Research
Stevia
31 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Effects of stevia consumption on appetite in adults: A systematic review and dose-response meta-analysis of randomized controlled trials.
This systematic review and meta-analysis examined the impact of stevia on appetite and energy intake in adults, including 11 clinical trials with 428 participants. The study found no significant changes in appetite scores following stevia consumption, although desires to eat increased significantly in the oral intake subgroup. The evidence certainty ranged from very low to moderate.
Effect of stevia on blood glucose and HbA1C: A meta-analysis.
Meta-analysis of 26 studies with 1439 participants examining stevia's impact on glycemic indices. Stevia consumption was associated with a significant reduction in blood glucose levels, particularly in individuals with higher BMI, diabetes, and hypertension. However, stevia did not significantly affect insulin concentration or HbA1C levels.
Effect of steviol glycosides as natural sweeteners on glucose metabolism in adult participants.
Systematic review and meta-analysis of 12 RCTs with 871 participants assessing the effect of steviol glycosides on glucose metabolism. Significant improvement in fasting blood glucose was found, but no significant difference in HbA1c. Subgroup analyses showed favorable effects in certain populations.
Clinical Effects of Sugar Substitutes on Cariogenic Bacteria: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis investigating the effects of sugar substitute consumption on cariogenic bacteria in dental plaque and saliva. The study found that low-intensity sweeteners like xylitol, sorbitol, erythritol, and maltitol significantly reduce cariogenic bacteria, while evidence for high-intensity sweeteners like stevia is limited.
Assessing the impact of non-nutritive sweeteners on anthropometric indices and leptin levels in adults: A GRADE-assessed systematic review, meta-analysis, and meta-regression of randomized clinical trials.
This GRADE-assessed systematic review and meta-analysis evaluated the effects of artificial- and stevia-based sweeteners on anthropometric indices and serum leptin levels. The analysis included 20 RCTs with 2158 subjects, showing that non-nutritive sweeteners significantly reduced body weight, fat mass, and fat-free mass, but had no significant effect on BMI, waist circumference, or serum leptin levels.
Antioxidant Activity of Leaf Extracts fromBertoni Exerts Attenuating Effect on Diseased Experimental Rats: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of stevia leaf extracts on oxidative stress markers in diseased rats. Stevia leaf extracts restored oxidative stress markers more effectively than pure glycosides, with organic extracts showing stronger antioxidant properties. Rats with diabetes mellitus showed the highest restorative response.
The effects of artificial- and stevia-based sweeteners on lipid profile in adults: a GRADE-assessed systematic review, meta-analysis, and meta-regression of randomized clinical trials.
Systematic review and meta-analysis of 14 RCTs evaluating the effects of artificial- and stevia-based sweeteners on lipid profile markers. The analysis found no significant effect on TG, TC, LDL, and HDL levels, though a small increase in LDL was noted in subjects with normal LDL levels.
Effect of Steviol Glycosides on Human Health with Emphasis on Type 2 Diabetic Biomarkers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Systematic review and meta-analysis of RCTs evaluating the effect of steviol glycosides on human health, particularly type 2 diabetic biomarkers. The meta-analysis included 9 RCTs with 462 participants and found a significant reduction in systolic blood pressure in favor of steviol glycosides, but non-significant effects on BMI, diastolic BP, fasting blood glucose, lipids, and glycated hemoglobin.
Comparison of a Daily Steviol Glycoside Beverage compared with a Sucrose Beverage for Four Weeks on Gut Microbiome in Healthy Adults.
RCT comparing the effects of steviol glycoside-sweetened beverages to sucrose-sweetened beverages on the gut microbiome and fecal short-chain fatty acid profiles in 59 healthy adults over 4 weeks. No significant differences were found in gut microbiome composition or fecal SCFA between the groups.
Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance.
RCT of 120 healthy adults assessing the impact of saccharin, sucralose, aspartame, and stevia on microbiome and glycemic responses. Saccharin and sucralose significantly impaired glycemic responses, with person-specific, microbiome-dependent effects observed.
Mapping the Homeostatic and Hedonic Brain Responses to Stevia Compared to Caloric Sweeteners and Water: A Double-Blind Randomised Controlled Crossover Trial in Healthy Adults.
Double-blind randomised controlled crossover trial comparing brain responses to beverages sweetened with stevia, glucose, maltodextrin, and water in healthy adults. Stevia-sweetened beverage resulted in greater BOLD decrease in motor, frontal, and insula cortices, especially in the 20-30 min period post-ingestion, compared to other beverages.
Biological effects of stevia, sucralose and sucrose in citrus-maqui juices on overweight subjects.
A 3-arm parallel, randomized, and triple-blind clinical trial evaluated the effects of stevia, sucralose, and sucrose in maqui-citrus beverages on antioxidant and inflammatory status in 138 overweight subjects over 60 days. Stevia showed an anti-inflammatory response with increased IL-10 concentration, while sucralose and sucrose increased homocysteine levels and cholesterol. Stevia may have antioxidative effects in individuals with lower antioxidant status.
An evidence-based systematic review of stevia by the Natural Standard Research Collaboration.
Systematic review evaluating scientific evidence on stevia, focusing on hypertension and hyperglycemia. Long-term studies suggest stevia may lower blood pressure in hypertensive patients, while small studies indicate potential positive effects on glucose tolerance. Further investigation is warranted.
Stevia (Stevia rebaudiana) a bio-sweetener: a review.
Systematic literature review summarizing evidence for Stevia as a bio-sweetener and its potential benefits, particularly for diabetic patients and those reducing caloric intake. Stevia is noted for its high-potency sweetening properties and medicinal uses such as lowering blood sugar.
Acute responses of stevia and d-tagatose intake on metabolic parameters and appetite/satiety in insulin resistance.
Randomized controlled crossover study examining the effects of stevia and d-tagatose preloads on carbohydrate metabolism markers and appetite in women with insulin resistance. Stevia intake resulted in higher C-peptide iAUC and increased serum glucose at earlier times compared to d-tagatose and control. Both stevia and d-tagatose increased subjective satiety compared to control.
The impact of nutritive and non-nutritive sweeteners on the central nervous system: preliminary study.
RCT evaluating the impact of sucrose, sucralose, and steviol glycosides on CNS activity in 39 participants. The sucralose group showed significant decreases in memory and executive functions, with increased theta wave power in qEEG analysis. The sucrose group showed decreased encoding memory, while the steviol glycosides group showed no significant changes.
Effects of the Daily Consumption of Stevia on Glucose Homeostasis, Body Weight, and Energy Intake: A Randomised Open-Label 12-Week Trial in Healthy Adults.
This randomised, controlled, open-label trial examined the effects of daily stevia consumption on glycaemia, body weight, and energy intake in 28 healthy adults over 12 weeks. Stevia consumption did not significantly affect glucose or insulin responses but helped maintain body weight and reduced energy intake compared to the control group.
Stevia Beverage Consumption prior to Lunch Reduces Appetite and Total Energy Intake without Affecting Glycemia or Attentional Bias to Food Cues: A Double-Blind Randomized Controlled Trial in Healthy Adults.
This double-blind randomized controlled trial examined the effects of stevia beverage consumption prior to lunch on appetite and energy intake in 20 healthy adults. The study found that stevia reduced appetite and total energy intake without affecting glycemia or attentional bias to food cues.
Chemical-specific adjustment factors (inter-species toxicokinetics) to establish the ADI for steviol glycosides.
The study investigates the pharmacokinetics of stevioside in rats and humans to establish chemical-specific adjustment factors for inter-species toxicokinetics. The findings suggest that a higher acceptable daily intake (ADI) for steviol glycosides is justified based on lower toxicokinetic adjustment factors compared to the default value.
Apparent lack of pharmacological effect of steviol glycosides used as sweeteners in humans. A pilot study of repeated exposures in some normotensive and hypotensive individuals and in Type 1 and Type 2 diabetics.
RCT evaluating the effects of steviol glycosides on blood glucose and blood pressure in Type 1 and Type 2 diabetics and normotensive/hypotensive individuals. No significant differences in systolic BP, diastolic BP, glucose, and HbA1c were observed post-treatment, indicating no pharmacological effect.
Investigation of the antihypertensive effect of oral crude stevioside in patients with mild essential hypertension.
RCT investigating the antihypertensive effect of crude stevioside in patients with mild essential hypertension. Stevioside was administered in increasing doses up to 15.0 mg/kg/day. Systolic and diastolic blood pressure decreased, but similar effects were observed in the placebo group, indicating no significant antihypertensive effect. Stevioside was found to be safe and well-tolerated.
Efficacy and tolerability of oral stevioside in patients with mild essential hypertension: a two-year, randomized, placebo-controlled study.
This 2-year randomized, placebo-controlled trial investigated the efficacy and tolerability of oral stevioside in 174 Chinese patients with mild essential hypertension. Stevioside significantly decreased systolic and diastolic blood pressure compared with placebo and improved quality of life scores, with no significant adverse effects noted.
A double-blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertension.
A double-blind, placebo-controlled RCT evaluated the effect of oral stevioside on hypertension in 106 Chinese subjects. The stevioside group showed significant reductions in systolic and diastolic blood pressure over one year, with no significant adverse effects or changes in blood biochemistry.
Ultrasound-Assisted Coupled with Resin-Based Purification for Sustainable Extraction of Steviosides fromLeaves.
The study optimized the extraction, decolorization, decontamination, and desalting processes for stevioside, a natural sweetener, using ultrasound-assisted and resin-based purification methods. The optimized process increased steviol glycoside yield and improved efficiency, sustainability, and quality for industrial-scale applications.
Effects of Stevia Extract on Postprandial Glucose Response, Satiety and Energy Intake: A Three-Arm Crossover Trial.
A three-arm crossover trial with 30 participants investigated the effects of stevia on postprandial glucose levels, appetite, and food intake. Stevia preload lowered appetite sensation without significantly affecting energy intake or postprandial glucose levels, suggesting potential benefits for obesity and diabetes management.
A polyol-stevia blended sugar replacer exhibits low glycemic response among human subjects.
This study evaluated the glycemic response of SUITENA™, a sweetener containing erythritol, xylitol, and Stevia, in six healthy human subjects. The mean area under the curve (AUC) for blood glucose was significantly lower for SUITENA™ compared to a dextrose standard, indicating a low glycemic response.
Effect of Consuming Tea with Stevia on Salivary pH - An In Vivo Randomised Controlled Trial.
This randomized controlled trial assessed the effect of consuming tea with stevia on salivary pH in 24 male students. The study found that salivary pH returned to baseline 1 hour after drinking stevia-sweetened tea, suggesting stevia's potential as a non-cariogenic sweetener.
Effects of non-nutritive (artificial vs natural) sweeteners on 24-h glucose profiles.
Randomized crossover study with 10 healthy males comparing the effects of aspartame, monk fruit, stevia, and sucrose-sweetened beverages on 24-hour glucose profiles. No significant differences were found in glucose measures between the beverages, indicating minimal effect on 24-hour glucose profiles.
An in vitro and in vivo comparison of the effect of Stevia rebaudiana extracts on different caries-related variables: a randomized controlled trial pilot study.
The study evaluated the effect of Stevia extracts on in vitro Streptococcus mutans biofilm formation and in vivo plaque pH. Twenty volunteers rinsed with solutions containing stevioside, rebaudioside A, or sucrose. Sucrose solution showed higher in vitro S. mutans biofilm formation and lower in vivo plaque pH compared to Stevia extracts, indicating Stevia extracts are nonacidogenic.
Effect of moderate intake of sweeteners on metabolic health in the rat.
Animal study comparing the effects of moderate consumption of fructose-containing and non-caloric sweetened beverages on metabolic health in rats. HFCS intake was highest, and fructose and HFCS groups showed higher serum cholesterol and alanine aminotransferase levels. IL-6 levels were lower with Hoodia ingestion. No significant differences in body weight or glucose tolerance were observed.
Antihyperglycemic effects of stevioside in type 2 diabetic subjects.
Acute, paired cross-over study in 12 type 2 diabetic patients testing stevioside supplementation with a test meal. Stevioside reduced the incremental area under the glucose response curve by 18% and increased the insulinogenic index by approximately 40% compared to control, indicating beneficial effects on glucose metabolism.