Research
Tart Cherry
28 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Dose-dependent effect of tart cherry on selected cardiometabolic risk factors: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials.
Systematic review and dose-response meta-analysis of RCTs assessing tart cherry's effects on cardiometabolic risk factors. Tart cherry showed no significant effects on anthropometric and glycemic indices but improved lipid profile, particularly in unhealthy populations, with a single dose and longer duration.
Efficacy and safety of tart cherry supplementary citrate mixture on gout patients: a prospective, randomized, controlled study.
A prospective, randomized controlled trial among 282 men with gout compared the effects of tart cherry supplementary citrate mixture (TaCCi), citrate mixture, and sodium bicarbonate on urine pH, serum urate, and other markers. The TaCCi mixture showed similar efficacy in urine alkalization and serum urate-lowering as the other treatments but resulted in greater improvements in urine albumin/creatinine ratio and C-reactive protein levels, suggesting additional renal protection and anti-inflammatory benefits.
The beneficial effect of tart cherry on plasma levels of inflammatory mediators (not recovery after exercise): A systematic review and meta-analysis on randomized clinical trials.
Systematic review and meta-analysis of 10 RCTs evaluating the effect of tart cherry on plasma levels of inflammatory mediators in non-exercise contexts. Tart cherry significantly decreased plasma CRP levels but had no significant effect on IL-6 or TNF-α levels.
Tart Cherry Supplementation and Recovery From Strenuous Exercise: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of 14 studies on tart cherry supplementation for recovery from strenuous exercise. Tart cherry supplementation showed small to moderate beneficial effects on muscle soreness, muscular strength, muscular power, and inflammation markers like C-reactive protein and Interleukin-6.
Pharmacokinetics and Pharmacodynamics of Anthocyanins after Administration of Tart Cherry Juice to Individuals with Gout.
This study investigates the pharmacokinetics and pharmacodynamics of anthocyanins in tart cherry juice concentrate in individuals with gout. It quantifies major anthocyanins and measures antioxidant and antiinflammatory mRNA expression, finding that cyanidin-3-glucosylrutinoside achieves the highest plasma concentration in a dose-dependent manner.
The Influence of Tart Cherry (Montmorency) Concentrate Supplementation for 3 Months on Cardiometabolic Risk Factors in Middle-Aged Adults: A Randomised, Placebo-Controlled Trial.
RCT of 50 middle-aged adults comparing tart cherry concentrate to placebo for 3 months. No significant effects on vascular function or metabolic health variables were observed, but the supplement was safe and well-tolerated.
Patient-Centered Outcomes and Key Study Procedure Finalization in the Pilot Feasibility Gout Randomized Trial: Comparative Feasibility Study in GOUt, CHerry Extract Versus Diet Modification (Mini-GOUCH).
This study reports on a 9-month pilot internet randomized controlled trial comparing cherry extract to diet modification in 84 people with gout. The cherry extract group showed significant improvements in six Health Assessment Questionnaire sections/domains from baseline to 9 months, indicating potential benefits for joint health. High participant satisfaction and feasibility were noted, supporting future internet-based trials.
A Randomized Internet-Based Pilot Feasibility and Planning Study of Cherry Extract and Diet Modification in Gout.
A 9-month Internet-based RCT assessed the feasibility of cherry extract and diet modification in 84 people with gout. Improvements were observed in gout flares and functional ability in both groups, with cherry extract showing a reduction in gout flares and HAQ scores compared to baseline.
Impact of Powdered Tart Cherry Supplementation on Performance Recovery Following Repeated Sprint Exercise.
This randomized, double-blind, placebo-controlled study examined the effects of powdered tart cherry supplementation on recovery and performance metrics following repeated sprint exercise in 40 physically active young adults. The study found no significant differences between the tart cherry and placebo groups in terms of recovery, readiness, soreness, exercise performance, and markers of muscle damage.
Acute Dosing Strategy with Vistula Tart Cherries for Recovery of Strenuous Exercise-A Feasibility Study.
Pilot RCT exploring the feasibility of using powdered Vistula tart cherry for recovery after muscle-damaging exercise in 22 recreationally active participants. No significant differences in recovery metrics (MVC, VAS, PPT, ROM, and girth) were found between the tart cherry and placebo groups.
Plasma-Induced Changes in the Metabolome Following Vistula Tart Cherry Consumption.
RCT evaluating the influence of acute high- and low-dose Vistula tart cherry supplementation on the metabolomic profile in 12 healthy participants. Significant differences in metabolomic profiles were observed, with phenolics like cyanidine-3-glucoside, cyanidine-3-rutinoside, and vanillic acid detected in plasma, indicating bioavailability and potential shifts in the metabolome.
Post-Exercise Hypotension after Exercising in Hypoxia with and Without Tart Cherry Supplementation.
This study investigated the effects of hypoxic exercise with and without tart cherry supplementation on post-exercise hypotension in 12 healthy young adults. Tart cherry supplementation did not increase post-exercise hypotension compared to exercise in normoxia.
Five Days of Tart Cherry Supplementation Improves Exercise Performance in Normobaric Hypoxia.
This study investigated the effects of 5 days of tart cherry supplementation on hypoxic exercise performance in 13 healthy participants. Tart cherry supplementation improved time to exhaustion and increased tissue oxygen saturation during submaximal hypoxic exercise compared to placebo.
Effects of Montmorency Tart Cherry and Blueberry Juice on Cardiometabolic and Other Health-Related Outcomes: A Three-Arm Placebo Randomized Controlled Trial.
RCT of 45 adults comparing tart cherry, blueberry, and placebo over 20 days. Blueberry intake significantly improved total and LDL cholesterol levels and psychological wellbeing indices compared to placebo, suggesting benefits for cardiometabolic health and mood.
Montmorency tart cherry supplementation does not impact sleep, body composition, cellular health, or blood pressure in healthy adults.
RCT with 44 participants comparing Montmorency tart cherry juice or capsules to placebo over 30 days. No significant differences in sleep time or quality, cellular health, or blood pressure were found, though body mass decreased in capsule groups. Results conflict with previous data on MTC and sleep and BP.
Tart Cherry Supplement Enhances Skeletal Muscle Glutathione Peroxidase Expression and Functional Recovery after Muscle Damage.
RCT investigating Montmorency cherry concentrate (MCC) supplementation on muscle recovery and antioxidant expression. MCC enhanced recovery of muscle strength and upregulated antioxidant gene and protein expression compared to placebo, with increased phenolic acid concentrations.
Acute Ingestion of Montmorency Tart Cherry Reduces Serum Uric Acid but Has no Impact on High Sensitivity C-Reactive Protein or Oxidative Capacity.
RCT with 48 participants comparing tart cherry juice and powdered capsules to placebo for 48 hours. Tart cherry ingestion transiently decreased serum uric acid but had no significant impact on high-sensitivity C-reactive protein or oxidative capacity. A single powdered capsule was most effective for lowering uric acid.
Effect of Tart Cherry on Aromatase Inhibitor-Induced Arthralgia (AIA) in Nonmetastatic Hormone-Positive Breast Cancer Patients: A Randomized Double-Blind Placebo-Controlled Trial.
Randomized, double-blind, placebo-controlled trial of tart cherry concentrate in 48 nonmetastatic hormone-positive breast cancer patients with aromatase inhibitor-induced arthralgia. Tart cherry group showed a 34.7% mean decrease in pain compared to 1.4% in the placebo group, a statistically significant improvement.
The Combined Effects of Tart Cherry Powder and Magnesium L-Threonate Supplementation on Cognitive Function and Sleep Architecture: A Pilot Study in Healthy Adults
Pilot study investigating the combined effects of tart cherry powder and magnesium L-threonate supplementation on cognitive function and sleep architecture in healthy adults. Tart cherry is noted for its melatonin content enhancing sleep, while magnesium L-threonate supports neuroplasticity and cognitive performance.
Tart Cherry Concentrate Does Not Alter the Gut Microbiome, Glycaemic Control or Systemic Inflammation in a Middle-Aged Population.
RCT with 28 middle-aged participants comparing Montmorency cherry supplementation to placebo for 4 weeks. No significant effects were observed on gut microbiome composition, glycaemic control, or systemic inflammation markers such as IL-6 and CRP.
Tart cherry consumption with or without prior exercise increases antioxidant capacity and decreases triglyceride levels following a high-fat meal.
This randomized crossover study tested the effects of Montmorency tart cherry consumption, with or without prior exercise, on antioxidant responses to a high-fat meal in 12 normal-weight men. Tart cherry consumption increased antioxidant capacity and decreased triglyceride levels postprandially compared to placebo, with or without prior exercise.
Montmorency cherry supplementation attenuates vascular dysfunction induced by prolonged forearm occlusion in overweight, middle-aged men.
A randomized, double-blind, placebo-controlled, crossover study investigated the effects of 4 weeks of Montmorency cherry supplementation on vascular function in 12 overweight, middle-aged men. The study found that Montmorency cherry supplementation significantly improved flow-mediated dilation (FMD) recovery after ischemia-reperfusion injury, suggesting enhanced endothelium-dependent vasodilation and increased nitric oxide availability.
Effects of powdered Montmorency tart cherry supplementation on acute endurance exercise performance in aerobically trained individuals.
RCT of 27 endurance-trained individuals examining the effects of Montmorency tart cherry supplementation on endurance exercise performance. The tart cherry group showed faster race times, reduced muscle catabolism, lower inflammatory markers, and improved antioxidant activity compared to placebo.
Montmorency Tart cherries (Prunus cerasus L.) modulate vascular function acutely, in the absence of improvement in cognitive performance.
RCT with 27 middle-aged volunteers using a cross-over design to test Montmorency tart cherry concentrate. The study found significant improvements in vascular function and reduced systolic blood pressure, but no effects on cognitive function or mood.
Effects of Montmorency tart cherry (Prunus Cerasus L.) consumption on vascular function in men with early hypertension.
A placebo-controlled, blinded, crossover RCT examined the acute effects of Montmorency tart cherry juice on vascular function in 15 men with early hypertension. MC consumption significantly lowered systolic blood pressure over 3 hours, with peak reductions 2 hours post-consumption, linked to increases in circulating phenolic acids.
Effects of powdered Montmorency tart cherry supplementation on an acute bout of intense lower body strength exercise in resistance trained males.
RCT examining the effects of powdered Montmorency tart cherry supplementation on muscle soreness and recovery in resistance-trained males. The tart cherry group showed reduced muscle soreness and strength decrement during recovery, with no significant effects on inflammatory markers.
Recovery facilitation with Montmorency cherries following high-intensity, metabolically challenging exercise.
RCT examining the effects of Montmorency tart cherry concentrate on recovery and inflammation in trained cyclists following high-intensity cycling. The Montmorency cherry group showed improved muscle function and reduced inflammation markers compared to placebo.
Antioxidant and Anti-Inflammatory Properties of Cherry Extract: Nanosystems-Based Strategies to Improve Endothelial Function and Intestinal Absorption
The paper reviews the antioxidant and anti-inflammatory activities of cherry extract (CE) using an in vitro model with Human Umbilical Vein Endothelial Cells (HUVEC). It discusses strategies to improve the bioavailability of CE using nanoparticles to enhance intestinal absorption and endothelial function.