Research
Saw Palmetto
82 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Saw Palmetto Treatment for Prostatitis: A Systematic Review of the Literature
This systematic review evaluated the safety and efficacy of Serenoa repens (saw palmetto) extract in treating chronic prostatitis. The review included 21 studies with 1666 patients, showing that saw palmetto extract provided symptom relief compared to placebo, with mixed results against alpha-blockers or 5-ARIs. Multimodal treatments including saw palmetto and antibiotics were more effective for Category II prostatitis.
Serenoa repens for the treatment of lower urinary tract symptoms due to benign prostatic enlargement.
Systematic review of 27 studies involving 4656 participants assessing the effects of Serenoa repens on lower urinary tract symptoms due to benign prostatic enlargement. The review found that Serenoa repens results in little to no difference in urologic symptoms, quality of life, or adverse events compared to placebo.
Clinical Efficacy of Serenoa repens Versus Placebo Versus Alpha-blockers for the Treatment of Lower Urinary Tract Symptoms/Benign Prostatic Enlargement: A Systematic Review and Network Meta-analysis of Randomized Placebo-controlled Clinical Trials.
This systematic review and network meta-analysis compared the efficacy of Serenoa repens (SeR) versus placebo and alpha-blockers for treating lower urinary tract symptoms (LUTS) due to benign prostatic enlargement (BPE). The analysis included 22 RCTs with 8564 patients and found that SeR did not show clinically meaningful improvement in LUTS and peak flow compared to placebo.
Natural Hair Supplement: Friend or Foe? Saw Palmetto, a Systematic Review in Alopecia
Systematic review of saw palmetto supplements for alopecia, summarizing evidence from five RCTs and two cohort studies. Positive effects on hair quality, hair count, and hair density were noted, with no serious adverse events reported. Further large-scale RCTs are needed to confirm efficacy.
Serenoa repens for benign prostatic hyperplasia.
This systematic review and meta-analysis assessed the effects of Serenoa repens on lower urinary tract symptoms in men with benign prostatic hyperplasia. The analysis of 32 randomized controlled trials found that Serenoa repens was not superior to placebo in improving urinary flow measures, prostate size, or nocturia.
Serenoa repens for benign prostatic hyperplasia.
Systematic review assessing the effects of Serenoa repens on urinary symptoms and flow measures in men with benign prostatic hyperplasia (BPH). Compared with placebo, Serenoa repens improved urinary symptom scores, symptoms, and flow measures. It produced similar improvements compared to finasteride with fewer adverse effects. Long-term effectiveness and safety remain unknown.
Saw palmetto extracts for treatment of benign prostatic hyperplasia: a systematic review.
Systematic review and meta-analysis of 18 RCTs involving 2939 men with symptomatic benign prostatic hyperplasia (BPH) treated with saw palmetto extract. Saw palmetto improved urinary tract symptoms and flow measures compared to placebo and had similar efficacy to finasteride with fewer adverse effects.
The Safety and Efficacy of a Novel Saw Palmetto (Serenoa repens) Extract for Promoting Hair Growth in Adults With Self-Perceived Thinning Hair: 180-Day Results.
This 6-month randomized, double-blind, placebo-controlled study assessed the efficacy and safety of a proprietary saw palmetto extract for treating self-perceived thinning hair in adults. The active treatment significantly outperformed placebo in improving total terminal hair count, vellus hair count, and hair density, with no treatment-related adverse events.
Efficacy of Oral Supplementation with Serenoa Repens, Pumpkin Seed Extract and Cysteine Combined with Topical Minoxidil 5% Vs Topical Minoxidil 5% Alone in Androgenic Alopecia A Randomised Assessor-Blinded 6-Month, Superiority Trial
Randomised assessor-blinded 6-month trial comparing oral supplementation with Serenoa Repens, Pumpkin Seed Extract, and Cysteine combined with topical Minoxidil 5% versus topical Minoxidil 5% alone in androgenic alopecia.
Beneficial effects of saw palmetto (Serenoa repens) fruit extract on the urinary symptoms of healthy Japanese adults with possible lower urinary tract symptoms: A randomized, double-blind, placebo-controlled study
Randomized, double-blind, placebo-controlled study of saw palmetto extract (320 mg) on urinary symptoms in healthy Japanese adults aged ≥50 years. The study found significant improvements in symptom bother by frequent urination and decreased daytime frequency of urination after 12 weeks of supplementation.
Oral and Topical Administration of a Standardized Saw Palmetto Oil Reduces Hair Fall and Improves the Hair Growth in Androgenetic Alopecia Subjects - A 16-Week Randomized, Placebo-Controlled Study.
A 16-week randomized, placebo-controlled study assessed the safety and efficacy of VISPO, a standardized saw palmetto oil, in subjects with mild-to-moderate androgenetic alopecia. Oral and topical formulations reduced hair fall and increased hair density, with oral ingestion also reducing serum dihydrotestosterone levels. No serious adverse effects were observed.
A Comparative Study of Topical Procapil With Platelet-Rich Plasma Therapy Versus Topical Redensyl, Saw Palmetto, and Biotin With Platelet-Rich Plasma Therapy in the Treatment of Androgenetic Alopecia
RCT comparing the efficacy of Procapil with PRP versus redensyl, saw palmetto, and biotin with PRP in 54 male patients with androgenetic alopecia. The study found significant differences in AGA grading scores, suggesting PRP with redensyl, saw palmetto, and biotin may be a better alternative.
Beneficial Effects of Saw Palmetto Fruit Extract on Urinary Symptoms in Japanese Female Subjects by a Multicenter, Randomized, Double-Blind, Placebo-Controlled Study.
RCT examining the efficacy and safety of a 12-week treatment with saw palmetto berry extract (SPE) in adult women with urinary symptoms. SPE significantly improved daytime frequency and nocturia scores compared to placebo, demonstrating potential to mitigate lower urinary tract symptoms in women.
Non-hormonal treatment for male infertility: the potential role of Serenoa repens, selenium and lycopene.
This systematic review explores the potential role of Serenoa repens, selenium, and lycopene in improving sperm quality and male infertility. The review suggests that their antioxidant and anti-inflammatory properties may improve sperm parameters, but emphasizes the need for further studies to confirm these effects.
Fixed-dose combination PRO 160/120 of sabal and urtica extracts improves nocturia in men with LUTS suggestive of BPH: re-evaluation of four controlled clinical studies.
Post hoc evaluation of four RCTs on the herbal combination PRO 160/120 (saw palmetto and stinging nettle) for nocturnal voiding frequency in men with LUTS/BPH. PRO 160/120 significantly improved nocturnal voiding frequency compared to placebo and showed similar efficacy to tamsulosin and finasteride.
Chronic bacterial prostatitis: efficacy of short-lasting antibiotic therapy with prulifloxacin (Unidrox®) in association with saw palmetto extract, lactobacillus sporogens and arbutin (Lactorepens®).
RCT of 210 patients with chronic bacterial prostatitis comparing prulifloxacin alone to prulifloxacin plus a supplement containing saw palmetto, lactobacillus sporogens, and arbutin. The supplement group showed better control and lower recurrence rates of prostatitis symptoms compared to the antibiotic-only group.
The effect of increasing doses of saw palmetto fruit extract on serum prostate specific antigen: analysis of the CAMUS randomized trial.
The CAMUS trial was a randomized, placebo-controlled study involving 369 men to assess the effect of increasing doses of saw palmetto on serum prostate specific antigen levels. The study found that saw palmetto extract does not affect serum prostate specific antigen more than placebo, even at high doses.
Relationships among participant international prostate symptom score, benign prostatic hyperplasia impact index changes and global ratings of change in a trial of phytotherapy in men with lower urinary tract symptoms.
RCT examining the relationship between symptom index scores and global ratings of change in men with lower urinary tract symptoms enrolled in a saw palmetto trial. Changes in American Urological Association symptom index scores were associated with global ratings of improvement.
Safety and toxicity of saw palmetto in the CAMUS trial.
The CAMUS trial randomized 357 patients to receive varying doses of saw palmetto extract or placebo over 18 months to assess safety and toxicity. The study found no significant differences in adverse events, vital signs, or laboratory test abnormalities between groups, indicating no evidence of toxicity at doses up to three times the usual clinical dose.
Associations between improvements in lower urinary tract symptoms and sleep disturbance over time in the CAMUS trial.
The CAMUS trial evaluated the relationship between lower urinary tract symptoms and sleep disturbance in men with benign prostatic hyperplasia, using saw palmetto as an intervention. No differences were found between the placebo and saw palmetto groups, but overall improvements in urinary symptoms were significantly associated with improvements in sleep disturbance over time.
Effect of increasing doses of saw palmetto extract on lower urinary tract symptoms: a randomized trial.
A double-blind, multicenter, placebo-controlled randomized trial of 369 men aged 45 years or older tested increasing doses of saw palmetto extract on lower urinary tract symptoms attributed to benign prostatic hyperplasia. The study found that saw palmetto extract was no more effective than placebo in reducing symptoms or improving secondary outcomes.
Recruitment of participants to a clinical trial of botanical therapy for benign prostatic hyperplasia.
The CAMUS trial is a randomized, double-blind, placebo-controlled study evaluating the effects of saw palmetto on benign prostatic hyperplasia (BPH) symptoms over 18 months. The study successfully recruited 350 men with lower urinary tract symptoms (LUTS) using mass mailing and advertising. CAMUS participants were younger, more educated, and had less severe symptoms compared to a similar trial using conventional medical therapy.
[Associating Serenoa repens, Urtica dioica and Pinus pinaster. Safety and efficacy in the treatment of lower urinary tract symptoms. Prospective study on 320 patients].
Prospective study on 320 patients with lower urinary tract symptoms treated with a combination of Serenoa repens, Urtica dioica, and Pinus pinaster. The treatment was well tolerated, with 85% of evaluable patients reporting significant improvement in symptoms such as pain, urgency, strangury, and nocturia. No significant changes in prostate volume or maximum flow rate were observed.
A detailed safety assessment of a saw palmetto extract.
The STEP study was a randomized clinical trial among 225 men with benign prostatic hyperplasia, comparing saw palmetto extract to placebo over 1 year. No significant differences were found in serious or non-serious adverse events, sexual functioning, or most laboratory tests, except for small differences in total bilirubin, potassium, and glycosuria incidence.
Saw palmetto for benign prostatic hyperplasia.
Double-blind RCT of 225 men with benign prostatic hyperplasia comparing saw palmetto extract to placebo over one year. Saw palmetto did not improve symptoms or objective measures of benign prostatic hyperplasia.
Combined sabal and urtica extract compared with finasteride in men with benign prostatic hyperplasia: analysis of prostate volume and therapeutic outcome.
RCT comparing the efficacy and safety of a combination of saw palmetto and nettle root extracts (PRO 160/120) with finasteride in 543 men with benign prostatic hyperplasia. Both treatments showed equivalent efficacy in improving urinary flow and prostate symptoms, regardless of prostate volume. PRO 160/120 had better tolerability with fewer adverse events compared to finasteride.
Measuring the efficacy of Serenoa repens (USPlus) extract with mobile uroflowmetry.
Prospective single-arm trial investigating the efficacy of a standardized USP-verified Saw Palmetto extract in treating male LUTS secondary to BPH. Significant improvements in IPSS and QoL scores were observed at 12 weeks, particularly in patients with moderate symptoms. Uroflowmetry parameters also improved, especially in patients with mild symptoms.
Effects of saw palmetto fruit extract intake on improving urination issues in Japanese men: A randomized, double‐blind, parallel‐group, placebo‐controlled study
RCT of 44 Japanese men with urination issues comparing 320 mg/day saw palmetto fruit extract to placebo for 12 weeks. The saw palmetto group showed significant improvement in urination symptoms as measured by the international prostate symptom score (IPSS) with no adverse effects.
Serenoa repens associated with selenium and lycopene extract and bromelain and methylsulfonylmethane extract are able to improve the efficacy of levofloxacin in chronic bacterial prostatitis patients.
Phase III RCT evaluating the efficacy of a combination of serenoa repens, selenium, lycopene, bromelain, and methylsulfonylmethane with levofloxacin in chronic bacterial prostatitis patients. Group A showed significant improvements in NIH-CPSI and IPSS scores compared to Group B, with fewer recurrences of symptoms and microbiological findings.
Effectiveness on urinary symptoms and erectile function of Prostamev Plus® vs only extract Serenoa repens.
RCT comparing Prostamev Plus® (Serenoa repens, Bromeline, Nettle) to Serenoa repens extract alone in 100 patients with prostatic inflammation. Prostamev Plus® showed better improvements in IPSS score, urinary flow, and sexual life.
Improving BPH symptoms and sexual dysfunctions with a saw palmetto preparation? Results from a pilot trial.
An open multicentric clinical pilot trial investigated the effects of a saw palmetto berry preparation on BPH symptoms and sexual dysfunctions in 82 elderly men. The trial found significant improvements in the International Prostate Symptom Score, Sexual Function Inventory, and Urolife BPH QoL-9 sex total, with good efficacy and tolerance reported.
Serenoa repens in benign prostatic hypertrophy: analysis of 2 Italian studies.
Systematic analysis of two Italian studies on 70 patients with benign prostatic hypertrophy treated with Serenoa repens. Treatment showed about 50% improvement in dysuria and pollakisuria, increased micturition rate, and reduced prostate size with good tolerability.
Analysis of the results obtained with a new phytotherapeutic association for LUTS versus control. [corrected].
RCT comparing a new phytotherapeutic combination containing Urtica Dioica, Serenoa Repens, avocado oil, and soya oil to no therapy in patients with BPH-induced LUTS. The treated group showed marked improvements in quality of life, IPSS score, uroflow, residual urine, and nocturia, with no significant changes in PSA or prostate volume.
Use of an embedded N-of-1 trial to improve adherence and increase information from a clinical study.
The paper describes the use of an N-of-1 trial embedded within a placebo-controlled trial of saw palmetto. It was used for a participant who considered withdrawing due to perceived side effects, specifically increased blood pressure. The N-of-1 trial reassured the patient and provided potentially useful information about the study medication.
Randomized trial of a combination of natural products (cernitin, saw palmetto, B-sitosterol, vitamin E) on symptoms of benign prostatic hyperplasia (BPH).
RCT of 127 patients with BPH comparing a combination of natural products (cernitin, saw palmetto, B-sitosterol, vitamin E) to placebo for 3 months. The combination significantly reduced nocturia and daytime frequency, and improved the total AUA Symptom Index score, with no significant adverse side effects.
Randomized, double-blind, placebo-controlled trial of saw palmetto in men with lower urinary tract symptoms.
RCT of 85 men with lower urinary tract symptoms comparing saw palmetto to placebo for 6 months. Saw palmetto significantly improved urinary symptoms compared to placebo, but had no effect on urinary flow rates or sexual function.
Effects of androstenedione-herbal supplementation on serum sex hormone concentrations in 30- to 59-year-old men.
RCT investigating the effects of a supplement containing androstenedione and various herbs on serum hormone concentrations in men aged 30-59. The supplement increased serum androstenedione, free testosterone, dihydrotestosterone, and estradiol levels, but did not prevent conversion to estradiol and dihydrotestosterone. HDL-C concentrations were reduced.
Phytotherapy for benign prostatic hyperplasia.
Systematic review of 44 studies on phytotherapeutic compounds for benign prostatic hyperplasia (BPH). Serenoa repens showed significant improvement in urinary tract symptoms and flow measures compared to placebo. Hypoxis rooperi and Secale cereale also improved BPH symptoms, while evidence for Pygeum africanum, Urtica dioica, and Curcubita pepo was less conclusive.
Design and Development of Novel Herbal Suppository Formulation for Prostatitis Treatment
The study designed and evaluated herbal suppository formulations for prostatitis treatment, using lovage, saw palmetto, and calendula extracts. Suppositories based on Witepsol® H15 showed satisfactory physicochemical and microbiological properties, with promising release rates of active compounds.
Lipid Profile and 5α-Reductase Inhibition Activity of Proprietary Ultrahigh-Pressure Supercritical Carbon Dioxide and Hexane Saw Palmetto Extracts
Preclinical study comparing two standardized lipidosterolic extracts of saw palmetto (UHP-sCESr and HESr) for 5α-reductase inhibition activity and lipid profiles. Both extracts showed nearly identical inhibition curves and comparable IC50 values for 5αR-1 and 5αR-2, as well as similar lipid profiles.
Antioxidant-polyphenols of saw palmetto seeds: statistical optimized production and improved functional properties under solid-state fermentation by Trichoderma reesei
The study optimized solid-state fermentation conditions to maximize the production of phenolic compounds from saw palmetto seeds. The fermentation increased total phenolic content and antioxidant activity significantly, and the fermented extract showed enhanced antibacterial and antifungal activities.
[Efficacy and safety of № I Empirical Prescription for Chronic Prostatitis in the treatment of type Ⅲ refractory chronic prostatitis].
RCT comparing № I Empirical Prescription for Chronic Prostatitis (EPCP) and saw palmetto extract in 53 patients with type Ⅲ refractory chronic prostatitis. Both groups showed significant improvements in NIH-CPSI scores, TCMSS, urinary flow rates, and HAMD and HAMA scores after 8 weeks, with no significant adverse reactions.
Saw Palmetto for Symptom Management During Radiation Therapy for Prostate Cancer.
Study evaluated the safety and preliminary efficacy of saw palmetto for managing lower urinary tract symptoms during radiation therapy for prostate cancer. No dose-limiting toxicities were reported, and the maximum tolerated dose was 960 mg daily. No significant differences in symptom scores were observed, but quality of life scores improved in the saw palmetto group.
Acute effectiveness of a "fat-loss" product on substrate utilization, perception of hunger, mood state and rate of perceived exertion at rest and during exercise.
RCT with 12 healthy recreationally active participants testing the acute thermogenic effectiveness of Shred-Matrix, a multi-ingredient supplement, on fatty acid oxidation, perception of hunger, mood state, and rate of perceived exertion during exercise. The supplement increased fatty acid oxidation and reduced perceived exertion, with no significant effects on mood state or hunger perception.
Multiple doses of saw palmetto (Serenoa repens) did not alter cytochrome P450 2D6 and 3A4 activity in normal volunteers.
The study investigated the effect of saw palmetto on cytochrome P450 2D6 and 3A4 activity in 12 healthy volunteers. Results showed no significant effect of saw palmetto on the metabolic activity of CYP2D6 or CYP3A4, suggesting it is unlikely to alter the disposition of medications dependent on these pathways.
Saw palmetto alters nuclear measurements reflecting DNA content in men with symptomatic BPH: evidence for a possible molecular mechanism.
A 6-month randomized trial comparing saw palmetto herbal blend (SPHB) to placebo in men with symptomatic benign prostatic hyperplasia. The study found that SPHB treatment altered DNA chromatin structure and organization in prostate epithelial cells, suggesting a possible molecular mechanism for its therapeutic effect.
A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia.
RCT testing botanically derived 5-alpha-reductase inhibitors, specifically Serenoa repens and beta-sitosterol, in males with androgenetic alopecia. 60% of subjects dosed with the active formulation showed improvement, indicating effectiveness against AGA.
Tissue effects of saw palmetto and finasteride: use of biopsy cores for in situ quantification of prostatic androgens.
The study compared the effects of a saw palmetto herbal blend (SPHB) and finasteride on prostatic tissue androgen levels in men with benign prostatic hyperplasia. In a 6-month randomized trial, SPHB reduced tissue DHT levels by 32%, suggesting inhibition of 5-alpha reductase as a mechanism of action.
Do saw palmetto extracts block human alpha1-adrenoceptor subtypes in vivo?
Placebo-controlled, double-blind, four-way cross-over study in 12 healthy young men testing saw palmetto extracts for alpha1-adrenoceptor antagonism in vivo. Saw palmetto did not result in alpha1-adrenoceptor subtype occupancy and had minor effects on supine blood pressure without affecting heart rate or plasma catecholamines.
Effects of a saw palmetto herbal blend in men with symptomatic benign prostatic hyperplasia.
RCT of 44 men with symptomatic benign prostatic hyperplasia comparing a saw palmetto herbal blend to placebo. Clinical parameters improved slightly more in the saw palmetto group, though not statistically significant. Saw palmetto was associated with epithelial contraction in the prostate transition zone, suggesting a potential mechanism of action.
Real-World, Open-Label Study of the Efficacy and Safety of a Novel Serum in Androgenetic Alopecia.
Real-world, open-label study of a novel topical serum, REVIVV®, containing a blend of phytochemicals including saw palmetto extract, in 150 participants with androgenetic alopecia. The serum significantly improved hair growth and reduced shedding after 8 weeks of use.
Development of Nanoliposomes Loaded with Carbon Dioxide Serenoa repens (Saw Palmetto) Extract.
The study investigates the development of nanoliposomes loaded with saw palmetto CO₂ extract for potential use in treating hair loss. The encapsulation efficiency and characteristics of the liposomes were analyzed, suggesting their suitability as drug delivery systems for hair loss treatment.
Effects of saw palmetto extract on the vanilloid receptor TRPV1
The study investigated the effects of saw palmetto extract on TRPV1-mediated Ca2+ influx and specific [3H]resiniferatoxin binding to TRPV1 in HEK293 cells expressing TRPV1.
Standardized Saw Palmetto Extract Directly and Indirectly Affects Testosterone Biosynthesis and Spermatogenesis
Animal study on 24-week-old male Sprague Dawley rats receiving oral supplementation of standardized saw palmetto extract. SP supplementation reduced body weight gain, decreased fat weights and cholesterol levels, increased muscle endurance, sperm counts, and testosterone biosynthesis, suggesting potential benefits for alleviating symptoms of andropause.
Diabetic complications and oxidative stress: The role of phenolic-rich extracts of saw palmetto and date palm seeds.
The study assessed the role of phenolic-rich extracts from date palm seed and saw palmetto in modulating diabetic complications and oxidative stress in STZ-induced diabetic rats. The extracts significantly reversed hyperglycemia and body weight alterations, improved antioxidant enzyme activities, and modulated damage in the pancreas, kidney, and liver.
A substitute variety for agronomically and medicinally important Serenoa repens (saw palmetto)
The study proposes the use of S. repens forma glauca (silver variety) as a substitute for the wild variety of saw palmetto to support conservation efforts. It compares tissue microstructures and metabolite distribution using 3D imaging and metabolomics.
Phytotherapy for Benign Prostatic Hyperplasia : The Clinical Efficay and Safety of Use of Prostacare in Patients with Mild to Moderate Lower Urinary Tract Symptoms
Prospective interventional study on 72 patients with mild to moderate lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH) using Prostacare, a saw palmetto supplement. After 6 weeks, 86.4% of patients showed improvement in LUTS, quality of life, and peak urinary flow rate, with no significant change in prostate size. Prostacare was generally safe with minimal side effects.
A phytochemical comparison of saw palmetto products using gas chromatography and 1H nuclear magnetic resonance spectroscopy metabolomic profiling
The study compares two analytical approaches to characterize the chemical variability, composition, and quality of 57 different saw palmetto products used in the treatment of benign prostatic hyperplasia (BPH).
Prospective trial of an herbal formula BYSH and Saw palmetto in patients with hormonal refractory prostate cancer: a pilot study.
Pilot study of BYSH herbal formula and Saw palmetto in patients with hormone refractory prostate cancer. Most patients had stable PSA levels during treatment, but PSA levels increased by the end. Liver and renal functions remained normal, and the treatment was well tolerated.
Observational study: daily treatment with a new compound "Tradamixina" plus serenoa repens for two months improved the lower urinary tract symptoms.
Observational study of 100 patients with lower urinary tract symptoms treated with 'Tradamixina plus Serenoa Repens' for 2 months. The treatment significantly improved IPSS, QoL, BII scores, and decreased serum PSA levels, indicating improved male sexual function and quality of life.
Clinical and instrumental study of the efficacy of a new sebum control cream.
RCT evaluating a sebum control cream containing polyphenol-rich extract from saw palmetto, sesame seeds, and argan oil in 20 subjects with oily facial skin. The cream reduced sebum levels by 20% and oily spots by 42% after 4 weeks, with high acceptance among volunteers.
Emerging and traditional 5-α reductase inhibitors and androgen receptor antagonists for male androgenetic alopecia
The article reviews the safety and effectiveness of traditional and emerging 5-α reductase inhibitors and androgen receptor antagonists, including natural products like saw palmetto and pumpkin seed oil, for treating male androgenetic alopecia. It highlights the need for further research to confirm the safety and efficacy of these alternatives.
Hexanic Extract of Serenoa repens (Permixon®): A Review in Symptomatic Benign Prostatic Hyperplasia
The hexanic extract of Serenoa repens (Permixon®) is reviewed for its use in treating symptomatic benign prostatic hyperplasia (BPH). Clinical trials and observational studies show it is as effective as α-blockers and 5α-reductase inhibitors in improving urinary symptoms, increasing flow rate, and reducing prostate volume, with fewer side effects on sexual function.
Rethinking the Role of Saw Palmetto Extract for Men with Lower Urinary Tract Symptoms in North America
An international panel of urology experts developed consensus statements on the use of saw palmetto extract (LSESr) for treating benign prostatic hyperplasia (BPH) and male lower urinary tract symptoms (LUTS). The panel recommends LSESr as a treatment option for men with mild-to-moderate BPH/LUTS.
The Therapeutic Potential of Saw Palmetto Extract in Urological Disorders
This narrative review summarizes the pharmacological properties and potential therapeutic mechanisms of saw palmetto extract (SPE) in urological diseases. SPE is used as an alternative therapy for benign prostatic hyperplasia (BPH) and may have positive effects on prostate cancer, chronic prostatitis, and erectile dysfunction due to its anti-androgenic, anti-inflammatory, anti-proliferative, and pro-apoptotic effects.
Biological Evaluation of Medical Devices in the Form of Suppositories for Rectal and Vaginal Use
Biological evaluation of medical devices in the form of vaginal suppositories based on octenidine dihydrochloride and rectal suppositories based on Saw palmetto, Levisticum officinale, and Calendula officinalis extracts. The study used in vitro and in vivo biological test systems to assess cytotoxicity and safety, finding an acceptable level of safety for the products.
Serenoa repens (Saw palmetto) for Lower Urinary Tract Symptoms (LUTS): The Evidence for Efficacy and Safety of Lipidosterolic Extracts. Part I
This narrative review discusses the efficacy and safety of lipidosterolic extracts of Serenoa repens (saw palmetto) for treating lower urinary tract symptoms (LUTS). It examines the literature and clinical practice guidelines for Serenoa repens in Europe and the US, highlighting the controversy over its efficacy due to variability in product quality and composition.
A Review on Serenoa serrulata: A Potential Medicinal Plant for Prostatic Diseases
This narrative review examines the use of Serenoa serrulata (saw palmetto) for treating prostatic diseases such as benign prostatic hyperplasia and prostate cancer. The review highlights the plant's antiandrogenic, anti-inflammatory, and anti-proliferative activities, and its effectiveness and safety when used alone or in combination with other medicinal plants.
A phytosterol-enriched saw palmetto supercritical CO2 extract ameliorates testosterone-induced benign prostatic hyperplasia by regulating the inflammatory and apoptotic proteins in a rat model
The study compared the efficacy of β-sitosterol enriched saw palmetto oil (VISPO) and conventional saw palmetto oil (SPO) in a testosterone-induced benign prostatic hyperplasia (BPH) rat model. VISPO showed superior efficacy in reducing prostate weight, serum testosterone levels, and improving prostate tissue histology compared to SPO. VISPO also significantly regulated inflammatory and apoptotic proteins in BPH rats.
New Natural Pigment Fraction Isolated from Saw Palmetto: Potential for Adjuvant Therapy of Hepatocellular Carcinoma
The study explores the anti-tumor potential of a red pigmented aqueous fraction of Saw Palmetto, NYG, on human hepatocellular carcinoma using subcutaneous xenograft and orthotopic implantation models. NYG significantly inhibited tumor growth in a dose-dependent manner by reducing migration and vessel formation activities of endothelial cells, suggesting its potential as an adjuvant treatment for HCC.
Saw Palmetto Extract Inhibits Metastasis and Antiangiogenesis through STAT3 Signal Pathway in Glioma Cell
The study investigates the effects of saw palmetto extract on glioma cell metastasis and antiangiogenesis through the STAT3 signal pathway. Results indicate that saw palmetto extract inhibits glioma cell proliferation and angiogenesis, suggesting its potential as a phytotherapeutic agent against glioma.
Effect of saw palmetto extract on PI3K cell signaling transduction in human glioma
The study investigated the effect of saw palmetto extract on the PI3K/Akt signaling pathway in human glioma U87 and U251 cell lines. Saw palmetto extract decreased PI3K protein expression and increased p53 protein expression, leading to glioma cell growth arrest and apoptosis.
Fatty Acid and Phytosterol Content of Commercial Saw Palmetto Supplements
The study quantified the major fatty acids and phytosterols in 20 commercially available saw palmetto supplements using GC-FID and GC-MS. Liquid saw palmetto supplements contained significantly higher concentrations of total fatty acids and phytosterols compared to other supplement forms, suggesting they may be the best choice for individuals seeking high concentrations of these components.
Estudo exploratório da utilização de saw palmetto no tratamento da hiperplasia benigna da próstata por urologistas de Porto Alegre
Cross-sectional exploratory study assessing the prescription of saw palmetto for benign prostatic hyperplasia (BPH) by urologists in Porto Alegre, Brazil. Saw palmetto was not a primary choice for treating BPH, though most urologists were aware of it from scientific literature.
Fixed drug eruption to Serenoa repens: First case report and consideration of the use of herbal medicine
Case report of a 61-year-old male who developed fixed drug eruption (FDE) after taking Serenoa repens for benign prostatic hyperplasia. Symptoms resolved after discontinuation of the supplement, and a causality assessment indicated a probable link between S. repens and FDE.
PHYTOTHERAPY FOR INFLAMMATORY DISEASES OF THE PROSTATE
This literature review discusses the effectiveness of herbal medicine in treating inflammatory diseases of the prostate, focusing on Urtica dioica, Cucurbita moschata, Saw palmetto, and zinc. These substances are effective in treating chronic prostatitis and relieving lower urinary tract symptoms due to their anti-inflammatory, antiproliferative, antiandrogenic, and antioxidant actions.
ФИТОТЕРАПИЯ ПРИ ВОСПАЛИТЕЛЬНЫХ ЗАБОЛЕВАНИЯХ ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ
This narrative review discusses the effectiveness of herbal medicine in treating inflammatory diseases of the prostate, focusing on Urtica dioica, Cucurbita moschata, Saw palmetto, and zinc. These substances are effective in treating chronic prostatitis and relieving lower urinary tract symptoms due to their anti-inflammatory, antiproliferative, antiandrogenic, and antioxidant actions.
Adulteration of Saw Palmetto (Serenoa repens)
The bulletin provides information and updates on issues of adulteration of saw palmetto (Serenoa repens) relevant to the herbal industry and natural health communities.
Saw Palmetto, Serenoa repens, in the Treatment of Benign Prostatic Hyperplasia, Mechanisms of Action and Reasons for its Use
Narrative review of saw palmetto (Serenoa repens) for treating benign prostatic hyperplasia and other prostate-related conditions. Clinical trials show mixed results, but meta-analyses suggest effectiveness for benign prostatic hyperplasia. Discusses potential mechanisms involving inflammation reduction.
Acute pancreatitis with saw palmetto use: a case report
Case report of a 61-year-old man who developed acute pancreatitis possibly secondary to saw palmetto use. The patient had elevated lipase and amylase levels, and imaging showed pancreatic inflammation. His condition improved with treatment, and he was advised to avoid saw palmetto.
Comparison of finasteride (Proscar), a 5 alpha reductase inhibitor, and various commercial plant extracts in in vitro and in vivo 5 alpha reductase inhibition.
The study compared the 5 alpha reductase inhibitory activity of finasteride and various plant extracts, including Permixon, in vitro and in vivo. Finasteride inhibited 5 alpha reductase and decreased serum DHT in a human trial, while Permixon and other plant extracts did not show significant inhibitory activity.
Benign prostatic hyperplasia treated with saw palmetto: a literature search and an experimental case study.
The paper includes a literature search and an experimental case study on the use of saw palmetto extract (SPE) for treating benign prostatic hyperplasia (BPH). A 67-year-old man with symptomatic BPH showed improvement in AUASI scores after SPE administration, with prostate volume reduction from 92 mL to 75 mL. The study highlights the inadequacy of MEDLINE for herbal medicine research and suggests SPE's potential benefit for BPH.