Research
Quercetin
338 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Evidence Synthesis and Mechanism Analysis of Quercetin Treatment for Atherosclerosis: A Preclinical Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of 22 preclinical studies involving 421 animals assessing quercetin's effects on atherosclerosis. Quercetin reduced aortic plaque area, adjusted lipid profiles, downregulated adhesion and pro-inflammatory factors, upregulated anti-inflammatory factors and antioxidant enzymes, and regulated atherosclerosis-related targets. Quercetin showed better effects at 25-100 mg/kg over 8-10 weeks.
Use quercetin for pulmonary fibrosis: a preclinical systematic review and meta-analysis.
Systematic review and meta-analysis of 20 studies with 44 experiments involving 1019 animals, evaluating quercetin's effects on pulmonary fibrosis. Quercetin significantly mitigated lung pathological tissue scores, fibrosis markers, inflammatory responses, oxidative stress, and other related mechanisms in PF animal models without significant hepatic and nephrotoxicity.
Effects of Quercetin on Metabolic Dysfunction‐Associated Steatotic Liver Disease: A Systematic Review and Meta‐Analysis
This systematic review and meta-analysis evaluated the effects of quercetin on liver function, lipid profiles, and inflammatory markers in patients with metabolic dysfunction-associated steatotic liver disease. Quercetin significantly reduced liver enzymes, direct bilirubin, and C-reactive protein, and improved lipid profiles. No significant effects were observed on kidney function, BMI, body fat, hematological markers, or TNF-α.
Effects of quercetin and its derivatives in in vivo models of neuroinflammation: A systematic review and meta-analysis
Systematic review and meta-analysis of quercetin and its derivatives in in vivo models of neuroinflammation. Quercetin treatment statistically reduced pro-inflammatory cytokines and microgliosis, exhibiting antioxidant and anti-apoptotic properties through Nrf2/HO-1 pathways. Despite promising results in animal models, further clinical studies are needed.
Therapeutic potential of quercetin in depressive symptoms: a systematic review and meta-analysis of preclinical studies.
This systematic review and meta-analysis of 52 animal studies evaluated the antidepressant effects of quercetin. Quercetin significantly reduced depressive symptoms, as evidenced by behavioral tests and biochemical markers, indicating its potential as an antidepressant.
The potential value of quercetin for colorectal cancer: a systematic review and a meta-analysis of preclinical studies.
Systematic review and meta-analysis of preclinical animal studies evaluating quercetin's therapeutic efficacy in colorectal cancer. Quercetin treatment significantly reduced CRC incidence, alleviated inflammation and oxidative stress, improved crypt lesions, and inhibited tumor cell proliferation.
Quercetin exhibits multi-target anti-allergic effects in animal models: a systematic review and meta-analysis of preclinical studies.
Systematic review and meta-analysis of 13 preclinical studies on quercetin's anti-allergic effects in animal models. Quercetin significantly decreased IgE, histamine, and inflammatory cytokines, and modulated immune cell populations, suggesting strong anti-allergic and anti-inflammatory effects.
Exploring the potential association and experimental validation of disrupted circadian rhythms with polycystic ovary syndrome via meta-analysis and bioinformatics: a possible pathogenic mechanism.
Meta-analysis and bioinformatics study exploring the association between circadian rhythm disruptions and polycystic ovary syndrome (PCOS). Quercetin was used as a treatment in a PCOS mouse model, improving disturbed expression of circadian core oscillations, suggesting a potential therapeutic strategy for PCOS.
Molecular mechanisms and therapeutic potential of quercetin in ovarian functions.
This systematic review summarizes current evidence on the therapeutic potential and molecular mechanisms of quercetin in treating ovarian-related reproductive conditions. Quercetin has shown efficacy in conditions like ovarian aging, PCOS, POI, and chemotherapy-induced ovarian damage by modulating pathways related to oxidative stress, inflammation, and hormone biosynthesis.
Improving quercetin bioavailability: A systematic review and meta-analysis of human intervention studies.
This systematic review and meta-analysis evaluated 31 human intervention studies on methods to improve quercetin bioavailability from different formulations and food matrices. Factors affecting bioavailability included chemical structure, modification of physicochemical properties, and food matrix effects, with significant increases in bioavailability observed with certain formulations.
Integration of Meta-Analysis and Network Pharmacology to Investigate the Pharmacological Mechanisms of Quercetin on Hepatocellular Carcinoma.
The study integrates meta-analysis and network pharmacology to investigate quercetin's pharmacological mechanisms on hepatocellular carcinoma (HCC). Quercetin significantly inhibited HCC growth and reduced mortality in tumor-bearing mice, likely via the PI3K/AKT pathway, without affecting body weight. The study supports quercetin as a promising candidate for HCC adjuvant treatment.
Yerba Mate () and Rheumatoid Arthritis: A Systematic Review of Mechanistic and Clinical Evidence.
Systematic review of 23 studies on yerba mate and its constituents in rheumatoid arthritis. Interventions with yerba mate infusions or extracts suggest reductions in inflammatory markers and improvements in oxidative balance. Evidence from isolated compounds like quercetin and rutin shows similar effects. Conclusions are tentative due to lack of clinical trials in RA patients and methodological heterogeneity.
Preventive and Therapeutic Effects of Plant-Derived Compounds on Tooth Erosion: A Systematic Review and Meta-Analysis of In Situ and In Vitro Studies.
Systematic review and meta-analysis of in vitro and in situ studies evaluating plant-derived compounds on tooth erosion. Quercetin significantly reduced dentin loss as a preventive measure, while green tea showed therapeutic effects. EGCG did not significantly decrease dentin loss.
Protective effects and mechanisms of quercetin in animal models of hyperuricemia: A systematic review and meta-analysis.
Systematic review and meta-analysis of animal studies on quercetin's effects on hyperuricemia. Quercetin alleviated kidney and liver injury, improved renal function indexes, and lowered uric acid by modulating oxidative stress, lipid metabolism, and transporter proteins. Quercetin showed significant effects in decreasing serum creatinine and blood urea nitrogen levels.
Therapeutic and prophylactic effects of quercetin in the treatment of Covid-19: a systematic review
Systematic review of randomized controlled trials evaluating quercetin for COVID-19 treatment and prevention. Quercetin contributed to rapid patient recovery and protection against COVID-19 development compared to placebo, with no adverse events reported. Further research is needed to confirm these findings.
Uncovering the therapeutic efficacy and mechanisms of Quercetin on traumatic brain injury animals: a meta-analysis and network pharmacology analysis.
Meta-analysis and network pharmacology analysis of quercetin's effects on traumatic brain injury (TBI) in animals. Quercetin was found to improve TBI by inhibiting inflammation, oxidative stress, and apoptosis, with mechanisms involving ferroptosis and several signaling pathways.
Effects of quercetin on polycystic ovary syndrome in animal models: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the efficacy of quercetin in treating polycystic ovary syndrome (PCOS) in animal models. Quercetin showed significant effects in reducing fasting insulin, blood glucose, cholesterol, triglyceride, testosterone, and luteinizing hormone levels, and improved the LH/FSH ratio. It also demonstrated antioxidative effects and regulated GLUT4 gene expression.
Quercetin as a therapeutic agent for skin problems: a systematic review and meta-analysis on antioxidant effects, oxidative stress, inflammation, wound healing, hyperpigmentation, aging, and skin cancer.
This systematic review and meta-analysis evaluated the effects of quercetin on skin-related issues, analyzing 65 studies. Quercetin demonstrated powerful antioxidant and anti-inflammatory properties, supported wound healing, reduced hyperpigmentation, and showed potential in reducing skin cancer risk.
Investigating the Neuroprotective and Cognitive-Enhancing Effects of Bacopa monnieri: A Systematic Review Focused on Inflammation, Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis
This systematic review examines the neuroprotective and cognitive-enhancing effects of Bacopa monnieri (BM) in neurodegenerative conditions. BM demonstrates anti-apoptotic and antioxidant actions, improves cognitive functions, emotional function, and reduces pro-inflammatory biomarkers and oxidative stress. The review highlights BM's potential as a complementary approach for brain health and neurodegenerative diseases.
Quercetin in the Prevention of Induced Periodontal Disease in Animal Models: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the effects of quercetin administration in animal models of experimental periodontitis. Quercetin administration decreased alveolar bone loss and prevented disease progression, suggesting potential benefits for periodontal tissue health.
Preclinical evidence of reno-protective effect of quercetin on acute kidney injury: a meta-analysis of animal studies.
Meta-analysis of 19 animal studies evaluating the reno-protective effects of quercetin in acute kidney injury models. Quercetin reduced blood urea nitrogen and serum creatinine levels, and exhibited antioxidant and anti-inflammatory effects, improving kidney injury scores.
Mechanism of action of quercetin in rheumatoid arthritis models: meta-analysis and systematic review of animal studies.
Meta-analysis and systematic review of 17 animal studies involving 251 animals evaluating quercetin's effects on rheumatoid arthritis. Quercetin reduced arthritis scores, paw swelling, and inflammatory markers, suggesting anti-inflammatory, anti-oxidative stress, and osteoprotective properties.
Therapeutic potential of senolytic agent quercetin in osteoarthritis: A systematic review and meta-analysis of preclinical studies.
Systematic review and meta-analysis of 12 in vivo animal studies on quercetin's effects on osteoarthritis (OA) cartilage. Quercetin significantly improved OA cartilage OARSI scores, indicating protective effects against OA during disease and aging.
Potential Therapeutic Targets of Quercetin in the Cutaneous Melanoma Model and Its Cellular Regulation Pathways: A Systematic Review.
Systematic review of 73 articles examining the therapeutic potential of quercetin in melanoma models. Quercetin demonstrated chemopreventive effects, reducing tumor growth and metastasis in murine models by regulating pathways like cell death and redox metabolism.
Chromatographic Methods Developed for the Quantification of Quercetin Extracted from Natural Sources: Systematic Review of Published Studies from 2018 to 2022.
Systematic review of chromatographic methods for detecting and quantifying quercetin from natural sources, focusing on studies published between 2018 and 2022. The review analyzed 17 studies, with spectrophotometry being the most commonly used detection method.
A comprehensive and systematic review of the potential neuroprotective effect of quercetin in rat models of spinal cord injury.
Systematic review of 18 animal studies examining the neuroprotective effects of quercetin in rat models of spinal cord injury. Quercetin improved BBB and inclined plane test scores, reduced MDA and MPO levels, and increased SOD levels, suggesting inhibition of oxidative stress, inflammation, autophagy, and apoptosis.
The Effect of Quercetin on Stress Oxidative Markers: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials
Systematic review and meta-analysis of 8 RCTs with 668 participants assessing the effect of quercetin on oxidative stress markers. Quercetin supplementation significantly increased FRAP levels but had no significant effect on TAC and MDA levels.
Preclinical evidence of the effect of quercetin on diabetic nephropathy: A meta-analysis of animal studies.
Meta-analysis of 20 animal studies with 378 animals evaluating quercetin's effects on diabetic nephropathy. Quercetin improved renal function indices and oxidative stress markers, and exhibited anti-inflammatory activity. No significant association was found with creatinine clearance.
The construction of preclinical evidence for the treatment of liver fibrosis with quercetin: A systematic review and meta-analysis.
Systematic review and meta-analysis of 15 preclinical studies involving 254 animals, evaluating quercetin's effects on liver fibrosis. Quercetin significantly improved liver function indexes and liver fibrosis indicators, with mechanisms involving anti-inflammatory and antioxidant activities.
Preclinical evidence for quercetin against inflammatory bowel disease: a meta-analysis and systematic review.
Meta-analysis and systematic review of 11 animal studies involving 199 animals, evaluating the effects of quercetin on inflammatory bowel disease (IBD). Quercetin was found to reduce histological score, Disease Activity Index, and inflammatory markers, while increasing colon length and antioxidant activity, suggesting potential benefits for IBD treatment.
Effect and Mechanisms of Quercetin for Experimental Focal Cerebral Ischemia: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis assessing quercetin's efficacy and mechanisms in treating experimental focal cerebral ischemia. Quercetin improved neurological function scores and reduced infarct volume, with mechanisms involving antioxidation, antiapoptotic, anti-inflammation, and calcium overload reduction.
The effect of quercetin on diabetic nephropathy (DN): a systematic review and meta-analysis of animal studies.
Systematic review and meta-analysis of 20 animal studies assessing the effect of quercetin on diabetic nephropathy. Quercetin significantly improved renal function and reduced oxidative stress and inflammatory markers in diabetic animal models.
Effective dose/duration of natural flavonoid quercetin for treatment of diabetic nephropathy: A systematic review and meta-analysis of rodent data.
Systematic review and meta-analysis of rodent studies on quercetin for diabetic nephropathy. Quercetin showed therapeutic benefits in reducing markers of kidney damage and improving renal pathology through various mechanisms. Optimal dosage was 90-150 mg/kg/d for 8-12 weeks.
Treatment of COVID-19 Patients with Quercetin: A Prospective, Single - Centre, Randomized, Controlled Trial
This single-centre, prospective randomized controlled trial compared routine care to QCB (quercetin, vitamin C, bromelain) supplementation in 447 COVID-19 patients with chronic diseases and moderate-to-severe respiratory symptoms. The QCB group showed higher decreases in CRP, procalcitonin, and ferritin levels, and increases in platelet and lymphocyte counts, but did not reduce the risk of events during follow-up. The study suggests that suboptimal bioavailability of QCB may limit its effectiveness.
Treatment of COVID-19 patients with quercetin: a prospective, single center, randomized, controlled trial
This prospective, single-center randomized controlled trial evaluated the effect of quercetin, vitamin C, and bromelain (QCB) supplementation in 429 COVID-19 patients with chronic diseases and moderate-to-severe respiratory symptoms. The QCB group showed higher decreases in CRP and ferritin levels and increases in platelet and lymphocyte counts, indicating a positive effect on laboratory recovery. However, QCB did not reduce the risk of events during follow-up, and further studies are needed to understand its role in COVID-19 treatment.
Quercetin Impairs HuR-Driven Progression and Migration of Triple Negative Breast Cancer (TNBC) Cells.
The study explored the role of HuR protein in triple negative breast cancer (TNBC) and found that quercetin treatment significantly inhibited cytoplasmic HuR in TNBC cell lines, reducing adhesion and migration. This suggests quercetin's potential as an anticancer agent for TNBC.
Effectiveness of supplementation with quercetin-type flavonols for treatment of viral lower respiratory tract infections: Systematic review and meta-analysis of preclinical studies.
Systematic review and meta-analysis of preclinical studies on quercetin-type flavonols for viral lower respiratory tract infections. The analysis showed antiviral activity with reduced mortality rate and viral load in infected animals, along with decreased proinflammatory cytokines, chemokines, reactive oxygen species, mucus production, and airway resistance.
The Effects of Quercetin on the Apoptosis of Human Breast Cancer Cell Lines MCF-7 and MDA-MB-231: A Systematic Review.
Systematic review of 31 articles evaluating the effects of quercetin on human breast cancer cell lines MCF-7 and MDA-MB-231. Quercetin was found to induce apoptosis in both cell lines, suggesting potential benefits in eliminating breast cancer cells. Further clinical trials are recommended.
A comprehensive systematic review of the therapeutic effects and mechanisms of action of quercetin in sepsis.
Systematic review of 35 articles examining the effects of quercetin on sepsis. Quercetin supplementation may benefit sepsis by reducing inflammation and oxidative stress, modulating immune response, and alleviating organ dysfunctions.
Quercetin- and rutin-based nano-formulations for cancer treatment: A systematic review of improved efficacy and molecular mechanisms.
Systematic review of 90 articles evaluating the anticancer ability of nano-formulations of quercetin and rutin. The review found that these formulations have greater anticancer activities compared to either agent alone, suggesting increased efficiency for treating cancer.
Effect of quercetin supplementation on plasma lipid profiles, blood pressure, and glucose levels: a systematic review and meta-analysis.
Systematic review and meta-analysis of 17 RCTs with 896 participants examining quercetin supplementation effects on plasma lipid profiles, blood pressure, and glucose levels. Quercetin significantly lowered systolic and diastolic blood pressure. Significant changes in high-density lipoprotein cholesterol and triglycerides were observed in trials with a parallel design and consumption for 8 weeks or more.
Effects of Quercetin on Cardiac Function in Pressure Overload and Postischemic Cardiac Injury in Rodents: a Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of 14 studies assessing quercetin's effects on cardiac function in pressure overload and ischemia-reperfusion injury models in rodents. Quercetin improved cardiac function and structure in both models, suggesting beneficial effects on cardiac left ventricular dysfunction.
Quercetin and polycystic ovary syndrome, current evidence and future directions: a systematic review.
This systematic review evaluated the efficacy of quercetin supplementation in subjects with PCOS, including 5 animal studies and 3 clinical trials. The majority of studies supported beneficial effects of quercetin on ovarian histomorphology, folliculogenesis, luteinisation, and reducing testosterone, LH, and insulin resistance. Quercetin improved dyslipidemia but had no significant effect on weight loss.
Quercetin in Animal Models of Alzheimer's Disease: A Systematic Review of Preclinical Studies.
Systematic review of 14 preclinical studies on quercetin's neuroprotective effects in animal models of Alzheimer's disease. The review highlights consistent neuroprotective effects and summarizes pharmacological mechanisms, while noting limitations such as absence of sample size calculations and low method quality in some studies.
Effects of quercetin supplementation on lipid profile: A systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of RCTs assessing quercetin supplementation on plasma lipids. No clinically relevant effects were found on LDL-C, HDL-C, or total cholesterol, but a significant reduction in triglycerides was observed at doses above 500 mg/day.
Effects of Quercetin on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Systematic review and meta-analysis of 7 randomized controlled trials with 9 treatment arms, involving 587 patients, assessing the effect of quercetin on blood pressure. Quercetin supplementation showed significant reductions in both systolic and diastolic blood pressure, particularly at doses ≥500 mg/day.
Quercetin and endurance exercise capacity: a systematic review and meta-analysis.
Systematic review and meta-analysis of 11 studies with 254 human subjects examining quercetin's effect on endurance exercise capacity. Quercetin ingestion showed a statistically significant but small improvement in VO2max and endurance performance compared to placebo.
Quercetin supplementation and upper respiratory tract infection: A randomized community clinical trial
Randomized, double-blinded, placebo-controlled trial of quercetin supplementation (500 and 1000 mg/day) on upper respiratory tract infection rates in 1002 subjects aged 18 to 85 years over 12 weeks. No significant differences in URTI outcomes were found overall, but a subgroup of subjects ≥ 40 years with high fitness levels showed reduced URTI severity and sick days with 1000 mg quercetin.
Effect of a Nutraceutical Combination on Oxidative Stress Biomarkers in Healthy Subjects and Patients with Alzheimer's Disease.
A randomized, double-blind, placebo-controlled 3-month trial assessed the effects of a nutraceutical blend (quercetin, rutin, genistein) on oxidative stress biomarkers in older healthy adults and Alzheimer's patients. Serum malondialdehyde decreased in both cohorts after supplementation, while urinary Nε-(carboxymethyl)lysine decreased only in the Alzheimer's group.
Immune Preconditioning with Oral Quercetin Supplement and COVID-19 mRNA Vaccine Responses: A Randomized, Double-Blind, Placebo-Controlled Trial.
This randomized, double-blind, placebo-controlled trial examined the effects of quercetin glycoside supplementation before mRNA COVID-19 vaccination in older or metabolically at-risk individuals. The study found no significant differences in vaccine-induced antibody responses or T-cell activation between the quercetin and placebo groups. Quercetin supplementation was well tolerated, with no significant impact on vaccine immunogenicity or reactogenicity.
The Adjunctive Effect of Quercetin on Postoperative Pain Management Following Cesarean Section: A Randomized Controlled Study
RCT assessing the efficacy of 500 mg oral Quercetin administered preoperatively on acute postoperative pain following cesarean section. The Quercetin group showed significantly lower pain scores, delayed time to first analgesic request, and earlier initiation of physical activity compared to placebo, with no increase in adverse effects.
Effects of Quercetin and Citrulline on Nitric Oxide Metabolites and Antioxidant Biomarkers in Trained Cyclists
RCT evaluating the effects of quercetin and citrulline supplementation on nitric oxide metabolites and antioxidant biomarkers in 50 trained cyclists during a 20 km time trial. No significant improvements in biomarkers were observed, suggesting inconclusive ergogenic efficacy.
Microbiological and Pharmacokinetic Aspects of a Water-Soluble Quercetin 3-O-rutinoside, EubioQuercetin: A Direct Comparison With Quercetin in In Vitro and Human Clinical Studies.
The study compared the microbiological and pharmacokinetic properties of EubioQuercetin, a water-soluble quercetin-3-O-rutinoside formulation, with conventional quercetin. EubioQuercetin significantly altered fecal microbiota and showed improved pharmacokinetic profiles, including increased Cmax and AUC, compared to quercetin. The study suggests that EubioQuercetin's increased water solubility enhances metabolic reactions in intestinal bacteria.
Characterization of Human Senescent Cell Biomarkers for Clinical Trials.
The study evaluates biomarkers of senescent cell burden to select participants for clinical trials. It highlights the senolytic combination of dasatinib and quercetin (D+Q) and its effects on bone metabolism in postmenopausal women. Women with high T-cell expression of p16_variant 5 showed robust skeletal responses to D+Q, suggesting p16_variant 5 as a predictive biomarker.
Synergistic effects of ursodeoxycholic acid, and quercetin on liver function and systemic inflammation in non-alcoholic fatty liver disease and atrial fibrillation patients
Prospective RCT of 127 patients with NAFLD and AF comparing standard treatment alone to standard treatment plus UDCA and quercetin. The combination of UDCA and quercetin significantly improved liver function, lipid profiles, and reduced systemic inflammation and fibrosis, with the most pronounced effects in the group receiving both supplements.
The combined effects of ursodesoxycholic acid and quercetin on liver health and cardiac function in patients with non-alcoholic fatty liver disease and atrial fibrillation
A randomized controlled trial evaluated the efficacy of combining ursodesoxycholic acid and quercetin with standard treatment in 127 patients with non-alcoholic fatty liver disease and atrial fibrillation. The combined treatment showed significant improvements in liver stiffness, fibrosis stages, steatosis levels, and cardiac function, particularly in the group receiving both UDCA and quercetin.
Benefits of Quercetin on Glycated Hemoglobin, Blood Pressure, PiKo-6 Readings, Night-Time Sleep, Anxiety, and Quality of Life in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial
This RCT investigated the effects of 500 mg quercetin daily on patients with type 2 diabetes mellitus over 32 weeks. Quercetin significantly decreased glycated hemoglobin levels, improved PiKo-6 readings, reduced systolic blood pressure, enhanced night-time sleep, lowered anxiety levels, and improved quality of life compared to the control group.
Quercetin Intake and Absolute Telomere Length in Patients with Type 2 Diabetes Mellitus: Novel Findings from a Randomized Controlled Before-and-After Study
RCT of 100 patients with type 2 diabetes mellitus examining the effect of quercetin supplementation on telomere length. Quercetin supplementation was associated with a significant increase in mean telomere length, suggesting it as a potentially promising supplementation option for longevity.
Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial.
Phase 2 RCT of intermittent dasatinib plus quercetin (D+Q) in 60 postmenopausal women. Primary endpoint of bone resorption marker CTx showed no difference between groups. Secondary endpoint of bone formation marker P1NP increased significantly in the D+Q group at 2 and 4 weeks but not at 20 weeks. Exploratory analyses suggest a greater response in women with high senescent cell burden.
Role of Quercetin Supplementation on C-reactive Protein, Tumor Necrosis Factor, and Hepcidin in Blood Transfusion-dependent Thalassemia Patients
RCT evaluating quercetin supplementation in transfusion-dependent thalassemia patients. The quercetin group showed decreased CRP and TNF-alpha levels and increased hepcidin levels, indicating a significant impact on inflammatory markers and iron overload.
Impact of quercetin in patients with myocardial infarction. A multicenter, randomized, and open-label pilot study.
Multicenter, open-label pilot study investigating the cardioprotective effect of quercetin in 143 patients with STEMI. Quercetin administration reduced infarct size and intramyocardial hemorrhage compared to control, though no significant differences were found in left ventricle ejection fraction and LV remodeling indicators.
The clinical effect of benesco™ on reflux symptoms: A double-blind randomized placebo-controlled trial.
Double-blind randomized placebo-controlled trial assessing the effect of benesco, a quercetin-based supplement, on reflux symptoms in 100 participants. The trial found no significant benefit of benesco over placebo in reducing reflux symptoms or improving GERD-related quality of life.
Quercetin as a possible complementary agent for early-stage COVID-19: Concluding results of a randomized clinical trial
Open-label randomized controlled trial of 100 outpatients with early-stage COVID-19 comparing standard care plus quercetin to standard care alone. The quercetin group showed faster recovery, with more patients testing negative for SARS-CoV-2 and resolving acute symptoms. Quercetin also significantly reduced serum lactate dehydrogenase levels and was well-tolerated.
Two-month period of 500 mg lecithin-based delivery form of quercetin daily dietary supplementation counterbalances chronic fatigue symptoms: A double-blind placebo controlled clinical trial.
Double-blind placebo-controlled clinical trial evaluating the effects of 500 mg quercetin supplementation for 2 months on chronic fatigue symptoms. The study found significant improvements in fatigue, sleep quality, and physical performance in the quercetin group compared to placebo.
Quercetin for the treatment of COVID-19 patients: A systematic review and meta-analysis.
Systematic review and meta-analysis of six RCTs assessing quercetin's effect on clinical outcomes in COVID-19 patients. Quercetin decreased the risk of ICU admission and hospitalization but did not affect all-cause mortality or recovery rates. Phytosome formulation may enhance bioavailability.
Quercetin and polycystic ovary syndrome; inflammation, hormonal parameters and pregnancy outcome: A randomized clinical trial.
RCT of 72 women with PCOS comparing 500mg quercetin to placebo for 40 days. Quercetin significantly reduced LH and TNF-alpha levels, improved oocyte and embryo grade, and increased pregnancy rate, suggesting benefits for managing PCOS.
Effects of repeated oral intake of a quercetin-containing supplement on allergic reaction: a randomized, placebo-controlled, double-blind parallel-group study.
RCT of 66 Japanese adults with allergic symptoms of pollinosis, testing 200 mg quercetin daily for 4 weeks. The quercetin group showed significant improvements in JRQLQ scores, including eye itching, sneezing, nasal discharge, and sleep disorder, compared to placebo.
Design of a Randomized Placebo-Controlled Trial to Evaluate the Anti-inflammatory and Senolytic Effects of Quercetin in Patients Undergoing Coronary Artery Bypass Graft Surgery
The Q-CABG study is a phase II randomized, double-blind, placebo-controlled trial evaluating the effects of quercetin supplementation on inflammation, myocardial injury, and senescence in patients undergoing coronary artery bypass graft surgery. The trial involves 100 patients and aims to assess quercetin's impact on blood inflammatory cytokines, myocardial injury markers, and endothelial function.
The effect of 24-week continuous intake of quercetin-rich onion on age-related cognitive decline in healthy elderly people: a randomized, double-blind, placebo-controlled, parallel-group comparative clinical trial
A 24-week randomized, double-blind, placebo-controlled trial studied the effects of quercetin-rich onion on cognitive function in 70 healthy elderly Japanese individuals. The quercetin group showed significant improvements in Mini-Mental State Examination scores and emotional function, suggesting quercetin may reduce age-related cognitive decline by improving depressive symptoms and motivation.
The therapeutic efficacy of quercetin in combination with antiviral drugs in hospitalized COVID-19 patients: A randomized controlled trial.
RCT evaluating the therapeutic efficacy of quercetin in combination with remdesivir and favipiravir in 60 severe hospitalized COVID-19 patients. Quercetin was associated with partial earlier discharge and reduced serum levels of ALP, q-CRP, and LDH, indicating its potential in lowering inflammation markers related to COVID-19 severity.
Cardio-metabolic benefits of quercetin in elderly patients with metabolic syndrome
Randomized, placebo-controlled, double-blind clinical trial evaluating the effects of quercetin on metabolic syndrome in patients aged 60+. Quercetin administration decreased body weight, body mass index, and systolic blood pressure, indicating potential effectiveness in treating metabolic syndrome.
Evaluation of the Effects of a Supplement Composed by Quercetin, Rutin, Bromelain and L-Carnosine in Patients with Borderline Uricemia
RCT evaluating the effects of a nutraceutical containing quercetin, rutin, bromelain, and L-carnosine (Uricemin®) on uric acid levels in patients with borderline uricemia. The study found a reduction in uricemia and Hs-CRP in the Uricemin® group compared to baseline and placebo.
Quercetin supplementation in non-alcoholic fatty liver disease
RCT of 90 NAFLD patients assessing quercetin supplementation (500 mg twice daily) versus placebo for 12 weeks. Quercetin group showed significant reductions in cholesterol, triglycerides, and TNF-α compared to control, but no significant changes in liver enzymes or fatty liver grade.
Effects of Quercetin Supplementation on Hematological Parameters in Non-Alcoholic Fatty Liver Disease: a Randomized, Double-Blind, Placebo-Controlled Pilot Study
A randomized, double-blind, placebo-controlled pilot study assessed the effect of quercetin supplementation on hematological parameters in 90 NAFLD patients. Quercetin significantly affected RBC, ferritin, MCV, and MCH levels compared to placebo, indicating its potential impact on hematological parameters in NAFLD.
Effects of quercetin supplementation on inflammatory factors and quality of life in post-myocardial infarction patients: A double blind, placebo-controlled, randomized clinical trial.
This double-blind, placebo-controlled RCT studied the effects of 500mg/day quercetin supplementation in 88 post-myocardial infarction patients over 8 weeks. Quercetin significantly increased serum total antioxidant capacity and improved the insecurity dimension of quality of life, but showed no significant effect on inflammatory factors, blood pressure, or other quality of life dimensions.
Randomised clinical trial to determine the safety of quercetin supplementation in patients with chronic obstructive pulmonary disease
Randomised clinical trial assessing the safety of quercetin supplementation in COPD patients. Quercetin was administered at 500, 1000, or 2000 mg/day for 1 week. No severe adverse events were reported, and quercetin was safely tolerated up to 2000 mg/day.
Antidiabetic effect of quercetin: A systematic review and meta-analysis of animal studies.
Systematic review and meta-analysis of animal studies evaluating the antidiabetic effect of quercetin. The meta-analysis showed that quercetin significantly lowers serum glucose levels at doses of 10, 25, and 50 mg/kg.
The Effects of Quercetin Supplementation on Blood Pressures and Endothelial Function Among Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Systematic review and meta-analysis of 8 RCTs assessing quercetin supplementation effects on blood pressures and endothelial function in patients with metabolic syndrome. Quercetin significantly reduced systolic blood pressure but did not affect diastolic blood pressure, VCAM-1, or ICAM-1.
Antitumor Effects of Quercetin in Hepatocarcinoma In Vitro and In Vivo Models: A Systematic Review.
Systematic review of 39 preclinical studies on quercetin's antitumor activities in hepatocarcinoma (HCC) models. The review highlights quercetin's antiproliferative and proapoptotic properties against HCC, with studies employing single, encapsulated, combined, or derived forms of quercetin. Few studies assessed specific cancer progression processes, and further research is needed to explore quercetin's mechanisms and potential in HCC.
Quercetin Actions on Lipid Profiles in Overweight and Obese Individuals: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of 9 randomized clinical trials assessing the effect of quercetin on plasma lipid levels in overweight and obese individuals. Quercetin administration significantly reduced LDL-cholesterol levels at doses of ≥250 mg/day and total dose ≥14,000 mg, but did not affect HDL-cholesterol, triglycerides, or total cholesterol levels.
Effects of quercetin supplementation on glycemic control among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis evaluated the effect of quercetin supplementation on glycemic control in patients with metabolic syndrome and related disorders. The pooled findings indicated no overall effect on fasting plasma glucose, insulin resistance, and hemoglobin A1c levels. However, subgroup analysis showed significant reductions in fasting plasma glucose and insulin concentrations with quercetin dosages of ≥500 mg/day and study durations of ≥8 weeks.
Effects of quercetin ingestion on neuromuscular system following single session of resistance exercise at differing intensities in older adults.
This study investigated the effects of quercetin ingestion on muscle contractile capacity in older adults following resistance exercise at different intensities. Quercetin ingestion decreased motor unit recruitment thresholds and accelerated the decline in muscle contractile capacity following low- or moderate-intensity exercise, but not high-intensity exercise.
Quercetin-Loaded Avocado Oil Nanoemulsion Reverses High-fat and High-carbohydrate Diet-Induced Testicular Dysfunction: Role of Oxidative Stress and NPY Signaling in a Randomized Trial
A randomized trial in rats fed a high-fat diet tested a nanoemulsion of avocado oil containing quercetin (NAOQu) for its effects on testicular dysfunction and metabolic disorders. NAOQu reduced body weight, improved lipid profiles, restored testosterone levels, and reduced oxidative stress markers, showing greater protective effects than quercetin or avocado oil alone.
Quercetin ingestion alters motor unit behavior and enhances improvement in muscle strength following resistance training in older adults: a randomized, double-blind, controlled trial
A randomized, double-blind, controlled trial investigated the effects of daily quercetin glucoside ingestion on muscle strength and motor unit behavior in older adults during resistance training. The quercetin group showed greater improvement in maximal voluntary force and higher motor unit firing rates compared to placebo, although muscle mass did not change significantly.
The effect of quercetin and citrulline on cycling time trial performance.
RCT examining 28-day supplementation of quercetin and citrulline on cycling time trial performance in 48 highly trained cyclists. No significant benefits were found for the combination on time trial performance, though individual improvements in VO2 were noted for quercetin and citrulline alone.
The Impact of Three-Month Quercetin Intake on Quality of Life and Anxiety in Patients With Type II Diabetes Mellitus: An Early Data Analysis From a Randomized Controlled Trial
RCT analyzing the impact of 500 mg daily quercetin intake on quality of life and anxiety in patients with type II diabetes mellitus. The treatment group showed significant improvements in anxiety levels and quality of life over 12 weeks, with no adverse effects reported.
Protocol for a pilot clinical trial of the senolytic drug combination Dasatinib Plus Quercetin to mitigate age-related health and cognitive decline in mental disorders
This pilot study assesses the feasibility and safety of the senolytic regimen dasatinib plus quercetin (D+Q) in older adults with schizophrenia, schizoaffective disorder, and treatment-resistant depression. The study aims to evaluate D+Q's potential to mitigate age-related health and cognitive decline, with assessments of health, cognitive function, and psychiatric function over a year.
One-week quercetin intervention modifies motor unit recruitment patterns before and during resistance exercise in older adults: A randomized controlled trial.
RCT investigating the effects of one-week quercetin ingestion on motor unit behavior and muscle contractile properties in older adults during resistance exercise. Quercetin lowered motor unit recruitment threshold and increased exerted force normalized by firing rate, suggesting altered motor unit recruitment patterns.
Effects of 7-day quercetin intervention on motor unit activity and muscle contractile properties before and after resistance exercise in young adults randomized controlled trials.
RCT investigating the effects of 7-day quercetin ingestion on motor unit activity and muscle contractile properties in young adults. Quercetin decreased the motor unit recruitment threshold and altered motor unit firing patterns during resistance exercise, suggesting potential benefits for physical performance.
Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: results of a phase I, single-blind, single-center, randomized, placebo-controlled pilot trial on feasibility and tolerability.
This phase I, single-blind, single-center, randomized, placebo-controlled pilot trial evaluated the feasibility and tolerability of the senolytic combination of dasatinib and quercetin in 12 patients with idiopathic pulmonary fibrosis (IPF). The study found that the regimen was generally well-tolerated, with no serious adverse events related to the treatment, although sleep disturbances and anxiety were more common in the treatment group.
Senolytic therapy in mild Alzheimer's disease: a phase 1 feasibility trial.
Phase I clinical trial of senolytic therapy using dasatinib and quercetin in early-stage Alzheimer's disease patients. The study assessed CNS penetrance, safety, feasibility, and efficacy. Dasatinib was detected in cerebrospinal fluid, while quercetin was not. The treatment was well-tolerated, with no significant cognitive or neuroimaging changes, but biomarker data suggested mechanistic insights into senolytic effects.
Memory-Enhancing Effect of 8-Week Consumption of the Quercetin-Enriched Culinary Herbs-Derived Functional Ingredients: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
RCT of 45 participants assessing the memory-enhancing effects of a quercetin-enriched herbal supplement derived from Polygonum odoratum and Morus alba. Participants consuming 1500 mg/day showed improved working memory and suppression of AChE, MAO-A, and MAO-B activities, indicating cognitive enhancement.
Senolytic Therapy to Modulate the Progression of Alzheimer's Disease (SToMP-AD): A Pilot Clinical Trial.
This pilot clinical trial investigates the use of dasatinib plus quercetin as a senolytic therapy in five older adults with early-stage Alzheimer's disease. The primary objective is to evaluate the central nervous system penetration of the compounds, with secondary measures assessing safety, feasibility, and efficacy in modulating Alzheimer's disease progression.
Potential Clinical Benefits of Quercetin in the Early Stage of COVID-19: Results of a Second, Pilot, Randomized, Controlled and Open-Label Clinical Trial
This randomized, open-label, controlled clinical study enrolled 42 COVID-19 outpatients to evaluate the effects of Quercetin Phytosome (QP) as an add-on to standard care. The QP group showed faster virus clearance and symptom reduction compared to the standard care group. QP also reduced blood markers like LDH, Ferritin, CRP, and D-dimer, indicating potential benefits in early-stage COVID-19.
Prospective randomized trial evaluating blood and prostate tissue concentrations of green tea polyphenols and quercetin in men with prostate cancer.
Prospective randomized trial evaluating the bioavailability of green tea polyphenols and quercetin in men with prostate cancer. Participants consumed green tea extract with quercetin or placebo for four weeks before prostatectomy. Quercetin levels increased significantly in plasma, urine, and prostate tissue in the treatment group. No significant differences were found in GTP content or methylation activity in prostate tissue.
Effects of Quercetin Supplementation on Oxidative Stress, Blood Pressure, Aerobic Power, Concentric Pathologic Hypertrophy and Cardiac Function in Men with Hypertension and Coronary Artery Disease After Percutaneous Coronary Intervention: a Randomized, Double-Blind Placebo-Controlled Trial
This randomized, double-blind placebo-controlled trial investigated the effects of quercetin supplementation on oxidative stress, blood pressure, aerobic power, and cardiac function in 24 men with hypertension and coronary artery disease after PCI. Quercetin significantly improved oxidative stress markers, blood pressure, systolic and diastolic functions, and aerobic power compared to placebo after eight weeks.
The effects of quercetin supplementation on metabolic and hormonal parameters as well as plasma concentration and gene expression of resistin in overweight or obese women with polycystic ovary syndrome
This randomized, double-blind, placebo-controlled trial investigated the effects of quercetin supplementation on metabolic and hormonal parameters in 78 overweight or obese women with PCOS. Quercetin significantly decreased resistin concentration and gene expression, as well as testosterone and LH concentrations, compared to placebo.
Effect of alpha-linolenic acid in combination with the flavonol quercetin on markers of cardiovascular disease risk in healthy, non-obese adults: A randomized, double-blinded placebo-controlled crossover trial.
RCT investigating the effects of 3.6 g/d ALA and 190 mg/d quercetin on cardiovascular risk markers in 67 healthy adults. The combination improved lipid profiles but had no significant effect on blood pressure, inflammation, or oxidative stress markers. No additive or synergistic effects were observed.
Oral Quercetin Supplementation Enhances Adiponectin Receptor Transcript Expression in Polycystic Ovary Syndrome Patients: A Randomized Placebo-Controlled Double-Blind Clinical Trial
This randomized clinical trial investigated the effect of quercetin supplementation on adiponectin receptor expression in PCOS patients. Quercetin supplementation significantly increased ADIPOR1 and ADIPOR2 transcript expression and enhanced AMPK levels, suggesting improvements in metabolic features of PCOS.
The Effect of Quercetin on Inflammatory Factors and Clinical Symptoms in Women with Rheumatoid Arthritis: A Double-Blind, Randomized Controlled Trial.
This double-blind, randomized controlled trial investigated the effect of quercetin supplementation on inflammation and clinical symptoms in 50 women with rheumatoid arthritis. Quercetin supplementation for 8 weeks significantly reduced early morning stiffness, morning pain, and after-activity pain, and improved DAS-28 and HAQ scores compared to placebo. Plasma hs-TNFα levels were significantly reduced in the quercetin group.