Research
Sheep Sorrel (Rumex acetosella) — Essiac Ingredient
18 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Essiac: systematic review by the natural standard research collaboration.
Systematic review evaluating the scientific evidence on the safety and efficacy of Essiac. The review found a lack of high-quality clinical trials to substantiate Essiac's traditional uses, with inconclusive results regarding its use for cancer. There is a general lack of safety and efficacy data for Essiac and its formulations.
Trial of Essiac to ascertain its effect in women with breast cancer (TEA-BC).
Retrospective cohort study of 510 women with primary breast cancer assessing the effects of Essiac on health-related quality of life and mood states. Essiac did not significantly improve HR-QOL or mood states, and appeared to have a negative effect on physical well-being and relationship with doctor subscales. Most women used Essiac to boost immunity or survival chances.
Rumex acetosella Inhibits Platelet Function via Impaired MAPK and Phosphoinositide 3-Kinase Signaling.
The study examines the antiplatelet and antithrombotic activity of Rumex acetosella extract. It inhibits platelet aggregation, calcium mobilization, granule secretion, and fibrinogen binding, and down-regulates MAPK and PI3K/Akt phosphorylation, suggesting potential protection against platelet-related cardiovascular diseases.
Inhibitory potential on key enzymes relevant to type II diabetes mellitus and antioxidant properties of the various extracts and phytochemical constituents from Rumex acetosella L.
The study investigated the antidiabetic profiles of various extracts and phytochemicals of Rumex acetosella, focusing on α-amylase and α-glucosidase inhibition and antioxidant properties. Ethanol and ethanol-water extracts showed significant α-glucosidase inhibition and antioxidant potential, supporting the ethnobotanical use of R. acetosella as an antidiabetic agent.
Study of phenolic content and urease and alpha-amylase inhibitory activities of methanolic extract of Rumex acetosella roots and its sub-fractions in different solvents.
The study investigated the urease and alpha-amylase inhibitory activities of methanolic extract of Rumex acetosella roots and its fractions in various solvents. The n-butanol fraction, with the highest phenolic content, showed significant inhibitory activity against both enzymes, suggesting a role of phenolics in enzyme inhibition.
In vitro analysis of the herbal compound Essiac.
In vitro study of the herbal compound Essiac, assessing its antioxidant, immunomodulatory, and cytotoxic properties. Essiac showed significant antioxidant activity, immunomodulatory effects, and cell-specific cytotoxicity towards ovarian epithelial carcinoma cells. It also inhibited several CYP450 enzymes and clot fibrinolysis.
Evaluation of the antiproliferative effects of Essiac on in vitro and in vivo models of prostate cancer compared to paclitaxel.
The study evaluated the antiproliferative effects of Essiac herbal tea on prostate cancer cells and xenografts. No significant differences in cell cycle distribution or tumor size were observed between control and Essiac-treated groups, suggesting Essiac has no marked antiproliferative effect on the models tested.
An in vivo analysis of the herbal compound essiac.
In vivo study of Essiac, a herbal compound, on Wistar rats and mice. Essiac showed a modest protective effect against ethanol-induced gastric ulceration but did not demonstrate significant hepatoprotective, hypoglycemic, or immunomodulatory properties.
Essiac and Flor-Essence herbal tonics stimulate the in vitro growth of human breast cancer cells.
In vitro study evaluating the effects of Flor-Essence and Essiac herbal tonics on the growth of human breast cancer cells. The tonics stimulated cell proliferation in both estrogen receptor positive and negative cell lines, suggesting potential negative effects on breast cancer through ER mediated and independent mechanisms.
Antioxidant and anti-inflammatory properties of ESSIAC and Flor-Essence.
In vitro study assessing the antioxidant and anti-inflammatory properties of Essiac and Flor-Essence herbal teas. Essiac increased nitric oxide production in non-stimulated cells and inhibited it in LPS-stimulated cells, while Flor-Essence did not significantly affect nitric oxide production. Both teas induced mRNA expression of pro-inflammatory molecules in RAW 264.7 cells.
Essiac tea: scavenging of reactive oxygen species and effects on DNA damage.
The study examined the effects of Essiac tea on free radical scavenging and DNA damage in a non-cellular system, as well as lipid peroxidation using the RAW 264.7 cell line. Essiac tea effectively scavenged hydroxyl and superoxide radicals and prevented hydroxyl radical-induced DNA damage and lipid peroxidation, indicating potent antioxidant and DNA-protective activity.
Inhibition of prostate cancer-cell proliferation by Essiac.
In vitro study assessing the effects of Essiac tea extracts on cancer cell proliferation and immune responsiveness. Essiac inhibited proliferation of both noncancerous and cancerous prostate cell lines, with a more selective effect on cancer cells. It also showed mixed effects on T-lymphocyte proliferation, enhancing at low doses and inhibiting at higher doses.
Author of CME article offers clarification about Essiac.
The article provides clarification about Essiac, a herbal supplement, but lacks an abstract or detailed study information.
Remission of hormone-refractory prostate cancer attributed to Essiac.
Case report of a 64-year-old man with hormone-refractory prostate cancer responding well to Essiac tea. Anecdotal evidence suggests potential cancer-fighting qualities of Essiac, though no clinical trials have been conducted.
Essiac for cancer?
The paper discusses Essiac in the context of cancer treatment. No abstract is available to provide further details.
Essiac.
The paper is titled 'Essiac', but no abstract is available to provide further details on the study's focus or findings.
Unconventional therapies for cancer: 1. Essiac. The Task Force on Alternative Therapies of the Canadian Breast Cancer Research Initiative.
The article is part of a series reviewing unconventional therapies for cancer, focusing on Essiac. It describes the methodology used to evaluate information on Essiac and summarizes findings, noting some indication of possible benefit but no definitive evidence.
Essiac: an historical perspective.
The article provides a historical perspective on Essiac, an unconventional therapy used by some cancer patients. It discusses the reasons patients might choose such therapies and emphasizes the need for scientific research on Essiac.