Research
Psyllium Husk
92 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
The effect of psyllium on fasting blood sugar, HbA1c, HOMA IR, and insulin control: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials
This systematic review and meta-analysis of 19 RCTs with 962 participants assessed the effect of psyllium on fasting blood sugar, HbA1c, insulin, and HOMA IR levels. Psyllium significantly decreased fasting blood sugar, HbA1c, and HOMA IR levels, but not insulin levels, compared to placebo.
Psyllium is a natural nonfermented gel-forming fiber that is effective for weight loss: A comprehensive review and meta-analysis.
A comprehensive review and meta-analysis of six studies assessing psyllium's impact on body weight, BMI, and waist circumference in overweight and obese participants. Psyllium, dosed just before meals, was effective in decreasing body weight, BMI, and waist circumference.
Effects of dietary fibers or probiotics on functional constipation symptoms and roles of gut microbiota: a double-blinded randomized placebo trial.
A 4-week double-blinded randomized placebo-controlled trial in 250 adults with functional constipation evaluated the effects of dietary fibers or probiotics on constipation symptoms and gut microbiota. Interventions included polydextrose, psyllium husk, wheat bran + psyllium husk, and probiotics subsp.HN019 + HN001. Results showed improvements in Bristol stool scale scores in intervention groups compared to placebo, with intervention-specific changes in gut microbiota.
The Effect of Fiber Supplementation on Chronic Constipation in Adults: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials.
This systematic review and meta-analysis of 16 RCTs with 1251 participants examined the effects of fiber supplementation on chronic constipation in adults. Psyllium and pectin were found to significantly improve stool frequency and consistency, particularly at doses greater than 10g/day and treatment durations of at least 4 weeks. Fiber supplementation was effective in improving constipation symptoms, though flatulence was more common in fiber groups.
The effect of psyllium supplementation on blood pressure: a systematic review and meta-analysis of randomized controlled trials
Systematic review and meta-analysis of 11 RCTs with 592 participants assessing the effect of psyllium supplementation on blood pressure in hypertensive patients. The meta-analysis found a significant reduction in systolic blood pressure by 2.04 mmHg, with stronger effects in subjects with higher baseline blood pressure.
The effect of psyllium consumption on weight, body mass index, lipid profile, and glucose metabolism in diabetic patients: A systematic review and dose‐response meta‐analysis of randomized controlled trials
Systematic review and meta-analysis of RCTs assessing psyllium consumption in diabetic patients. Found significant reductions in triglycerides, low-density lipoprotein, fasting blood sugar, and hemoglobin A1c, but no significant changes in high-density lipoprotein, body mass index, cholesterol, and weight.
The Relationship between Prebiotic Supplementation and Anthropometric and Biochemical Parameters in Patients with NAFLD-A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Systematic review and meta-analysis of six RCTs with 242 NAFLD patients assessing the effects of fiber supplementation. Fiber supplements, including psyllium and inulin, improved BMI, liver enzymes, fasting insulin, and insulin resistance, suggesting benefits for NAFLD populations.
The effects of psyllium supplementation on body weight, body mass index and waist circumference in adults: A systematic review and dose-response meta-analysis of randomized controlled trials
Systematic review and meta-analysis of 22 RCTs assessing the effects of psyllium supplementation on body weight, BMI, and waist circumference in adults. The analysis found no significant effect of psyllium on these obesity measures.
Effect of psyllium (Plantago ovata) fiber on LDL cholesterol and alternative lipid targets, non-HDL cholesterol and apolipoprotein B: a systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of 28 RCTs assessing the effect of psyllium fiber on blood lipids in individuals with or without hypercholesterolemia. Psyllium supplementation significantly reduced LDL cholesterol, non-HDL cholesterol, and apolipoprotein B, suggesting potential cardiovascular benefits.
The effect of viscous soluble fiber on blood pressure: A systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of RCTs assessing the effects of viscous soluble fiber supplementation on blood pressure. Viscous fiber reduced systolic and diastolic blood pressure, with significant reductions observed for psyllium fiber supplementation.
Cholesterol-lowering effects of psyllium intake adjunctive to diet therapy in men and women with hypercholesterolemia: meta-analysis of 8 controlled trials.
Meta-analysis of 8 controlled trials with 384 subjects receiving psyllium and 272 receiving placebo. Psyllium intake of 10.2 g/day adjunctive to a low-fat diet significantly lowered serum total cholesterol by 4% and LDL cholesterol by 7% compared to placebo, with no effect on HDL or triacylglycerol concentrations.
Role of dietary fiber and lifestyle modification in gut health and sleep quality
Interventional study over 16 weeks examined the impact of psyllium husk fiber with and without lifestyle modification on gut health and sleep quality in 120 people with central obesity. Psyllium husk fiber significantly improved gastrointestinal tract symptoms, but no significant effect was observed on sleep quality.
The postprandial glucose-lowering effect of dietary fiber (Psyllium Husk) in patients with type 2 diabetes mellitus.
RCT comparing the effect of psyllium husk dietary fiber on postprandial plasma glucose in 60 type 2 diabetes mellitus patients. The psyllium husk group showed a greater mean reduction in postprandial glucose compared to the control group, with a significant p-value of 0.0001.
Comparing the Effect of Polyethylene Glycol, Psyllium Seed Husk Powder, and Probiotics on Constipation in Children
RCT comparing the effects of polyethylene glycol, psyllium seed husk powder, and probiotics on constipation in 144 children. Polyethylene glycol was more effective than psyllium in improving constipation symptoms. Probiotics enhanced the effect of psyllium but not polyethylene glycol.
Efficacy of Oral Psyllium in Pediatric Irritable Bowel Syndrome: A Double-Blind Randomized Control Trial.
Double-blind randomized controlled trial evaluating the efficacy of psyllium husk in pediatric IBS patients. The study found a significant reduction in IBS severity scores in the psyllium group compared to placebo, with 43.9% of the psyllium group attaining remission.
The Effect of Preoperative Fiber on Postoperative Bowel Function After Pelvic Reconstructive Surgery: A Randomized Controlled Trial
RCT of 71 women undergoing pelvic organ prolapse surgery, comparing preoperative psyllium fiber supplementation to no supplementation. No difference was found in time to first bowel movement or pain associated with the first bowel movement between the groups.
Randomized controlled trial demonstrates nutritional management is superior to metronidazole for treatment of acute colitis in dogs.
RCT comparing dietary management strategies for canine noninfectious acute colitis. Dogs were randomized into three groups: easily digestible diet with placebo, easily digestible diet with metronidazole, and psyllium-enhanced diet with placebo. Psyllium-enhanced diet showed superior outcomes in remission time and reduced negative impact on intestinal microbiota compared to metronidazole.
The effect of fiber supplementation on the prevention of diarrhea in hospitalized patients receiving enteral nutrition: A meta-analysis of randomized controlled trials with the GRADE assessment.
Meta-analysis of 16 RCTs evaluating fiber supplementation in hospitalized patients receiving enteral nutrition. Fiber supplementation reduced the occurrence of diarrhea by 36%, with mixed fiber and partially hydrolyzed guar gum showing significant effects.
Micronutrient status of individuals with overweight and obesity following 3 months’ supplementation with PolyGlycopleX (PGX®) or psyllium: a randomized controlled trial
RCT investigating the effects of 3-month supplementation with psyllium or PGX® fibre on micronutrient status in overweight and obese adults. No significant differences in serum micronutrient concentrations were found between fibre supplement groups after 3 months.
The effects of psyllium husk on gut microbiota composition and function in chronically constipated women of reproductive age using 16S rRNA gene sequencing analysis.
RCT comparing the effects of psyllium husk to placebo on gut microbiota composition and function in 54 chronically constipated women of reproductive age. Psyllium husk relieved constipation symptoms and altered gut microbiota composition, with enriched metabolism-related KEGG pathways.
Canadian Association of Gastroenterology Clinical Practice Guideline for the Management of Irritable Bowel Syndrome (IBS)
The guideline provides recommendations for managing IBS, suggesting psyllium supplementation to help reduce symptoms. It also suggests alternative therapies like peppermint oil and probiotics, while not recommending herbal therapies and acupuncture.
A randomised, placebo-controlled trial in healthy humans of modified cellulose or psyllium evaluating the role of gelation in altering colonic gas production during inulin co-administration.
A randomised, placebo-controlled trial in healthy humans evaluated the role of psyllium and methylcellulose in altering colonic gas production during inulin co-administration. Psyllium significantly reduced initial breath hydrogen production compared to placebo, while methylcellulose did not demonstrate a non-inferior effect. The study suggests psyllium's effectiveness may be due to its polysaccharide network's self-healing properties.
Donor composition and fiber promote strain engraftment in a randomized controlled trial of fecal microbiota transplant for ulcerative colitis.
RCT examining the efficacy of fecal microbiota transplantation (FMT) with and without psyllium fiber supplementation in 27 patients with mild to moderate ulcerative colitis. FMT induced clinical response, remission, and endoscopic improvement compared to placebo, but fiber did not improve clinical outcomes. The study highlights the role of donor selection and prebiotic fiber in shaping strain-level engraftment.
Mode of Action of Psyllium in Reducing Gas Production from Inulin and its Interaction with Colonic Microbiota: A 24-hour, Randomized, Placebo-Controlled Trial in Healthy Human Volunteers.
This randomized, placebo-controlled trial investigated the effect of psyllium on gas production from inulin in 17 healthy adults. Psyllium did not reduce mean breath hydrogen area under the curve (BHAUC) compared to control, but both psyllium and divided doses of inulin significantly reduced BHAUC compared to control. The study suggests psyllium delays transit to the colon without reducing colonic fermentation over 24 hours.
Effects of short-term psyllium husk and selected mixed herbal supplementation on health indicators in healthy male subjects
RCT involving 30 healthy male subjects to assess the effects of psyllium husk and mixed herbal supplementation on health indicators. The supplemental group showed improvements in bowel movement and headache, with total bilirubin also improving after 1 month of intervention.
Psyllium reduces inulin-induced colonic gas production in IBS: MRI and in vitro fermentation studies
A randomized, placebo-controlled crossover trial in 19 IBS patients tested the effect of psyllium coadministered with inulin on colonic gas production. Psyllium reduced inulin-induced gas production, as measured by MRI and breath hydrogen, suggesting increased tolerability of prebiotics in IBS.
The Short-Term Effects and Tolerability of Low-Viscosity Soluble Fibre on Gastroparesis Patients: A Pilot Clinical Intervention Study
A randomized controlled crossover pilot clinical study compared partially-hydrolysed guar gum, gum Arabic, and psyllium husk in 10 female gastroparesis patients. The study found that PHGG and gum Arabic regulated blood glucose levels comparable to psyllium husk while causing fewer symptoms. The test fibres did not significantly delay mouth-to-caecum transit.
Influence of Lactitol and Psyllium on Bowel Function in Constipated Indian Volunteers: A Randomized, Controlled Trial
RCT of 172 constipated adults comparing 10 g lactitol, 3.5 g psyllium, a combination of both, and placebo over 4 weeks. Bowel movement frequency increased similarly across all groups, including placebo, with no significant differences. Treatments were well tolerated.
Effect of Psyllium Fiber Supplementation on Diarrhea Incidence in Enteral Tube-Fed Patients: A Prospective, Randomized, and Controlled Trial.
Prospective, randomized, double-blind, controlled trial assessing psyllium fiber supplementation in enteral tube-fed patients. The study found no significant effect of psyllium on reducing the incidence of diarrhea compared to a fiber-free formula.
Effect of Psyllium Supplementation on Insulin Resistance and Lipid Profile in Non-diabetic Women With Polycystic Ovary Syndrome: A Randomized Placebo-Controlled Trial
This randomized double-blind placebo-controlled trial evaluated the effect of psyllium supplementation on insulin resistance and lipid profile in 54 non-diabetic women with PCOS. Psyllium supplementation significantly decreased fasting blood sugar, fasting insulin, total cholesterol, LDL-C, and insulin resistance indicators, while improving insulin sensitivity compared to placebo.
Effects of psyllium vs. placebo on constipation, weight, glycemia, and lipids: A randomized trial in patients with type 2 diabetes and chronic constipation.
Single-blinded RCT of 51 patients with type 2 diabetes and chronic constipation comparing 10g psyllium in cookies to placebo for 12 weeks. Psyllium improved constipation symptoms, reduced body weight, fasting plasma glucose, HbA1c, cholesterol, and triglycerides compared to baseline and placebo.
The Effect of Oral Psyllium Herbal Laxative Powder in Prevention of Hemorrhoids and Anal Fissure during Pregnancy, a Randomized Double Blind Clinical Trial
Randomized clinical trial assessing the preventative effect of psyllium powder on constipation, anal fissure, and hemorrhoidal diseases during pregnancy. Psyllium consumption significantly prevented these conditions compared to placebo.
Different effect of psyllium and guar dietary supplementation on blood pressure control in hypertensive overweight patients: a six-month, randomized clinical trial.
RCT of 141 hypertensive, overweight patients comparing psyllium powder, guar gum, and standard diet over six months. Psyllium significantly improved plasma TG concentration, SBP, and DBP, while both fibers improved BMI, FPG, FPI, HOMA Index, HbA1c, LDL-C, and ApoB.
Effect of combining psyllium fiber with simvastatin in lowering cholesterol.
A 12-week blinded placebo-controlled study evaluated the LDL-C-lowering effect of psyllium husk added to low-dose simvastatin therapy in 68 patients. The combination of 10 mg simvastatin with 15 g psyllium was as effective in lowering LDL-C as 20 mg simvastatin alone, suggesting psyllium as a safe and well-tolerated dietary supplement option.
Effect of time of administration on cholesterol-lowering by psyllium: a randomized cross-over study in normocholesterolemic or slightly hypercholesterolemic subjects
Randomized cross-over study of 63 subjects with normal or slightly elevated cholesterol levels, testing the effect of psyllium administration timing on cholesterol levels. No effect on cholesterol-lowering was observed, regardless of whether psyllium was taken in the morning or evening.
Sex and hormonal status influence plasma lipid responses to psyllium.
Crossover trial with 24 men, 23 premenopausal women, and 21 postmenopausal women examining the effects of 15 g/day psyllium supplementation on plasma lipids. Psyllium lowered plasma LDL-cholesterol by 7-9% and had varying effects on plasma triacylglycerol based on sex and hormonal status, lowering it in men and raising it in postmenopausal women.
Long-term cholesterol-lowering effects of psyllium as an adjunct to diet therapy in the treatment of hypercholesterolemia.
Multicenter RCT evaluating psyllium husk fiber as an adjunct to diet in treating hypercholesterolemia. Psyllium group showed 4.7% and 6.7% reductions in serum total and LDL-cholesterol concentrations compared to placebo after 24-26 weeks.
Application of Chicken Sausage Using Psyllium Husk Flour as a Natural Antioxidant
The study developed chicken sausages using Psyllium Husk Flour (PHF) as a natural antioxidant. Adding PHF decreased moisture content and cooking loss, increased water holding capacity, yield, antioxidants, and improved organoleptic qualities. The best results were with 15% PHF addition.
Improving the Gelation Properties of Pea Protein Isolates Using Psyllium Husk Powder: Insight into the Underlying Mechanism
The study evaluated the effects of psyllium husk powder on improving the gelation properties of pea protein isolate gel. It found that moderate levels of psyllium husk powder improved textural properties, water holding capacity, and viscoelasticity of the gel, with enhanced hydrophobic interactions and hydrogen bonding. Excessive psyllium husk weakened molecular interactions, reducing gel strength.
Mixed Psyllium Fiber Improves the Quality, Nutritional Value, Polyphenols and Antioxidant Activity of Rye Bread
The study investigated the effects of adding psyllium fiber to rye bread on its quality, nutritional value, polyphenolic content, and antioxidant activity. Psyllium fiber improved the nutritional profile and antioxidant activity of the bread, though it affected some physical properties like loaf volume and crumb texture.
Effects of Xanthan Gum, Lambda-Carrageenan and Psyllium Husk on the Physical Characteristics and Glycaemic Potency of White Bread
The study investigated the effects of xanthan gum, lambda-carrageenan, and psyllium husk on the physical characteristics and glycaemic potency of white bread. Adding nonstarch polysaccharides increased loaf volumes and decreased hardness, with psyllium husk significantly reducing glycaemic potency from ~49 GGE/100 g to 32 GGE/100 g.
Developing psyllium fibre gel-based foods: Physicochemical, nutritional, optical and mechanical properties
The study evaluated the physicochemical, nutritional, optical, and mechanical properties of two psyllium fibres, Plantago Husk and Plantago Powder, to assess their potential as functional ingredients in foods. Both fibres showed good gelling properties and high antioxidant activity, indicating their suitability as dietary fibre sources.
Structural and nutritional properties of psyllium husk arabinoxylans with special reference to their antioxidant potential
The study extracted and characterized arabinoxylans (AX) from psyllium seed husk for their nutritional and structural properties. Psyllium husk was found to be a good source of dietary fibers and exhibited antioxidant activity, indicating its potential nutritional benefits.
Studies on Development of Fibre Rich Probiotic Frozen Yogurt
The study investigates the use of acid modified psyllium husk in the preparation of probiotic frozen yogurt. The yogurt was analyzed for sensorial, physicochemical, and microbial quality parameters, showing high consumer acceptability with the addition of psyllium husk and encapsulated probiotic cultures.
Physico-Functional, Nutritional and Sensorial Features of Psyllium Husk Enriched Gluten-Free Oat Cookies
The study formulated gluten-free cookies with varying levels of psyllium husk to enhance dietary fiber content. The cookies with 5% psyllium husk showed improved functional properties, higher fiber content, and better sensory evaluation scores, suggesting psyllium husk as a beneficial addition for gluten-intolerant diets.
The Effect of Psyllium Husk on Intestinal Microbiota in Constipated Patients and Healthy Controls.
Two randomised, placebo-controlled, double-blinded trials assessed the impact of psyllium on faecal microbiota in 8 healthy volunteers and 16 constipated patients. Psyllium supplementation increased stool water and significantly altered microbiota composition, with more pronounced effects in constipated patients.
Comparison of Two Calorie-Reduced Diets of Different Carbohydrate and Fiber Contents and a Simple Dietary Advice Aimed to Modify Carbohydrate Intake on Glycemic Control and Inflammatory Markers in Type 2 Diabetes: A Randomized Trial
This randomized trial compared the effects of simple dietary advice with two calorie-restricted diets differing in carbohydrate and fiber content on glycemic control and inflammatory markers in 47 patients with type 2 diabetes over 8 weeks. The calorie-restricted high-fiber diet supplemented with psyllium showed better effects on plasma insulin and pro-inflammatory cytokines compared to simple dietary advice.
Soluble fibers from psyllium improve glycemic response and body weight among diabetes type 2 patients (randomized control trial)
RCT of 40 type 2 diabetes patients assessing the effects of soluble fiber from psyllium on glycemic control and body weight. The intervention group showed significant reductions in BMI, fasting blood sugar, HbA1c, insulin levels, C-peptide, HOMA.IR, and improvements in HOMA-β % after 8 weeks.
Psyllium Supplementation in Adolescents Improves Fat Distribution & Lipid Profile: A Randomized, Participant-Blinded, Placebo-Controlled, Crossover Trial
A randomized, participant-blinded, placebo-controlled, crossover trial assessed the effects of psyllium supplementation on metabolic syndrome parameters in 47 adolescent males. Psyllium supplementation led to a 4% reduction in android fat to gynoid fat ratio and a 6% reduction in LDL cholesterol, with no adverse events recorded.
Psyllium decreased serum glucose and glycosylated hemoglobin significantly in diabetic outpatients.
Double-blind placebo-controlled RCT of 49 diabetic outpatients testing 5.1g b.i.d. psyllium husk fiber as an adjunct to dietary and drug therapy. Psyllium significantly reduced fasting plasma glucose and glycosylated hemoglobin, increased HDL-C, and decreased LDL/HDL ratio, indicating improved glycemic control and heart health.
Long-term effects of water-soluble dietary fiber in the management of hypercholesterolemia in healthy men and women.
RCT of 51 healthy, moderately hypercholesterolemic men and women comparing 15 g/day supplemental water-soluble dietary fiber to an inactive control over 6 months. The WSDF mixture reduced mean plasma total and LDL cholesterol concentrations by 6.4% and 10.5%, respectively, with no changes in HDL cholesterol or triglycerides.
Chronic and postprandial responses of plasma insulin, glucose and lipids in volunteers given dietary fibre supplements.
Two studies were conducted to assess the effects of dietary fibre supplements on plasma cholesterol, glucose, and insulin concentrations in healthy middle-aged volunteers. The first study with psyllium and psyllium-citrus pectin showed no significant effects on postprandial plasma measurements. The second study with sugar-beet fibre significantly decreased the glucose response curve and increased HDL-cholesterol concentration, while also lowering fasting total- and LDL-cholesterol concentrations after 3 weeks.
Psyllium husk fibre supplementation to soybean and coconut oil diets of humans: effect on fat digestibility and faecal fatty acid excretion.
The study investigated the effects of psyllium fibre supplementation on fat digestibility and faecal fatty acid excretion in healthy humans consuming soybean and coconut oil diets. Psyllium supplementation resulted in significantly lower fat digestibility and higher faecal fat excretion compared to diets without psyllium. The findings suggest that psyllium may contribute to its hypocholesterolaemic action.
Modulating Starch Properties Through Hydrothermal Treatment and Psyllium Fibre Supplementation: Influence of Amylose Contents
The study investigated the impact of hydrothermal treatment and annealing combined with 3% psyllium husk fiber on the structural, rheological, and digestibility properties of maize starch with varying amylose content. Psyllium significantly increased slowly digested starch and resistant starch levels, suggesting potential health benefits for diabetes management and improved gut health.
Rheological properties and in vitro digestibility of chicken breast myofibrillar protein containing various psyllium (Plantago ovata) husk concentrations
The study evaluated the rheological properties and digestibility of chicken myofibrillar protein containing various concentrations of psyllium husk powder. The addition of psyllium husk improved water retention capacity, protein-protein interactions, and protein digestibility during in vitro digestion.
Synergistic effects of Ligilactobacillus salivarius Li01 and psyllium husk prevent mice from developing loperamide-induced constipation.
The study investigates the effects of a combined treatment of Ligilactobacillus salivarius Li01 and psyllium husk on mice with loperamide-induced constipation. The combination improved GI transit rates, increased fecal water content, and regulated serum concentrations of GI hormones more effectively than either substance alone.
Effect of Inulin and Psyllium Husk Powder on Gel Properties and In Vitro Digestion of Hypophthalmichthys molitrix and Argopecten irradians Blended Surimi
The study investigated the effects of inulin and psyllium husk powder on the textural properties and in vitro digestibility of blended surimi from silver carp and bay scallops. Psyllium husk powder improved gel strength, water-holding capacity, and digestibility, while inulin negatively affected gel strength.
Psyllium Fiber Protects Against Colitis Via Activation of Bile Acid Sensor Farnesoid X Receptor
Animal study investigating the effects of psyllium fiber on colitis in mice. Psyllium-enriched diets protected against colitis by altering bile acid metabolism and activating the farnesoid X receptor, which suppresses pro-inflammatory signaling.
The different effects of psyllium husk and orlistat on weight control, the amelioration of hypercholesterolemia and non-alcohol fatty liver disease in obese mice induced by a high-fat diet.
The study compared the effects of psyllium husk and orlistat on weight control, hypercholesterolemia, and non-alcoholic fatty liver disease in obese mice induced by a high-fat diet. Psyllium husk was more effective at reducing serum and liver cholesterol and triglyceride levels, while orlistat had a greater effect on weight loss. Both treatments had similar effects on body fat rate and bile acid regulation, but differed in gut microbiota effects.
The use of soluble fibre for the management of chronic idiopathic large-bowel diarrhoea in police working dogs
The study evaluated the effectiveness of psyllium husk supplementation in police working dogs with chronic large-bowel diarrhoea. Psyllium husk was added to the diet of 22 dogs, resulting in decreased defecation frequency, improved stool consistency, and weight gain. Beneficial effects persisted beyond the supplementation period.
Saccharomyces cerevisiae Fermentation Product Did Not Attenuate Clinical Signs, but Psyllium Husk Has Protective Effects in a Murine Dextran Sulfate Sodium–Induced Colitis Model
Animal study investigating the effects of Saccharomyces cerevisiae fermentation product (SCFP) and psyllium husk (PH) on gut health in a dextran sulfate sodium-induced colitis model. SCFP increased species richness of gut microbiota but did not attenuate clinical signs of colitis, while PH showed protective effects by lowering disease activity index.
Cellulose fibrillation and interaction with psyllium seed husk heteroxylan
The study investigates the interaction between fibrillated cellulose and psyllium seed husk powder to explore new applications. The research focuses on the structural and rheological properties of the composite mixtures formed by these materials, highlighting the role of fibrillation in enhancing interactions.
Physicochemical and textural properties of yogurt fortified with psyllium (Plantago ovate) husk
The study evaluated the incorporation of psyllium husk into yogurt to determine its effect on quality and acceptability. Yogurt fortified with 0.5% psyllium husk scored highest in overall acceptability. The study suggests that fiber-fortified yogurt could enhance gut health by promoting probiotic growth.
Studies on exploration of psyllium husk as prebiotic for the preparation of traditional fermented foods ( Buttermilk & Shrikhand )
The paper explores the use of psyllium husk as a prebiotic for the preparation of traditional fermented foods like buttermilk and shrikhand. It discusses the composition and properties of psyllium husk, including its mucilaginous polysaccharides.
Development of functional foods using psyllium husk and wheat bran fractions: Phytic acid contents
The study determined the phytic phosphorus content in psyllium, coarse and fine wheat bran enriched breads. It found that breads containing coarse and fine bran had higher phytic phosphorus levels, suggesting potential health benefits.
Effects of psyllium on glucose and serum lipid responses in men with type 2 diabetes and hypercholesterolemia.
RCT of 34 men with type 2 diabetes and mild-to-moderate hypercholesterolemia comparing 5.1 g psyllium to cellulose placebo twice daily for 8 weeks. The psyllium group showed significant improvements in glucose and lipid values, with lower serum total and LDL-cholesterol concentrations and reduced postprandial glucose concentrations compared to placebo.
Psyllium husk fiber supplementation to the diets rich in soybean or coconut oil: hypocholesterolemic effect in healthy humans.
This study investigated the effect of psyllium husk fiber supplementation on serum lipids in normolipidemic humans over a 28-day period using a randomized crossover design. Psyllium fiber supplementation significantly reduced serum cholesterol, LDL cholesterol, and apolipoprotein B levels when added to diets rich in soybean or coconut oil.
Effect of Plantago ovata (psyllium) husk and seeds on sterol metabolism: studies in normal and ileostomy subjects.
The study supplemented the diet of normal and ileostomy subjects with 10 g/d Plantago ovata psyllium husk or seed for 3 weeks. Psyllium seed reduced total and high-density-lipoprotein-cholesterol concentrations in normal subjects, while the husk had no effect on cholesterol or triglyceride levels. Ileostomy bile acids increased after seed supplementation, suggesting different effects of husk and seed on sterol metabolism.
Psyllium: A Nutraceutical and Functional Ingredient in Foods.
This narrative review discusses the current knowledge of psyllium, focusing on its health benefits, uses as a functional additive in foods, hydrogel delivery carrier, and potential side effects. It also explores approaches to modify its molecular and chemical structures and nonfood utilizations.
Psyllium husk powder increases defecation frequency and faecal score, bulk and moisture in healthy cats
The study evaluated the effect of dietary psyllium on faecal characteristics in healthy cats. Cats fed a diet containing 6% psyllium showed significantly more bowel movements, higher faecal scores, and increased faecal moisture compared to a control diet with 6% cellulose.
The role and therapeutic effectiveness of Plantago ovata seed husk (psyllium husk) in the prevention and non-pharmacological treatment of gastrointestinal diseases. Part 1. Clinical use of psyllium husk in the treatment of irritable bowel syndrome, ulcerative colitis, and colorectal cancer
Narrative review of clinical trials demonstrating the therapeutic efficacy of psyllium husk for gastrointestinal disorders such as irritable bowel syndrome, ulcerative colitis, and prevention of colorectal cancer. Psyllium exhibits antioxidant, immunomodulatory, antiproliferative, anticancer, and antiviral effects.
The role and therapeutic effectiveness of Plantago ovata husk (psyllium husk) in the prevention and non-pharmacological treatment of gastrointestinal diseases. Part 2. Clinical use of psyllium husk in the treatment of constipation and diarrhea
Narrative review of clinical studies on the use of psyllium husk from Plantago ovata in treating constipation and diarrhea. Psyllium husk is highlighted as a gold standard for regulating bowel movements, showing higher efficacy than pharmacological preparations like sodium docusate or loperamide.
Review on psyllium husk: nutritional, functional, health benefits, food industry applications, waste treatment, and potential negative effects
Narrative review on psyllium husk, highlighting its nutritional profile, functional benefits for digestive health, blood sugar regulation, and cholesterol lowering. Discusses its applications in food industry and waste treatment, as well as potential negative effects like gastrointestinal discomfort and allergic reactions.
[Correction of intestinal microbial composition disturbances as a potential link in complex therapy of patients with COVID-19].
The article discusses the potential of correcting intestinal microbiota disorders in COVID-19 therapy, highlighting the role of dietary fiber and psyllium (Mucofalk) in protecting intestinal barrier integrity and limiting bacterial translocation. It also covers the use of probiotics, synbiotics, and short-chain fatty acid preparations in reducing disease severity. A study showed that Zacofalk administration improved stool normalization and reduced bloating and abdominal pain in COVID-19 patients.
Beneficial effects of psyllium on the prevention and treatment of cardiometabolic diseases.
This narrative review summarizes studies on the therapeutic potential and mechanisms of psyllium in treating cardiometabolic diseases, including hyperlipidemia, diabetes mellitus, hypertension, hyperuricemia, and obesity. Psyllium is highlighted for its antioxidant, antidiabetic, hypotensive, anti-inflammatory, and other beneficial activities.
A Preliminary Study on the Effect of Psyllium Husk Ethanolic Extract on Hyperlipidemia, Hyperglycemia, and Oxidative Stress Induced by Triton X-100 Injection in Rats
The study evaluated the effect of psyllium husk ethanolic extract (PHEE) on hyperlipidemia, hyperglycemia, and oxidative stress in Triton X-100 induced hyperlipidemic rats. PHEE administration reduced hyperlipidemia, improved antioxidant activity, and alleviated negative impacts on hepatic and pancreatic function.
Mucoadhesive microspheres of glutaraldehyde crosslinked mucilage of Isabgol husk for sustained release of gliclazide
The study developed gliclazide-loaded mucoadhesive microspheres using Isabgol husk mucilage as a polymeric backbone, crosslinked with glutaraldehyde. The microspheres were evaluated for surface morphology, swelling behavior, particle size, in vitro release, release kinetics, in vitro mucoadhesion, and gamma scintigraphy in rabbits, showing sustained release and prolonged retention in the gastrointestinal tract.
Occupational IgE-mediated psyllium allergy in contemporary gluten-free and vegan baking: A case of allergic rhinitis.
Case report of a 24-year-old female baker with occupational IgE-mediated allergy to psyllium, used in gluten-free and vegan baking. The patient developed rhino-conjunctival symptoms and was confirmed to have occupational allergic rhinitis to psyllium through skin prick and nasal provocation tests.
Psyllium husk intake and risk of type 2 diabetes: an evidence-based scientific and regulatory review of a qualified health claim conducted by the US Food and Drug Administration.
The FDA reviewed a petition for a qualified health claim regarding psyllium husk and reduced risk of type 2 diabetes. Of 6 studies reviewed, only 1 showed significant improvement in plasma glucose levels and insulin sensitivity. The FDA concluded there is very little scientific evidence supporting the claim.
Nutritional Composition and Health Benefits of Psyllium (Plantago ovata) Husk and Seed
The paper discusses the nutritional composition and health benefits of psyllium husk and seed, highlighting its use in treating gastrointestinal problems and improving food fiber content. It also notes potential side effects such as flatulence, bloating, and rare allergic reactions.
Immunomodulatory Effects of Psyllium Extract on Helicobacter pylori Interaction With Gastric Epithelial Cells
In vitro study on the immunomodulatory effects of Psyllium extract on gastric epithelial cells infected with Helicobacter pylori. Psyllium extract significantly reduced IL-8 and NF-κB secretion, indicating its anti-inflammatory properties.
Sodium ion interaction with psyllium husk (Plantago sp.).
In vitro study investigating sodium interactions with psyllium husk. Psyllium mucilage gel retained at least 50% of sodium across various concentrations and pH environments. The study evaluated psyllium husk as a binding agent for reducing bioavailable sodium, showing high sodium retention in a simulated gastrointestinal tract model.
Evaluation of Phosphorylated Psyllium Seed Polysaccharide as a Release Retardant
The study modified psyllium seed polysaccharide to evaluate its use as a release retardant in tablets with ciprofloxacin hydrochloride. Phosphorylated psyllium polysaccharide was compared to hydroxypropyl methylcellulose K100M, showing extended drug release over 12 hours. The study focused on the polysaccharide's role in drug release kinetics.
Thiol Modification of Psyllium Husk Mucilage and Evaluation of Its Mucoadhesive Applications
The study involved thiol functionalization of psyllium to enhance its mucoadhesive potential. Thiolated psyllium showed increased mucoadhesive strength and provided prolonged release of metronidazole in formulated gels.
Dietary management of chronic constipation: a review of evidence-based strategies and clinical guidelines.
This review examines evidence on dietary management of chronic constipation, highlighting effective supplements like psyllium, probiotics, magnesium oxide, and foods like kiwifruits and prunes. It notes discrepancies between evidence and clinical guidelines, which often lack specific recommendations.
[Plantago psyllium-secondary anaphylaxis. Case report].
Case report of a 43-year-old female nurse who developed anaphylactic reaction symptoms after preparing and administering a psyllium-based laxative. Hypersensitivity to plantago psyllium was confirmed through skin prick tests and specific IgE assays.
Dietary fiber in irritable bowel syndrome (Review)
Narrative review discussing the role of dietary fiber in managing irritable bowel syndrome (IBS). It highlights that psyllium, a long-chain soluble fiber, is effective in improving IBS symptoms by reducing gas production and associated discomfort.
Evaluation of the Association Metformin: Plantago ovata Husk in Diabetic Rabbits
Experimental study in diabetic rabbits evaluating the effects of Plantago ovata husk as a coadjuvant with metformin. Rabbits fed with fiber-supplemented chow showed lower plasma glucose concentrations and altered glucose and insulin pharmacokinetics, suggesting potential benefits in oral antihyperglycemic treatment.
Industrial Application Of Psyllium: An Overview
Narrative review highlighting the industrial and therapeutic uses of psyllium (isabgol) seed husk. Discusses its role in the treatment and prevention of gastrointestinal and bowel diseases, and its application in food products and supplements.
Three-week psyllium-husk supplementation: effect on plasma cholesterol concentrations, fecal steroid excretion, and carbohydrate absorption in men.
This study investigated the effect of psyllium husk supplementation on plasma cholesterol levels in seven healthy males. After 3 weeks of supplementation, reductions in total, low-density, and high-density cholesterol were observed, suggesting a cholesterol-lowering effect of psyllium husk.
Diagnosis and Clinical Management of Eosinophilic Gastroenteritis in an African Pygmy Hedgehog (Atelerix albiventris)
Case report of a 2-month-old African pygmy hedgehog with eosinophilic gastroenteritis. Treatment included prednisolone, omeprazole, and psyllium supplementation, with no relapse of vomiting 20 months postdiagnosis.
Letter: dietary fibre benefits for the oesophagus—physical rather than metabolic action?
The letter discusses the effects of soluble fibre, particularly psyllium, on GERD symptoms. It argues that soluble fibre improves symptoms in non-erosive GERD patients by decreasing gastro-oesophageal refluxes and increasing lower oesophageal sphincter pressure, suggesting benefits are more physical than metabolic.