Research
Sophora Flavescens (Ku Shen)
6 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
The efficacy and safety of compound kushen injection for adults with esophageal cancer: A meta-analysis of randomized controlled trials.
Meta-analysis of 35 RCTs with 2491 esophageal cancer patients evaluating the efficacy and safety of Compound Kushen Injection (CKI). CKI showed significant improvements in clinical efficacy, complete response, and quality of life, with reduced adverse events and serious adverse events, suggesting it may be a valuable alternative treatment.
Meta-analysis: therapeutic effect of transcatheter arterial chemoembolization combined with compound kushen injection in hepatocellular carcinoma.
Meta-analysis confirmed that Compound Kushen Injection (CKI) combined with transcatheter arterial chemoembolization (TACE) is more effective than TACE alone for patients with unresectable hepatocellular carcinoma.
Whitening effect of Sophora flavescens extract.
The study investigated the whitening effect of Sophora flavescens extract, focusing on its ability to inhibit tyrosinase and affect melanosome formation and transport. A clinical trial showed that a cream containing 0.05% S. flavescens extract significantly improved skin whitening.
Prenylated flavonoids from Sophora flavescens inhibit mushroom tyrosinase activity and modulate melanogenesis in murine melanoma cells and zebrafish
The study investigated prenylated flavonoids from Sophora flavescens for their effects on tyrosinase activity and melanogenesis in murine melanoma cells and zebrafish. Isoanhydroicaritin (IAI) was found to inhibit melanin biosynthesis, while kurarinone (KR) enhanced melanin production. These findings suggest contrasting roles of IAI and KR in melanin modulation, highlighting potential cosmeceutical applications.
Sophora flavescens Containing-QYJD Formula Activates Nrf2 Anti-Oxidant Response, Blocks Cellular Transformation and Protects Against DSS-Induced Colitis in Mouse Model.
The study investigates the anticancer effects of Qu-Yu-Jie-Du decoction (QYJD), a traditional Chinese medicine containing Sophora flavescens, in human colon cancer HT29 cells and a DSS-induced colitis mouse model. QYJD and its constituents, matrine and oxymatrine, inhibited cell proliferation, activated Nrf2-mediated antioxidant responses, and reduced disease activity in the mouse model, suggesting potential anti-inflammatory and antioxidative effects.
New approach in asthma treatment using excitatory modulator.
Retrospective study of 14 chronic refractory asthmatics using an extract of Sophora flavescens Ait. over a 3-year follow-up. Quality of life, clinical symptoms, and respiratory function improved, with reduced or eliminated use of inhaled corticosteroids and beta-agonists. No significant adverse reactions reported.