Research
Rhodiola Rosea
98 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Rhodiola rosea supplementation on sports performance: A systematic review of randomized controlled trials.
Systematic review of 13 RCTs with 263 participants assessing Rhodiola rosea supplementation on muscle damage and physical performance. Acute supplementation showed positive effects on endurance performance and perceived exertion, while chronic supplementation improved anaerobic performance and may reduce muscle damage. Results were heterogeneous, with some studies showing no effect.
Effects of Rhodiola Rosea Supplementation on Exercise and Sport: A Systematic Review.
Systematic review of 10 studies evaluating Rhodiola rosea supplementation for exercise and sport. Most studies reported positive effects on athletic ability, sports performance, reduction in pain and muscle damage, improved antioxidant capacity, and enhanced athletic explosive power.
Preclinical Evidence and Possible Mechanisms of Rhodiola rosea L. and Its Components for Ischemic Stroke: A Systematic Review and Meta-Analysis
Systematic review and meta-analysis of preclinical studies evaluating Rhodiola rosea L. and its components (RRC) on ischemic stroke in animal models. RRC improved neural functional deficit scores, infarct volume, brain edema, cell viability, and reduced apoptotic markers, suggesting neuroprotective effects through antioxidant, anti-apoptosis, and anti-inflammatory mechanisms.
Rhodiola rosea L. Improves Learning and Memory Function: Preclinical Evidence and Possible Mechanisms
Systematic review and meta-analysis of 36 preclinical studies involving 836 animals assessing Rhodiola rosea's effects on learning and memory function. Results showed significant improvements in learning and memory, with mechanisms including antioxidant, cholinergic regulation, anti-apoptosis activities, anti-inflammatory effects, and improved cerebral metabolism.
Combined effects of Rhodiola rosea and caffeine supplementation on aerobic endurance and muscle explosiveness: a synergistic approach
This study examined the synergistic effects of Rhodiola rosea and caffeine supplementation on muscle endurance and explosiveness in SD rats and human subjects. The RHO+CAF group showed significantly greater effects on aerobic endurance and muscle explosiveness compared to RHO or CAF alone. Improvements were observed in VO2max, running, and jumping performance in both untrained and trained individuals.
Rhodiola rosea for physical and mental fatigue: a systematic review.
Systematic review of 11 studies on Rhodiola rosea for physical and mental fatigue. Some evidence suggests effectiveness, but methodological flaws and high risk of bias limit accurate assessment of efficacy.
[Three preparations of compound Chinese herbal medicines for de-adaptation to high altitude: a randomized, placebo-controlled trial].
RCT of 543 soldiers experiencing de-adaptation symptoms after high-altitude missions, testing Sankang Capsule, Rhodiola Rosea Capsule, and Shenqi Pollen Capsule against placebo. All three herbal preparations improved symptoms, with Shenqi Pollen Capsule showing the highest efficacy.
The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials.
Systematic review of 11 RCTs assessing the efficacy of Rhodiola rosea on physical performance, mental performance, and mental health conditions. The review suggests potential benefits, though more independent replications are needed.
The Effect of Short-Term Rhodiola rosea Supplementation on Simulated Game Time, Perceived Fatigue, and Performance in Basketball Players
RCT of 48 professional male basketball players evaluating short-term Rhodiola rosea supplementation. The Rhodiola group showed significant improvements in simulated game performance, aerobic capacity, and reduced perceived fatigue compared to the control group.
Effects of the Combined Supplementation of Caffeine and Rhodiola Rosea with Resistance Training on Lower Limb Explosive Power in Male Volleyball Players.
RCT investigating the effects of combined Rhodiola rosea and caffeine supplementation on lower limb explosive power and fatigue recovery in 48 male volleyball players. The combined supplementation group showed significant improvements in jump height, reduced power decline during high-frequency jumps, and lower perceived fatigue compared to other groups.
Can Rhodiola rosea supplementation mitigate digital eye strain? A triple-blinded placebo-controlled study.
Triple-blind, placebo-controlled crossover study with 18 young adults assessing Rhodiola rosea supplementation on digital eye strain (DES) symptoms and accommodative response. RR supplementation reduced variability of accommodation and one DES symptom, but did not affect the lag of accommodation or other DES symptoms.
The Impact of Rhodiola Rosea Extract on Strength Performance in Alternative Bench-Press and Bench-Pull Exercises Under Resting and Mental Fatigue Conditions: A Randomized, Triple-Blinded, Placebo-Controlled, Crossover Trial.
This randomized, triple-blinded, placebo-controlled, crossover trial explored the effects of four days of Rhodiola Rosea supplementation on bench-press and bench-pull exercises under resting or mental fatigue conditions in 18 young healthy individuals. Rhodiola Rosea was significantly superior to placebo in increasing strength performance during some sets, particularly in the control video condition, while having trivial-to-small effects on mental fatigue and visuo-cognitive processing.
Immediate and residual effects of functional chewing gum on sustained attention and mood.
RCT comparing functional gum containing Rhodiola rosea and B-vitamins to regular and placebo gum in 36 healthy young participants. Chewing both functional and regular gum reduced errors on a digit vigilance task compared to placebo, but there were no additional benefits from the functional ingredients.
Dose-Response Effects of Short-Term Rhodiola rosea Supplementation on Anaerobic Exercise Performance in Resistance-Trained Athletes: A Randomized, Crossover, Double-Blind, and Placebo-Controlled Study
This randomized, crossover, double-blind, placebo-controlled study investigated the effects of short-term Rhodiola rosea supplementation on anaerobic exercise performance in 27 resistance-trained athletes. Both low and high doses of Rhodiola rosea significantly enhanced strength and endurance compared to baseline and placebo, particularly in bench press and leg press exercises. However, metrics such as peak power and average velocity remained unchanged.
The Acute Effects of a Multi-Ingredient Herbal Supplement on Performance Fatigability: A Double-Blind, Randomized, and Placebo-Controlled Trial.
This double-blind, randomized, placebo-controlled trial examined the acute effects of an herbal supplement containing Rhaponticum carthamoides and Rhodiola rosea on performance fatigability and affective responses in 30 men. The study found no significant effect on performance fatigability, but participants reported improved mood and arousal following testing.
[Effects of rhodiola rosea on oxidative stress and negative emotional states in patients with obstructive sleep apnea].
RCT investigating the effects of rhodiola rosea on oxidative stress, anxiety, and depression in 90 patients with obstructive sleep apnea. Rhodiola rosea combined with non-invasive ventilation improved anxiety and depression scores compared to non-invasive ventilation alone, while rhodiola alone increased these scores. Serum SOD levels increased and MDA levels decreased in all groups after treatment.
The Effects of Rhodiola rosea L. Extract on Anxiety, Stress, Cognition and Other Mood Symptoms.
This trial evaluated the impact of Rhodiola rosea L. extract on anxiety, stress, cognition, and mood symptoms in 80 mildly anxious participants. The Rhodiola group showed significant reductions in anxiety, stress, anger, confusion, and depression, and improvements in total mood over 14 days compared to controls. No differences in cognitive performance were observed.
Rhodiola rosea versus sertraline for major depressive disorder: A randomized placebo-controlled trial.
Phase II randomized placebo-controlled trial comparing Rhodiola rosea to sertraline and placebo in 57 subjects with mild to moderate major depressive disorder. Rhodiola rosea showed modest, non-significant reductions in depression scores and fewer adverse events compared to sertraline, suggesting a more favorable risk to benefit ratio.
Changes of cytokines during a spaceflight analog--a 45-day head-down bed rest.
A 45-day head-down bed rest study examined immune cell distribution and function changes in response to microgravity analog. Rhodiola rosea treatment decreased IFN-γ levels and slowed IL-1 cytokine upregulation, suggesting a role in suppressing proinflammatory cytokines but not boosting protective T cell immunity.
Protective effects of salidroside on epirubicin-induced early left ventricular regional systolic dysfunction in patients with breast cancer.
RCT of 60 breast cancer patients assessing salidroside's protective effects against epirubicin-induced cardiotoxicity. Salidroside normalized strain rate at higher epirubicin doses and prevented increases in reactive oxygen species, indicating a protective effect on early left ventricular regional systolic dysfunction.
Neuroimmunomodulatory compound for sensitive skin care: in vitro and clinical assessment.
A double-blind RCT on 124 volunteers with sensitive skin tested a formulation containing 1% Rhodiola rosea extract and L-carnosine (RCAC) against placebo. RCAC improved skin barrier function, reduced transepidermal water loss, and enhanced skin comfort. In vitro studies showed RCAC modulated neuropeptides and cytokines production in keratinocytes under UV stress.
A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue.
RCT of 60 individuals with stress-related fatigue comparing SHR-5 extract of Rhodiola rosea to placebo. The SHR-5 group showed significant improvements in fatigue symptoms, mental performance, and cortisol response to awakening stress compared to placebo.
Efficacy and tolerability of a Rhodiola rosea extract in adults with physical and cognitive deficiencies.
A 12-week study tested the efficacy and safety of Rhodiola rosea extract combined with vitamins and minerals in 120 adults with physical and cognitive deficiencies. Significant improvements in physical and cognitive symptoms were observed, with better results in the group taking 2 capsules after breakfast compared to 1 capsule after breakfast and 1 after lunch. The treatment was rated as 'very good' or 'good' by 81% of patients and physicians, with no adverse events reported.
Impact of Chisan (ADAPT-232) on the quality-of-life and its efficacy as an adjuvant in the treatment of acute non-specific pneumonia.
A double-blind, placebo-controlled RCT of Chisan (ADAPT-232) as an adjuvant in treating acute non-specific pneumonia in 60 patients. Chisan reduced the duration of antibiotic therapy by 2 days and improved quality-of-life and mental performance compared to placebo.
A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work.
A randomized, double-blind, placebo-controlled study on 161 cadets tested the effect of SHR-5 Rhodiola rosea extract on mental work capacity under fatigue and stress. Both doses showed a significant antifatigue effect compared to placebo, with no significant difference between the two doses.
Rhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty.
Double-blind cross-over study of 56 healthy physicians examining the effect of low-dose Rhodiola rosea extract (RRE) on fatigue during night duty. Statistically significant improvements in mental performance tests were observed in the RRE group, suggesting reduced general fatigue under stress.
[The effect of the preparation rodakson on the psychophysiological and physical adaptation of students to an academic load].
RCT evaluating the effect of rhodaxon, based on Rhodiola rosea extract, on foreign students' physical and intellectual capacity and psychoemotional state during study. Rhodaxon increased veloergometric work, kinesthesiometric sensitivity, general condition, and decreased psychic fatigue and situational anxiety.
A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen.
Double-blind, placebo-controlled pilot study of Rhodiola rosea extract SHR-5 on foreign students during a stressful examination period. Significant improvements were observed in physical fitness, mental fatigue, and neuro-motoric tests in the SHR-5 group compared to placebo, although the dose level was considered suboptimal.
Study on the activity of targeted delivery of DOX against melanoma by exosome-like nanovesicles of Rhodiola rosea.
The study constructs an engineering system using exosome-like nanovesicles of Rhodiola rosea (RELNs) to deliver Doxorubicin (DOX) for targeted melanoma treatment. The pYEEIE-RELNs-DOX system showed better inhibitory effects on melanoma cell proliferation and improved targeting compared to DOX alone.
STUDY OF ANTIOXIDANT ACTIVITY OF RHODIOLA ROSEA EXTRACTS (RHODIOLA ROSEA L.)
The study investigates the antioxidant and antibacterial activities of Rhodiola rosea extracts, including dry capsulated food extract and supercritical fluid CO2-extract. The extracts contain polyphenols, flavonoids, glycosides, phytosteroids, and terpenoids. The dry extract shows greater antiradical activity, while the CO2-extract has a higher content of polyphenolic compounds. No antibacterial activity was found, and the CO2-extract does not adversely affect mononuclear cell viability.
Phenolic compounds from the aerial parts of Rhodiola rosea in Japan, and their antioxidant activity and chemical adaptation to alpine environment
The study isolated and identified twelve flavonoids, ten galloylglucoses, and three phenolic acids from Rhodiola rosea in Japan. Antioxidant activity was measured, with two flavonols showing the strongest activity. The paper also discusses the chemical adaptation of R. rosea to alpine environments.
Studies on the biological activity of different populations of the medicinal plant Rhodiola rosea L. (golden root)
The study analyzed the phytochemical composition and biological activity of Rhodiola rosea from Kazakhstan Altai and Austrian Alps. It found high percentages of cinnamyl alcohol and tyrosol in the roots, with antioxidant activity and cytotoxicity against Artemia salina larvae. The essential oil showed low antioxidative activity compared to BHA.
Effects of short-term Rhodiola Rosea (Golden Root Extract) supplementation on anaerobic exercise performance.
This study examined the effects of short-term Rhodiola Rosea supplementation on anaerobic exercise performance in 11 physically active college-aged females. The GRE treatment improved mean watts, anaerobic capacity, anaerobic power, peak watts, and total work during repeated Wingate Anaerobic Tests compared to placebo, suggesting ergogenic benefits for anaerobic performance.
Influence of Rhodiola rosea on the heat acclimation process in young healthy men.
RCT investigating the effect of Rhodiola rosea on heat acclimation in 20 young healthy men. The study found that Rhodiola rosea had no beneficial performance, physiological, or perceptual effects during the heat acclimation process.
Effects of Rhodiola rosea supplementation on mental performance, physical capacity, and oxidative stress biomarkers in healthy men
RCT of 26 healthy male students receiving 600 mg/day Rhodiola rosea or placebo for 4 weeks. Rhodiola rosea improved reaction time and increased the number of correct responses in psychomotor tests but did not affect endurance exercise capacity or hormonal profile. It raised plasma total antioxidant capacity.
Effect of commercial Rhodiola rosea on CYP enzyme activity in humans.
Randomized cross-over study in 13 healthy volunteers evaluating the effect of Rhodiola rosea on CYP enzyme activity. R. rosea pretreatment resulted in a 21% decrease in the EXP-3174/losartan ratio, indicating reduced CYP2C9 metabolic activity. No significant effects were observed for other CYP enzymes.
Rhodiola rosea for mental and physical fatigue in nursing students: a randomized controlled trial.
RCT of 48 nursing students on shift work comparing 364 mg Rhodiola rosea to placebo over 42 days. Rhodiola rosea worsened fatigue compared to placebo, with significant differences in Vitality-subscale and VAS-F scores favoring placebo.
Evaluation of Rhodiola rosea supplementation on skeletal muscle damage and inflammation in runners following a competitive marathon.
RCT of 48 experienced marathon runners assessing the effects of 600mg/day Rhodiola rosea supplementation for 30 days on muscle damage, DOMS, and inflammation post-marathon. The study found no significant differences between the Rhodiola rosea and placebo groups in muscle function, muscle damage, DOMS, or plasma cytokines.
Double-blind, placebo-controlled, randomised study of single dose effects of ADAPT-232 on cognitive functions.
Double-blind, placebo-controlled, randomised study assessing the effect of a single dose of ADAPT-232 on cognitive functions in 40 healthy females under stress. The ADAPT-232 group showed significant improvements in attention, speed, and accuracy during cognitive tasks compared to placebo.
Effects of chronic Rhodiola Rosea supplementation on sport performance and antioxidant capacity in trained male: preliminary results.
RCT investigating chronic Rhodiola Rosea supplementation in 14 trained male athletes. The study found no significant effect on physical performance parameters like HR Max and VO2 max, but a reduction in plasma free fatty acids, blood lactate, and creatine kinase levels. Antioxidant status and inflammatory parameters were unaffected.
The influence of adaptogens on ultraweak biophoton emission: a pilot-experiment.
Randomized double-blind placebo-controlled study with 30 subjects assessing the effect of Rhodiola rosea and ADAPT-232 on ultra-weak photon emission and fatigue. Rhodiola rosea significantly decreased photon emission and fatigue levels compared to placebo, while ADAPT-232 showed no significant changes.
The influence of supplementation with Rhodiola rosea L. extract on selected redox parameters in professional rowers.
Double-blinded RCT with 22 professional rowers investigating Rhodiola rosea supplementation on redox balance. The supplemented group showed significantly higher total plasma antioxidant capacity and lower superoxide dismutase activity compared to placebo, indicating increased antioxidant levels but no effect on oxidative damage from exercise.
A pilot study of Rhodiola rosea (Rhodax) for generalized anxiety disorder (GAD).
Pilot study of 10 participants with generalized anxiety disorder receiving 340 mg of Rhodiola rosea extract daily for 10 weeks. Significant decreases in mean HARS scores were observed, indicating improvement in GAD symptoms.
Failure of Rhodiola rosea to alter skeletal muscle phosphate kinetics in trained men.
RCT with 12 resistance-trained men examining the effect of Rhodiola rosea on skeletal muscle phosphocreatine recovery after exhaustive exercise. No significant differences were found between Rhodiola rosea and placebo groups in ATP turnover or exercise performance metrics.
Acute Rhodiola rosea intake can improve endurance exercise performance.
A double-blind placebo-controlled randomized study investigated the effects of acute and 4-week Rhodiola rosea intake on physical performance. Acute intake increased time to exhaustion, VO2peak, and VCO2peak, indicating improved endurance exercise capacity. Four-week intake did not alter these variables.
Rhodiola rosea L. roots powder strongly reduces anxiety and corticosterone level induced by chronic stress in a murine model
This study investigated the adaptogenic effects of Rhodiola rosea root powder on stress-induced behavioral and physiological changes in a murine model of chronic mild stress. Mice receiving Rhodiola rosea supplementation showed significant improvements in anxiety-related behaviors and reduced serum corticosterone levels, supporting its anxiolytic and adaptogenic properties.
Components of Panax ginseng and Rhodiola rosea regulate mitophagy via the SIRT1/3-PGC-1α-NRF2 pathway to improve myocardial ischemia-reperfusion injury.
The study investigates the cardioprotective effects of a combination of ginsenoside Rg1 and salidroside (PRC) against myocardial ischemia-reperfusion injury (MIRI) in an in vivo rat model and an in vitro H9c2 cardiomyocyte model. PRC was found to reduce infarct size, improve mitochondrial function, and attenuate oxidative stress by activating the SIRT1/3-PGC-1α-NRF2 pathway and modulating mitophagy.
Revealing the Antidepressant Mechanism of Rhodiola rosea via Network Pharmacology: Integrated Molecular Docking and Dynamics Simulation Validation.
The study explores the antidepressant mechanism of Rhodiola rosea using network pharmacology, molecular docking, and dynamics simulation. It identifies bioavailable compounds in R. rosea that target depression-related pathways and confirms its effect on the serotonergic system via ESR1 in CORT-induced HT-22 cells.
Comprehensive profiling of Rhodiola rosea roots and corresponding products: phytochemical insights and modulation of neuroinflammation in BV2 microglial cell model
The study performed a phytochemical analysis of 13 dietary supplements claiming to contain Rhodiola rosea using HPTLC and LC-MS techniques. It found that nearly 60% of the tested preparations did not contain the declared amount of Rhodiola rosea or its marker compounds. Rosavin, a key compound, significantly inhibited IL-6 and TNF-α secretion in LPS-stimulated microglial cells, indicating anti-inflammatory activity.
Hong-Bai-Lan-Shen Extract Alleviates the CoCl2-Induced Apoptosis in H9C2 Cells by Regulating the AMPK Pathway
The study investigates the protective mechanism of Hong-bai-lan-shen extract on H9C2 myocardial cells, focusing on its ability to alleviate CoCl2-induced apoptosis by regulating the AMPK pathway. The research aims to provide a theoretical basis for the development of new drugs and understanding the mechanism of traditional Chinese medicine in animal heart health.
Structural characterization and anti-tumor mechanisms of an arabinan polysaccharide isolated from Rhodiola rosea.
The study isolated and characterized an arabinan polysaccharide, HJBP85-1, from Rhodiola rosea rhizomes. In vivo experiments using a zebrafish xenograft model showed that HJBP85-1 significantly inhibited tumor progression, with inhibition rates of up to 93% for tumor proliferation and 85% for metastasis. The polysaccharide exhibited anti-tumor effects by inhibiting tumor cell migration and angiogenesis, and modulating the immune response.
Multi-level fingerprint and immune activity evaluation of polysaccharides from Rhodiola rosea L.
The study established a polysaccharide-based quality control method for Rhodiola rosea L., identifying key markers for differentiating its origin. It found that Rhodiola rosea L. polysaccharides with specific characteristics displayed higher immune activity in vitro.
Rhodiola rosea Stimulates Brain Microcirculation in Rats with Hypoxic Brain Injury at High Altitude
Animal study evaluating the protective effects of Rhodiola rosea on brain microcirculation and oxidative stress in rats with hypoxic brain injury at high altitude. Rhodiola rosea enhanced antioxidant enzyme activities and improved cerebral blood flow, suggesting protective effects on brain health.
Mixture of Rhodiola rosea and Nelumbo nucifera Extracts Ameliorates Sleep Quality of Adults with Sleep Disturbance
Study investigated the efficacy of a compound derived from Rhodiola rosea and Nelumbo nucifera extracts (RNE) in improving sleep quality in adults with subthreshold insomnia. Participants took 750 mg of RNE daily for two weeks, showing significant improvements in sleep quality and overall wellbeing without significant side effects.
Exploring the anti‑oxidative mechanisms of Rhodiola rosea in ameliorating myocardial fibrosis through network pharmacology and in vitro experiments
The study used network pharmacology and in vitro assays to explore the anti-oxidative mechanisms of Rhodiola rosea in ameliorating myocardial fibrosis. Salidroside, a principal component, was validated in H9c2 cardiomyocytes, showing dose-dependent effectiveness in reversing myocardial fibrosis by modulating multiple molecular targets and signaling pathways.
Rhodiola rosea L. improved intestinal digestive enzyme activities, inflammatory response, barrier and microbiota dysbiosis in Lateolabrax maculatus juveniles fed with high-carbohydrate diets.
A 56-day feeding trial evaluated the effects of Rhodiola rosea L. on digestive enzyme activities, intestinal barrier, inflammatory response, and microbiota dysbiosis in Lateolabrax maculatus juveniles fed high-carbohydrate diets. Rhodiola rosea L. supplementation improved intestinal health markers and reduced inflammation, with 0.6 mg/kg being the optimal dose.
Elucidating the role of Rhodiola rosea L. in sepsis-induced acute lung injury via network pharmacology: emphasis on inflammatory response, oxidative stress, and the PI3K-AKT pathway
The study investigates the molecular mechanisms of Rhodiola rosea against sepsis-induced acute lung injury using network pharmacology and molecular docking. Rhodiola rosea was found to inhibit inflammation, oxidative stress, cell apoptosis, and PI3K-AKT activation in lipopolysaccharide-stimulated HUVECs and ALI mice.
Controlled Cultivation Confers Rhodiola rosea Synergistic Activity on Muscle Cell Homeostasis, Metabolism and Antioxidant Defense in Primary Human Myoblasts
In vitro study on human skeletal myoblasts showing that Rhodiola rosea extract modulates transcription factors involved in muscle differentiation and recovery. The extract promotes ROS scavenging, ATP production, and mitochondrial respiration, contributing to muscle repair and recovery.
Salidroside exerts anti-tumor effects in ovarian cancer by inhibiting STAT3/c-Myc pathway-mediated glycolysis
The study investigates the anti-tumor effects of salidroside on ovarian cancer cells by inhibiting the STAT3/c-Myc pathway-mediated glycolysis. Salidroside reduced cell viability, clone formation, migration, and invasion, and induced apoptosis in ovarian cancer cells. It also decreased glucose consumption, lactate and ATP production, and extracellular acidification rate, showing good binding activity with STAT3 and c-Myc.
Mechanism and Experimental Verification of Rhodiola rosea L. for the Treatment of Acute Lung Injury Through Network Pharmacology and Molecular Docking
The study investigates the bioactive elements and mechanisms of Rhodiola rosea L. for treating acute lung injury using network pharmacology and in vivo validation. Kaempferol was identified as a major component, showing good binding ability to key receptors and reducing inflammatory cytokines in ALI rats.
Investigating the Effects and Mechanism of Rhodiola Rosea Injection on Cardiac Function in Rats with Chronic Heart Failure.
The study investigated the effects of Rhodiola rosea injection on cardiac function and the renin-angiotensin-aldosterone system in a rat model of chronic heart failure. Results showed that Rhodiola rosea injection improved cardiac function, reduced plasma levels of certain miRNAs and BNP, and restored RASS indexes to normal levels.
Food Supplements for Skin Health: In Vitro Efficacy of a Combination of Rhodiola rosea, Tribulus terrestris, Moringa oleifera and Undaria pinnatifida on UV-Induced Damage
In vitro study of Venerinase®, a combination of Rhodiola rosea, Tribulus terrestris, Moringa oleifera, Undaria pinnatifida, folic acid, and vitamin B12, on UV-induced skin damage. The product prevented UV-induced morphological changes and inhibited senescence-related and proinflammatory pathways.
Mechanism of Rhodiola rosea–Euonymus alatus drug pair against rheumatoid arthritis: Network pharmacology and experimental validation
The study explores the potential components and mechanisms of the Rhodiola rosea–Euonymus alatus drug pair in ameliorating rheumatoid arthritis using network pharmacology and experimental validation.
Phytochemical Profiles, Antioxidant Activity and Antiproliferative Mechanism of Rhodiola rosea L. Phenolic Extract
The study analyzed the phenolic profiles, antioxidant activity, and antiproliferative mechanisms of Rhodiola rosea phenolic extract. Rhodiola rosea rhizome free phenolic extract (RFE) showed higher phenolic content and stronger antioxidant activity compared to bound phenolic extract (RBE). RFE and its main compounds exhibited antiproliferative activity, inducing cell apoptosis and cell cycle arrest via the p53 signaling pathway.
Rhodiola rosea Reduces Intercellular Signaling in Campylobacter jejuni
The study investigated the antimicrobial activity of Rhodiola rosea extracts against Campylobacter jejuni, focusing on AI-2-mediated intercellular signaling. Fractions rich in proanthocyanidins and flavonoids showed strong antimicrobial effects, with significant reductions in bioluminescence and low minimal inhibitory concentrations.
EXPERIMENTAL STUDY OF THE EFFECT OF RHODIOLA ROSEA L. ON THE HEMOTOLOGICAL BLOOD ANALYSIS OF OBESE MALE RATS
The study investigated the effect of Rhodiola rosea root alcohol extract on hematological blood analysis in obese male rats. Results showed that the extract provided significant protection against oxidative damage in erythrocytes and influenced hematological parameters, suggesting potential benefits in managing obesity-related hematopoietic pathology.
Rhodiola rosea polysaccharides promote the proliferation of bone marrow haematopoietic progenitor cells and stromal cells in mice with aplastic anaemia
The study investigated the effects of Rhodiola rosea polysaccharides (RRPs) on haematopoiesis in mice with aplastic anaemia. High-dose RRPs significantly increased red and white blood cells, bone marrow stromal cells, and the formation of various colony-forming units, indicating a promotion of haematopoietic recovery.
Rhodiola rosea L. Attenuates Cigarette Smoke and Lipopolysaccharide-Induced COPD in Rats via Inflammation Inhibition and Antioxidant and Antifibrosis Pathways
The study evaluated the effects of Rhodiola rosea L. extract on COPD in rats induced by cigarette smoke and lipopolysaccharide. The extract improved lung tissue structure, reduced inflammation and oxidative stress, and modulated signaling pathways related to inflammation and fibrosis.
GC-MS analysis of the lipophilic compounds of medicinal plant Rhodiola rosea L.
Phytochemical study of Rhodiola rosea conducted in Kazakhstan, identifying 28 compounds in its composition. The study highlights the adaptogenic, antioxidant, antidepressant, and immunomodulatory properties of Rhodiola rosea.
Systems pharmacology approach to investigate the molecular mechanisms of herb Rhodiola rosea L. radix
The paper uses a systems pharmacology approach to investigate the molecular mechanisms of Rhodiola rosea L. radix (RRL), identifying 56 potential active compounds and 62 targets. It suggests that RRL may enhance therapeutic effects through multiple targets and pathways, including neuroactive ligand-receptor interaction and calcium signaling, for treating various diseases.
Understanding molecular mechanisms of Rhodiola rosea for the treatment of acute mountain sickness through computational approaches (a STROBE-compliant article)
The paper investigates the therapeutic mechanism of Rhodiola rosea for acute mountain sickness (AMS) using computational approaches. It explores the relationship between R. rosea compositions and the hypoxia-inducible factor 1 (HIF-1) degradation pathway, suggesting that certain components of R. rosea could inhibit targets in the HIF-1 degradation pathway.
Rhodiola rosea in Subjects with Prolonged or Chronic Fatigue Symptoms: Results of an Open-Label Clinical Trial.
Open-label clinical trial of Rhodiola rosea (WS® 1375) in 100 subjects with prolonged or chronic fatigue symptoms. Subjects received 2 × 200 mg daily over 8 weeks. Significant improvement in fatigue symptoms was observed, with the greatest change after 1 week. The safety profile was favorable, with most adverse events being mild and unrelated to the study drug.
Therapeutic effects and safety of Rhodiola rosea extract WS® 1375 in subjects with life-stress symptoms--results of an open-label study.
Open-label study of Rhodiola rosea extract WS® 1375 in 101 subjects with life-stress symptoms. The study found clinically relevant improvements in stress symptoms, disability, and functional impairment over 4 weeks. The extract was safe and well tolerated.
RHODIOLA ROSEA AS A NATURAL ADAPTOGEN: A REVIEW OF ITS EFFECTS ON STRESS REDUCTION, MOOD ENHANCEMENT, AND COGNITIVE FUNCTION
This narrative review summarizes current knowledge on Rhodiola rosea, focusing on its effects on stress reduction, mood enhancement, and cognitive function. It discusses the herb's phytochemistry, mechanisms of action, and evidence from preclinical and clinical studies. Rhodiola rosea shows potential in modulating neurotransmission, enhancing antioxidant defenses, and improving mitochondrial function, leading to reduced stress and fatigue, improved mood, and enhanced cognitive performance.
Rhodiola rosea as a Medicinal Adaptogen: A Review of Its Antidepressant, Anti-Stress, and Performance-Enhancing Effects
Narrative review of Rhodiola rosea's pharmacological action, bioactive compounds, and therapeutic applications. The review highlights its benefits in reducing fatigue, improving cognitive function, enhancing physical performance, and stabilizing mood, with a favorable safety profile.
Research Progress on the Promotion of Human Umbilical Vein Endothelial Cell (HUVECs) angiogenesis by Rhodiola Rosea and Exosomes through SDF-1/CXCR4 under High Glucose Environment
This narrative review discusses the promotion of angiogenesis in human umbilical vein endothelial cells (HUVECs) by Rhodiola rosea and exosomes through the SDF-1/CXCR4 signaling pathway in a high glucose environment. It highlights the potential of Rhodiola rosea's active ingredients, such as salidroside and tyrosol, in improving high glucose-induced oxidative stress and inflammatory microenvironment.
Effects of nano-Rhodiola rosea combined with treadmill exercise on anti-exercise fatigue in rats
Animal study exploring the effects of nano-Rhodiola rosea combined with treadmill exercise on anti-exercise fatigue in rats. The study found that Rhodiola rosea, particularly in nano-dosage form, had a positive effect on reducing exercise-induced fatigue, with enhanced efficacy when combined with aerobic exercise.
Rhodiola Rosea, an adaptogen useful in fatigue – from research to practice
The paper reviews the adaptogenic properties of Rhodiola Rosea, highlighting its ability to reduce mental fatigue, improve mental performance, stimulate physical work capacity, and increase resistance to fatigue through mechanisms involving the hypothalamic pituitary-adrenal axis and cortisol regulation.
Advances in the study of anti-tumor effects of Rhodiola rosea
The paper reviews the anti-tumor effects of Rhodiola rosea and its active ingredient Salidroside, highlighting mechanisms such as inhibiting tumor cell proliferation, promoting apoptosis, and enhancing immunity. It aims to provide a theoretical basis for the clinical application of Rhodiola rosea in cancer treatment.
Phenolic Compounds of Rhodiola rosea L. as the Potential Alternative Therapy in the Treatment of Chronic Diseases
This narrative review discusses the beneficial effects of Rhodiola rosea extract and its phenolic compounds, which have antioxidant, immunomodulatory, anti-aging, and anti-fatigue activities. The paper highlights its potential use in treating chronic diseases, enhancing mental and cognitive functions, and protecting the central nervous system and heart during stress.
Rosavin: Research Advances in Extraction and Synthesis, Pharmacological Activities and Therapeutic Effects on Diseases of the Characteristic Active Ingredients of Rhodiola rosea L.
This narrative review provides a comprehensive overview of Rosavin, a key active ingredient in Rhodiola rosea, focusing on its extraction, synthesis, pharmacological activities, and therapeutic effects on various chronic diseases. The paper highlights Rosavin's potential as a therapeutic agent due to its antioxidant, lipid-lowering, analgesic, antiradiation, antitumor, and immunomodulation effects.
THE OBTAINING RHODIOLA ROSEA L. BIOLOGICALLY ACTIVE COMPOUNDS BY BIOTECHNOLOGICAL METHODS (OVERVIEW)
The paper reviews biotechnological methods for obtaining biologically active compounds from Rhodiola rosea, focusing on callus tissue culture and transgenic hairy roots cultivation. It discusses the biosynthesis and genetic regulation of secondary metabolites like salidroside and rosin, highlighting the use of metabolic precursors to enhance compound accumulation.
Rhodiola rosea as an adaptogen to enhance exercise performance: a review of the literature
Narrative review of Rhodiola rosea as an adaptogen to enhance exercise performance. Studies indicate acute RR supplementation may improve time-to-exhaustion and time trial performance, with mixed results on muscle damage, inflammation, and perceived exertion. Variability in dose, duration, and participant characteristics may explain disparate findings.
Effects of Rhodiola rosea on indomethacin-induced gastric injury
The study evaluated the effects of Rhodiola rosea on indomethacin-induced gastric injury in rats. Rhodiola rosea alleviated ulcer formation by reducing oxidative stress, regulating COX enzymes, and suppressing inflammatory markers like TNF-α and IL1β. It also modulated the NF-κB signaling pathway and down-regulated caspase-3 expression, suggesting its potential as a therapeutic agent for gastric protection.
Effects of Modulation of Ion Channel Currents by Salidroside in H9C2 Myocardial Cells in Hypoxia and Reoxygenation
The study investigated the effects of salidroside on sodium and potassium channel currents in H9C2 myocardial cells under hypoxia and reoxygenation conditions. Salidroside significantly restored channel function and altered activation/inactivation kinetics, demonstrating cardioprotective effects.
Reduction of acute mild stress corticosterone response and changes in stress‐responsive gene expression in male Balb/c mice after repeated administration of a Rhodiola rosea L. root extract
The study investigated the effect of repeated doses of Rhodiola rosea hydroethanolic root extract on stress response in Balb/c mice. The extract reduced corticosterone levels and altered stress-responsive gene expression in brain regions, suggesting potential benefits for modulating acute mild stress reactivity.
Salidroside protects SH-SY5Y from pathogenic α-synuclein by promoting cell autophagy via mediation of mTOR/p70S6K signaling
The study investigates the protective effects of salidroside on SH-SY5Y cells from pathogenic α-synuclein by promoting cell autophagy via mTOR/p70S6K signaling. Salidroside increased cell proliferation and alleviated pathogenic α-syn expression, suggesting its potential role in protecting against neurodegeneration in Parkinson's disease models.
Influence of extracts from Rhodiola rosea and Rhodiola kirilowii on the development of alcohol tolerance in rats
Animal study investigating the effects of Rhodiola rosea and Rhodiola kirilowii extracts on the development of alcohol tolerance in rats. Both extracts inhibited the development of tolerance to the hypothermic action of ethanol, with RK extract also prolonging the hypnotic action of ethanol.
The impact of Rhodiola rosea on the gut microbial community of Drosophila melanogaster
The study investigates the impact of Rhodiola rosea on the gut microbial community of Drosophila melanogaster. Rhodiola rosea treatment increased the abundance of Acetobacter and decreased Lactobacillales in the fly gut, altering the microbial community without displaying general antibacterial activity.
Influence of salidroside, a neuroactive compound of Rhodiola rosea L., on alcohol tolerance development in rats
The study investigated the ability of salidroside to inhibit the development of alcohol tolerance in rats. Salidroside at a dose of 45 mg/kg inhibited the development of tolerance to the hypothermic and sedative effects of ethanol, suggesting an influence on the central nervous system.
Noncompetitive inhibition of human CYP2C9 in vitro by a commercial Rhodiola rosea product
In vitro study of a commercial Rhodiola rosea product 'Arctic Root' demonstrating noncompetitive inhibition of human CYP2C9. The study used losartan as a substrate and determined kinetic constants, showing an IC50 of 19.2 ± 2.7 μg/mL. Ethanol also inhibited CYP2C9 activity in a concentration-dependent manner.
Preventive Effects of Rhodiola rosea L. on Bleomycin-Induced Pulmonary Fibrosis in Rats
The study investigated the lung-protective activity of Rhodiola rosea L. in a pulmonary fibrosis rat model induced by bleomycin. Rhodiola rosea L. alleviated body weight loss, reduced hydroxyproline, and increased glutathione and superoxide dismutase levels. It also decreased inflammatory markers and fibrosis-related proteins, suggesting its protective effects against fibrotic lung injury are due to anti-inflammatory, antioxidative, and anti-fibrotic properties.
Rhodiola rosea suppresses thymus T-lymphocyte apoptosis by downregulating tumor necrosis factor-α-induced protein 8-like-2 in septic rats
The study investigated the effects of Rhodiola rosea on thymus T-lymphocyte apoptosis and immunity in a mouse model of sepsis. Rhodiola rosea treatment decreased the expression of apoptotic genes, increased Th1 cytokines, and improved survival rates, suggesting protective effects against sepsis.
Rhodiola rosea in vitro culture - phytochemical analysis and antioxidant action
In vitro study of Rhodiola rosea organs and tissues focusing on phytochemical analysis and antioxidant activity. Salidroside, rosavin, triandrin, and caffeic acid were identified, with the highest antioxidant activity observed in extracts from 1.5-year-old callus containing caffeic acid and triandrin.
Extension of Drosophila Lifespan by Rhodiola rosea through a Mechanism Independent from Dietary Restriction
The study investigates the effect of Rhodiola rosea on lifespan extension in Drosophila, finding that it extends lifespan independently of dietary restriction pathways. The extract decreased water content and increased fat content in flies, with some sex-specific differences in gene expression and stress response.
ASSESSMENT OF THE EFFICIENCY OF PREVENTION OF CHRONIC FLUORINE INTOXICATION WITH RHODIOLA ROSEA L. ADAPTOGEN
Animal study on 45 rats assessing the effectiveness of Rhodiola Rosea L. in preventing chronic fluorine intoxication. Rhodiola Rosea L. was effective in normalizing oxidative metabolism, reducing degenerative changes in the liver and kidneys, and restoring liver and kidney functions.
Anti-inflammatory effects of Rhodiola rosea L.: A review.
This review examines the anti-inflammatory effects of Rhodiola rosea L., highlighting its protective effects against inflammatory injury in various diseases such as cardiovascular diseases, neurodegenerative diseases, diabetes, sepsis, and cancer. It discusses recent clinical and experimental research on Rhodiola rosea L. extracts, preparations, and active compounds.
Approaches of Rhodiola kirilowii and Rhodiola rosea field cultivation in Poland and their potential health benefits.
The paper reviews the cultivation of Rhodiola kirilowii and Rhodiola rosea in Poland and their potential health benefits. It discusses various compounds isolated from these plants and their claimed adaptogenic, neuroprotective, anti-depressive, anti-tumor, and cardioprotective activities. The paper highlights the need for further studies to establish their potential as drugs.