Research
Sea Buckthorn (Hippophae rhamnoides)
30 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Rosacea and: A Phytonutrient Approach to Skin Repair (The Systematic Review).
Systematic review of studies on sea buckthorn extracts, oils, or bioactive compounds, focusing on their effects on rosacea-related mechanisms. Sea buckthorn compounds modulate inflammation, oxidative stress, vascular and immune responses, and barrier function in preclinical models, suggesting potential benefits for inflammatory skin disorders like rosacea. Most evidence is preclinical, with limited clinical data for rosacea.
A prospective study of vaginal topical pretreatment of compound sea-buckthorn oil suppository in postmenopausal women prior to colposcopy.
RCT evaluating the clinical efficacy of compound sea-buckthorn oil suppository as a topical vaginal pretreatment in postmenopausal women prior to colposcopy. The study found that sea-buckthorn oil improved the integrity of vaginal epithelium and satisfaction of colposcopy without significant side effects, compared to estrogen ointment.
Research progress on antitumor effects of sea buckthorn, a traditional Chinese medicine homologous to food and medicine.
This systematic review discusses the anti-tumor, antioxidant, and liver-protecting properties of sea buckthorn, a traditional Chinese medicine. It highlights the active components such as isorhamnetin, quercetin, gallic acid, and protocatechuic acid, which have significant anti-tumor effects. The review provides a theoretical basis for the development of sea buckthorn products in anti-tumor research and clinical application.
Effects of sea buckthorn (Hippophae rhamnoides L.) on factors related to metabolic syndrome: A systematic review and meta-analysis of randomized controlled trial.
This meta-analysis of 15 RCTs explored the effects of sea buckthorn supplementation on factors related to metabolic syndrome. Sea buckthorn reduced triglycerides, total cholesterol, and low-density lipoprotein cholesterol, and increased high-density lipoprotein cholesterol, particularly in people with abnormal lipid metabolism. It had no effect on blood sugar, blood pressure, and BMI.
L. Fruit Extract Relieves Chronic Idiopathic Constipation and Improves Bowel Function: A Monocentric, Randomized, Double-Blind, Placebo-Controlled, Clinical Trial.
This randomized clinical trial evaluated the efficacy and tolerability of sea buckthorn fruit extract in adults with chronic idiopathic constipation. The extract significantly improved spontaneous complete bowel movements and normalized stool consistency compared to placebo, with reductions in bloating, abdominal pain, and heaviness.
Efficacy and safety of a new vaginal gel for the treatment of symptoms associated with vulvovaginal atrophy in postmenopausal women: A double-blind randomized placebo-controlled study.
RCT assessing the efficacy and safety of a new vaginal gel containing sea buckthorn oil, aloe vera, 18β-glycyrrhetic acid, hyaluronic acid, and glycogen in postmenopausal women with vulvovaginal atrophy. The gel significantly improved vaginal health and sexual function over 12 weeks.
To compare the effect of sea buckthorn and silver sulfadiazine dressing on period of wound healing in patients with second-degree burns: A randomized triple-blind clinical trial.
Randomized triple-blind clinical trial comparing sea buckthorn cream to 1% silver sulfadiazine for second-degree burn healing in 55 patients. Sea buckthorn cream resulted in a shorter healing period, demonstrating greater clinical efficacy.
Management of cognitive determinants in senile dementia of Alzheimer's type: therapeutic potential of a novel polyherbal drug product.
A randomized double-blind placebo- and active-controlled clinical trial evaluated a polyherbal formulation containing Bacopa monnieri, Hippophae rhamnoides, and Dioscorea bulbifera in 109 healthy elderly subjects and 123 SDAT patients. The formulation improved cognitive functions and reduced inflammation and oxidative stress in SDAT patients compared to donepezil, and showed protective effects in healthy elderly subjects.
Effect of a low dose of sea buckthorn berries on circulating concentrations of cholesterol, triacylglycerols, and flavonols in healthy adults.
RCT with 229 healthy participants consuming 28 g of sea buckthorn berries (SBB) or placebo daily for 3 months. SBB increased plasma concentrations of flavonols quercetin and isorhamnetin but did not affect serum cholesterol or triacylglycerol concentrations. No correlation was found between changes in flavonol and CRP concentrations.
Effects of sea buckthorn berries on infections and inflammation: a double-blind, randomized, placebo-controlled trial.
Double-blind, randomized, placebo-controlled trial with 254 healthy volunteers to study the effect of sea buckthorn berries on common cold infections, digestive and urinary tract infections, and serum C-reactive protein concentrations. Sea buckthorn did not prevent common cold or digestive tract infections but significantly reduced serum CRP concentrations, indicating a positive effect on inflammation.
Effects of a sea buckthorn oil spray emulsion on dry eye.
RCT investigating the effects of a sea buckthorn oil and sodium hyaluronate-containing eyelid spray emulsion on dry eye symptoms. The study found that the SB spray significantly decreased OSDI scores and symptoms of dryness and watering compared to a reference spray and untreated control.
[Comparative study of the clinical observation on traumatic perforation of tympanic membrane].
Prospective, randomized study of 199 outpatients with traumatic perforation of tympanic membrane comparing sea buckthorn oil treatment to self-healing. The treatment group showed higher healing rates and shorter healing times for middle and large perforations compared to the control group, suggesting sea buckthorn oil is beneficial for these cases.
Effects of sea buckthorn oil intake on vaginal atrophy in postmenopausal women: a randomized, double-blind, placebo-controlled study.
RCT of 116 postmenopausal women comparing 3g daily sea buckthorn oil to placebo for three months. Sea buckthorn oil showed beneficial effects on vaginal health, improving the integrity of vaginal epithelium and showing a trend towards better vaginal health index.
Influence of hippophae rhamnoides on two appetite factors, gastric emptying and metabolic parameters, in children with functional dyspepsia.
RCT in 120 children with functional dyspepsia comparing hippophae rhamnoides, domperidone, and their combination. Hippophae rhamnoides increased plasma levels of leptin and neuropeptide Y, improved gastric emptying, and enhanced growth and development indicators.
Effects of sea buckthorn and bilberry on serum metabolites differ according to baseline metabolic profiles in overweight women: a randomized crossover trial.
Randomized crossover trial with 80 overweight women studying the effects of sea buckthorn and bilberry on serum metabolome. Interventions included dried sea buckthorn berries, sea buckthorn oil, sea buckthorn phenolics ethanol extract with maltodextrin, and frozen bilberries. Significant effects on metabolic profiles were observed, with variations depending on baseline cardiometabolic risk profiles.
Immunomodulating and antiproteinuric effect of Hippophae rhamnoides (Badriphal) in idiopathic nephrotic syndrome.
RCT with 56 patients of idiopathic nephrotic syndrome comparing standard treatment to Hippophae rhamnoides (Badriphal) as add-on. The herbal group showed improvement in symptoms like oedema, anorexia, oliguria, and significant decrease in urinary protein and inflammatory cytokines.
Pathology of ochratoxin A-induced nephrotoxicity in Japanese quail and its protection by sea buckthorn (Hippophae rhamnoides L.).
The study investigated the protective effect of sea buckthorn (SBT) against renal damage induced by ochratoxin A (OTA) in Japanese quail. Quail chicks were divided into groups receiving different treatments, including SBT leaf powder and extract. SBT-treated groups showed less severe renal damage compared to the group fed OTA alone, indicating partial protection against OTA-induced nephropathy.
Effects of oral sea buckthorn oil on tear film Fatty acids in individuals with dry eye.
RCT of 100 participants with dry eye, comparing 2 g daily oral sea buckthorn oil to placebo for 3 months. No significant changes in tear film fatty acid composition were observed, suggesting benefits may be due to carotenoids, tocopherols, or eicosanoids affecting inflammation and meibomian gland cell differentiation.
Oral sea buckthorn oil attenuates tear film osmolarity and symptoms in individuals with dry eye.
Double-blind, randomized trial of 100 participants with dry eye symptoms consuming 2 g of sea buckthorn oil or placebo daily for 3 months. Sea buckthorn oil attenuated the increase in tear film osmolarity and positively affected dry eye symptoms compared to placebo.
Absorption of flavonols derived from sea buckthorn (Hippophaë rhamnoides L.) and their effect on emerging risk factors for cardiovascular disease in humans.
RCT studying the absorption of flavonols derived from sea buckthorn and their effect on cardiovascular risk factors in humans. Flavonols were rapidly absorbed but did not significantly affect oxidized LDL, CRP, homocysteine levels, plasma antioxidant potential, or paraoxonase activity.
Effect of sea buckthorn on liver fibrosis: a clinical study.
RCT of 50 cirrhotic patients comparing sea buckthorn extract to vitamin B complex over 6 months. Sea buckthorn treatment significantly reduced serum levels of LN, HA, collagen types III and IV, and total bile acid, and shortened the duration for normalization of aminotransferases, suggesting potential benefits for liver fibrosis.
Sea buckthorn decreases and delays insulin response and improves glycaemic profile following a sucrose-containing berry meal: a randomised, controlled, crossover study of Danish sea buckthorn and strawberries in overweight and obese male subjects.
Randomised, controlled, crossover study in 18 overweight or obese male subjects examining the effects of sea buckthorn and strawberry on postprandial glycaemia and insulinemia. Sea buckthorn improved glycaemic profile and decreased insulin response compared to control, while strawberry had no such effects.
The effect of sea buckthorn supplement on oral health, inflammation, and DNA damage in hemodialysis patients: a double-blinded, randomized crossover study.
This randomized, double-blinded, placebo-controlled crossover study evaluated the effects of sea buckthorn oil (SBO) on oxidative stress, saliva production, and inflammation in 45 hemodialysis patients. The study found no significant changes in DNA breaks, oxidative DNA lesions, salivary flow rates, or inflammation after SBO supplementation, although plasma levels of phosphate and sodium increased and plasma levels of iron decreased.
Effect of sea buckthorn berries and pulp in a liquid emulsion on gastric ulcer scores and gastric juice pH in horses.
This study tested the efficacy of SeaBuck SBT Gastro-Plus, a sea buckthorn berry and pulp formulation, on gastric ulcers in horses. The study found that while nonglandular ulcer scores increased with feed deprivation, glandular ulcer scores were significantly lower in SBT-treated horses compared to controls, suggesting potential efficacy in preventing glandular ulcers.
Potential of Newly Synthesized Sea Buckthorn Phytocarriers as Anti-Inflammatory Active Agents
The study assessed the morphology, intracellular delivery, and anti-inflammatory effect of sodium cholate and sodium deoxycholate-based phytocarriers loaded with sea buckthorn berry extract. NaC-derived phytocarriers loaded with sea buckthorn extract showed anti-inflammatory properties by lowering IL-8 cytokine production in human monocytes.
The fibres and polyphenols in sea buckthorn (Hippophaë rhamnoides) extraction residues delay postprandial lipemia.
Postprandial cross-over study with healthy normal-weight male volunteers examining the triacylglycerol response to fatty meals containing sea buckthorn berries and extraction residues. All berry meals delayed lipemia compared to the control, with the effect largely attributed to fiber rather than polyphenols.
Sea buckthorn, its bioactive constituents, and mechanism of action: potential application in female reproduction
This narrative review examines the bioactive constituents of sea buckthorn and their potential mechanisms of action in female reproductive health. It discusses the plant's compounds, such as flavonoids and fatty acids, and their possible roles in managing gynecological issues and improving postmenopausal symptoms.
Phytochemistry, health benefits, and food applications of sea buckthorn (Hippophae rhamnoides L.): A comprehensive review
This comprehensive review discusses the phytochemistry, nutrients, health benefits, and food applications of sea buckthorn (Hippophae rhamnoides L.). It highlights the plant's antioxidant, anticancer, anti-hyperlipidemic, anti-obesity, anti-inflammatory, antimicrobial, antiviral, dermatological, neuroprotective, and hepatoprotective activities, as well as its potential in the human food industry.
Nutritional Value, Health-promoting Benefits and Food Application of Sea Buckthorn
This narrative review discusses the nutritional value and health-promoting benefits of sea buckthorn (SB) berries, highlighting their bioactive compounds such as vitamin C, flavonoids, free fatty acids, and carotenoids. It covers SB's anti-inflammatory, skin healing, and cardiovascular disease risk reduction properties.
Remedial Prospective of Hippophae rhamnoides Linn. (Sea Buckthorn)
The paper reviews the pharmacological actions of sea buckthorn (Hippophae rhamnoides), highlighting its rich vitamin and antioxidant content. It discusses its potential benefits in reducing inflammation, improving heart health, exerting anti-cancer effects, and providing anti-stress and adaptogenic activity. Further research is needed to explore its mechanisms and effects on various conditions.