Research
Pterostilbene
29 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
A Short-Term Safety Evaluation of Silbinol- an Extract fromin Healthy Adults- a Randomized, Double-Blind, Placebo-Controlled Study.
A randomized, double-blind, placebo-controlled study evaluated the clinical safety of a standardized extract containing 90% pterostilbene (200 mg per day) in 60 healthy adults. The study found no significant differences in laboratory parameters, vital signs, or adverse events between the PME and placebo groups, establishing the safety of PME for human use.
Analysis of the Effects of Short-Term Pterostilbene Intake on Healthy Participants: A Pilot Study.
A double-blind, placebo-controlled pilot study investigated the effects of pterostilbene intake on blood biochemistry and miRNA expression levels in 30 healthy men over 12 weeks. Pterostilbene intake at doses of 10 or 100 mg/d showed high increases in miR-34a and miR-193b expression levels, with no adverse events reported.
Pterostilbene on Metabolic Parameters: A Randomized, Double-Blind, and Placebo-Controlled Trial
RCT evaluating the effect of pterostilbene on metabolic parameters in 80 patients with high cholesterol or LDL. Pterostilbene increased LDL levels but reduced both systolic and diastolic blood pressure. Minor weight loss was observed in patients not on cholesterol medication.
Analysis of Safety from a Human Clinical Trial with Pterostilbene
This prospective, randomized, double-blind placebo-controlled trial evaluated the safety of long-term pterostilbene administration in 80 patients with hypercholesterolemia. The study found no adverse drug reactions on hepatic, renal, or glucose markers, and no statistically significant self-reported or major adverse drug reactions, concluding that pterostilbene is generally safe for use in humans up to 250 mg/day.
Selective COX-2 inhibition by a Pterocarpus marsupium extract characterized by pterostilbene, and its activity in healthy human volunteers.
The study evaluated the PGE2-inhibitory and COX-2 selective inhibitory activity of Pterocarpus marsupium extract containing pterostilbene in LPS-stimulated PBMC and healthy human volunteers. The extract showed COX-2 specific inhibition in vitro, but did not decrease PGE2 production ex vivo in humans. Pterostilbene levels increased in serum, but were below the active concentration observed in vitro. The extract was considered safe with no adverse events.
Pterostilbene suppresses oxidative stress and allergic airway inflammation through AMPK/Sirt1 and Nrf2/HO‐1 pathways
The study explores the pharmacological effects of pterostilbene on oxidative stress and allergic inflammatory response in asthma, focusing on the AMPK/Sirt1 and Nrf2/HO‐1 pathways.
Pterostilbene could alleviate diabetic cognitive impairment by suppressing TLR4/NF‐кB pathway through microbiota‐gut‐brain axis
The study explored the effects of pterostilbene on diabetic cognitive impairment in mice. Pterostilbene treatment improved cognitive dysfunction, regulated glycolipid metabolism, reduced neuronal damage, and decreased inflammation by modulating the TLR4/NF-κB pathway through the microbiota-gut-brain axis.
Oral Delivery of Pterostilbene by L-Arginine-Mediated “Nano-Bomb” Carrier for the Treatment of Ulcerative Colitis
The study investigates the use of hyaluronic acid-modified L-arginine CO2 nanoparticles loaded with pterostilbene for treating ulcerative colitis. The nanoparticles show biocompatibility and target the colon effectively, reducing pro-inflammatory cytokines and intestinal permeability in vitro, suggesting potential benefits for ulcerative colitis treatment.
Based on Network Pharmacology and Gut Microbiota Analysis to Investigate the Mechanism of the Laxative Effect of Pterostilbene on Loperamide-Induced Slow Transit Constipation in Mice
The study investigates the laxative effect of pterostilbene on loperamide-induced slow transit constipation in mice. Pterostilbene improved intestinal motility, reduced oxidative stress, and restored microbial diversity, potentially through the PI3K/AKT/Nrf2 signaling pathway.
Comparison of the effects of resveratrol and its derivative pterostilbene on hepatic oxidative stress and mitochondrial dysfunction in piglets challenged with diquat.
This study investigated the effects of resveratrol and pterostilbene on diquat-induced hepatic oxidative damage and mitochondrial dysfunction in piglets. Pterostilbene was more effective than resveratrol in reducing oxidative stress and mitochondrial dysfunction, suggesting its superior antioxidant properties.
Pterostilbene alleviates Aβ1-42 -induced cognitive dysfunction via inhibition of oxidative stress by activating Nrf2 signaling pathway.
The study investigated the effect of pterostilbene on Aβ1-42 induced cognitive impairment in mice. Pterostilbene alleviated cognitive dysfunction and neuron loss, reduced ROS accumulation, and activated Nrf2 signaling, enhancing antioxidant gene expression.
Pterostilbene complexed with cyclodextrin exerts antimicrobial and anti-inflammatory effects
The study investigated the antimicrobial and anti-inflammatory effects of pterostilbene (PTS) complexed with cyclodextrin against Fusobacterium nucleatum, a periodontal pathogen. PTS showed potent antibacterial effects and inhibited biofilm formation, while also exerting immunomodulatory effects by upregulating antioxidant pathways and inhibiting NF-κB activation.
Neuroprotective and anti-inflammatory effects of pterostilbene metabolites in human neuroblastoma SH-SY5Y and RAW 264.7 macrophage cells.
In vitro study evaluating the effects of pterostilbene and its metabolites on oxidative stress and inflammation. 3-methyl-4'-glucuronate-resveratrol prevented neuronal death and reduced ROS levels in neuroblastoma cells, and ameliorated inflammation in macrophages by inhibiting IL-6 and NO production.
Comparative Effects of Pterostilbene and Its Parent Compound Resveratrol on Oxidative Stress and Inflammation in Steatohepatitis Induced by High-Fat High-Fructose Feeding
Animal study comparing the effects of pterostilbene and resveratrol on oxidative stress and inflammation in a high-fat high-fructose diet-induced steatohepatitis model. Pterostilbene was more effective than resveratrol in preventing oxidative stress and inflammation, likely due to its higher bioavailability and antioxidant activity.
Pterostilbene in the treatment of inflammatory and oncological diseases
This comprehensive review discusses the pharmacological properties, mechanisms of action, and therapeutic potential of pterostilbene (PTS) in treating inflammatory and oncological diseases. PTS exhibits anti-inflammatory, antioxidant, and antitumour properties, with a favorable pharmacokinetic profile and better oral bioavailability compared to other stilbenoids.
Pterostilbene in Cancer Therapy
The review discusses the potential of pterostilbene (PT) in cancer therapy, highlighting its effectiveness against melanoma in vivo through mechanisms like inhibition of adrenocorticotropic hormone production and lysosomal membrane permeabilization. PT was found to be pharmacologically safe in mice, showing no organ-specific or systemic toxicity even at high doses. The review emphasizes the need for improved bioavailability to enhance PT's therapeutic efficacy.
Chemistry of pterostilbene and its metabolic effects.
This narrative review discusses the chemistry and metabolic effects of pterostilbene, a resveratrol analogue. It highlights research showing pterostilbene's potential to reduce weight gain, liver fat, plasma cholesterol, adiposity, inflammatory biomarkers, and blood glucose in animal models, suggesting benefits for metabolic diseases.
Occurrence, bioavailability, anti-inflammatory and anti-cancer effects of pterostilbene.
This narrative review discusses the bioavailability, anti-inflammatory, and anti-cancer effects of pterostilbene, a natural stilbenoid found in blueberries. Pterostilbene is more lipophilic than resveratrol, leading to higher intestinal permeability and cellular uptake. It exhibits detoxification activities, mediates anti-inflammation response, regulates the cell cycle, augments apoptosis, enhances autophagy, and inhibits tumor angiogenesis, invasion, and metastasis.
Dietary pterostilbene supplementation attenuates intestinal damage and immunological stress of broiler chickens challenged with lipopolysaccharide1.
The study investigated the effects of pterostilbene supplementation on intestinal damage and immunological stress in broiler chickens challenged with lipopolysaccharide (LPS). Pterostilbene supplementation improved intestinal integrity and reduced inflammatory responses, suggesting a protective role against LPS-induced damage.
PGC1α activation by pterostilbene ameliorates acute doxorubicin cardiotoxicity by reducing oxidative stress via enhancing AMPK and SIRT1 cascades
The study investigates the effects of pterostilbene on doxorubicin-induced cardiotoxicity in H9c2 cells and C57BL/6 mice. Pterostilbene alleviated myocardial injury by reducing oxidative stress and mitochondrial damage through PGC1α upregulation and deacetylation, activating AMPK and SIRT1 pathways.
Effect of pterostilbene on in vitro drug metabolizing enzyme activity
In vitro study assessing the inhibitory effect of pterostilbene on drug metabolizing enzymes. Pterostilbene significantly inhibited CYP2C8 and UGT1A6 activities, suggesting potential for in vivo interactions. Clinical studies are recommended to evaluate these interactions further.
Pterostilbene restores carbapenem susceptibility in New Delhi metallo‐β‐lactamase‐producing isolates by inhibiting the activity of New Delhi metallo‐β‐lactamases
The study investigates the ability of pterostilbene to restore carbapenem susceptibility in bacteria producing New Delhi metallo‐β‐lactamase‐1 (NDM‐1) by inhibiting the activity of NDM‐1 enzymes.
Resveratrol and Pterostilbene Exhibit Anticancer Properties Involving the Downregulation of HPV Oncoprotein E6 in Cervical Cancer Cells
In vitro study of resveratrol and pterostilbene on cervical cancer cells, showing anticancer and anti-HPV activity. Both polyphenols downregulate HPV oncoprotein E6, induce caspase-3 activation, and upregulate p53 protein levels, with pterostilbene being more effective.
Colon targeted beads loaded with pterostilbene: Formulation, optimization, characterization and in vivo evaluation
The study formulated pterostilbene into oral colon-targeted beads using ionic gelation with pectin and zinc acetate to overcome low bioavailability. The optimized beads showed satisfactory entrapment efficiency and in vitro release, with pharmacokinetic studies in rats confirming targeted release in the colon.
Stilbenoid pterostilbene complexed with cyclodextrin preserves left ventricular function after myocardial infarction in rats: possible involvement of thiol proteins and modulation of phosphorylated GSK-3β
The study investigates the effects of oral administration of pterostilbene complexed with hydroxypropyl-β-cyclodextrin on myocardial infarction in rats. The PTS:HPβCD complex decreased lipid peroxidation, modulated thiol-dependent enzyme activity, and improved systolic function, suggesting cardioprotective effects.
Pterostilbene, a Methoxylated Resveratrol Derivative, Efficiently Eradicates Planktonic, Biofilm, and Intracellular MRSA by Topical Application
The study investigates the antibacterial activity of pterostilbene against drug-resistant Staphylococcus aureus using in vitro and in vivo models. Pterostilbene showed superior biocidal activity compared to resveratrol, reduced MRSA biofilm thickness, and improved skin architecture in a mouse model of cutaneous infection.
Pterostilbene Decreases the Antioxidant Defenses of Aggressive Cancer Cells In Vivo: A Physiological Glucocorticoids- and Nrf2-Dependent Mechanism
The study investigates the effects of pterostilbene on human melanoma and pancreatic cancer cells in vivo using nude mice as xenografts. Pterostilbene decreased tumor growth by downregulating glucocorticoid production and Nrf2-dependent antioxidant defenses, although it did not affect melanoma growth in vitro. The study suggests that pterostilbene may interfere with cancer cell growth and defense mechanisms.
ATM/CHK/p53 Pathway Dependent Chemopreventive and Therapeutic Activity on Lung Cancer by Pterostilbene
The study investigates the chemopreventive and therapeutic activity of pterostilbene on lung cancer cells. Pterostilbene was found to inhibit cancer cell proliferation more efficiently than other stilbenoids, with its action being dependent on the presence of p53. It activated ATM and CHK1/2 pathways, suggesting a potential chemopreventive effect on p53-positive cells during early carcinogenesis.
Pterostilbene: Mechanisms of its action as oncostatic agent in cell models and in vivo studies.
This narrative review summarizes in vitro and in vivo studies on the anticancer actions of pterostilbene, highlighting its oncostatic effects such as inhibition of tumor growth, metastasis, angiogenesis, and cancer stem cells, as well as activation of apoptosis and enhancement of immunotherapy. The review also discusses pterostilbene's potential as an adjuvant therapeutic agent in chemotherapy and radiotherapy.