Research
Sea Cucumber (Holothurian species)
7 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
The effectiveness of pure Stichopus horrens extract toothpaste in reducing plaque-induced gingivitis following orthodontic bonding: A triple-blinded randomized controlled trial.
Triple-blinded RCT assessing the effects of toothpaste containing Stichopus horrens extract on plaque-induced gingivitis in 40 patients with fixed appliances. The 9% SH-containing toothpaste showed the most substantial reduction in gingival inflammation and bleeding on probing.
The effect of eating sea cucumber jelly on Candida load in the oral cavity of elderly individuals in a nursing home.
Double-blind randomized controlled study of elderly individuals in a nursing home to investigate the effect of sea cucumber jelly on oral Candida load. The jelly contained a hydrolysate of Stichopus japonicus with triterpene glycosides called holotoxins. The sea cucumber jelly showed inhibitory effects on oral Candida, suggesting potential to reduce Candida load.
Efficacy of 'Gamadent' toothpaste on the healing of gingival tissues: a preliminary report.
RCT evaluating 'Gamadent' toothpaste containing sea cucumber extract on gingival healing in 28 patients with chronic gingivitis or early periodontitis. Significant improvements in clinical parameters like Plaque Index, Gingival Index, Papilla Bleeding Index, and Probing Pocket Depth were observed in the test group compared to placebo over 3 months.
Ameliorative effect of sea cucumber on physical fatigue induced by forced ambulation and its underlying mechanism.
The study investigated the effects of sea cucumber on physical fatigue in mice. Administration of sea cucumber before and after forced walking mitigated decreases in locomotor activity and enhanced expression of antioxidative-related proteins in the soleus muscle, suggesting an anti-fatigue effect through modulation of the Sirt1/NRF2/SOD1-GPx1-catalase pathway.
Sea cucumber extract enhances glutathione-related antioxidant defense and reduces apoptosis in Eimeria papillata-infected mice.
The study evaluated the anticoccidial, antioxidant, and anti-apoptotic effects of Holothuria polii extract (HpE) in mice infected with Eimeria papillata. HpE at 200 mg/kg significantly reduced oocyst output, enhanced oxidative status, and reduced apoptosis compared to untreated controls, suggesting its therapeutic potential.
Anti-inflammatory and skin-regenerative properties of Red Sea: in vitro wound healing activity of the methanolic extract and in silico anti-Tumor Necrosis Factor-evaluation of its bioactive metabolites.
The study evaluated the in vitro wound healing and anti-inflammatory properties of methanolic extract from sea cucumber. The extract enhanced keratinocyte wound healing and showed TNF-binding ability in molecular docking studies, suggesting potential benefits for skin health and inflammation.
Rational discovery of testosterone-enhancing peptide (AGNYGLPT) from sea cucumber: targeting T-type calcium channels through docking, molecular dynamics simulations, and cellular validation.
The study used computer-guided peptide screening to explore how a sea cucumber peptide (SCP) enhances testosterone synthesis via T-type calcium channels. The peptide AGNYGLPT was identified as stabilizing Cacna1g and increasing intracellular calcium levels, enhancing testosterone synthesis in vitro.