Research
Rosmarinic Acid
21 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Microbiological and Clinical Short-Term Evaluation of the Efficacy of an Herbal Tincture as an Adjunctive Treatment in the Management of Stage II, Grade A Periodontitis.
RCT evaluating Tinctura paradentoica as an adjunct to non-surgical periodontal therapy in 60 patients with moderate periodontitis. The intervention group showed a significant reduction in periodontopathogenic microorganisms and short-term improvement in periodontal clinical parameters.
A phase II randomized, double-blind, placebo-controlled study of Nuvastatic (C50SEW505OESA), a standardized rosmarinic acid-rich polymolecular botanical extract formulation to reduce cancer-related fatigue in patients with solid tumors.
Phase II RCT evaluating Nuvastatic, a rosmarinic acid-rich botanical extract, in 110 cancer patients with solid tumors undergoing chemotherapy. The Nuvastatic group showed significant reductions in fatigue scores and improvements in quality of life compared to placebo.
Scalp condition improvement with botanical extracts possessing chemical and physical antioxidant activity.
The study investigated the antioxidant activity of botanical extracts, including rosemary extract, on scalp and hair health. Using ORAC and Nrf-2 assays, the extracts demonstrated antioxidant activity, reducing lipid oxidation in a consumer study with 56 participants.
Effects ofPhytosome on Sleep Quality: Results of a Prospective, Double-Blind, Placebo-Controlled, and Cross-Over Study.
Prospective, double-blind, placebo-controlled, cross-over study evaluating the effects of Phytosome™ (MOP) on sleep quality. The treated group showed a significant reduction in ISI score and improved sleep quality compared to placebo, suggesting Phytosome may be a natural alternative for insomnia treatment.
Effects of Continuous Intake of Rosemary Extracts on Mental Health in Working Generation Healthy Japanese Men: Post-Hoc Testing of a Randomized Controlled Trial.
Post-hoc analysis of a 4-week RCT on rosemary extract intake in working generation healthy Japanese men. Significant improvements were observed in mood states, fatigue, cognitive function, and sleep quality in the rosemary group compared to control.
Spearmint Extract Improves Working Memory in Men and Women with Age-Associated Memory Impairment.
Double-blind, placebo-controlled trial with 90 subjects with age-associated memory impairment. Supplementation with 900 mg/day spearmint extract improved working memory, sleep, and mood compared to placebo.
Safety and tolerability of a dried aqueous spearmint extract.
Double-blind, randomized, placebo-controlled trial evaluated the safety and tolerability of a dried aqueous spearmint extract standardized to rosmarinic acid in healthy adults with age-associated memory impairment. Ingestion of 600 and 900 mg/day for 90 days showed no significant effects on hormone levels or safety parameters, and no severe adverse events were reported.
Anti-inflammatory and anti-allergic effect of rosmarinic acid (RA); inhibition of seasonal allergic rhinoconjunctivitis (SAR) and its mechanism.
The study investigated the effects of oral supplementation with rosmarinic acid (RA) on seasonal allergic rhinoconjunctivitis (SAR) in a clinical trial and its anti-inflammatory mechanism in animal models. RA supplementation significantly decreased symptom responder rates and reduced neutrophil and eosinophil numbers in nasal lavage fluid compared to placebo. In animal models, RA showed anti-inflammatory activity by inhibiting neutrophil infiltration and reducing reactive oxygen radical production.
Anti-Cholinergic Effects of the Phenolic Extract from the Astragalus crenatus Plant: A Computational and Network Pharmacology Study
The study investigates the anti-cholinergic effects of the phenolic extract from Astragalus crenatus, identifying 21 compounds with LC-ESI-MS/MS. Hesperidin was found to be the most potent inhibitor of AChE and BChE, suggesting potential for Alzheimer's disease treatment.
Subcritical Water Extraction of Rosmarinic Acid from Lemon Balm (Melissa officinalis L.) and Its Effect on Plant Cell Wall Constituents
The study investigated subcritical water extraction (SWE) for recovering rosmarinic acid (RA) from lemon balm as an alternative to hydro-alcoholic extraction. SWE at 100 °C was as effective as 50% ethanol, but higher temperatures led to RA degradation. SWE increased extract yield by degrading plant material, suggesting its efficiency for extracting RA and other antioxidants for use in food supplements.
Effect of Spearmint Extract Containing Rosmarinic Acid on Physical and Executive Functioning After a Tactical Operation.
RCT examining the effect of spearmint extract containing rosmarinic acid on physical, cognitive, and executive functioning in elite counterterrorism operators after a tactical operation. Differences in physical and cognitive measures were unclear, but subjective feelings of energy, alertness, and focus were better for the spearmint extract group.
Impact of cooked functional meat enriched with omega-3 fatty acids and rosemary extract on inflammatory and oxidative status; a randomised, double-blind, crossover study.
A randomised, double-blind, crossover study assessed the effects of functional meat enriched with omega-3 fatty acids and rosemary extract on inflammatory and oxidative status in 33 subjects with CVD risk. The functional meat significantly improved markers like PAI-1, fibrinogen, and 8-iso-PGF2, suggesting benefits for oxidative and inflammatory status.
Effect of rosmarinic acid on atopic dermatitis.
RCT evaluating the effect of rosmarinic acid on atopic dermatitis in 21 subjects. Topical application of rosmarinic acid significantly reduced erythema and transepidermal water loss, and improved dryness, pruritus, and general AD symptoms over 8 weeks.
Extract of Perilla frutescens enriched for rosmarinic acid, a polyphenolic phytochemical, inhibits seasonal allergic rhinoconjunctivitis in humans.
This 21-day randomized, double-blind, placebo-controlled study evaluated the effects of Perilla frutescens extract enriched for rosmarinic acid on seasonal allergic rhinoconjunctivitis (SAR) in humans. The treatment significantly improved symptoms and reduced neutrophils and eosinophils in nasal lavage fluid compared to placebo, with no adverse events reported.
Absorption, metabolism, degradation and urinary excretion of rosmarinic acid after intake of Perilla frutescens extract in humans.
This study investigated the absorption, metabolism, and urinary excretion of rosmarinic acid (RA) in six healthy men after a single intake of Perilla frutescens extract containing 200 mg RA. RA and its metabolites were detected in plasma and urine, with a small proportion being excreted in the urine within 6 hours.
The dietary phytochemicals carnosic acid and sulforaphane regulate inflammatory markers in ulcerative colitis patient-derived colonoids
The study evaluated the anti-inflammatory potential of carnosic acid and sulforaphane in ulcerative colitis patient-derived colonoids. Both phytochemicals decreased inflammatory markers and promoted NRF2 activity, suggesting their potential as complementary therapies for ulcerative colitis.
The Stimulating Effect of Rosmarinic Acid and Extracts from Rosemary and Lemon Balm on Collagen Type I Biosynthesis in Osteogenesis Imperfecta Type I Skin Fibroblasts
In vitro study evaluating the effect of rosmarinic acid and extracts from rosemary and lemon balm on collagen type I biosynthesis in osteogenesis imperfecta type I skin fibroblasts. The study found that both extracts and rosmarinic acid significantly increased collagen type I levels, with lemon balm extract showing a greater effect likely due to higher rosmarinic acid content.
Protective Effect and Mechanism of Action of Rosmarinic Acid on Radiation-Induced Parotid Gland Injury in Rats
The study investigates the protective effects of rosmarinic acid (RA) on radiation-induced parotid gland injury in rats. RA treatment significantly reduced oxidative stress, apoptosis, and fibrosis in the parotid glands, showing potential as a therapeutic radioprotective agent.
A pilot trial evaluating Meta050, a proprietary combination of reduced iso-alpha acids, rosemary extract and oleanolic acid in patients with arthritis and fibromyalgia.
Open-label, 8-week observational trial of Meta050, a combination of reduced iso-alpha acids, rosemary extract, and oleanolic acid, in patients with arthritis and fibromyalgia. Significant pain reduction was observed in arthritis patients, but not in fibromyalgia patients. A decreasing trend in C-reactive protein was noted in subjects with elevated levels.
Rosmarinic Acid–Human Pharmacokinetics and Health Benefits
Narrative review of rosmarinic acid's pharmacokinetics and health benefits. Discusses its metabolism, elimination, and positive effects on dermatological, allergic, osteoarthritic disorders, cognitive performance, and metabolic syndrome.
Effect of Rosmarinic Acid on the Serum Parameters of Glucose and Lipid Metabolism and Oxidative Stress in Estrogen-Deficient Rats
The study investigated the effect of rosmarinic acid on glucose and lipid metabolism and oxidative stress in estrogen-deficient rats. Rosmarinic acid decreased fructosamine concentration and HOMA-IR, increased reduced glutathione concentration, and decreased advanced oxidation protein products. At 50 mg/kg, it also decreased total cholesterol and triglyceride concentrations, suggesting potential benefits in preventing metabolic disorders associated with estrogen deficiency.