Research
Smilax Glabra (Tu Fu Ling)
34 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Corrigendum to "Smilax glabra Roxb. extract alleviates psoriasis-like lesions in mice by the synergistic effects of TOP2A inhibition and AhR activation" [Int. Immunopharmacol. 164 (2025) 115408].
Corrigendum to a study on Smilax glabra Roxb. extract, which was found to alleviate psoriasis-like lesions in mice through the synergistic effects of TOP2A inhibition and AhR activation.
Exploring the Potential Mechanism of Smilax Glabra Roxb in Periodontitis Through Network Pharmacology and Molecular Docking.
The study explores the potential mechanisms of Smilax Glabra Roxb (SGR) in treating periodontitis using network pharmacology and molecular docking. It identifies 15 active components and 527 potential targets of SGR, with 75 overlapping targets related to periodontitis. Key genes involved in inflammatory and metabolic pathways were identified, suggesting SGR's therapeutic potential in periodontitis.
Identification of chemical constituents of Smilax glabra Roxb. and comparative study on pharmacokinetics of 12 main bioactive components in normal and hyperuricemia rats by UPLC-Q-Exactive Orbitrap-HRMS method.
The study characterized the chemical profile of Smilax glabra and compared the pharmacokinetics of 12 bioactive components in normal and hyperuricemic rats using UPLC-Q-Exactive Orbitrap-HRMS. It identified 89 compounds and found increased systemic exposure and prolonged time for seven key constituents in hyperuricemic rats.
20 potentially new compounds and 11 new bioactive constituents found in Smilacis Glabrae Rhizoma utilizing HPLC-DAD-ESI-IT-TOF-MS.
The study analyzed the chemical constituents of Smilacis Glabrae Rhizoma (SGR) using liquid chromatography-mass spectrometry, identifying 20 potentially new compounds and 161 known ones. The research provides further information on the chemical composition of SGR, laying the foundation for understanding its pharmacodynamic substances.
Rapid evaluation of the quality of Smilax glabra Roxb. using QADS based on FT-NIR combined with multiple intelligent algorithms.
The study evaluates the quality of Smilax glabra Roxb. using FT-NIR technology combined with intelligent algorithms to detect adulteration and measure astilbin content. The method enhances the accuracy and reliability of quantitative models for comprehensive quality evaluation in functional health foods.
Integrated network pharmacology and molecular docking to investigate the potential mechanism of Tufuling on Alzheimer's disease.
The study investigates the mechanism of Tu Fu Ling in treating Alzheimer's disease using network pharmacology and molecular docking. It identifies active ingredients and target genes, performs enrichment analyses, and suggests a potential multi-target and multi-pathway mechanism to improve AD symptoms.
The Effects ofLedeb,Bunge, andRoxb on Broiler Performance, Nutrient Digestibility, and Gastrointestinal Tract Microorganisms.
This study evaluates the effects of three medicinal plants, Anemone chinensis Bunge, Smilax glabra Roxb, and Agrimonia pilosa Ledeb, on broiler performance, nutrient digestibility, and gastrointestinal microorganisms over a 35-day trial with 420 male Ross 308 broilers. S. glabra Roxb and A. chinensis Bunge showed comparable effects to amoxicillin, significantly increasing weight gain and improving feed conversion ratio. S. glabra Roxb also decreased E. coli and Campylobacter spp. and increased lactic acid bacteria, highlighting its potential as a beneficial feed material.
Influence of different pretreatments and drying methods on the chemical compositions and bioactivities of Smilacis Glabrae Rhizoma.
The study investigates the influence of different pretreatments and drying methods on the chemical compositions and bioactivities of Smilacis Glabrae Rhizoma (SGR). It identifies fifty-two compounds from un-pretreated and pretreated samples and forty-nine from dried samples, with variations in astilbin isomers. The study concludes that SGR slices prepared with no pretreatment followed by sun-drying have higher astilbin content and better bioactivities.
A comprehensive quality control evaluation for standard decoction of Smilax glabra Roxb based on HPLC-MS-UV/CAD methods combined with chemometrics analysis and network pharmacology.
The paper develops a method for quality control evaluation of the standard decoction of Smilax glabra Roxb using HPLC-MS-UV/CAD methods combined with chemometrics analysis and network pharmacology. It identifies six quality markers and optimizes extraction parameters for rapid quantification in SGR samples.
Sihe Tufuling formula alleviates imiquimod-induced psoriasis-like skin lesions in mice by modulating the HIF-1 signaling pathway.
The study investigates the anti-psoriatic activity of Sihe Tufuling formula and its principal herb, Smilax glabra, in an imiquimod-induced psoriasis-like mouse model. Results show that both SHTFL and SGR reduce psoriasis symptoms by inhibiting keratinocyte hyperproliferation and inflammation through the HIF-1 signaling pathway.
Spectrum-Effect Relationship Between HPLC Fingerprints and Antigouty Arthritis of Smilax Glabra Roxb.
The study used chemometric methods to analyze the spectral effect relationship between HPLC fingerprints and antigouty arthritis activities of Smilax glabra Roxb. extracts. It found significant variation in chemical composition across samples from different regions, with neoisoastilbin and isoastilbin being significantly correlated with antigouty arthritis activity.
Smilax glabra Roxb. extract alleviates psoriasis-like lesions in mice by the synergistic effects of TOP2A inhibition and AhR activation.
The study investigates the effects of Smilax glabra Roxb. extract on psoriasis-like lesions in mice. It found that the extract, containing astilbin, quercetin, and resveratrol, alleviates psoriasis through the synergistic effects of TOP2A inhibition and AhR activation.
Comprehensive characterisation of the active ingredients ofRoxb based on chemical fingerprinting, metabolic fingerprinting and pharmacodynamic fingerprinting.
The study characterizes the active ingredients of Smilax glabra Roxb (SGR) using chemical, metabolic, and pharmacodynamic fingerprinting. It identifies medium polar compounds in SGR with significant uric acid-lowering effects in hyperuricemic mice and highlights key components and target organs through metabolic fingerprinting and tissue distribution analysis.
Smilax glabra Roxb. Meliorates Hyperuricemia via Regulating Renal Urate Transporter and Remodelulating Intestinal Microbiota in Mice.
The study investigates the effects of Smilax glabra Roxb. on hyperuricemia in a mouse model. It found that various extracts of the herb could lower uric acid levels, regulate renal urate transporters, and remodel intestinal microbiota by increasing probiotic bacteria and reducing pathogenic bacteria.
Smilax glabra roxb. alleviates cisplatin-induced acute kidney injury in mice by activating the Nrf2/HO-1 Signalling Pathway.
The study investigated the nephroprotective effects of Smilax glabra Roxb. (TFL) in alleviating cisplatin-induced acute kidney injury (AKI) in mice. TFL treatment activated the Nrf2/HO-1 signalling pathway, promoting antioxidant enzyme expression and ameliorating oxidative stress, mitochondrial dysfunction, and renal cell apoptosis.
Component characterization ofRoxb., and its inhibitory activity againstthrough targeted suppression of its secreted urease.
The study characterizes the components of Smilax glabra Roxb. (SGR) and examines its inhibitory activity against Helicobacter pylori through targeted suppression of its secreted urease. SGR was found to inhibit the growth of H. pylori strains and exert significant inhibitory effects on urease, suggesting its potential as a natural treatment for H. pylori-associated gastrointestinal diseases.
Exploring the Phytochemical Diversity and Antioxidant Potential of the Vietnamese Smilax glabra Roxb: Insights from UPLC-QTOF-MS/MS and Zebrafish Model Studies.
The study investigates the phytochemical diversity and antioxidant potential of Vietnamese Smilax glabra Roxb using UPLC-QTOF-MS/MS and zebrafish model studies. The extracts improved the survival rate of zebrafish larvae exposed to oxidative stress, suggesting new antioxidative pathways beyond the Keap1/Nrf2 pathway.
Therapeutic Effect of Smilax glabra Roxb. on Weaning Rats Against Pb-Induced Nephrotoxicity Based on Network Pharmacology.
The study investigated the therapeutic effect of Smilax glabra flavonoid extract (SGF) on lead-induced nephrotoxicity in weaning rats. Network pharmacology and in vivo experiments showed that SGF alleviated pathological damage by downregulating the NF-κB/MAPK signaling pathway, indicating a strong therapeutic effect against lead poisoning.
Integrating larval zebrafish model and network pharmacology for screening and identification of edible herbs with therapeutic potential for MAFLD: A promising drug Smilax glabra Roxb.
The study evaluated the therapeutic potential of Smilax glabra Roxb. (SGR) and other herbs on MAFLD using a larval zebrafish model. SGR significantly decreased lipid accumulation, alleviated oxidative stress, and modulated intestinal microbiota composition, suggesting its potential as a dietary supplement for MAFLD therapy.
Integrated network pharmacological analysis revealed that Smilax glabra Roxb. alleviates IMQ-induced psoriatic skin inflammation through regulating T cell immune response.
The study investigates the therapeutic potential of Smilax glabra Roxb. (SGR) in psoriasis using a mouse model. SGR treatment regulated T cell differentiation and inhibited insulin receptor signaling pathways, suggesting its potential as a treatment for psoriatic skin inflammation.
Investigation of the molecular mechanism ofRoxb. in treating hypertension based on proteomics and bioinformatics.
The study investigated the antihypertensive effects of SGR (Roxb., tufuling) in an L-NAME-induced hypertension rat model. SGR reduced blood pressure and improved lipid profiles, with ALDH2 identified as a core target. Proteomics and bioinformatics analyses revealed SGR's role in regulating immune cell infiltration and signaling pathways.
Effect of Smilax spp. and Phellinus linteus combination on cytotoxicity and cell proliferation of breast cancer cells.
The study investigated the effects of Smilax corbularia, Smilax glabra, and Phellinus linteus extracts on breast cancer cell lines. The extracts exhibited significant cytotoxicity and inhibited cell proliferation through cell cycle arrest and apoptosis induction, with downregulation of genes involved in proliferative and apoptotic pathways.
Structural characterization and anti-inflammatory activity of a novel neutral polysaccharide isolated from Smilax glabra Roxb.
The study isolated a novel neutral polysaccharide, S1, from Smilax glabra and investigated its structural characteristics and anti-inflammatory effects. S1 was found to inhibit NO secretion, reduce pro-inflammatory factors, and mitigate LPS-stimulated inflammatory damage in RAW 264.7 cells by inhibiting the NF-κB pathway.
Smilax glabra Roxb. flavonoids protect against pathological cardiac hypertrophy by inhibiting the Raf/MEK/ERK pathway: In vivo and in vitro studies.
The study investigates the effects of Smilax glabra flavonoids (TFLF) on cardiac hypertrophy using a transverse aortic constriction model in rats and cellular assays in vitro. TFLF attenuated cardiac hypertrophy and fibrosis, improved cardiac dysfunction, and reduced serum NT-proBNP levels by inhibiting the Raf/MEK/ERK pathway.
A network pharmacology-based approach to explore the active ingredients and molecular mechanism of Lei-gong-gen formula granule on a spontaneously hypertensive rat model.
The study investigates the antihypertensive effects of Lei-gong-gen formula granule (LFG) on spontaneously hypertensive rats. LFG reduced blood pressure, increased serum NO content, and ameliorated cardiac hypertrophy and inflammation. Network pharmacology and molecular biology experiments suggest LFG activates the PI3K-AKT-NOS3 signaling pathway, with nicotinic acid identified as a potential active compound.
Rapid discrimination of raw and sulfur-fumigated Smilax glabra based on chemical profiles by UHPLC-QTOF-MS/MS coupled with multivariate statistical analysis.
The study explores chemical differences between non-fumigated and sulfur-fumigated Smilax glabra using UHPLC-QTOF-MS/MS with multivariate statistical analysis. Fifty-eight compounds were identified, with six sulfur-containing compounds serving as markers for distinguishing the two types of samples.
Chemical profiles, antioxidant activity and acute toxicity of raw and sulfur-fumigated Smilacis Glabrae Rhizoma.
The study investigates the chemical changes, antioxidant activity, and acute toxicity of Smilacis Glabrae Rhizoma (SGR) after sulfur fumigation. Results show decreased levels of key compounds and antioxidant activity in sulfur-fumigated samples. High doses of sulfur-fumigated SGR caused liver damage in mice, suggesting potential safety concerns.
Gold nanoparticles synthesized with Smilax glabra rhizome modulates the anti-obesity parameters in high-fat diet and streptozotocin induced obese diabetes rat model.
The study investigates the synthesis of gold nanoparticles using Smilax glabra rhizome and their effects on anti-obesity and anti-diabetic parameters in a high-fat diet and streptozotocin-induced obese diabetes rat model. The findings indicate that these nanoparticles have therapeutic effects on blood glucose, insulin release, lipid profile, and inflammatory markers, and they restore liver and heart tissue structures in obese and diabetic rats.
The anti-hyperuricemic effect of four astilbin stereoisomers in Smilax glabra on hyperuricemic mice.
The study investigated the effects of total flavonoids from Smilax glabra, including four astilbin stereoisomers, on hyperuricemic mice. The flavonoids significantly reduced serum uric acid content and hepatic xanthine oxidase activity, while up-regulating renal transport proteins OAT1 and OCTN2.
Therapeutic effects of Smilax glabra and Bolbostemma paniculatum on rheumatoid arthritis using a rat paw edema model.
The study investigates the therapeutic effects of Smilax glabra and Bolbostemma paniculatum on rheumatoid arthritis using a rat paw edema model. The couplet medicine showed significant inhibitory activity on carrageenan-induced paw edema and downregulated levels of IL-1β, IL-6, and TNF-α, indicating significant anti-RA and anti-inflammatory effects.
Total flavonoids from Smilax glabra Roxb blocks epithelial-mesenchymal transition and inhibits renal interstitial fibrosis by targeting miR-21/PTEN signaling.
The study investigates the protective effect of pure total flavonoids from Smilax glabra Roxb (PTFS) on renal interstitial fibrosis (RIF) and its mechanism. PTFS treatment decreased mesenchymal marker expression and increased epithelial marker expression, inhibiting TGF-β1-induced EMT by blocking miR-21/PTEN/PI3K/Akt signaling in both in vivo and in vitro models.
Proapoptic and immunotoxic effects of sulfur-fumigated polysaccharides from Smilax glabra Roxb. in RAW264.7 cells.
The study compared sulfur-fumigated and non-fumigated Smilax glabra polysaccharides on RAW264.7 macrophage cells. Sulfur-fumigated polysaccharides inhibited cell viability and induced apoptosis, while non-fumigated polysaccharides showed immunomodulatory activity. Sulfur-fumigation was found to have significant immunotoxic effects.
The flavonoid-rich fraction from rhizomes of Smilax glabra Roxb. ameliorates renal oxidative stress and inflammation in uric acid nephropathy rats through promoting uric acid excretion.
The study investigated the effects of the flavonoid-rich fraction from rhizomes of Smilax glabra Roxb. (SGF) on uric acid nephropathy in rats. SGF improved kidney function, reduced renal oxidative stress and inflammation, and promoted uric acid excretion by increasing the expression of specific transporters.
Ethnomedicine, Phytochemistry and Pharmacology of Smilax glabra: An Important Traditional Chinese Medicine.
The paper reviews the ethnopharmacology, phytochemistry, and pharmacology of Smilax glabra (SG) Roxb., a traditional Chinese medicine. It discusses the pharmacological activities of SG Roxb., including cytotoxic, anti-inflammatory, immune-modulatory, antioxidant, hepatoprotective, antiviral, antibacterial, and cardiovascular protective effects, and highlights the need for further research on its chemical compositions and pharmacological effects.