Research
Resveratrol
317 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Resveratrol Supplementation and its Potential Benefits in Obesity-related Non-communicable Diseases.
Meta-analysis of 40 RCTs involving 2551 participants evaluating resveratrol supplementation in adults with obesity-related metabolic disorders. Resveratrol significantly reduced insulin resistance, cholesterol levels, blood pressure, and inflammatory markers, but showed no consistent changes in HDL cholesterol, body weight, or liver enzymes.
Efficacy of different nasal irrigation treatments versus placebo in allergic rhinitis: a systematic review and network meta-analysis
Systematic review and network meta-analysis comparing the efficacy of different nasal irrigation treatments for allergic rhinitis. Resveratrol was found to be the most efficacious in relieving nasal symptoms, while cinnamon bark was most effective in improving quality of life.
The effect of resveratrol supplementation on anthropometric indices, adiponectin and leptin levels in individuals with overweight and obesity: a graded, systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis of 23 RCTs involving 1005 participants evaluated the effects of resveratrol supplementation on anthropometric indices, adiponectin, and leptin levels in individuals with overweight and obesity. Resveratrol supplementation did not significantly affect most measures but significantly reduced waist circumference. Subgroup analyses showed reductions in body weight and BMI with doses <1000 mg/day, longer interventions, and in females.
Effects of resveratrol on postmenopausal women: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the impact of resveratrol on postmenopausal women, analyzing ten RCTs with 928 participants. Resveratrol significantly reduced pain scores and CTX levels, indicating potential benefits for pain and bone metabolism. No significant effects were observed on cognition, mood, metabolic parameters, blood pressure, sleep disturbance, menopausal symptoms, or other bone markers.
A Systematic Review and Meta-Analysis of Randomized Controlled Trials on the Impact of Resveratrol Supplementation on Anthropometric Indices in Patients With Type 2 Diabetes.
This systematic review and meta-analysis evaluated the impact of resveratrol supplementation on anthropometric indices in patients with type 2 diabetes. The analysis included 11 trials with 614 participants and found that resveratrol significantly decreased body weight, BMI, and waist circumference, but had no significant effect on hip circumference or waist-to-hip ratio.
The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis
Meta-analysis of six randomized controlled trials involving 533 participants with type 2 diabetes mellitus. Resveratrol supplementation significantly reduced C-reactive protein, lipid peroxide, 8-isoprostanes, and oxidative stress score, and increased glutathione peroxidase and catalase levels. No significant effects were observed on interleukin-6, tumor necrosis factor α, superoxide dismutase, total antioxidant capacity, and malondialdehyde levels.
Therapeutic effects and safety of resveratrol for lung cancer: an updated preclinical systematic review and meta-analysis.
Systematic review and meta-analysis of 23 preclinical studies involving 425 animals assessing the effects of resveratrol on lung cancer. Resveratrol significantly reduced tumor volume, tumor weight, and lung metastases number, and increased apoptotic cell proportion, with no effect on body weight. The optimal dose and duration were identified as 30-100 mg/kg and 25-28 days, respectively.
Effects of Resveratrol Supplementation as an Adjunct to Nonsurgical Periodontal Therapy: A Systematic Review and Meta-analysis
Systematic review and meta-analysis of seven RCTs with 402 patients assessing resveratrol supplementation as an adjunct to nonsurgical periodontal therapy. Resveratrol significantly improved periodontal probing depth, clinical attachment level, and inflammatory markers compared to therapy alone, with greater efficacy at higher dosages and in patients with systemic conditions like diabetes.
Resveratrol in animal models of pancreatitis and pancreatic cancer: A systematic review with machine learning.
Systematic review and meta-analysis of 50 animal studies on resveratrol's effects in pancreatitis and pancreatic cancer models. Resveratrol improved pancreatic histopathology, function parameters, inflammatory and oxidative markers in pancreatitis, and reduced tumour weight and volume in cancer models. Machine learning identified optimal dosage and treatment factors.
The efficacy of resveratrol in the treatment of liver fibrosis: a systematic review and meta-analysis of preclinical studies.
Systematic review and meta-analysis of 46 animal studies evaluating resveratrol's effects on liver fibrosis. Resveratrol significantly reduced collagen deposition, hydroxyproline levels, and extracellular matrix components, while improving liver function markers. It exerted anti-inflammatory and antioxidant effects, suggesting potential for liver fibrosis treatment.
A Systematic Review on the Molecular Mechanisms of Resveratrol in Protecting Against Osteoporosis.
This systematic review analyzes the molecular pathways through which resveratrol protects against osteoporosis. It includes 28 studies, comprising in vitro, in vivo, and one cross-sectional study, highlighting resveratrol's role in enhancing osteoblast differentiation and inhibiting osteoclastogenesis. The review suggests resveratrol as a potential natural alternative for osteoporosis prevention and treatment, though its low bioavailability poses a challenge.
Protective effect of resveratrol on retinal damage in glaucoma: a systematic review and meta-analysis of preclinical studies.
Systematic review and meta-analysis of 30 animal studies examining the effects of resveratrol on retinal damage in glaucoma. Resveratrol was found to enhance SIRT1 protein expression, boost retinal ganglion cell survival, decelerate retinal thinning, and improve visual function, suggesting its potential in mitigating glaucoma-related retinal damage.
Resveratrol in oral cancer: a systematic review of preclinical studies on its anticancer mechanisms and therapeutic potential.
This systematic review evaluated preclinical evidence on resveratrol's therapeutic effects in oral cancer, focusing on mechanisms such as apoptosis induction, metastasis inhibition, autophagy regulation, and immune modulation. Resveratrol exhibited potent anticancer effects, reducing oral cancer cell viability and tumor growth in animal models, and impaired metastatic progression by downregulating EMT-related transcription factors.
Impact of Resveratrol Supplementation on Human Sirtuin 1: A Grading of Recommendations Assessment, Development and Evaluation-Assessed Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials.
This systematic review and meta-analysis assessed the impact of resveratrol supplementation on Sirt1 levels in adults, analyzing data from 11 RCTs. The overall findings showed no significant impact of resveratrol on Sirt1 gene expression, protein expression, or serum levels. However, subgroup analyses indicated a significant increase in Sirt1 gene expression in studies with an intervention duration of less than 12 weeks and evaluating blood tissue, suggesting the effect may depend on dosage regimen.
Effects of resveratrol on the anthropometric indices and inflammatory markers: an umbrella meta-analysis.
Umbrella meta-analysis of 19 meta-analyses covering 81 RCTs with 4088 participants. Resveratrol supplementation reduced BMI, waist circumference, C-reactive protein, and TNF-α levels. Significant weight reduction was observed in trials with ≥12 weeks duration and ≥500 mg/day dosage.
The effects of resveratrol in animal models of primary osteoporosis: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the effects of resveratrol in animal models of primary osteoporosis. Resveratrol was found to significantly increase bone mineral density, improve trabecular microstructure, and positively affect serum bone turnover markers, suggesting a protective effect against primary osteoporosis.
Effects of Resveratrol on Liver Function Tests in Patients with Non-Alcoholic Fatty Liver Disease: a Systematic Review and Meta-Analysis of Randomized Controlled Trials
Systematic review and meta-analysis of six RCTs with 256 NAFLD patients assessing resveratrol's effect on liver enzymes ALT and AST. Resveratrol supplementation showed no significant effect on serum ALT and AST levels.
Resveratrol as an Anti-inflammatory Agent in Coronary Artery Disease: A Systematic Review, Meta-Analysis and Meta-Regression.
Systematic review and meta-analysis of resveratrol's effects on inflammatory mediators and endothelial function in coronary artery disease. Resveratrol significantly reduced TNF-α expression and increased eNOS expression, suggesting potential cardioprotective effects. No significant effect on IL-6 was observed.
Effects of resveratrol on the lipid profile of post-menopause women: Systematic review and meta-analysis.
Systematic review and meta-analysis evaluating the effects of resveratrol on the lipid profile of postmenopausal women. The analysis found no significant differences in total cholesterol, HDL, LDL, or triglyceride levels between groups. The evidence was low-quality, and further studies are needed to clarify resveratrol's therapeutic potential.
Resveratrol delays the progression of diabetic nephropathy through multiple pathways: A dose-response meta-analysis based on animal models.
This meta-analysis assessed the effects of resveratrol on diabetic nephropathy in animal models. Resveratrol significantly improved kidney function and reduced diabetic nephropathy markers, with optimal effects at specific dose ranges. The benefits are attributed to its anti-inflammatory, antioxidant, metabolic regulatory, and autophagy-promoting effects.
Resveratrol and Female Fertility: A Systematic Review.
Systematic review of 24 studies examining the effects of resveratrol on female fertility. The review suggests resveratrol may positively impact reproductive outcomes by improving ovarian function, though further research is needed to optimize dosage and understand potential adverse effects.
Resveratrol for the Management of Human Health: How Far Have We Come? A Systematic Review of Resveratrol Clinical Trials to Highlight Gaps and Opportunities.
Systematic review of clinical trials on resveratrol over the last 20 years, evaluating its effects across multiple morbidities including cancer, menopause symptoms, diabetes, metabolic syndrome, and cardiovascular disease. Resveratrol is generally well-tolerated and consistently reduces inflammatory markers and improves aspects of a dysregulated metabolism, though more high-quality trials are needed.
A systematic review and meta-analysis of the impact of resveratrol on oral cancer: potential therapeutic implications.
Systematic review and meta-analysis investigating the impact of resveratrol on oral neoplastic parameters in animal models. Resveratrol treatment showed a statistically significant decrease in neoplastic proliferation and promotion of apoptosis, suggesting potential therapeutic implications for oral cancer management.
Efficacy of resveratrol supplementation on lipid profile parameters: An umbrella of meta-analysis.
Umbrella meta-analysis of resveratrol supplementation effects on lipid profile parameters. Resveratrol was effective in reducing serum triglyceride and total cholesterol levels based on standardized mean difference analysis, but not high-density or low-density lipoprotein cholesterol. The decreases were not clinically important, suggesting resveratrol as an adjunctive therapy for dyslipidemia.
Systematic review and meta-analysis of the interventional effects of resveratrol in a rat model of myocardial ischemia-reperfusion injury.
Systematic review and meta-analysis of 43 studies evaluating the effects of resveratrol on myocardial ischemia-reperfusion injury in rats. Resveratrol was found to reduce myocardial injury markers, improve hemodynamic indicators, and reduce inflammatory response and oxidative damage. However, the methodological quality of the included studies was low.
Resveratrol's bibliometric and visual analysis from 2014 to 2023.
Bibliometric and visual analysis of 16,934 resveratrol-related papers from 2014-2023 using Web of Science Core Collection and CiteSpace. The study highlights trends in resveratrol research, including its integration with nanoparticles, antibacterial and antiviral properties, and potential applications in medicine and healthcare.
Effects of resveratrol in an animal model of osteoporosis: a meta-analysis of preclinical evidence.
This meta-analysis included 15 animal experiments with 438 OP rats, examining the effects of resveratrol on osteoporosis. Resveratrol significantly increased bone mineral density (BMD) in femoral and lumbar regions and improved bone microstructure in OP rat models. It also affected calcium and phosphorus metabolism, though it had no significant effect on serum ALP and osteocalcin.
Effects of resveratrol on renal ischemia-reperfusion injury: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the protective effects of resveratrol against renal ischemia-reperfusion injury in animal models. The analysis included 19 studies with 249 animals, showing that resveratrol significantly decreased serum creatinine and blood urea nitrogen levels, reduced oxidative stress, and increased antioxidant enzyme levels. The findings suggest resveratrol's potential for renal protection through multiple mechanisms.
Protective effect and possible mechanisms of resveratrol in animal models of osteoporosis: A preclinical systematic review and meta-analysis.
This preclinical systematic review and meta-analysis assessed the efficacy of resveratrol in animal models of osteoporosis. The study found that resveratrol significantly improved bone mineral density, bone volume, trabecular density, and bone biomechanical indexes, while reducing serum phosphorus and trabecular separation. These findings suggest resveratrol's potential as a treatment for osteoporosis.
Efficacy of resveratrol in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized clinical trials.
Systematic review and meta-analysis of four RCTs with 218 women evaluating the efficacy of resveratrol in treating PCOS. Resveratrol significantly reduced testosterone, luteinizing hormone, and dehydroepiandrosterone sulfate levels compared to placebo, indicating its effectiveness in managing PCOS symptoms.
Therapeutic advances for treating memory impairments in perinatal brain injuries with implications for cerebral palsy: a systematic review and meta-analysis of preclinical studies.
This systematic review and meta-analysis of 52 preclinical studies examined interventions for memory impairments in cerebral palsy models. Treatments with oxygen interventions, resveratrol, and erythropoietin were found to reduce hippocampal damage and improve memory and behavior, with resveratrol showing positive effects on brain health.
[Effect of resveratrol on cognitive functions in older adults: a systematic review and meta-analysis].
Systematic review and meta-analysis of resveratrol's effect on cognitive functions in older adults. No significant effect was found on delayed, immediate, and working memory, or processing speed.
Resveratrol may mildly improve renal function in the general adult population: A systematic review and meta-analysis of randomized controlled clinical trials.
Systematic review and meta-analysis of randomized controlled trials assessing resveratrol supplementation on renal health biomarkers. Resveratrol significantly decreased blood urea nitrogen and creatinine levels, and increased glomerular filtration rate, suggesting a mild renal protective effect. Further high-quality evidence is needed.
A comprehensive insight into the molecular and cellular mechanisms of action of resveratrol on complications of sepsis a systematic review.
Systematic review of 72 studies on resveratrol's effects on sepsis complications. Resveratrol reduces sepsis complications by affecting inflammatory pathways, oxidative stress, and modulating immune responses. Future human RCTs are needed to confirm therapeutic effects.
Recent update on the protective potentials of resveratrol against cisplatin-induced ototoxicity: a systematic review.
Systematic review of resveratrol's potential otoprotective effects against cisplatin-induced ototoxicity. In vitro and in vivo studies suggest resveratrol co-treatment protects against cisplatin-induced decreases in cell viability and auditory function, likely through antioxidant, anti-apoptotic, and anti-inflammatory mechanisms.
Effect and mechanisms of resveratrol in animal models of ischemic stroke: A systematic review and Bayesian meta-analysis.
This systematic review and Bayesian meta-analysis assessed the effects and mechanisms of resveratrol in animal models of ischemic stroke. The analysis included 75 rodent studies for qualitative synthesis and 57 for quantitative synthesis. Resveratrol showed beneficial effects on infarct size, edema size, BBB impairment, neurofunctional impairment, and motor performance, with underlying mechanisms involving reduction of oxidative stress, inflammation, and apoptosis.
Therapeutic Potential of Resveratrol for Glioma: A Systematic Review and Meta-Analysis of Animal Model Studies.
Systematic review and meta-analysis of animal model studies evaluating resveratrol's anti-tumor impact in glioma. Resveratrol administration decreased tumor volume in murine glioma-bearing xenografts, with combined administration with temozolomide being more effective than temozolomide alone.
Integrative evidence construction for resveratrol treatment of nonalcoholic fatty liver disease: preclinical and clinical meta-analyses.
Meta-analysis of 27 studies evaluating resveratrol's efficacy in treating nonalcoholic fatty liver disease (NAFLD). Resveratrol improved liver function and reduced fatty liver indicators in preclinical studies, with mixed results in clinical trials. It significantly reduced tumor necrosis factor-α levels, suggesting a protective effect against NAFLD via AMPK/Sirt1 and anti-inflammatory pathways.
The effect of resveratrol supplementation on biomarkers of liver health: A systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of 37 RCTs evaluating resveratrol's effect on liver biomarkers. Overall, no significant change was found, but subgroup analysis showed improvement in ALT and glutamyl transferase in patients with liver disorders and younger adults. High-dose resveratrol increased alkaline phosphatase and ALT in older adults.
Efficacy of Resveratrol Supplementation on Glucose and Lipid Metabolism: A Meta-Analysis and Systematic Review.
Meta-analysis and systematic review of 25 RCTs with 1,171 participants assessing the effects of resveratrol supplementation on glucose and lipid metabolism. Results showed significant decreases in waist circumference, hemoglobin A1c, total cholesterol, and low-density lipoprotein cholesterol, and an increase in high-density lipoprotein cholesterol following resveratrol administration.
Effects of Resveratrol on Metabolic Indicators in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis examined the effects of resveratrol on metabolic indicators in patients with type 2 diabetes, including 19 studies with 1151 patients. Resveratrol reduced fasting blood glucose and both systolic and diastolic blood pressure but did not affect waist circumference, triglyceride levels, or high-density lipoprotein cholesterol.
Antioxidant and Anti-inflammatory Properties of Resveratrol in Diabetic Nephropathy: A Systematic Review and Meta-analysis of Animal Studies
Systematic review and meta-analysis of 36 animal studies involving 726 animals evaluating resveratrol's antioxidant and anti-inflammatory properties in diabetic nephropathy. Resveratrol showed significant effects on blood glucose, serum creatinine, blood urea nitrogen, and various antioxidant markers, but had mixed effects on inflammatory cytokines, reducing IL-1β but not affecting IL-6 and TNF-α.
The anti-inflammatory activity of resveratrol in acute kidney injury: a systematic review and meta-analysis of animal studies.
Systematic review and meta-analysis of 25 animal studies assessing resveratrol's effect on acute kidney injury. Resveratrol treatment was associated with lower serum creatinine and blood urea nitrogen levels, with greater effects at low doses and shorter intervention durations.
A meta-analysis of resveratrol protects against cerebral ischemia/reperfusion injury: Evidence from rats studies and insight into molecular mechanisms
Meta-analysis of 41 studies evaluating the neuroprotective effect of resveratrol in rat models of cerebral ischemia/reperfusion injury. Resveratrol significantly reduced cerebral infarct volume, brain water content, and improved neurological function. The optimal therapeutic dose was suggested to be 30 mg/kg.
Effects of resveratrol supplementation on nitric oxide-mediated vascular outcomes in hypertension: A systematic review.
Systematic review of ten animal studies evaluating resveratrol supplementation on nitric oxide-mediated vascular outcomes in hypertension. Nine studies reported positive effects on NO outcomes and blood pressure reduction, suggesting resveratrol's potential for improving vascular health in hypertension.
The therapeutic effects and mechanisms of action of resveratrol on polycystic ovary syndrome: A comprehensive systematic review of clinical, animal and in vitro studies
This systematic review investigates the therapeutic effects and mechanisms of resveratrol on polycystic ovary syndrome (PCOS). It includes 24 studies (10 in vitro, 10 animal, and 4 human) and suggests that resveratrol supplementation may improve PCOS-related symptoms by reducing insulin resistance, alleviating dyslipidaemia, improving ovarian morphology, regulating reproductive hormones, and reducing inflammation and oxidative stress.
Resveratrol supplementation efficiently improves endothelial health: A systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of RCTs assessing resveratrol supplementation on endothelial function. Resveratrol significantly improved flow-mediated dilation and reduced ICAM-1 concentrations, suggesting benefits for endothelial health, particularly in cardiovascular disease patients.
A systematic review of the therapeutic effects of resveratrol in combination with 5-fluorouracil during colorectal cancer treatment: with a special focus on the oxidant, apoptotic, and anti-inflammatory activities
Systematic review of the therapeutic effects of resveratrol in combination with 5-fluorouracil for colorectal cancer treatment. The review found that resveratrol increased 5-FU-induced cytotoxicity and mitigated adverse effects, enhancing the chemotherapeutic efficacy through mechanisms like cell cycle regulation, oxidant, apoptotic, and anti-inflammatory activities.
Influence of Age and Dose on the Effect of Resveratrol for Glycemic Control in Type 2 Diabetes Mellitus: Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of resveratrol's effects on glycemic control in type 2 diabetes mellitus. Resveratrol decreases glucose levels, HbA1c, and insulin levels in subjects aged 45-59 years at various doses, with some effects also observed in subjects older than 60 years. The study highlights a dose-response effect but lacks sufficient evidence to propose a therapeutic dose.
The Effect of Resveratrol on Blood Lipid Profile: A Dose-Response Meta-Analysis of Randomized Controlled Trials.
This meta-analysis of randomized controlled trials explored the effects of resveratrol supplementation on blood lipid profiles. Resveratrol intake significantly decreased total cholesterol, triglycerides, and low-density lipoprotein cholesterol levels, but did not alter high-density lipoprotein cholesterol levels. The dosage of resveratrol was a significant factor affecting LDL-C levels, with more pronounced effects in trials lasting 12 weeks or more and in subjects with type 2 diabetes.
Anti-inflammatory effects of resveratrol in patients with cardiovascular disease: A systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of RCTs evaluating the effect of resveratrol supplements on inflammatory biomarkers in patients with cardiovascular diseases. Resveratrol significantly decreased serum levels of CRP and TNF-α, but had no significant effect on IL-6 levels.
Effects of Resveratrol Supplementation on the Cognitive Function of Patients with Alzheimer's Disease: A Systematic Review of Randomized Controlled Trials.
Systematic review of randomized controlled trials evaluating the effects of resveratrol supplementation on cognitive function in Alzheimer's disease patients. The review included four RCTs and suggests that resveratrol may delay cognitive impairment in AD patients.
The Role of Resveratrol in Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review.
Systematic review assessing the effects of resveratrol on mild cognitive impairment (MCI) and Alzheimer's Disease (AD). Resveratrol was found to improve cerebrovascular function, reduce Alevels, improve brain volume, and enhance cognitive scores in AD patients. In MCI patients, it prevented decline in brain function and increased functional connectivity. Resveratrol's anti-inflammatory and antioxidant effects may contribute to its neuroprotective benefits.
Benefits and Implications of Resveratrol Supplementation on Microbiota Modulations: A Systematic Review of the Literature.
This systematic review examines the effects of resveratrol supplementation on human microbiota and its implications for immune response, thrombotic complications, gene therapy, and bone regeneration. The review includes 18 studies and highlights resveratrol's beneficial activity on genetic expression and gastrointestinal microbial community, suggesting potential therapeutic applications for inflammatory diseases, degenerative diseases, tumors, obesity, diabetes, and metabolic syndrome.
Efficacy of Resveratrol in Experimental Subarachnoid Hemorrhage Animal Models: A Stratified Meta-Analysis.
Meta-analysis of 16 studies evaluating the efficacy of resveratrol in experimental subarachnoid hemorrhage animal models. Resveratrol treatment showed significant improvements in brain water content and neurological scores, indicating positive effects on pathological and behavioral outcomes.
The effects of resveratrol on glycemic control and cardiometabolic parameters in patients with T2DM: A systematic review and meta-analysis.
This systematic review and meta-analysis of 17 RCTs with 871 patients with T2DM found that resveratrol supplementation improved fasting blood glucose, total cholesterol, HbA1c, and systolic blood pressure compared to placebo. Resveratrol beneficially modulates glycemic control and cardiometabolic parameters in patients with T2DM.
The effects of resveratrol supplementation in patients with type 2 diabetes, metabolic syndrome, and nonalcoholic fatty liver disease: an umbrella review of meta-analyses of randomized controlled trials.
Umbrella review of meta-analyses assessing resveratrol supplementation effects on cardiometabolic risk factors in patients with type 2 diabetes, metabolic syndrome, and nonalcoholic fatty liver disease. Resveratrol showed beneficial effects on some outcomes like blood pressure and glycemic control, but the effects were generally trivial with low certainty of evidence. A clinically important effect was noted for HbA1c in the short term.
Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of 10 RCTs involving 698 subjects to assess the effects of resveratrol supplementation on bone mineral density (BMD) and serum bone biomarkers. Resveratrol supplementation showed no statistically significant effects on BMD or serum bone markers.
The pharmacological assessment of resveratrol on preclinical models of rheumatoid arthritis through a systematic review and meta-analysis.
This systematic review and meta-analysis assessed the efficacy of resveratrol in preclinical models of rheumatoid arthritis. The analysis of 18 studies involving 544 animals showed that resveratrol administration reduced paw volume, polyarthritis score, and arthritis index, and improved histopathological score and cartilage loss. Resveratrol also reduced oxidative stress markers and pro-inflammatory cytokines, suggesting potential clinical efficacy for RA.
The impact of resveratrol on skin wound healing, scarring, and aging.
Systematic review of 41 studies on resveratrol's effects on wound healing, scarring, and photo-aging of the skin. The review highlights promising results suggesting resveratrol may support wound healing, reduce scarring, and prevent photo-aging, though more evidence is needed.
Effect of resveratrol on inflammatory cytokines: A meta-analysis of randomized controlled trials.
Meta-analysis of randomized clinical trials assessing the effect of resveratrol on inflammatory cytokines. Resveratrol significantly reduced serum TNF-α levels and IL-6 levels at doses ≥500 mg/day, but had no significant effect on IL-1 and IL-8 levels.
Resveratrol in Rodent Models of Parkinson’s Disease: A Systematic Review of Experimental Studies
Systematic review of 18 studies on resveratrol's neuroprotective effects in rodent models of Parkinson's disease. The review analyzes the therapeutic effects and mechanisms of resveratrol, highlighting its antioxidation, anti-inflammation, and mitochondrial function improvement properties. The study supports resveratrol's significant neuroprotective effects in various PD models.
Can resveratrol modulate sirtuins in obesity and related diseases? A systematic review of randomized controlled trials.
Systematic review of seven RCTs assessing resveratrol supplementation on sirtuins' gene expression/protein levels in obesity and related diseases. Four studies showed a significant increase in SIRT-1, with improvements in insulin sensitivity, lipid profile, metabolic flexibility, total antioxidant capacity, energy expenditure, and reduction of ectopic fat accumulation.
Resveratrol supplementation and type 2 diabetes: a systematic review and meta-analysis.
Systematic review and meta-analysis of 30 studies evaluating resveratrol supplementation on diabetes parameters. Resveratrol showed significant effects in reducing insulin resistance, glycated hemoglobin, and fasting blood glucose in individuals with diabetes.
A Systematic Review of the Potential Chemoprotective Effects of Resveratrol on Doxorubicin-Induced Cardiotoxicity: Focus on the Antioxidant, Antiapoptotic, and Anti-Inflammatory Activities
Systematic review of 33 studies examining the chemoprotective effects of resveratrol against doxorubicin-induced cardiotoxicity. Resveratrol coadministration was found to alleviate cardiotoxic effects through antioxidant, antiapoptotic, and anti-inflammatory mechanisms.
Resveratrol and Markers of Polycystic Ovary Syndrome: a Systematic Review of Animal and Clinical Studies.
Systematic review of animal studies and RCTs evaluating the effects of resveratrol on PCOS features. Resveratrol showed beneficial effects on histomorphological features, sex hormones, glycemic control, inflammation, and oxidative stress in PCOS. The review suggests resveratrol might be effective in managing PCOS, particularly hormonal and reproductive abnormalities.
The bioactivities of resveratrol and its naturally occurring derivatives on skin.
Systematic review of resveratrol and its derivatives on skin health, focusing on their antioxidative activity and benefits for conditions like skin cancer, photoaging, and dermatitis. The review discusses the chemical classification, treatment cases, and use of nanocarriers for resveratrol delivery.
Effect of resveratrol on C-reactive protein: An updated meta-analysis of randomized controlled trials.
Meta-analysis of 35 RCTs assessing resveratrol's effect on CRP and hs-CRP levels as markers of inflammation. Resveratrol significantly reduced hs-CRP and CRP levels, particularly with supplementation for ≥10 weeks and doses ≥500 mg/day.
Effects of resveratrol supplementation on liver enzymes: A systematic review and meta-analysis of randomised controlled trials.
Systematic review and meta-analysis of 15 RCTs with 714 participants investigating the effects of resveratrol supplementation on liver enzymes. The analysis found no significant changes in liver enzyme levels, but results may vary based on dose, study duration, and population status.
The effect of resveratrol supplementation on C-reactive protein (CRP) in type 2 diabetic patients: Results from a systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of six trials with 491 subjects evaluating the effect of resveratrol supplementation on CRP levels in type 2 diabetic patients. The results showed a significant reduction in CRP levels, indicating resveratrol's anti-inflammatory effect.
Efficacy of resveratrol supplementation on liver enzymes in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis.
Systematic review and meta-analysis of RCTs examining resveratrol supplementation on liver enzymes in NAFLD patients. The pooled results showed no significant changes in serum ALT and AST levels overall, though subgroup analysis indicated reductions in specific demographics and conditions.
Resveratrol for adults with type 2 diabetes mellitus.
Meta-analysis of three RCTs with 50 participants assessing the efficacy and safety of resveratrol supplementation in adults with type 2 diabetes mellitus. Resveratrol showed neutral effects on HbA1c levels, fasting blood glucose levels, and insulin resistance compared to placebo. No adverse events were reported, but the evidence is of very low certainty due to short follow-up periods.
Fine wine or sour grapes? A systematic review and meta-analysis of the impact of red wine polyphenols on vascular health.
Systematic review and meta-analysis of red wine polyphenols (RWP) and resveratrol on vascular health in animals and humans. Significant improvements in systolic blood pressure were observed in human studies, particularly with pure resveratrol, though effects were more pronounced in animal studies.
The Effects of Resveratrol on Oxidative Stress Markers: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
Systematic review and meta-analysis of randomized clinical trials investigating the effect of resveratrol supplementation on oxidative stress parameters. Resveratrol increased GPx serum levels significantly but had no significant effect on SOD concentrations, MDA serum levels, and TAC compared to placebo. The study concludes that resveratrol may not have a clinically significant effect on oxidative stress.
What is the effect of resveratrol on obesity? A systematic review and meta-analysis.
Systematic review and meta-analysis of 19 studies on resveratrol supplementation for obesity treatment. The analysis found no significant effect on weight loss or BMI, with only a small effect on waist circumference.
Resveratrol: A "miracle" drug in neuropsychiatry or a cognitive enhancer for mice only? A systematic review and meta-analysis.
Systematic review and meta-analysis comparing the effects of resveratrol on cognition, mood, and brain function in human and animal studies. Animal studies reported positive outcomes, while human trials showed no statistically significant effects on cognition, mood, grey matter volume, or blood pressure.
Leishmanicidal effects of resveratrol and its derivatives: a systematic review and meta-Analysis
Systematic review and meta-analysis assessing the leishmanicidal effects of resveratrol and its derivatives. The study found significant reducing effects on Leishmania viability in both promastigote and amastigote stages. Publication bias and heterogeneity were noted, with subgroup analysis indicating effects varied by type of stilbenes and Leishmania species.
Efficacy of resveratrol supplementation in patients with nonalcoholic fatty liver disease: A systematic review and meta-analysis of clinical trials.
Systematic review and meta-analysis of 6 RCTs evaluating resveratrol supplementation in patients with nonalcoholic fatty liver disease (NAFLD). Resveratrol significantly reduced levels of TNF-alpha and hs-CRP, indicating improvement in some inflammatory markers, but showed no significant effect on other health markers related to NAFLD management.
The effects of resveratrol on lipid profiles and liver enzymes in patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis evaluated the effects of resveratrol supplementation on lipid profiles and liver enzymes in patients with metabolic syndrome and related disorders. Resveratrol significantly decreased total cholesterol and increased gamma-glutamyl transferase (GGT) concentrations, but had no significant effect on triglycerides, LDL-, HDL-cholesterol, ALT, and AST concentrations.
Exploring the effects of phenolic compounds to reduce intestinal damage and improve the intestinal barrier integrity: A systematic review of in vivo animal studies.
Systematic review of in vivo animal studies assessing the effects of phenolic compounds on intestinal barrier integrity. Resveratrol and other phenolic compounds like grape seed extract and curcumin improve intestinal barrier integrity and reduce inflammation by downregulating pro-inflammatory molecules and enhancing antioxidant activity.
Effect of Resveratrol on Blood Lipid Levels in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of 10 RCTs involving 363 patients with type 2 diabetes. Resveratrol intervention for ≥6 months reduced triglyceride levels but increased total cholesterol and low-density lipoprotein levels in patients with obesity and those on lipid-lowering drugs.
Effects of resveratrol supplementation on bone biomarkers: a systematic review and meta-analysis.
Systematic review and meta-analysis of RCTs on resveratrol supplementation and bone health biomarkers. No significant reduction in serum Ca, osteocalcin, C-terminal telopeptide of type I collagen, and procollagen I N-terminal propeptide values was found, but a significant increase in serum alkaline phosphatase (ALP) and bone alkaline phosphatase (BAP) was observed.
Effect of Resveratrol Supplementation on Inflammatory Markers: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Systematic review and meta-analysis of 17 RCTs with 736 subjects assessing resveratrol supplementation on inflammatory markers. Resveratrol significantly reduced TNF-α and hs-CRP levels, but had no significant effect on IL-6. The findings support resveratrol as an adjunct to pharmacologic management of metabolic diseases.
Can resveratrol supplement change inflammatory mediators? A systematic review and meta-analysis on randomized clinical trials.
Systematic review and meta-analysis of 15 trials involving 658 adults assessed the effect of resveratrol on serum inflammatory mediators. Resveratrol significantly reduced serum CRP levels but had no significant effect on serum IL-6 and TNF-α levels overall, though it reduced TNF-α in young and obese individuals.
Effects of resveratrol on glucose control and insulin sensitivity in subjects with type 2 diabetes: systematic review and meta-analysis
Systematic review and meta-analysis of nine RCTs involving 283 participants with type 2 diabetes mellitus. Resveratrol supplementation significantly improved fasting plasma glucose and insulin levels, and reduced insulin resistance, systolic and diastolic blood pressure. Higher doses of resveratrol showed more favorable results.
Effect of resveratrol on cognitive and memory performance and mood: A meta-analysis of 225 patients.
Meta-analysis of 225 patients from four randomized clinical trials assessing resveratrol's effects on cognition, memory, and mood. Resveratrol showed no significant effect on memory and cognitive performance but had a positive impact on mood, specifically reducing vigor and fatigue.
Effect of resveratrol on glucose control and insulin sensitivity: a meta-analysis of 11 randomized controlled trials.
Meta-analysis of 11 randomized controlled trials with 388 subjects evaluating the effects of resveratrol on glucose control and insulin sensitivity. Resveratrol significantly reduced fasting glucose, insulin, glycated hemoglobin, and insulin resistance in participants with diabetes, but had no significant effect on glycemic measures in nondiabetic participants.
Effect of resveratrol on blood pressure: a meta-analysis of randomized controlled trials.
Meta-analysis of six RCTs with 247 subjects evaluating resveratrol's effects on blood pressure. Resveratrol consumption did not significantly reduce SBP and DBP overall, but higher doses (≥ 150 mg/d) significantly reduced SBP by -11.90 mmHg. No significant effects on DBP were observed.
Effects of resveratrol supplementation on plasma lipids: a systematic review and meta-analysis of randomized controlled trials.
A systematic review and meta-analysis of seven randomized controlled trials with 282 subjects assessed the lipid-modulating effects of resveratrol. Resveratrol supplementation had no significant effect on total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, or triglycerides. The results were consistent across sensitivity analyses and independent of dose, duration, or cardiovascular risk status.
Resveratrol improves lipid profile and recovers heart function in postoperative CABG patients.
This randomized, double-blind, placebo-controlled trial investigated the effect of resveratrol on cardiovascular indices and oxidative stress in 60 patients after CABG surgery. Resveratrol intake significantly reduced systolic blood pressure, triglycerides, total cholesterol, and low-density lipoprotein, and improved ejection fraction compared to the control group.
Beneficial Role of Resveratrol on Oxidative Stress in Women with Polycystic Ovary Syndrome: A Randomized Controlled Trial.
RCT of 56 women with PCOS evaluating the antioxidant effect of 800 mg/day resveratrol supplementation for 60 days. Resveratrol reduced oxidative stress markers in follicular fluid and granulosa cells, increased total antioxidant capacity, and improved gene expression related to oxidative stress responses.
A randomized controlled trial comparing the efficacy of resveratrol combined with metformin versus resveratrol monotherapy in the management of polycystic ovary syndrome.
RCT comparing resveratrol monotherapy to resveratrol combined with metformin in women with PCOS over 6 months. Resveratrol monotherapy improved BMI, ovarian volume, LH levels, and quality of life, while the combination therapy showed greater improvements in metabolic parameters and oxidative stress markers. Both treatments improved menstrual regularity and stress levels.
Effects of resveratrol supplementation on serum concentrations of plasminogen activator inhibitor-1, fibroblast growth factor 21, and adiponectin in patients with nonalcoholic fatty liver disease
Double-blind randomized controlled trial of 50 adults with NAFLD evaluating the effect of 300 mg resveratrol supplementation on serum levels of PAI-1, adiponectin, FGF-21, and hs-CRP. After 12 weeks, resveratrol did not cause significant changes in these serum levels or liver enzymes compared to placebo.
Oral resveratrol in adults with knee osteoarthritis: A randomized placebo-controlled trial (ARTHROL).
The ARTHROL trial was a double-blind, randomized, placebo-controlled Phase 3 trial assessing the effect of oral resveratrol on knee pain in adults with knee osteoarthritis. The study found no significant difference in knee pain reduction between the resveratrol and placebo groups after 3 months.
Impact of Resveratrol and Pharmaceutical Care on Type 2 Diabetes Mellitus and Its Neuropathic Complication: A Randomized Placebo Controlled Clinical Trial
A four-arm randomized placebo-controlled clinical trial with 120 patients evaluated the effects of resveratrol and pharmaceutical care on glycemic control and diabetic neuropathic complications. Resveratrol with pharmaceutical care significantly improved hyperglycemic status and neuropathic signs and symptoms, as evidenced by decreased MNSI and DN4 scores and improved nerve conduction studies.
The impact of resveratrol on the outcome of the in vitro fertilization: an exploratory randomized placebo-controlled trial.
Exploratory RCT evaluating the effect of resveratrol supplementation on IVF outcomes in women over 35 with good ovarian reserve. No significant differences in pregnancy rates were observed, but resveratrol improved follicle output rate and follicle-to-oocyte index, suggesting enhanced ovarian sensitivity to FSH.
Resveratrol ameliorates mitochondrial biogenesis and reproductive outcomes in women with polycystic ovary syndrome undergoing assisted reproduction: a randomized, triple-blind, placebo-controlled clinical trial.
This randomized, triple-blind, placebo-controlled clinical trial examined the effect of resveratrol on mitochondrial biogenesis, oxidative stress, and assisted reproductive technology outcomes in 56 women with polycystic ovary syndrome. Resveratrol significantly reduced oxidative stress and increased mitochondrial biogenesis markers, mtDNA copy number, and ATP content in granulosa cells. Clinically, resveratrol improved oocyte maturity and high-quality embryo rates, though it did not significantly affect pregnancy rates.
Effects of resveratrol supplementation on inflammatory markers, fatigue scale, fasting blood sugar and lipid profile in relapsing-remitting multiple sclerosis patients: a double-blind, randomized placebo-controlled trial
Double-blind, randomized placebo-controlled trial examining the effects of 500 mg/day resveratrol supplementation for 8 weeks in 55 MS patients. Resveratrol significantly decreased TNF-α and MDA levels, indicating anti-inflammatory and antioxidant effects. No significant changes were observed in fatigue scale or triglyceride levels.
Resveratrol for inflammatory bowel disease in preclinical studies: a systematic review and meta-analysis.
Systematic review and meta-analysis of 28 preclinical studies evaluating the effects of resveratrol on animal models of inflammatory bowel disease (IBD). Resveratrol was found to significantly improve histopathological indices and alleviate intestinal mucosal pathological injury, particularly at doses exceeding 80 mg/kg. The compound also affected various biochemical indicators, suggesting its potential in regulating immune response and inhibiting oxidative stress.
A Randomized Trial on Resveratrol Supplement Affecting Lipid Profile and Other Metabolic Markers in Subjects with Dyslipidemia
RCT of 168 subjects with dyslipidemia comparing placebo to resveratrol supplementation at doses of 100 mg/d, 300 mg/d, and 600 mg/d over 8 weeks. Resveratrol did not significantly change the lipid profile but decreased serum uric acid and xanthine oxidase activity in a dose-response manner.