Research
Sacha Inchi (Plukenetia volubilis)
10 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Effects of Sacha Inchi (Plukenetia volubilis L.) Oil Supplementation on Hyperglycaemia, Hypertension and Hyperlipidaemia (3Hs) Patients: A Preliminary Human Trial.
A randomized, double-blind, placebo-controlled trial investigated the effects of Sacha Inchi oil supplementation on 54 patients with hyperglycaemia, hypertension, and hyperlipidaemia. The SIO group showed significant reductions in systolic and diastolic blood pressure, total cholesterol, and LDL-C, with improved HDL-C levels, but no effect on glycaemic markers.
Disease aetiology-based design of multifunctional microemulsion eye drops for moderate or severe dry eye: a randomized, quadruple-masked and active-controlled clinical trial.
This randomized, quadruple-masked, active-controlled clinical trial assessed the safety and efficacy of sacha inchi microemulsion (SIME) eye drops in 64 adult patients with moderate or severe dry eye. SIME significantly improved tear film break-up time, ocular protection index, and reduced tear osmolarity, corneal and nasal conjunctival staining, conjunctival and lid redness. Both SIME and hyaluronic acid treatments decreased symptoms by about 25 OSDI units.
Evaluation of moisturizing and irritation potential of sacha inchi oil.
The study evaluated the moisturizing and irritation potential of sacha inchi oil compared to olive oil. In a clinical study with 13 volunteers, sacha inchi oil improved moisture content and skin dryness appearance, showing comparable effects to olive oil. The oil was mild to the skin and benefited dry skin.
Carbohydrate metabolism and gene expression of sirtuin 1 in healthy subjects after Sacha inchi oil supplementation: a randomized trial.
A double-blind randomized trial with 42 adult men studied the effects of Sacha inchi oil on postprandial glycemic state after meals rich in saturated fat. Sacha inchi oil addition attenuated glucose increase in 38.1% of participants and improved insulin sensitivity, with sirtuin-1 expression correlating with postprandial insulin sensitivity.
Metabolic status is related to the effects of adding of sacha inchi (Plukenetia volubilis L.) oil on postprandial inflammation and lipid profile: Randomized, crossover clinical trial.
A randomized crossover clinical trial evaluated the effects of Sacha inchi oil on postprandial lipids and inflammation in 20 metabolically healthy and 22 metabolically unhealthy subjects. Sacha inchi oil reversed cholesterol increase and decreased interleukin-6 concentration in the metabolically healthy group, and attenuated lipopolysaccharides increase and interleukin-6 expression in the metabolically unhealthy group.
Nitrogen balance after a single oral consumption of sacha inchi (Plukenetia volúbilis L.) protein compared to soy protein: a randomized study in humans.
This randomized study compared the nitrogen balance after a single consumption of 30g of sacha inchi flour versus 30g of soybean flour in 15 men and 15 women. The nitrogen balance was negative but similar between both groups, and no significant differences were observed in lipid profile or inflammatory markers. Plasma insulin levels increased post-prandial with similar changes in both groups.
A randomized, double-blind placebo-controlled study on acceptability, safety and efficacy of oral administration of sacha inchi oil (Plukenetia volubilis L.) in adult human subjects.
RCT assessing acceptability, safety, and efficacy of sacha inchi oil in 30 adults over 4 months. Acceptability increased significantly after week-1. No significant side-effects on hepatic and renal markers. Both sacha inchi and sunflower oils lowered total and LDL cholesterol, with sacha inchi oil also increasing HDL cholesterol.
Exposure of fatty acids after a single oral administration of sacha inchi (Plukenetia volubilis L.) and sunflower oil in human adult subjects.
The study evaluated the exposure of fatty acids after a single oral administration of sacha inchi or sunflower oil in 18 healthy volunteers. Sacha inchi oil increased plasma levels of ALA and DHA, while sunflower oil did not affect ALA levels. The maximal concentration of ALA was higher in women than in men.
[Effect of sacha inchi oil (plukenetia volúbilis l) on the lipid profile of patients with hyperlipoproteinemia].
Pilot, experimental study on the effect of sacha inchi oil on lipid profiles in 24 patients with hypercholesterolemia. Sacha inchi oil intake decreased total cholesterol and non-esterified fatty acids, and increased HDL levels. The 10 ml subgroup showed an increase in insulin levels.
Evaluation of Sacha Inchi (Plukenetia volubilis L.) By-Products as Valuable and Sustainable Sources of Health Benefits
The study investigates the nutritive values, antioxidant activities, phenolics, and in vitro health-related activities of sacha inchi husk and shell by-products. The husk showed higher protein, carbohydrates, and dietary fiber, while the shell had higher fat content and energy. The shell also exhibited greater total phenolic content and antioxidant activity compared to the husk.