Research
Scutellaria baicalensis (Chinese Skullcap / Baicalin)
20 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
The effect of scutellaria baicalensis and its active ingredients on major depressive disorder: a systematic review and meta-analysis of literature in pre-clinical research.
Systematic review and meta-analysis of pre-clinical studies on Scutellaria baicalensis for depression. Analyzed 13 studies showing antidepressant effects and underlying mechanisms in animal models. Results suggest Scutellaria baicalensis can alleviate depressive behaviors and modulate mechanisms, indicating potential as an antidepressant.
Therapeutic efficacy and safety of Yinzhihuang granules with phototherapy in neonatal pathologic jaundice: An updated systematic review and meta-analysis.
This meta-analysis evaluated the efficacy and safety of Yinzhihuang granules combined with phototherapy for treating neonatal pathologic jaundice. The study included 19 trials with 2,221 newborns, showing that Yinzhihuang granules improved clinical efficacy measures such as bilirubin levels and recovery time compared to controls. The incidence of adverse reactions was also lower in the trial group.
Pharmacological properties of total flavonoids in Scutellaria baicalensis for the treatment of cardiovascular diseases.
Systematic review of the pharmacological properties of total flavonoids in Scutellaria baicalensis (TFSB) for cardiovascular diseases. The review discusses the pharmacokinetics, clinical application, and safety of TFSB, highlighting its potential to protect against CVDs through various mechanisms such as inhibiting apoptosis and regulating oxidative stress.
Gentiana scabra Bunge. Formula for Herpes Zoster: Biological Actions of Key Herbs and Systematic Review of Efficacy and Safety.
Systematic review and meta-analysis of 26 clinical studies involving 2955 participants on the efficacy and safety of Gentiana formula for herpes zoster. The formula, including key herbs like Gentiana scabra, showed anti-inflammatory actions and resolved pain earlier than pharmacotherapy, with a lower incidence of postherpetic neuralgia. Mild adverse events were reported.
The Effects of Combined Scutellaria and Saffron Supplementation on Mood Regulation in Participants with Mild-to-Moderate Depressive Symptoms: A Randomized, Double-Blind, Placebo-Controlled Study.
RCT of 180 participants with mild-to-moderate depressive symptoms comparing scutellaria extract, saffron extract, their combination, and placebo over six weeks. The combination showed enhanced improvements in depressive and anxious symptoms and emotional well-being, with minimal adverse effects.
A study on the impact of gargling with compound Scutellaria baicalensis Georgi on oral health and microflora changes in fixed orthodontic patients: An experimental study.
RCT investigating the effect of Scutellaria baicalensis Georgi gargle on oral health in 110 orthodontic patients. The experimental group showed lower levels of Plaque Index, gingival bleeding index, and periodontal depth compared to the control group after 3 months, indicating effective inhibition of oral pathogens and maintenance of periodontal health.
A combination of Scutellaria baicalensis and Acacia catechu extracts for short-term symptomatic relief of joint discomfort associated with osteoarthritis of the knee.
A 1-week double-blind randomized control trial comparing UP446 (a blend of Scutellaria baicalensis and Acacia catechu) to naproxen in 79 adults with mild to moderate osteoarthritis. The UP446 group experienced significant decreases in perceived pain and stiffness, and increases in knee range of motion, suggesting effectiveness in reducing physical symptoms associated with knee OA.
Baicalin from the extract of Scutellaria baicalensis affects the innate immunity and apoptosis in leukocytes of children with acute lymphocytic leukemia.
The study investigates the effects of Scutellaria baicalensis extract enriched in baicalin on leukocytes of children with acute lymphoblastic leukemia. The extract reduced viability of leukemic leukocytes, increased IFNγ production, reduced TNFα and IL-10 production, and enhanced apoptosis in leukemic cells without affecting healthy leukocytes.
The safety of flavocoxid, a medical food, in the dietary management of knee osteoarthritis.
This 12-week, randomized, double-blind, placebo-controlled trial assessed the safety of flavocoxid, a medical food, in 59 patients with moderate knee osteoarthritis. The study found no significant differences in adverse events or laboratory values between the flavocoxid and placebo groups, except for a higher incidence of upper respiratory adverse events in the placebo group.
Study of Banxia Xiexin Prescription Combined with Diet Nursing on Improving the Clinical Symptoms, Inflammatory Factor Levels and Prognosis of Hospitalized Patients with Peptic Ulcer
The study investigated the effects of Banxia Xiexin decoction combined with diet nursing on peptic ulcer (PU) in a rat model and in hospitalized patients. The decoction reduced ET-1 and NO levels in PU rats and improved clinical symptoms and inflammatory state in patients compared to conventional western medicine.
Identification and verification of effective components of Huanghuai for dysfunctional uterine bleeding based on network pharmacology and molecular docking
The study investigates the traditional Chinese formula Huanghuai (HH), made from Scutellaria baicalensis and Sophora japonica, for treating dysfunctional uterine bleeding (DUB). Network pharmacology and molecular docking identified six compounds as potential active components, and in vivo tests confirmed their efficacy in reducing bleeding and other symptoms in animal models.
Clinical and antibacterial effect of an anti-inflammatory toothpaste formulation with Scutellaria baicalensis extract on experimental gingivitis.
RCT evaluating the clinical and antibacterial effect of a toothpaste containing Scutellaria baicalensis extract versus placebo in an experimental gingivitis model. The SB group showed significantly reduced gingival index, plaque index, and biofilm vitality compared to the placebo group, suggesting the toothpaste formulation effectively reduced gingivitis and plaque development.
[Dry extract of Scutellaria baicalensis as a hemostimulant in antineoplastic chemotherapy in patents with lung cancer].
Study of 88 lung cancer patients undergoing antitumor chemotherapy with and without dry extract of Scutellaria baicalensis. The plant preparation stimulated hemopoiesis, intensified bone-marrow erythro- and granulocytopoiesis, and increased circulating precursors of erythroid and granulomonocytic colony-forming units.
[Effect of Scutellaria baicalensis extract on the immunologic status of patients with lung cancer receiving antineoplastic chemotherapy].
RCT studying the effect of Scutellaria baicalensis extract on the immunologic status of lung cancer patients undergoing chemotherapy. The extract showed a tendency to increase T-lymphocytes and immunoglobulin A levels, suggesting a positive impact on immune parameters.
Chemical Characterization of the Precipitate Found in and Its Effect on Drug Release of the Scutellaria baicalensis‐Coptis chinensis Extract
The study investigates the chemical composition and effect on drug release of the precipitate formed in Scutellaria baicalensis-Coptis chinensis paired extract. Baicalin, berberine, and starch-arginine-rich polymers were identified in the precipitate, affecting the solubility and release of active compounds.
Therapeutic efficacy of Pudilan Xiaoyan Oral Liquid (PDL) for COVID-19 in vitro and in vivo
The study evaluated the efficacy of Pudilan Xiaoyan Oral Liquid (PDL) against SARS-CoV-2 in vitro and in vivo. PDL effectively suppressed viral replication in Vero E6 cells and reduced viral RNA copies in SARS-CoV-2-infected hACE2 mice, improving weight loss and reducing pneumonia symptoms.
In vivo effect of quantified flavonoids-enriched extract of Scutellaria baicalensis root on acute lung injury induced by influenza A virus.
The study evaluated the therapeutic effects of flavonoids-enriched extract from Scutellaria baicalensis root (FESR) on acute lung injury induced by influenza A virus in mice. FESR showed significant antiviral, anti-inflammatory, and anti-complementary properties, improving survival rates and lung health in infected mice compared to baicalin alone.
Antifungal activity and mechanism of action of Ou-gon (Scutellaria root extract) components against pathogenic fungi
The study investigated the antifungal activity and mechanism of action of Ou-gon, an extract from Scutellaria baicalensis root, against pathogenic fungi. Baicalein and wogonin were identified as active components, with baicalein showing potent antifungal activity against all tested fungi, and wogonin effective against all except C. albicans. The components induce apoptosis-like cell death via reactive oxygen species.
Scutellaria baicalensis Georgi. (Lamiaceae): a review of its traditional uses, botany, phytochemistry, pharmacology and toxicology
This paper provides a systematic and comprehensive overview of Scutellaria baicalensis, covering its traditional uses, botany, phytochemistry, pharmacology, pharmacokinetics, and toxicology. It discusses the plant's role in traditional Chinese medicine and its distribution across several countries.
Effects of a skullcap root supplement on haematology, serum parameters and antioxidant enzymes in rabbits on a high-cholesterol diet.
The study investigated the effects of Scutellaria baicalensis root on blood parameters and antioxidant enzyme activities in rabbits on a high-cholesterol diet. The skullcap root supplement improved antioxidant enzyme activities, such as GSH-Px and SOD, suggesting potential protective effects against high-cholesterol diet risks.