and tolerability of the herbal formulation LI73014F2 in managing symptoms of osteoarthritis of the knee. The study involved 105 subjects and demonstrated significant pain relief, improved physical function, and quality of life in OA patients, with efficacy observed as early as 14 days.
Effects of dietary supplementation with a standardized aqueous extract of Terminalia chebula fruit (AyuFlex) on joint mobility, comfort, and functional capacity in healthy overweight subjects: a randomized placebo-controlled clinical trial.
RCT of 105 healthy overweight subjects evaluating the effects of AyuFlex (Terminalia chebula extract) on joint mobility, comfort, and functional capacity. AyuFlex significantly improved mKOOS global scores, knee joint discomfort with activity, 6-min walk test distance, and overall joint function without adverse effects. Both 250 mg and 500 mg doses were effective.
Effects of an Herbal Combination on Glycemic Control and Lipid Profile in Diabetic Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
RCT exploring the efficacy and safety of a herbal combination containing Terminalia chebula, Commiphora mukul, and Commiphora myrrha in women with hyperlipidemic type 2 diabetes. The herbal combination improved fasting blood glucose, total cholesterol, and low-density lipoprotein cholesterol levels, and increased high-density lipoprotein cholesterol levels significantly compared to placebo.
Comparative evaluation of terminalia chebula extract mouthwash and chlorhexidine mouthwash on plaque and gingival inflammation - 4-week randomised control trial.
A double-blind randomized control trial comparing Terminalia chebula mouthwash to chlorhexidine and distilled water in 90 undergraduate students. Terminalia chebula was found to be as effective as chlorhexidine in reducing dental plaque and gingival inflammation over 15 and 30 days.
The effects of an Ayurvedic medicinal toothpaste on clinical, microbiological and oral hygiene parameters in patients with chronic gingivitis: a double-blind, randomised, placebo-controlled, parallel allocation clinical trial.
RCT of 66 participants with chronic gingivitis comparing an Ayurvedic herbal toothpaste to placebo. The herbal toothpaste significantly reduced plaque index, bleeding on probing, probing pocket depth, and salivary anaerobic bacterial counts compared to placebo, with effects increasing over time.
Effect of Terminalia chebula extract and chlorhexidine on salivary pH and periodontal health: 2 weeks randomized control trial.
A double-blind, randomized controlled trial with 78 patients compared the efficacy of Terminalia chebula 10% mouth rinse to chlorhexidine 0.12% mouth rinse and saline solution over 2 weeks. Both Terminalia chebula and chlorhexidine significantly reduced dental plaque and gingival inflammation, with no significant difference between them.
Effectiveness of mouthrinse formulated from ethanol extract of Terminalia chebula fruit on salivary Streptococcus mutans among 12 to 15 year old school children of Belgaum city: a randomized field trial.
RCT evaluating the effectiveness of a mouthrinse formulated from ethanol extract of Terminalia chebula on salivary Streptococcus mutans in 60 children. The study found a significant reduction in Streptococcus mutans colony forming units, with a 44.42% reduction at 5 minutes and 64.14% reduction at 60 minutes post-rinsing.
Formulation and characterization of a cream containing terminalia chebula extract.
This study formulated a water-in-oil emulsion containing 5% Terminalia chebula extract and tested its effects on skin parameters in human volunteers over 8 weeks. The formulation increased skin moisture content and reduced skin erythema, showing a positive rejuvenating effect on human skin.
In vitro and in vivo skin anti-aging evaluation of gel containing niosomes loaded with a semi-purified fraction containing gallic acid from Terminalia chebula galls.
The study evaluated the skin anti-aging effects of a gel containing niosomes loaded with a semi-purified fraction containing gallic acid from Terminalia chebula galls. The gel showed no skin irritation and improved skin elasticity and reduced roughness in human volunteers, indicating enhanced anti-aging activities.
Effect of Terminalia chebula and Allium sativum on in vivo methane emission by sheep.
RCT evaluating the effect of Terminalia chebula and Allium sativum as feed additives on methane emission and nutrient digestibility in sheep. T. chebula showed antimethanogenic activity, and both T. chebula and A. sativum improved nutrient digestibility.
The efficacy of Terminalia chebula rinse on Streptococcus mutans count in saliva and its effect on salivary pH.
RCT assessing the effectiveness of Terminalia chebula aqueous extract rinse on salivary pH and Streptococcus mutans in 30 subjects. The extract significantly reduced S. mutans count and maintained alkaline salivary pH for 1 hour post-rinse. The mouthrinse was acceptable to 80% of participants.