Research
Sutherlandia Frutescens (Cancer Bush)
64 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Biopolitics and Boundary Work in South Africa's Sutherlandia Clinical Trial.
RCT conducted between 2008 and 2011 to assess the safety and efficacy of Sutherlandia frutescens, an African traditional medicine, in HIV-seropositive but asymptomatic South Africans. The study explores the cross-cultural challenges and biopolitical implications of transforming Sutherlandia into a clinical trial substance.
Consumption of Sutherlandia frutescens by HIV-Seropositive South African Adults: An Adaptive Double-Blind Randomized Placebo Controlled Trial.
An adaptive double-blind randomized placebo-controlled trial evaluated the safety of consuming Sutherlandia frutescens by HIV seropositive adults. The study found no change in HIV viral load or CD4 T-lymphocyte count, but a greater burden of infection in the S. frutescens group, possibly due to interaction with isoniazid preventive therapy.
A randomized, double-blind, placebo-controlled trial of Lessertia frutescens in healthy adults.
A randomized, double-blind, placebo-controlled trial of Sutherlandia leaf powder in 25 healthy adults over 3 months. The study found no significant differences in adverse events or physiological indices between the treatment and placebo groups, though participants consuming Sutherlandia reported improved appetite.
The Implication of Chemotypic Variation on the Anti-Oxidant and Anti-Cancer Activities of(L.) R.Br. (Fabaceae) from Different Geographic Locations.
In vitro study of Sutherlandia extracts from different geographic locations assessing antioxidant and anti-cancer activities. Extracts showed variability in bioactive capacities, with coastal plants exhibiting superior antioxidant activity and Colesburg plants showing the highest anti-cancer activity against DLD-1 colon cancer cells.
Identification of Mechanism and Pathway of the Interaction between the African Traditional Medicine, Sutherlandia Frutescens, and the Antiretroviral Protease Inhibitor, Atazanavir, in Human Subjects Using Population Pharmacokinetic (PK) Analysis.
The study investigates the interaction between Sutherlandia frutescens and the antiretroviral protease inhibitor atazanavir using population pharmacokinetic analysis. It suggests that Sutherlandia frutescens may reduce the bioavailability of atazanavir by inhibiting the active absorption process.
Isolation of sutherlandins A, B, C and D from Sutherlandia frutescens (L.) R. Br. by counter-current chromatography using spiral tubing support rotors.
The paper describes the use of spiral countercurrent-chromatography for isolating flavonoids, specifically sutherlandins A-D, from the medicinal plant Sutherlandia frutescens. The study highlights the efficiency of different rotor systems in purifying these compounds.
Short communication. Challenges relating to comparison of flavonoid glycosides dissolution profiles from Sutherlandia frutescens products.
The study investigated the dissolution profiles of flavonoid glycosides from Sutherlandia frutescens products using different dissolution media. Variations in dissolution profiles were observed across different products, suggesting the potential use of this method for comparing orally administered S. frutescens products.
Immunomodulating polysaccharides from Lessertia frutescens leaves: isolation, characterization and structure activity relationship.
The study isolated and characterized polysaccharides from the leaves of Sutherlandia frutescens, testing their bioactivity in the complement assay. It found that certain polysaccharide fractions, particularly those rich in galactose and xylose, had significant immunomodulating effects.
Comparison of the selected secondary metabolite content present in the cancer-bush Lessertia (Sutherlandia) frutescens L. Extracts.
The study analyzed extracts of in vitro leaves, field leaves, and seeds of Lessertia frutescens to compare their phenolic, flavonoid, alkaloid, and saponin contents. Saponins were most abundant in in vitro leaves, followed by phenolics, flavonoids, and alkaloids. The presence of tannins, phlobatannins, and cardiac glycosides was also noted, suggesting potential therapeutic uses.
Quantitative determination of flavonoids and cycloartanol glycosides from aerial parts of Sutherlandia frutescens (L.) R. BR. by using LC-UV/ELSD methods and confirmation by using LC-MS method.
The paper describes an analytical method for determining flavonoids (sutherlandins A-D) and cycloartanol glycosides (sutherlandiosides A-D) from Sutherlandia frutescens using LC-UV/ELSD and LC-MS methods. The method was validated for linearity, repeatability, limits of detection, and quantification, with considerable variation found in the major compound, sutherlandioside B.
Flavonol glycosides from the south African medicinal plant Sutherlandia frutescens.
Phytochemical investigation of Sutherlandia frutescens leaves led to the isolation of four new flavonol glycosides, sutherlandins A-D. Their structures were elucidated using chemical and spectroscopic methods.
Cycloartane glycosides from Sutherlandia frutescens.
The paper reports the isolation and structural elucidation of four new cycloartane glycosides, sutherlandiosides A-D, from the South African folk medicine Sutherlandia frutescens. The structures were established using spectroscopic methods and X-ray crystallography.
Impact of African herbal medicines on antiretroviral metabolism.
The study examined the effects of African herbal medicines Hypoxis and Sutherlandia on antiretroviral metabolism. Both herbs significantly affected cytochrome P450 3A4 metabolism and activated the pregnane X receptor. P-glycoprotein expression was inhibited, with Hypoxis showing 42-51% and Sutherlandia showing 19-31% of activity compared with verapamil. The findings suggest potential risks of treatment failure, viral resistance, or drug toxicity when combining these herbal medicines with antiretroviral agents.
Phytochemistry, Ethnopharmacology, and Pharmacology of(Cancer Bush): A Comprehensive Review.
This comprehensive review examines the phytochemistry, ethnopharmacology, and pharmacology of cancer bush, a South African medicinal plant. It highlights its phytochemical profile and therapeutic effects, including immunomodulatory, antioxidant, anti-inflammatory, antidiabetic, neuroprotective, antistress, and antimicrobial activities, based on 154 articles.
The "Cancer Bush" Sutherlandia (syn. Lessertia) frutescens. An Example of Promotional Research, or Is There Scientific Merit?
Narrative review of Sutherlandia (Lessertia frutescens) evaluating its traditional use and scientific data regarding antiproliferative properties. The review concludes that despite some studies suggesting potential effects, the evidence is insufficient and biased, with many studies lacking proper controls and realistic dosages. Sutherlandia is not recommended for cancer treatment due to these limitations and potential herb-drug interactions.
Antibacterial activity of biogenic silver and gold nanoparticles synthesized from Salvia africana-lutea and Sutherlandia frutescens.
The study synthesized biogenic silver and gold nanoparticles using water extracts of Salvia africana-lutea and Sutherlandia frutescens. The antibacterial activity of these nanoparticles was tested against Staphylococcus epidermidis and P. aeruginosa. SAL AgNP and SF AgNP displayed high antibacterial activity, while SAL AuNP and the water extracts did not show significant activity.
Comparative cardio and developmental toxicity induced by the popular medicinal extract of Sutherlandia frutescens (L.) R.Br. detected using a zebrafish Tuebingen embryo model.
The study investigated the cardio and developmental toxicity of Sutherlandia frutescens extracts using a zebrafish embryo model. Both ethanol and water extracts caused bleeding and pericardial cyst formation at high concentrations, with the aqueous extract being less toxic. Chemical differences between the extracts were analyzed using LC-MS/MS, highlighting sutherlandiosides as distinguishing features.
The mutagenic and antimutagenic activity of Sutherlandia frutescens extracts and marker compounds.
The study investigated the mutagenic and antimutagenic activity of Sutherlandia frutescens extracts and marker compounds using the Ames assay. The ethylacetate extract exhibited antimutagenicity against all bacterial strains, while the methanol extract showed both pro-mutagenic and antimutagenic activities. L-canavanine showed co-mutagenicity, whereas L-arginine and GABA exhibited antimutagenic responses. The ethylacetate extract had higher phenolic content and antioxidant potential.
Sutherlandia frutescens modulates adrenal hormone biosynthesis, acts as a selective glucocorticoid receptor agonist (SEGRA) and displays anti-mineralocorticoid properties.
The study investigated the effects of Sutherlandia frutescens and sutherlandioside B on adrenal hormone biosynthesis and steroid receptor interaction in COS-1 and H295R cell models. The extracts inhibited key steroidogenic enzymes and decreased cortisol and androgen precursors, suggesting anti-stress, anti-inflammatory, and anti-hypertensive properties.
Ethnobotanical survey of medicinal plants used to manage High Blood Pressure and Type 2 Diabetes Mellitus in Bitterfontein, Western Cape Province, South Africa.
Ethnobotanical survey in Bitterfontein, Western Cape Province, South Africa, documenting medicinal plants used to manage High Blood Pressure and Type 2 Diabetes Mellitus. Twenty-four plant species were identified, with Lessertia frutescens being the most commonly used. The study highlights the widespread use of medicinal plants alongside allopathic medicine.
The Induction of Apoptosis in A375 Malignant Melanoma Cells by Sutherlandia frutescens.
The study investigates the effect of Sutherlandia frutescens extract on A375 melanoma cells, demonstrating its ability to induce apoptosis through both caspase-dependent and caspase-independent pathways. The findings suggest potential for further in vivo studies.
An Investigation into the Immunomodulatory Activities of Sutherlandia frutescens in Healthy Mice.
Animal study investigating the immunomodulatory effects of Sutherlandia frutescens in healthy mice. Consumption of S. frutescens did not significantly alter host response to systemic infection and tended to diminish in vivo inflammatory responses.
Unveiling the anti-inflammatory activity of Sutherlandia frutescens using murine macrophages.
The study investigates the anti-inflammatory activities of Sutherlandia frutescens extract (SFE) on murine macrophage cell lines and primary mouse macrophages. SFE exhibited anti-inflammatory effects, but these were not mediated by sutherlandiosides or sutherlandins, with chlorophyll contributing to the observed activity.
Inhibition of Hedgehog-Signaling Driven Genes in Prostate Cancer Cells by Sutherlandia frutescens Extract.
The study investigates the effect of Sutherlandia frutescens extract on Hedgehog-signaling driven genes in TRAMPC2 murine prostate cancer cells. Sutherlandia ethanol extract repressed 50% of Hh-responsive genes, including Gli1 and Ptch1.
Sutherlandia frutescens may exacerbate HIV-associated neuroinflammation.
In vitro study using a co-culture model of the blood-brain barrier to investigate the effects of Sutherlandia frutescens on HIV-associated neuroinflammation. S. frutescens decreased IL-1β secretion but exacerbated monocyte chemoattractant protein-1 and CD14+ monocyte infiltration, suggesting potential negative effects on neuroinflammation in HIV/AIDS.
Immuno-stimulatory activity of a polysaccharide-enriched fraction of Sutherlandia frutescens occurs by the toll-like receptor-4 signaling pathway.
The study investigated the immuno-stimulatory activity of a polysaccharide-enriched fraction from Sutherlandia frutescens using RAW 264.7 murine macrophage cells. SFPS increased the production of ROS, NO, and TNF-α in a dose-dependent manner, effects that were blocked by a TLR4-specific inhibitor, suggesting the involvement of TLR4 and NF-κB signaling pathways.
Inhibition of Gli/hedgehog signaling in prostate cancer cells by "cancer bush" Sutherlandia frutescens extract.
The study investigates the anti-cancer effects of Sutherlandia frutescens extract on prostate cancer cells. It found dose- and time-dependent growth inhibition in human and mouse prostate cancer cells, linked to inhibition of the Gli/hedgehog signaling pathway. Sutherlandioside D was identified as a potent compound in the extract.
The immunostimulatory and antimicrobial property of two herbal decoctions used in the management of HIV/AIDS in Ghana.
The study investigated the efficacy of Betula alba and Sutherlandia frutescens decoctions in managing HIV/AIDS in Ghana. The herbal decoctions significantly reduced viral loads in patients and increased total WBC and lymphocyte counts in immunosuppressed mice. They also exhibited antimicrobial activity against various bacteria and Candida albicans.
Antioxidant potential of Sutherlandia frutescens and its protective effects against oxidative stress in various cell cultures.
The study assessed the antioxidant potential of Sutherlandia frutescens extracts in cell-free systems and various cell lines. The extracts showed significant antioxidant activity, and the freeze-dried hot water extract protected against oxidative stress induced by tert-butyl hydroperoxide in cell cultures.
Dietary Sutherlandia and elderberry mitigate cerebral ischemia-induced neuronal damage and attenuate p47phox and phospho-ERK1/2 expression in microglial cells.
Animal study where C57BL/6J male mice were fed diets with Sutherlandia or American elderberry for 2 months before inducing cerebral ischemia. The supplemented diets ameliorated sensorimotor impairment and reduced neuronal cell death and microglial activation, demonstrating neuroprotective effects against oxidative and inflammatory responses.
Sutherlandia frutescens ethanol extracts inhibit oxidative stress and inflammatory responses in neurons and microglial cells.
In vitro study of Sutherlandia frutescens ethanol extracts showing suppression of NMDA-induced ROS production in neurons and LPS- and IFNγ-induced ROS and NO production in microglial cells. The extracts inhibit the IFNγ-induced p-ERK1/2 signaling pathway, suggesting potential therapeutic applications for stress and inflammatory diseases in the brain.
Effect of the African Traditional Medicine, Sutherlandia frutescens, on the Bioavailability of the Antiretroviral Protease Inhibitor, Atazanavir.
The study investigated the effect of Sutherlandia frutescens on the bioavailability of atazanavir in twelve healthy male subjects. Sutherlandia frutescens significantly reduced the bioavailability of atazanavir, potentially resulting in subtherapeutic plasma concentrations and reduced anti-HIV efficacy.
Sutherlandia frutescens: the meeting of science and traditional knowledge.
The paper discusses Sutherlandia frutescens, a plant used in traditional medicine, and its intersection with scientific research. Specific study details are not available due to the lack of an abstract.
Sutherlandia frutescens prevents changes in diabetes-related gene expression in a fructose-induced insulin resistant cell model.
The study investigated the effects of Sutherlandia frutescens on insulin resistance in a human liver cell culture model. Sutherlandia frutescens prevented insulin resistance parameters such as reduced glucose uptake, increased glucose release, and lipid accumulation. It also regulated the expression of 27 diabetes-related genes, suggesting potential anti-diabetic mechanisms.
Central and peripheral effects of Sutherlandia frutescens on the response to acute psychological stress.
The study investigated the effects of Sutherlandia frutescens on acute psychological stress in a rodent model. A low dose of S. frutescens extract was administered before stress exposure, and it was found to abolish stress-induced down-regulation of glucocorticoid receptors, suggesting central mechanisms of action supporting its use in stress-related disorders.
Differential signaling involved in Sutherlandia frutescens-induced cell death in MCF-7 and MCF-12A cells.
In vitro study evaluating the effects of aqueous extracts of Sutherlandia frutescens on MCF-7 breast adenocarcinoma and MCF-12A non-tumorigenic cell lines. The study found that Sutherlandia frutescens induced apoptosis and autophagy, with the MCF-7 cell line being more susceptible to its cytostatic and cytotoxic effects compared to the MCF-12A cell line.
Interactions between phytochemical components of Sutherlandia frutescens and the antiretroviral, atazanavir in vitro: implications for absorption and metabolism.
In vitro study investigating the interaction between Sutherlandia frutescens extracts and the antiretroviral drug atazanavir. The study found that Sutherlandia frutescens components affected atazanavir absorption and metabolism, with implications for its oral bioavailability.
The potential of Sutherlandia frutescens for herb-drug interaction.
The study investigated the inhibitory effects of Sutherlandia frutescens on major cytochrome P450 isozymes using human liver microsomes and its effect on midazolam clearance using hepatocytes. S. frutescens showed inhibitory potency for several CYP enzymes and transporters, indicating potential herb-drug interactions.
The immunomodulatory effects of Sutherlandia frutescens extracts in human normal peripheral blood mononuclear cells.
In vitro study investigating the immunomodulatory effects of Sutherlandia frutescens extracts on normal human peripheral blood mononuclear cells. High doses of the extract significantly decreased cytokines TNF-α and IL 1β, while low doses did not change TNF-α and IL 1β secretion. The study suggests that SF extracts can modulate cytokine secretion in unstimulated normal PBMCs.
Effect of Sutherlandia frutescens on the lipid metabolism in an insulin resistant rat model and 3T3-L1 adipocytes.
The study evaluated the effects of Sutherlandia frutescens on lipid metabolism in an insulin resistant rat model and 3T3-L1 adipocytes. Rats treated with S. frutescens showed lower body weight and decreased levels of insulin, free fatty acids, and triglycerides. In 3T3-L1 cells, S. frutescens decreased triglyceride accumulation and increased glucose consumption and lactate production, suggesting improved insulin sensitivity.
Effects of Sutherlandia frutescens extracts on normal T-lymphocytes in vitro.
In vitro study examining the effects of Sutherlandia frutescens extracts on normal human T cells. High concentrations of ethanol extracts induced significant necrosis, ATP depletion, and inhibition of caspase-3/-7 activity, while water extracts were less toxic. DNA fragmentation was observed with high doses of both extracts over 48 hours.
Effect of short term and chronic administration of Sutherlandia frutescens on pharmacokinetics of nevirapine in rats.
The study investigated the effects of Sutherlandia frutescens on the pharmacokinetics of nevirapine in Sprague Dawley rats. Short-term co-administration showed no significant effect, but chronic exposure led to a 50% decrease in the AUC and C(max) values of nevirapine. The study also found increased mRNA expression of CYP3A2 in rats and CYP3A4 in human cell models, suggesting a potential drug-herb interaction.
The apoptosis inducing effects of Sutherlandia spp. extracts on an oesophageal cancer cell line.
In vitro study investigating the apoptosis-inducing effects of Sutherlandia frutescens and Sutherlandia tomentosa extracts on oesophageal cancer cell line SNO. The extracts induced apoptosis and were more cytotoxic to cancerous cells compared to non-cancerous cells, showing promise as anti-cancer agents.
Sutherlandia frutescens limits the development of insulin resistance by decreasing plasma free fatty acid levels.
The study investigated the effects of Sutherlandia frutescens on insulin resistance in rats fed a high fat diet. S. frutescens reduced plasma free fatty acid levels and prevented the development of insulin resistance over twelve weeks, also decreasing total cholesterol levels and the LDL/HDL ratio.
In vitro effects of Sutherlandia frutescens water extracts on cell numbers, morphology, cell cycle progression and cell death in a tumorigenic and a non-tumorigenic epithelial breast cell line.
In vitro study of Sutherlandia frutescens water extracts on tumorigenic and non-tumorigenic breast cell lines. The extracts decreased cell growth and induced apoptosis, with more pronounced effects in the tumorigenic MCF-7 cells. The study suggests differential mechanisms of action in the two cell lines.
Impact of traditional medicinal plant extracts on antiretroviral drug absorption.
In vitro study investigating the effect of Hypoxis hemerocallidea and Sutherlandia frutescens extracts, as well as l-canavanine, on the transport of nevirapine across human intestinal epithelial cells. Hypoxis hemerocallidea and l-canavanine decreased nevirapine efflux, potentially increasing its bioavailability.
The influence of Sutherlandia frutescens on adrenal steroidogenic cytochrome P450 enzymes.
The study investigated the interaction of Sutherlandia frutescens with cytochrome P450 enzymes involved in glucocorticoid biosynthesis. The extracts inhibited progesterone and pregnenolone metabolism, suggesting a mechanism by which Sutherlandia frutescens may reduce glucocorticoid levels and alleviate stress symptoms.
Anticonvulsant property of Sutherlandia frutescens R. BR. (variety Incana E. MEY.) [Fabaceae] shoot aqueous extract.
The study examined the anticonvulsant properties of Sutherlandia frutescens shoot aqueous extract against seizures induced by pentylenetetrazole, picrotoxin, and bicuculline in mice. The extract significantly delayed the onset of and antagonized pentylenetetrazole-induced seizures, profoundly antagonized picrotoxin-induced seizures, and weakly antagonized bicuculline-induced seizures. The findings suggest potential use as a supplementary remedy for childhood convulsions and epilepsy.
Influence of Sutherlandia frutescens extracts on cell numbers, morphology and gene expression in MCF-7 cells.
The study investigated the effects of Sutherlandia frutescens extracts on MCF-7 human breast adenocarcinoma cells. A significant decrease in malignant cell numbers and apoptotic morphological changes were observed after exposure to the extract. Gene expression analysis provided insights into the molecular mechanisms involved.
Anti-diabetic effects of Sutherlandia frutescens in Wistar rats fed a diabetogenic diet.
Study investigated the effects of Sutherlandia frutescens on glucose uptake and insulin levels in pre-diabetic rats fed a high fat diet. The plant extract normalized insulin levels, increased glucose uptake in muscle and adipose tissue, and decreased intestinal glucose uptake, showing promise as a type 2 anti-diabetes medication.
Inhibitory effects of the extracts of Sutherlandia frutescens (L.) R. Br. and Harpagophytum procumbens DC. on phorbol ester-induced COX-2 expression in mouse skin: AP-1 and CREB as potential upstream targets.
The study investigated the effects of methanolic extracts of Sutherlandia frutescens and Harpagophytum procumbens on TPA-induced COX-2 expression in mouse skin. Topical application of both extracts inhibited COX-2 expression by diminishing ERK catalytic activity and inhibiting AP-1 activation, suggesting anti-inflammatory properties.
Anti-HIV activities of organic and aqueous extracts of Sutherlandia frutescens and Lobostemon trigonus.
The study screened extracts from Sutherlandia frutescens and Lobostemon trigonus for anti-HIV activity. Sutherlandia extracts showed inhibitory compounds against HIV target enzymes, while aqueous Lobostemon leaf extracts inhibited HIV-1 reverse transcriptase with an IC50 of 49 microg/ml.
Antibacterial and antioxidant activity of Sutherlandia frutescens (Fabaceae), a reputed anti-HIV/AIDS phytomedicine.
The study investigated the antibacterial and antioxidant activity of Sutherlandia frutescens extracts. The hexane extract showed significant antibacterial activity against S. aureus, E. faecalis, and E. coli. Antioxidant activity was demonstrated using the DPPH free-radical scavenging assay.
Sutherlandia frutescens extracts can induce apoptosis in cultured carcinoma cells.
In vitro study showing that crude aqueous Sutherlandia frutescens extracts induced cytotoxicity and apoptosis in cervical carcinoma and CHO cell lines. Apoptotic responses were confirmed through morphological observation, chromatin condensation, phosphotidyl serine externalisation, DNA fragmentation patterns, and flow cytometric analysis.
In vitro culture studies of Sutherlandia frutescens on human tumor cell lines.
In vitro study of Sutherlandia frutescens on human tumor cell lines. The herb showed a concentration dependent antiproliferative effect on several tumor cell lines but did not show significant antioxidant effects.
The antioxidant potential of Sutherlandia frutescens.
The study investigates the antioxidant potential of Sutherlandia frutescens extract, focusing on its superoxide and hydrogen peroxide scavenging activities. The extract showed significant scavenging activities, which may contribute to its anti-inflammatory properties.
Analgesic, antiinflammatory and hypoglycemic effects of Sutherlandia frutescens R. BR. (variety Incana E. MEY.) [Fabaceae] shoot aqueous extract.
Animal study investigating the analgesic, antiinflammatory, and hypoglycemic effects of Sutherlandia frutescens shoot aqueous extract. The extract showed significant analgesic effects in mice and inhibited inflammation and caused hypoglycemia in rats, supporting its traditional use in managing pain, inflammation, and type-2 diabetes.
Does Concurrent Use of Some Botanicals Interfere with Treatment of Tuberculosis?
The paper discusses the potential interference of botanicals, specifically Sutherlandia frutescens, with tuberculosis treatment. Sutherlandia suppresses reactive oxygen species production and microglial activation, which may reduce the host's immune response to Mycobacterium tuberculosis. It is recommended that individuals on isoniazid avoid concurrent use of botanicals with antioxidant activity.
Daily brief restraint stress alters signaling pathways and induces atrophy and apoptosis in rat skeletal muscle.
The study investigated the effects of restraint stress on muscle atrophy and apoptosis in 40 male Wistar rats, and the potential protective effects of Sutherlandia frutescens. Restraint stress increased myostatin and apoptosis, and attenuated MyoD expression and PI3-Kinase/Akt signaling, all of which were counteracted by Sutherlandia treatment.
A review of the taxonomy, ethnobotany, chemistry and pharmacology of Sutherlandia frutescens (Fabaceae).
Narrative review of Sutherlandia frutescens, a plant used in traditional medicine for a variety of ailments including stress, inflammation, and cancer. The review discusses its taxonomy, ethnobotany, chemistry, and pharmacology, highlighting its antiproliferative, anti-HIV, anti-diabetic, anti-inflammatory, and anti-stress activities. Preclinical data suggest efficacy and safety, supporting the need for controlled clinical studies.
Evaluation of the mutagenic and antimutagenic effects of South African plants.
In vitro study screening dichloromethane and methanol extracts of 42 South African plants for mutagenicity and antimutagenicity using the Ames test. Methanol extracts of Helichrysum species showed mutagenicity, while several other species showed antimutagenic properties in the presence of S9.
African herbal medicines in the treatment of HIV: Hypoxis and Sutherlandia. An overview of evidence and pharmacology.
The paper reviews the evidence and safety concerns related to the use of two African herbal medicines, African Potato and Sutherlandia, in the treatment of HIV/AIDS. It discusses the pharmacology, toxicology, and pharmacokinetics of these herbs, highlighting the lack of clinical trials and potential for drug interactions with antiretroviral drugs.
The effect of Sutherlandia frutescens on steroidogenesis: confirming indigenous wisdom.
The study investigated the effect of Sutherlandia frutescens on stress-related steroidogenesis in 40 male Wistar rats. Sutherlandia extract significantly decreased corticosterone levels in stressed rats and inhibited substrate binding and conversion in adrenal steroidogenesis assays.
Spotlight on ethnomedicine: usability of Sutherlandia frutescens in the treatment of diabetes.
The paper discusses the usability of Sutherlandia frutescens in the treatment of diabetes, focusing on its role in ethnomedicine.