Research
Soy Isoflavones
69 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Isoflavones improve vaginal atrophy, skin health, and sex-related hormones in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of 47 RCTs with 2,657 postmenopausal women evaluating isoflavone interventions. Isoflavones significantly reduced vaginal dryness, improved vaginal maturation, enhanced skin health, and increased estradiol levels.
Isoflavone intervention and its impact on bone mineral density in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of 63 RCTs evaluating isoflavone interventions on bone mineral density in postmenopausal women. Isoflavones significantly improved BMD at the lumbar spine, femoral neck, and distal radius, especially with genistein doses of at least 50 mg/day over 12 months.
Dietary Isoflavone Intake and Breast Cancer Prognosis: A Prospective Analysis and Meta-Analysis.
This study examined the association between dietary isoflavone intake and breast cancer prognosis in 592 breast cancer survivors. A meta-analysis of 14 studies found that higher isoflavone intake was associated with a better prognosis, showing a reduced risk of recurrence and all-cause mortality.
Soy Consumption and the Risk of Type 2 Diabetes and Cardiovascular Diseases: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of 29 articles examining the association between soy consumption and the risk of type 2 diabetes and cardiovascular diseases. High soy consumption was associated with a reduced risk of T2D, CVDs, coronary heart disease, and stroke. Specific soy products like tofu and natto were particularly beneficial.
Identification of the Key Active Pharmaceutical Ingredients of Yishen Qutong Granule, A Chinese Medicine Formula, In The Treatment of Primary Lung Cancer.
The study investigates the antitumor efficacy of Yishen Qutong granule (YSQTG) in primary lung cancer treatment, identifying genistein and quercetin as key active pharmaceutical ingredients. YSQTG was shown to inhibit lung cancer cell proliferation and induce apoptosis in vitro, with oxidative stress-related pathways as a possible mechanism.
Soy consumption and serum uric acid levels: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the effects of soy intake on plasma uric acid levels. It included 17 studies, finding that soy consumption increased serum uric acid concentration in acute human studies, while soy-derived products had no significant effect. Long-term human studies showed no significant effects of soy protein and isoflavones on uric acid levels, but animal trials indicated a significant reduction in serum uric acid concentrations.
Systematic review of the impact of genistein on diabetes-related outcomes.
This systematic review evaluated the impact of genistein on diabetes-related outcomes. Preclinical studies showed genistein decreased body weight, glucose, and triglycerides, while increasing insulin levels and sensitivity. Clinical studies found genistein improved insulin sensitivity and serum triglyceride concentrations, and delayed the onset of type 2 diabetes, though it generally showed no significant effect on body mass, glucose, or A1C concentrations.
Intake of Soy, Soy Isoflavones and Soy Protein and Risk of Cancer Incidence and Mortality.
Meta-analysis of 81 prospective cohort studies examining the association of soy, soy isoflavones, and soy protein intake with cancer incidence and mortality. Higher intake of soy and soy isoflavones was inversely associated with cancer incidence, particularly lung and prostate cancer, but not with cancer mortality.
Neither soy nor isoflavone intake affects male reproductive hormones: An expanded and updated meta-analysis of clinical studies.
Meta-analysis of 41 studies assessing the effects of soy protein and isoflavone intake on male reproductive hormones. No significant effects on total testosterone, free testosterone, estradiol, estrone, or sex hormone binding globulin levels were found, regardless of dose and study duration.
The effect of soy intervention on insulin-like growth factor 1 levels: A meta-analysis of clinical trials.
This meta-analysis of eight clinical trials assessed the effect of soy consumption on plasma IGF-1 levels. The study found a significant increase in IGF-1 levels following soy intervention, with greater effects observed at dosages ≤40g/day, intervention durations <12 weeks, and among non-healthy subjects.
Soy, Soy Isoflavones, and Protein Intake in Relation to Mortality from All Causes, Cancers, and Cardiovascular Diseases: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.
Systematic review and dose-response meta-analysis of 23 prospective studies with 330,826 participants. Soy and soy products consumption was inversely associated with mortality from cancers and cardiovascular diseases. Higher intake of soy isoflavones and soy protein was linked to decreased risk of mortality from all causes, cancers, and breast cancer.
Effects of phytoestrogens on bone mineral density during the menopause transition: a systematic review of randomized, controlled trials.
Systematic review of 23 RCTs with 3494 participants examining the effects of phytoestrogens on bone mineral density in postmenopausal women. The review suggests isoflavones may have beneficial effects on bone health, though results on BMD changes were controversial.
Effects of isoflavones on breast density in pre- and post-menopausal women: a systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of 8 RCTs involving 1287 women assessing the effects of isoflavone-rich foods or supplements on mammographic density. Isoflavone intake did not alter breast density in post-menopausal women but may cause a small increase in breast density in premenopausal women.
A Randomized Controlled Trial of the Genistein Plus Bakuchiol and Vitamins (GEN) Product for Male Facial Skin: Effects on Skin Appearance and Properties.
A randomized, double-blind, placebo-controlled trial evaluated the efficacy and safety of the Genistein Plus Bakuchiol and Vitamins (GEN) product on male facial skin in 80 participants. The GEN group showed significant improvements in cheek skin lightening, color consistency, and reduction in forehead spots after 12 weeks. The product was well-tolerated with mild adverse events.
Comparison of the Effects of Vitagnus, Soy, and Vitagnus-soy Capsules on Premenstrual Syndrome in University Students: A Randomized Clinical Trial.
This triple-blind, three-arm clinical trial compared the effects of Vitagnus, soy, and a Vitagnus-soy combination on PMS symptoms in 108 university students. All groups showed significant reduction in PMS symptoms, with the Vitagnus-soy combination being more effective in decreasing psychological and total PMS symptoms than either substance alone.
Isoflavones and changes in body weight and severe hot flashes in postmenopausal women: A secondary analysis of a randomized clinical trial.
Secondary analysis of an RCT with 84 postmenopausal women comparing a low-fat vegan diet supplemented with soybeans to a control diet over 12 weeks. The vegan group showed increased intake of isoflavones, significant weight loss, and a 92% reduction in severe hot flashes. Increased daidzein intake was the main predictor of reduced hot flashes.
Genistein, A Phytoestrogen, Delays the Transition to Dementia in Prodromal Alzheimer's Disease Patients.
Double-blind, placebo-controlled bicentric pilot clinical trial showing significant cognitive preservation with genistein, a phytoestrogen, in individuals with prodromal Alzheimer's disease. Genistein demonstrated anti-amyloid-β, antioxidant, anti-inflammatory, and antiapoptotic effects.
Efficacy and Safety of the Genistein Nutraceutical Product Containing Vitamin E, Vitamin B3, and Ceramide on Skin Health in Postmenopausal Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
This randomized, double-blind, placebo-controlled trial evaluated the efficacy and safety of a Genistein Nutraceutical product containing genistein, vitamin E, vitamin B3, and ceramide on the facial skin of 50 postmenopausal women. The GEN product improved skin hydration, reduced wrinkles, and enhanced redness, particularly in older women.
Effects of daidzein and genistein on markers of cardiovascular disease risk among women with impaired glucose regulation: a double-blind, randomized, placebo-controlled trial.
This double-blind, randomized, placebo-controlled trial evaluated the effects of isolated daidzein and genistein on cardiovascular risk markers in 165 Chinese women with impaired glucose regulation. The study found no significant differences in lipid profiles, hs-CRP, and uric acid levels between the treatment groups over 24 weeks.
Soy and the risk of type 2 diabetes mellitus: A systematic review and meta-analysis of observational studies.
This meta-analysis evaluated the relationship between soy intake and type 2 diabetes mellitus risk, finding a significant inverse association. The overall relative risk was 0.77, indicating a protective effect, particularly in women, cross-sectional studies, and Asian populations.
Effect of Soy and Soy Isoflavones on Obesity-Related Anthropometric Measures: A Systematic Review and Meta-analysis of Randomized Controlled Clinical Trials.
This systematic review and meta-analysis evaluated the effects of soy and soy isoflavones on obesity-related measures. Soy showed no overall significant effect on weight, waist circumference, or fat mass, but increased weight in certain conditions. Soy decreased waist circumference in older adults, women, and at lower doses. Isoflavones, studied only in women, showed potential BMI reduction, especially at lower doses and shorter durations.
In vivo immunomodulatory effects of plant flavonoids in lipopolysaccharide-challenged broilers.
This study investigated the immunomodulatory effects of plant flavonoids, genistein and hesperidin, in LPS-challenged broilers. Both flavonoids improved plasma antioxidant status and immune response, with combined supplementation showing further improvement than individual compounds.
Comparison of the symptomatic response in Indian menopausal women with different estrogen preparations for the treatment of menopausal symptoms: a randomized controlled trial.
RCT comparing symptomatic response in Indian menopausal women using estradiol valerate, conjugated equine estrogen, isoflavones, and placebo for menopausal symptoms. Isoflavones group showed a 60.42% decrease in mean hot flash score and improvement in vaginal health index after 24 weeks.
Can soy intake affect serum uric acid level? Pooled analysis from two 6-month randomized controlled trials among Chinese postmenopausal women with prediabetes or prehypertension.
Pooled analysis from two 6-month RCTs among 450 Chinese postmenopausal women with prediabetes or prehypertension examined the effect of soy foods and isoflavone extracts on serum uric acid levels. The study found a lower decrease in uric acid levels among women in the combined soy foods group compared to the placebo group, indicating that soy intake did not increase urate levels.
Individual and combined effects of genistein and hesperidin on immunity and intestinal morphometry in lipopolysacharide-challenged broiler chickens.
This study investigated the effects of genistein and hesperidin on immunity and intestinal morphometry in LPS-challenged broiler chickens. Both compounds improved phagocytic activity and intestinal morphometry, suggesting potential as feed additives to promote gut health and immunity in poultry.
Effects of isoflavones and amino acid therapies for hot flashes and co-occurring symptoms during the menopausal transition and early postmenopause: a systematic review.
Systematic review of controlled clinical trials on isoflavones and amino acids for hot flashes and co-occurring symptoms during menopause. Isoflavones, particularly soy and red clover, significantly reduced hot flashes and symptoms like mood, sleep, pain, and cognitive function. Amino acids showed no significant effects.
Soy, red clover, and isoflavones and breast cancer: a systematic review.
Systematic review of soy and red clover isoflavones for menopausal symptoms and breast cancer risk in women. Soy intake consistent with a traditional Japanese diet may reduce breast cancer risk and recurrence without estrogenic effects. Evidence on red clover is limited, but suggests no breast cancer-promoting effects.
Long-term soy isoflavone supplementation and cognition in women: a randomized, controlled trial.
RCT of 313 healthy postmenopausal women assessing the cognitive effects of long-term dietary soy isoflavone supplementation. No significant effect on global cognition was found, but there was a positive effect on visual memory.
Randomized controlled study on clinical efficacy of isoflavones plus Lactobacillus sporogenes, associated or not with a natural anxiolytic agent in menopause.
RCT evaluating the efficacy of magnolia bark extract added to isoflavones and lactobacilli in menopausal women with psychoaffective and sleep alterations. Both treatments reduced menopausal symptoms, with magnolia bark extract showing greater efficacy on insomnia, irritability, anxiety, and mood. Positive outcomes were reported in over 70% of participants.
Isoflavones: effects on bone health.
Systematic review of in vitro, animal, and human studies on isoflavones and bone health. Isoflavones appear to stimulate osteoblastic bone formation and inhibit osteoclastic bone resorption, with evidence of beneficial effects on bone health in peri- and postmenopausal women. Inconsistencies among studies are noted, and further research is recommended.
Clinical studies show no effects of soy protein or isoflavones on reproductive hormones in men: results of a meta-analysis.
Meta-analysis evaluating the effects of soy protein or isoflavone intake on reproductive hormones in men. The study found no significant effects on testosterone, SHBG, free testosterone, or free androgen index.
Critical review of health effects of soyabean phyto-oestrogens in post-menopausal women.
This meta-analysis reviews the health effects of soyabean phyto-oestrogens, primarily genistein and daidzein, in post-menopausal women. It suggests potential benefits on bone health and lipid markers of cardiovascular risk, but evidence is inconclusive. Limited evidence supports the effectiveness of soyabean isoflavone extracts in reducing menopausal symptoms like hot flushes.
Effect of isoflavones on lipids and bone turnover markers in menopausal women.
This 12-week randomized, double-blind, placebo-controlled trial studied the effects of isoflavones from red clover on lipids and bone turnover markers in 252 menopausal women. Isoflavones significantly decreased triglyceride levels, especially in women with elevated baseline levels, but had no significant effect on HDL-cholesterol or bone turnover markers.
The effects of phytoestrogen isoflavones on bone density in women: a double-blind, randomized, placebo-controlled trial.
Double-blind, randomized, placebo-controlled trial of 205 women aged 49-65 years studying the effects of a red clover-derived isoflavone supplement on bone density. The isoflavone group showed significantly lower loss of lumbar spine bone mineral content and density compared to placebo, suggesting a protective effect on the lumbar spine.
Phytoestrogen supplements for the treatment of hot flashes: the Isoflavone Clover Extract (ICE) Study: a randomized controlled trial.
RCT comparing the efficacy and safety of two red clover-derived isoflavone supplements, Promensil and Rimostil, to placebo in menopausal women experiencing hot flashes. The study found no clinically important effect on hot flashes or other menopause symptoms, although Promensil showed a more rapid reduction in hot flashes compared to placebo.
Effect of 4-Week Consumption of Soy Kori-tofu on Cardiometabolic Health Markers: A Double-Blind Randomized Controlled Cross-Over Trial in Adults with Mildly Elevated Cholesterol Levels.
Double-blind randomized controlled cross-over trial with 45 adults aged 40-70 years with mildly elevated cholesterol levels, comparing a four-week Kori-tofu intervention to a whey protein control. Significant decreases in cholesterol, HbA1c, fructosamine, and systolic blood pressure were observed within the Kori-tofu intervention, but similar changes were seen in the control group. Only adiponectin changes differed between treatments, but not significantly within interventions.
Genistein effect on cognition in prodromal Alzheimer's disease patients. The GENIAL clinical trial.
Double-blind, placebo-controlled clinical trial evaluating the effect of 120 mg daily genistein supplementation for 12 months on 24 prodromal Alzheimer's disease patients. Genistein treatment resulted in significant improvement in neurocognitive tests and prevented increased amyloid-beta deposition in the anterior cingulate gyrus compared to placebo.
Genistein stimulates insulin sensitivity through gut microbiota reshaping and skeletal muscle AMPK activation in obese subjects.
RCT of 45 obese participants with insulin resistance, comparing genistein (50 mg/day) to placebo for 2 months. Genistein reduced insulin resistance, modified gut microbiota, increased AMPK phosphorylation, and enhanced fatty acid oxidation in skeletal muscle.
The effect of dietary soy intake on weight loss, glycaemic control, lipid profiles and biomarkers of inflammation and oxidative stress in women with polycystic ovary syndrome: a randomised clinical trial.
A randomized clinical trial among 60 women with PCOS evaluated the effects of dietary soy intake. The test diet with soy protein resulted in significant decreases in BMI, fasting plasma glucose, total testosterone, insulin, insulin resistance, triglycerides, and malondialdehyde, and significant increases in nitric oxide and glutathione compared to the control diet.
Novel effects of phytoestrogenic soy isoflavones on serum calcium and chloride in premenopausal women: A 2-year double-blind, randomized, placebo-controlled study.
A 2-year double-blind, randomized, placebo-controlled study on 197 premenopausal women to assess the effects of soy isoflavones on serum calcium and chloride levels. Significant associations were found between urinary isoflavone levels and serum calcium and chloride concentrations, suggesting implications for cardiovascular health.
Genistein supplementation improves insulin resistance and inflammatory state in non-alcoholic fatty liver patients: A randomized, controlled trial.
RCT of 82 patients with NAFLD comparing 250 mg genistein supplementation to placebo for 8 weeks. Genistein group showed reduced insulin resistance, oxidative and inflammatory indices, and improvements in fat metabolism compared to placebo.
Effects of fermented soymilk with Lactobacillus casei Shirota on skin condition and the gut microbiota: a randomised clinical pilot trial.
Randomised, double-blind, placebo-controlled trial with 60 healthy premenopausal Japanese women comparing fermented soymilk with Lactobacillus casei Shirota to soymilk. Both groups showed improved skin condition and increased urinary isoflavones, but only the fermented soymilk group showed beneficial modifications in gut microbiota.
Comparison of vaginal gel isoflavones versus no topical treatment in vaginal dystrophy: results of a preliminary prospective study.
RCT comparing vaginal gel containing isoflavones to no topical treatment in 186 menopausal women with vaginal dystrophy. The gel significantly reduced symptoms like itching, burning, erythema, dryness, and dyspareunia compared to no treatment.
Activity of isoflavones and berberine on vasomotor symptoms and lipid profile in menopausal women.
RCT of 120 menopausal women comparing a supplement combination of isoflavones and berberine (EL) to calcium and vitamin D3 (CaD). EL treatment significantly lowered plasma total cholesterol, LDL cholesterol, and triglycerides, and improved menopausal symptoms compared to CaD treatment.
The effect of soy food intake on mineral status in premenopausal women.
RCT examining the effect of consuming soy foods on mineral status in premenopausal women over 10 weeks. No significant changes were observed in iron or zinc status, bone resorption or formation, or thyroid hormone status. Plasma zinc decreased in both soy and animal food groups.
Women's perception of the efficacy of a soy extract with probiotic: the M3 study.
A prospective multi-center survey of 2044 women aged 40-65 years assessed the perception of soy extract with probiotic on climacteric-related symptoms. After 6 months, the soy extract improved climacteric symptoms and sexuality, with both patients and gynecologists expressing satisfaction.
Soy protein and bone mineral density in older men and women: a randomized trial.
RCT with 145 participants aged 50-80 testing soy isoflavone supplementation on bone mineral density (BMD). Soy protein with isoflavones showed a modest benefit in preserving spine BMD in older women, but not in hip BMD or in men.
Effect of a novel dietary supplement on skin aging in post-menopausal women.
A 6-month double-blind, placebo-controlled RCT on 80 post-menopausal women assessed the effects of Imedeen Prime Renewal, a dietary supplement, on skin aging. The active group showed significant improvements in wrinkles, pigmentation, laxity, and overall skin appearance compared to placebo.
Isoflavones reduce arterial stiffness: a placebo-controlled study in men and postmenopausal women.
A randomized, double-blind trial with 80 healthy subjects examined the effects of isoflavones enriched in biochanin or formononetin on arterial stiffness. Isoflavone intervention significantly reduced arterial stiffness and total peripheral resistance, with improvements attributed to formononetin-enriched isoflavones. No effects were observed on blood pressure or flow-mediated vasodilation.
Mothers' Consumption of Soy Drink But Not Black Tea Increases the Flavonoid Content of Term Breast Milk: A Pilot Randomized, Controlled Intervention Study.
Pilot RCT investigating the effect of soy drink and decaffeinated black tea consumption on flavonoid content in breast milk. Soy drink consumption increased isoflavone content in breast milk, while black tea did not affect flavonoid concentrations. Total antioxidant capacity of breast milk was unaffected by both interventions.
Consumption effect of a synbiotic beverage made from soy and yacon extracts containing Bifidobacterium animalis ssp. lactis BB-12 on the intestinal polyamine concentrations in elderly individuals.
This randomized, double-blinded, placebo-controlled trial investigated the effect of a synbiotic beverage containing soy and yacon extracts with Bifidobacterium animalis ssp. lactis BB-12 on intestinal polyamine concentrations in elderly individuals. The study found that both synbiotic and placebo beverages increased fecal polyamine levels without affecting inflammatory cytokine production.
Probiotic Soy Product Supplemented with Isoflavones Improves the Lipid Profile of Moderately Hypercholesterolemic Men: A Randomized Controlled Trial.
RCT investigating the effect of an isoflavone-supplemented probiotic soy product on cardiovascular risk markers in moderately hypercholesterolemic men. After 42 days, the isoflavone-supplemented group showed improved total cholesterol, non-HDL-C, and electronegative LDL concentrations, suggesting potential cardiovascular benefits.
Effect of soy on metabolic syndrome and cardiovascular risk factors: a randomized controlled trial.
RCT evaluating the effect of whole soy foods (30g/day soy protein) on metabolic syndrome and cardiovascular risk factors over 12 weeks. Soy intervention reduced MetS features in 13/26 subjects and improved body weight, BMI, and lipid markers, indicating a positive impact on cardiovascular risk.
The steady-state serum concentration of genistein aglycone is affected by formulation: a bioequivalence study of bone products.
An 8-day steady-state pharmacokinetic study compared the serum concentration of genistein from different formulations in healthy postmenopausal women. The study found that the prescription medical food and a clinically proven bone formulation were equivalent in genistein pharmacokinetics, while the OTC supplement showed altered absorption characteristics.
Genistein alters caffeine exposure in healthy female volunteers.
This study investigated the effect of 1 g genistein daily for 14 days on caffeine-based metrics of CYP1A2, CYP2A6, NAT2, and XO in 18 healthy female volunteers. Genistein decreased CYP1A2 and XO activity and increased CYP2A6 activity, while NAT2 activity did not change.
Antiresorptive effects of phytoestrogen supplements compared with estradiol or risedronate in postmenopausal women using (41)Ca methodology.
This randomized-order, crossover, blinded trial in 11 healthy postmenopausal women compared the antiresorptive effects of isoflavones from soy cotyledon, soy germ, kudzu, and red clover with estradiol and risedronate. Soy isoflavones from cotyledon and germ significantly decreased net bone resorption by 9% and 5%, respectively, over a 50-day intervention period.
No effect of red clover-derived isoflavone intervention on the insulin-like growth factor system in women at increased risk of colorectal cancer.
A randomized, placebo-controlled, double-blinded, crossover trial investigated the effect of 8-week supplementation with red clover-derived isoflavones on serum IGF system components in 34 postmenopausal women at increased risk of colorectal cancer. The study found no significant effect on serum concentrations of IGF-I, IGF-II, IGFBPs, or colorectal tissue mRNA expression of IGF system components.
Pueraria mirifica phytoestrogens improve dyslipidemia in postmenopausal women probably by activating estrogen receptor subtypes.
RCT examining the effects of Pueraria mirifica on serum lipid parameters in 19 postmenopausal women. The PM group showed significant improvements in HDL cholesterol, apo A-1, LDL cholesterol, and apo B levels, suggesting a beneficial effect on lipid metabolism potentially through activation of estrogen receptor subtypes.
Clinical effects of a proprietary combination isoflavone nutritional supplement in menopausal women: a pilot trial.
Pilot trial assessing a nutritional supplement containing isoflavones from kudzu and red clover on menopausal symptoms and markers of breast cancer and CVD risk in 25 menopausal women. The supplement reduced hot flushes by 46% and improved quality of life, with modest improvements in CVD risk markers and a significant improvement in a breast cancer risk marker.
Urinary isoflavonoid excretion is inversely associated with the ratio of protein to dietary fibre intake in young women.
The study examined urinary isoflavonoid excretion in premenopausal women during isoflavone supplementation. Isoflavone supplementation increased urinary isoflavonoid excretion by 15-fold, with individual variation partly explained by the interaction between dietary fibre and protein intake.
Drug interaction potential of soy extract and Panax ginseng.
RCT investigating the effect of soy extract and Panax ginseng on CYP3A enzyme induction using the urinary 6-beta-hydroxycortisol/cortisol ratio. Neither significantly altered the ratio, suggesting they are not CYP3A inducers. In vitro studies showed soy extract had minimal inhibition of several CYPs and a trend of activation of CYP3A4, with hydrolyzed soy extract inhibiting CYP2C9 and CYP3A4.
Phytoestrogens increase the capacity of serum to stimulate prostacyclin release in human endothelial cells.
RCT involving 25 postmenopausal women receiving 55 mg/day isoflavones from soy and red clover for 6 months. Serum from treated women increased prostacyclin production in cultured endothelial cells, suggesting a potential cardiovascular benefit of phytoestrogens.
A double-blind randomized controlled trial of isoflavones in the treatment of cyclical mastalgia.
A double-blind randomized controlled trial tested isoflavones for cyclical mastalgia in 18 women. The study found that 40 mg and 80 mg doses of isoflavones significantly reduced pain compared to placebo, with reductions of 44% and 31% respectively.
Absorption in humans of isoflavones from soy and red clover is similar.
Single-blind, randomized, placebo-controlled, crossover trial in 14 subjects comparing absorption of isoflavones from soy and red clover. Approximately 25% of each isoflavone was recovered in urine, indicating similar absorption irrespective of their glycoside/aglycone nature or source composition.
A Dopamine‐Modified Hyaluronic Acid‐Based Mucus Carrying Phytoestrogen and Urinary Exosome for Thin Endometrium Repair
The study constructs an artificial mucus based on dopamine-modified hyaluronic acid combining phytoestrogen cajaninstilbene acid and rat urinary exosomes for thin endometrium treatment using a rat model. The treatment significantly increases endometrial thickness and promotes receptivity and fertility, demonstrating potential for TE treatment.
Dimiristoylphosphatidylcholine/ Genistein Molecular Interactions: a Physico-Chemical Approach to Anti-Glioma Drug Delivery Systems.
The study investigates the physico-chemical parameters of dimiristoylphosphatidylcholine liposome-loaded genistein for drug delivery to the central nervous system. It examines genistein's in vitro activity against DPPH radicals and glioma cells, highlighting its potential as an antioxidant and anti-glioma agent. The liposomal system showed higher stability and efficiency compared to free genistein.
Absorption Study of Genistein Using Solid Lipid Microparticles and Nanoparticles: Control of Oral Bioavailability by Particle Sizes
The study investigated the effect of particle size on the dissolution behavior and oral bioavailability of genistein-loaded solid lipid microparticles and nanoparticles. Results showed increased drug dissolution rates and enhanced oral bioavailability in rats compared to genistein bulk powder and suspension, with microparticles showing greater bioavailability than nanoparticles.
Induction of apoptosis in low to moderate-grade human prostate carcinoma by red clover-derived dietary isoflavones.
Nonrandomized, nonblinded trial with historically matched controls to assess the effects of red clover-derived dietary isoflavones on prostate cancer. 20 men consumed 160 mg/day of isoflavones before surgery. Apoptosis in prostate tumor cells was significantly higher in treated patients compared to controls, suggesting potential benefits in halting cancer progression.
Isoflavone aglycon produced by culture of soybean extracts with basidiomycetes and its anti-angiogenic activity.
The study assessed the anti-angiogenic effects of a cultivated product rich in genistein, named GCP, derived from soybean extracts cultured with Ganoderma lucidum mycelia. GCP showed greater inhibition of angiogenesis in chick chorioallantoic membranes and a mouse dorsal air-sac model compared to soybean extracts alone. Serum concentrations of genistein were significantly higher in volunteers treated with GCP.