Research
Rhubarb Root (Rheum palmatum)
11 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Optimized therapeutic potential of Yinchenhao decoction for cholestatic hepatitis by combined network meta-analysis and network pharmacology.
This meta-analysis and network pharmacology study evaluated the therapeutic potential of Yinchenhao decoction (YCHD) for cholestatic hepatitis. The study identified optimal ingredient ratios for efficacy and safety, highlighting Artemisia capillaris' role in modulating the IL-17 signaling pathway. The analysis revealed mixed effects, with potential hepatotoxicity risks from Gardenia jasminoides and Rheum palmatum.
[Effects of Yiqi Huoxue Jiedu formula on the gut microbiota in elderly patients with pulmonary-derived sepsis based on 16S rDNA sequencing: a multicenter prospective randomized double-blind controlled trial].
A multicenter prospective randomized double-blind controlled trial investigated the effects of Yiqi Huoxue Jiedu formula on gut microbiota in elderly patients with pulmonary-derived sepsis. The study found alterations in intestinal microbiota structure, with significant changes in specific microbial taxa compared to the control group.
Constipation Mitigation by Rhubarb Extract in Middle-Aged Adults Is Linked to Gut Microbiome Modulation: A Double-Blind Randomized Placebo-Controlled Trial.
Double-blind randomized placebo-controlled trial investigating rhubarb extract supplementation in middle-aged adults with chronic constipation. The study found that rhubarb extract improved stool frequency, consistency, and other constipation symptoms, and promoted butyrate-producing bacteria and short-chain fatty acids, contributing to gut health.
Prospective multicenter clinical trial of Chinese herbal formula JZQG (Jiangzhuoqinggan) for hypertension.
A prospective multicenter clinical trial compared the effects of the Chinese herbal formula Jiangzhuoqinggan (JZQG) and the antihypertension drug irbesartan in 240 patients with mild to moderate hypertension. The JZQG group showed significant reductions in systolic and diastolic blood pressure and waist circumference, suggesting therapeutic value for hypertension and metabolic syndrome.
[Application of dannang recipe no. 2 in the perioperative stage of laparoscopic cholecystectomy].
RCT of 360 patients undergoing laparoscopic cholecystectomy comparing Dannang Recipe No. 2 (DNR2) to antibiotics. DNR2 group showed shorter recovery times for gastrointestinal motility and better outcomes in other recovery indexes, except for similar incidence of postoperative infectious complications.
[Effect of Rhubarb Combined Medicinal Activated Carbon on Levels of Serum Phosphorus, Calci- um-Phosphorus Product, and Parathyroid Hormone in Hemodialysis Patients with Hyperphosphatemia].
RCT of 126 hemodialysis patients with hyperphosphatemia comparing rhubarb combined with medicinal activated carbon to medicinal activated carbon alone. The treatment group showed a significant reduction in serum phosphorus, calcium-phosphorus product, and parathyroid hormone levels from week 2 to 8, with fewer gastrointestinal side effects compared to the control group.
Chinese herbal medicine for obesity: a randomized, double-blinded, multicenter, prospective trial.
This randomized, double-blinded, multicenter trial evaluated the safety and effectiveness of the TCM herbal formulation xin-ju-xiao-gao-fang (XJXGF) in 140 obese subjects over 24 weeks. The XJXGF group showed significant reductions in body weight and insulin resistance compared to the low-dose control group, with no serious adverse events reported.
Effects of rhubarb extract on radiation induced lung toxicity via decreasing transforming growth factor-beta-1 and interleukin-6 in lung cancer patients treated with radiotherapy.
RCT investigating the effects of rhubarb extract on radiation induced lung toxicity (RILT) in lung cancer patients undergoing radiotherapy. The trial group receiving rhubarb extract showed significantly lower incidence of RILT and improved pulmonary function compared to the control group, likely due to decreased levels of TGF-beta1 and IL-6.
Combined herbal preparation for topical treatment of Herpes labialis.
RCT comparing the efficacy of a combined topical preparation with rhubarb and sage extracts, a single-agent sage cream, and Zovirax cream in 145 patients with herpes labialis. The rhubarb-sage cream showed similar effectiveness to aciclovir cream and was more effective than the sage cream alone in reducing pain.
Some parameters of hydroponic and soil Rhubarb cultivated in the Ararat Valley of Armenia
The study investigates the cultivation of rhubarb in hydroponic and soil conditions in the Ararat Valley of Armenia, focusing on growth period optimization for quality indicators like Brix value, juice density, total titratable acidity, and vitamin C content. Hydroponic cultivation increased rhubarb petiole weight and influenced vitamin C content and acidity profile throughout the growing season.
Pharmacokinetic of rhein in healthy male volunteers following oral and retention enema administration of rhubarb extract: a single dose study.
Prospective crossover study comparing pharmacokinetic parameters of rhein in rhubarb extract administered orally versus retention enema in 8 healthy male volunteers. Oral administration resulted in higher C(max), AUC(0-infinity), and AUMC compared to retention enema, while V(d) was lower. No significant differences in other pharmacokinetic parameters were observed.