Research
Propolis
82 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Superiority of propolis and honey over topical acyclovir for herpes simplex: A meta-analysis.
This meta-analysis compared the efficacy and safety of propolis and/or honey with 5% topical acyclovir for herpes simplex lesions. Propolis and/or honey were associated with quicker lesion resolution, higher healing rates by day 7, reduced pain duration and intensity, and comparable safety to acyclovir.
Mechanistic Insights into Propolis in Targeting Type 2 Diabetes Mellitus: A Systematic Review.
Systematic review examining the mechanisms by which propolis may aid in T2DM management. Propolis may enhance pancreatic-cell function, improve insulin sensitivity, regulate glucose and lipid metabolism, modulate gut microbiota, and reduce oxidative stress and inflammation. Further clinical trials are needed to confirm efficacy and determine optimal dosing.
Molecular mechanisms of propolis in adipogenesis, lipid metabolism and white adipose tissue Browning: a systematic review of preclinical studies.
Systematic review of 7 preclinical studies on propolis and its bioactive compounds in adipogenesis, lipid metabolism, and WAT browning. Propolis modulates adipogenic transcription factors, reduces lipid accumulation, and increases browning markers, leading to reduced body weight and fat accumulation in animal and in vitro models.
Effects of propolis-modified glass ionomer cement on antimicrobial activity and physico-mechanical properties: a systematic review.
This systematic review evaluates the effects of propolis-modified glass ionomer cement (GIC) on antimicrobial activity and physico-mechanical properties. Propolis-modified GIC generally demonstrated enhanced antibacterial activity against Streptococcus mutans, Lactobacillus, and Candida albicans, particularly at concentrations of 25-50%. Mechanical outcomes varied with concentration, with 25% often balancing antimicrobial efficacy and mechanical stability.
The effect of propolis supplementation on blood pressure: a systematic review and meta-analysis of controlled trials.
Systematic review and meta-analysis of controlled trials assessing the effects of propolis supplementation on blood pressure. A significant decrease in systolic blood pressure was observed following propolis supplementation, while no significant change was found in diastolic blood pressure levels.
Efficacy of natural products in preventing oral mucositis resulting from cancer therapies: A network meta-analysis of randomized controlled trials.
Network meta-analysis of 36 RCTs involving 2083 patients evaluated the effectiveness of natural products in preventing or alleviating oral mucositis from cancer treatments. Honey significantly reduced the incidence and severity of oral mucositis compared to standard care. Propolis, chamomile, and P. major L. also showed efficacy in reducing oral mucositis incidence.
The impact of propolis supplementation on inflammatory biomarkers: A meta-analysis and systematic review of randomized controlled clinical trials.
Meta-analysis and systematic review of 20 RCTs with 1139 participants assessing the effects of propolis supplementation on inflammatory biomarkers. Propolis significantly reduced IL-6 and TNF-α levels, suggesting a beneficial effect on inflammation. CRP levels were not significantly reduced overall, but showed reduction in studies with supplementation durations ≥ 10 weeks.
Effects of propolis consumption on blood pressure, lipid profile and glycemic parameters in adults: a GRADE-assessed systematic review and dose-response meta-analysis.
This systematic review and dose-response meta-analysis evaluated the effects of propolis consumption on cardiovascular risk factors. Propolis intake significantly decreased TAG, LDL-cholesterol, fasting blood glucose, HbA1c, insulin, insulin resistance, and systolic blood pressure, while increasing HDL-cholesterol levels. No significant effects were found on total cholesterol and diastolic blood pressure.
Effects of Propolis Consumption on Glycemic Indices and Liver Enzymes in Adults: A Grading of Recommendations Assessment, Development, and Valuation-assessed Systematic Review and Dose-Response Meta-analysis.
This systematic review and meta-analysis evaluated the effects of propolis consumption on glycemic indices and liver enzymes in adults. The analysis of 21 RCTs showed that propolis significantly reduced fasting blood glucose, insulin, glycosylated hemoglobin, insulin resistance, alanine transaminase, and aspartate aminotransferase, but had no significant effect on gamma-glutamyl transferase.
Propolis supplementation can reduce serum level of interleukin-6, C-reactive protein, and tumor necrosis factor-α: an updated systematic review and dose-response meta-analysis on randomized clinical trials.
Systematic review and meta-analysis of randomized clinical trials assessing the effect of propolis supplementation on serum levels of inflammatory mediators. Propolis significantly reduced serum levels of IL-6, CRP, and TNF-α, suggesting its potential as a complementary therapy for chronic diseases.
The effect of propolis supplementation in improving antioxidant status: A systematic review and meta-analysis of controlled clinical trials.
Systematic review and meta-analysis of controlled clinical trials assessing the effect of propolis supplementation on oxidative status. Propolis significantly increased levels of GSH, GPX, and TAC, and decreased MDA levels at higher doses and shorter durations, suggesting beneficial effects on oxidative stress.
Propolis effects in periodontal disease seem to affect coronavirus disease: a meta-analysis.
This meta-analysis investigated the effects of propolis on the severity of coronavirus disease symptoms by reducing periodontal disease. Propolis flavonoids were found to inhibit viral replication in several viruses, including coronaviruses, and showed favorable results on periodontal health indicators. Propolis's antibacterial activity and immune system stimulation may contribute to its effects against SARS-CoV-2.
Use of propolis for skin wound healing: systematic review and meta-analysis.
Systematic review and meta-analysis of 43 studies on the use of propolis for skin wound healing. Propolis was found to be effective for treating skin ulcers, promoting a higher percentage of healing compared to traditional interventions. The application methods of propolis have evolved, often being combined with other substances for enhanced effects.
Recent Update on the Anti-Inflammatory Activities of Propolis.
This systematic review examines the anti-inflammatory properties of propolis based on experimental evidence from 2017-2022. Propolis is shown to modulate inflammation by inhibiting pathways such as TLR4, MyD88, IRAK4, TRIF, NLRP inflammasomes, NF-κB, and reducing pro-inflammatory cytokines and immune cell migration.
Propolis and Its Gastroprotective Effects on NSAID-Induced Gastric Ulcer Disease: A Systematic Review.
Systematic review evaluating the gastroprotective potential of propolis against NSAID-induced gastric ulcers. Propolis showed antioxidant, antisecretory, and cytoprotective effects, suggesting it as a good alternative for treating gastric ulcer disease.
Effect of honey and propolis, compared to acyclovir, against Herpes Simplex Virus (HSV)-induced lesions: A systematic review and meta-analysis.
Systematic review and meta-analysis comparing the effectiveness of honey and propolis with acyclovir in treating cold sores and genital herpes. Propolis showed superior healing properties compared to acyclovir, and honey also presented a better healing effect, inducing complete re-epithelization of herpetic lesions faster than acyclovir.
The effectiveness of propolis extract in reducing dentin hypersensitivity: A systematic review.
Systematic review evaluating the effectiveness of propolis on dentin hypersensitivity reduction. Six clinical trials were selected, all reporting that propolis was more effective than placebo in reducing hypersensitivity, with no side effects observed.
Evaluation of the efficacy of local application of bee products in the care of diaper dermatitis in infants: A randomized controlled trial.
RCT comparing the effects of a barrier cream containing propolis, beeswax, queen bee larvae, and vegetable oil with zinc oxide and olive oil on mild diaper dermatitis in infants. The propolis-containing cream showed superior effectiveness in reducing dermatitis severity compared to the other treatments.
Comparative evaluation of propolis, fluoride and probiotic mouthwashes on streptococcus mutans and oxidative stress in fixed orthodontic patients: A triple-blind, randomized controlled trial with 9-month follow-up.
Triple-blind RCT comparing propolis, fluoride, and probiotic mouthwashes in 90 orthodontic patients over 9 months. Propolis significantly reduced Streptococcus mutans levels and oxidative stress markers more than fluoride and probiotics, suggesting strong antimicrobial and anti-inflammatory effects.
Does Preoperative Gum Chewing Reduce Postoperative Sore Throat?
RCT comparing the efficacy of mastic, xylitol, and propolis gum on postoperative sore throat management in 72 patients undergoing cholecystectomy. Propolis gum significantly reduced sore throat and throat dryness within the first 2 hours postoperatively compared to other groups.
Evaluation of Zinc Oxide-Eugenol, Zinc Oxide-Propolis and Endoflas as an Obturating Materials in Primary Molar Pulpectomies - A Comparative Study.
RCT comparing zinc oxide eugenol, zinc oxide-Propolis, and endoflas as obturating materials in pulpectomy of primary teeth in 50 children. Endoflas and zinc oxide-Propolis showed 100% success, while zinc oxide eugenol had an 85% success rate.
Evaluating the cytotoxicity and efficacy of nanoemulsion containing propolis plus Nigella sativa nanoparticles for pulpotomy of primary teeth: randomised split-mouth clinical trial pilot study.
This randomized split-mouth clinical trial evaluated the cytotoxicity and efficacy of a nanoemulsion containing propolis and Nigella sativa nanoparticles for direct pulp capping of primary teeth. The study found that NEPNS led to mild inflammation compared to calcium-enriched mixture (CEM), but dentine bridge formation and pre-dentin production were similar to the control group after 30 days.
Adding collagen, propolis plus quercetin, bacillus coagulans, hyaluronic acid and chondroitin sulphate to D-mannose avoids symptoms and prevents recurrence in women with recurrent urinary tract infections: a single-blind randomized controlled trial.
Single-blind RCT evaluating a D-mannose dietary supplement with additional ingredients in women with recurrent urinary tract infections (rUTIs). The combination of fosfomycin and the supplement showed the greatest reduction in rUTI episodes and improved quality of life compared to monotherapies.
Comparative evaluation of propolis mouthwash with 0.2% chlorhexidine mouthwash as an adjunct to mechanical therapy in improving the periodontitis among perimenopausal women: a randomized controlled trial.
A double-blind, randomized controlled trial comparing the efficacy of propolis mouthwash to 0.2% chlorhexidine mouthwash as an adjunct to mechanical therapy in perimenopausal women with chronic periodontitis. Propolis was found to be significantly more effective in improving bleeding on probing compared to chlorhexidine.
Effect of propolis mouthwash on the incidence of ventilator-associated pneumonia in intensive care unit patients: a comparative randomized triple-blind clinical trial.
Triple-blind, comparative randomized controlled trial of 110 ICU patients assessing the effect of propolis mouthwash on the incidence of ventilator-associated pneumonia (VAP). The intervention group using propolis mouthwash showed a significantly lower incidence of VAP compared to the control group using chlorhexidine mouthwash on the third, fifth, and seventh days.
The Clinical Effect of a Propolis and Mangosteen Extract Complex in Subjects with Gingivitis: A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial.
RCT of 104 subjects with gingivitis and incipient periodontitis comparing a propolis-mangosteen extract complex (PMEC) to placebo for eight weeks. The PMEC group showed significantly reduced inflammatory biomarkers in gingival crevicular fluid, though clinical parameter improvements were not statistically significant.
Anti-wrinkle efficacy of standardized phenolic acids polymer extract (PAPE) from propolis: Implications for antiaging and skin health.
The study assessed the anti-wrinkle efficacy of a standardized phenolic acids polymer extract (PAPE) from propolis using in vitro and clinical methodologies. A double-blind, randomized clinical trial with female participants aged 30-70 years showed significant wrinkle reduction with PAPE-enriched creams, achieving 25% and 34% improvements for 1.5% and 3% formulations, respectively.
A Propolis-Based Protocol for Oral Health in Palliative Care: Results from a Phase II Trial.
Phase II trial evaluating a propolis-based product combined with basic oral hygiene in palliative care patients. Improvement or maintenance of oral health was observed in 89.6% of cases, with significant reductions in severity of oral disorders, oropharyngeal pain, and dysgeusia. Meal comfort, completion, and quality of life improved, and the protocol was safe and well-accepted.
The influence of propolis plus Hyoscyamus niger L. against COVID-19: A phase II, multicenter, placebo-controlled, randomized trial.
A phase II, multicenter, placebo-controlled, randomized trial evaluated the effect of propolis syrup with Hyoscyamus niger L. extract in 140 hospitalized COVID-19 patients. The syrup significantly reduced cough, shortness of breath, CRP levels, and increased arterial blood oxygen pressure compared to placebo, also reducing hospitalization duration by 3.6 days.
Propolis as an adjunctive therapy for treatment of uncomplicated cystitis in women: A randomized double-blind placebo-controlled trial.
RCT investigating the effect of propolis supplementation on clinical symptoms in 120 women with uncomplicated cystitis. Propolis significantly reduced days of urinary frequency, dysuria, and urgency compared to placebo, but no significant difference was found for hematuria and suprapubic pain. Bacteriuria severity decreased in both groups.
Effect of propolis on mood, quality of life, and metabolic profiles in subjects with metabolic syndrome: a randomized clinical trial
RCT of 66 patients with metabolic syndrome assessing the effects of 250 mg propolis extract twice daily for 12 weeks. Propolis supplementation significantly reduced waist circumference and improved physical functioning, general health, and quality of life compared to placebo.
Efficacy of Propolis in the Prevention of Oral Mucositis in Patients Undergoing High-Dose Chemotherapy: A Randomized Controlled Trial.
RCT of 64 patients with hematological cancer undergoing high-dose chemotherapy, comparing propolis mouthwash to standard oral care. Propolis significantly reduced the incidence and duration of oral mucositis and delayed its onset.
Evaluation of the remineralization and antibacterial effect of natural versus synthetic materials on deep carious dentin: A randomized controlled trial.
RCT comparing the remineralization and antibacterial effects of natural agents (propolis, hesperidin) versus synthetic agent (silver diamine fluoride) on deep carious dentin in 64 human molar teeth. Propolis showed the highest radiodensity, indicating better remineralization, while both natural agents showed promising effects in hindering caries progression.
Cumulative effects of exercise training and consumption of propolis on managing diabetic dyslipidemia in adult women: a single-blind, randomized, controlled trial with pre-post-intervention assessments.
Single-blind, randomized controlled trial with 60 women with type 2 diabetes and dyslipidemia. Participants were divided into four groups to assess the effects of combined exercise training and 500 mg propolis supplementation. The EXR + SUPP group showed improved lipid profiles, decreased inflammation, and increased antioxidant defense after 8 weeks.
The effects of propolis supplementation on high-sensitivity C-reactive protein, testosterone hormone, and metabolic profile in women with polycystic ovary syndrome: A randomized, triple-blinded, placebo-controlled clinical trial.
This randomized, triple-blinded, placebo-controlled clinical trial evaluated the effects of propolis supplementation on metabolic factors, high-sensitivity C-reactive protein, and testosterone in women with PCOS. Propolis supplementation significantly decreased hip circumference, fasting insulin, insulin resistance, testosterone, and LDL/HDL ratio compared to placebo.
Brazilian Propolis Intake Decreases Body Fat Mass and Oxidative Stress in Community-Dwelling Elderly Females: A Randomized Placebo-Controlled Trial.
This double-blind randomized placebo-controlled trial investigated the effects of Brazilian propolis on body fat mass and oxidative stress in 78 community-dwelling elderly females. The propolis group showed a significant decline in body fat mass and oxidative stress markers compared to the placebo group.
The impact of Propolis on catheter exit site infection and peritonitis in peritoneal Dialysis patients: a clinical trial.
Double-blind clinical trial with 90 peritoneal dialysis patients allocated to placebo, control, and intervention groups. Catheter exit site was treated with normal saline, mupirocin, or propolis. No significant differences in catheter exit site infection and peritonitis incidence were observed among the groups, but propolis is recommended due to its plant origin and lack of drug resistance.
Propolis add-on therapy alleviates depressive symptoms; A randomized placebo-controlled clinical trial.
A double-blind, randomized, placebo-controlled trial evaluated the efficacy of propolis as an adjunctive therapy for depressive disorder in 54 participants. The propolis group showed a significant reduction in HAMD and BDI scores compared to placebo, indicating that propolis can safely attenuate symptoms of moderate-severe MDD.
A comparative study on the effect of propolis and dentine bonding agent in treating dentine hypersensitivity.
Randomised, single-blind study comparing the efficacy of 30% ethanolic extract of propolis and dentine bonding agent in reducing dentine hypersensitivity in 52 patients. Both treatments significantly reduced dentine hypersensitivity, with no significant difference between the two.
Potential effects of propolis and honey in COVID-19 prevention and treatment: A systematic review of in silico and clinical studies.
Systematic review of in silico and clinical studies on propolis and honey for COVID-19 prevention and treatment. In silico studies suggest propolis compounds interact with SARS-CoV-2 proteins, while clinical studies indicate potential improvement in COVID-19 symptoms and decreased viral clearance time with propolis or honey as adjuvant therapy.
Oral Propolis, Nutritional Status and Quality of Life with Chemotherapy for Breast Cancer: A Randomized, Double-Blind Clinical Trial.
This randomized, double-blind, placebo-controlled clinical trial assessed the effect of propolis on nutritional status and quality of life in breast cancer patients receiving chemotherapy. Propolis significantly increased energy intake and improved quality of life, particularly in emotional functioning, global QoL functioning, and financial difficulties, compared to placebo.
Advantages of using toothpaste containing propolis and plant oils for gingivitis prevention and oral cavity hygiene in cleft lip/palate patients.
RCT assessing the effect of toothpaste containing Polish propolis and plant oils on oral cavity health in 50 patients with oral cleft. Group using the active toothpaste showed improved oral hygiene and decreased gingival bleeding index compared to placebo.
Efficacy of different endodontic irrigants in the lesion sterilization and tissue repair technique in primary molars: A randomized controlled clinical trial.
RCT evaluating the efficacy of different endodontic irrigants in the LSTR technique for primary molars in 40 children. Group A used 20% propolis, Group B used 2% sodium hypochlorite, Group C used 2% chlorhexidine gluconate, and Group D used saline. Chlorhexidine showed the best clinical success, while sodium hypochlorite showed the best reduction in furcation radiolucency.
Artepillin C-rich propolis extract supplementation promotes muscle recovery following exercise-induced muscle damage in resistance-trained young females: a randomized, placebo-controlled trial.
RCT of 22 resistance-trained females assessing the effects of Brazilian green propolis extract (EPP-AF) on recovery from exercise-induced muscle damage. EPP-AF supplementation attenuated delayed onset muscle soreness, mitigated increases in muscle thickness and echo intensity, and accelerated recovery of maximal voluntary isokinetic torque compared to placebo.
Investigating the effect of propolis-containing chewing gum in comparison with propolis-containing mouthwash on reducing gingival inflammation in patients with gingivitis.
This parallel clinical trial investigated the effectiveness of propolis-containing chewing gum and mouthwash in reducing gingival inflammation in 20 patients with gingivitis. Both products significantly reduced dental plaque, papillary bleeding, and gingival inflammation, with no significant difference in effectiveness between the two groups.
Efficacy of toothpaste containing Brazilian green propolis extracts with an optimal kaempferide/betuletol ratio for improving oral microbiota: A randomized, controlled, paired crossover study.
RCT evaluating the efficacy of Brazilian green propolis-containing toothpaste in 48 student volunteers. The BGP group showed a reduction in plaque index score and certain periodontal pathogens compared to placebo, suggesting its usefulness in maintaining oral health.
Comparative effectiveness of Propolis with chlorhexidine mouthwash on gingivitis - a randomized controlled clinical study.
A randomized controlled clinical trial comparing the effectiveness of propolis mouthwash with chlorhexidine mouthwash in reducing plaque and gingivitis in 45 subjects. Propolis mouthwash showed a higher reduction in plaque and gingival scores compared to chlorhexidine and placebo, suggesting it as an effective herbal alternative.
Effects of Propolis Supplementation on Gut Microbiota and Uremic Toxin Profiles of Patients Undergoing Hemodialysis.
This clinical trial evaluated the effects of 400 mg/day green propolis extract supplementation on gut microbiota and uremic toxin plasma levels in 41 hemodialysis patients. No significant changes were observed in uremic toxin levels or fecal microbiota composition after the intervention.
Effect of Brazilian green propolis in chronic ulcer treatment: a randomized clinical trial.
RCT assessing the effectiveness of 5% Brazilian green propolis ointment in 40 patients with chronic ulcers. The experimental group showed greater effectiveness in healing characteristics compared to the control group after 30 days.
The effects of high-intensity interval training and Iranian propolis extract on serum levels of TRPV4 and CYP2E1 proteins in patients with nonalcoholic fatty liver.
RCT investigating the effects of high-intensity interval training (HIIT) and Iranian propolis extract on serum levels of TRPV4 and CYP2E1 proteins in 32 patients with NAFLD. HIIT significantly reduced TRPV4 levels, while propolis supplementation showed a significant decrease in TRPV4 and CYP2E1, suggesting potential benefits in reducing oxidative stress and inflammation.
Comparison of the effect of propolis and Gluma desensitizer on the management of dentin hypersensitivity: A randomized controlled trial.
RCT comparing the effect of propolis and Gluma desensitizers on dentin hypersensitivity in 22 patients. Both agents reduced hypersensitivity immediately, but Gluma was more effective than propolis after one month.
The effect of propolis supplementation on cardiovascular risk factors in women with rheumatoid arthritis: A double-blind, placebo, controlled randomized clinical trial.
This randomized, double-blind, placebo-controlled clinical trial evaluated the effects of 1000 mg/day propolis supplementation on cardiovascular risk factors in 48 women with rheumatoid arthritis over 12 weeks. The intervention group showed significant reductions in atherogenic index of plasma, cholesterol ratios, and hs-CRP levels compared to placebo, suggesting propolis may benefit cardiovascular health and inflammation in this population.
The effects of propolis on pro-oxidant-antioxidant balance, glycemic control, and quality of life in chronic kidney disease: a randomized, double-blind, placebo-controlled trial.
RCT of 44 CKD patients comparing 250 mg daily propolis to placebo for three months. Propolis improved some dimensions of health-related quality of life, but did not significantly affect blood pressure, glycemic status, or pro-oxidant-antioxidant balance.
Effects of propolis on inflammation markers in patients undergoing hemodialysis: A randomized, double-blind controlled clinical trial.
This randomized, double-blind, placebo-controlled trial evaluated the effects of propolis supplementation on inflammatory markers in patients with chronic kidney disease on hemodialysis. Propolis significantly reduced serum levels of TNFα and tended to reduce MIP-1β levels, indicating its potential to mitigate inflammation.
Propolis consumption by asymptomatic HIV-individuals: Better redox state? A prospective, randomized, double-blind, placebo-controlled trial.
This double-blind RCT evaluated the effects of Brazilian green propolis (500 mg/day for three months) on oxidative stress in virologically suppressed HIV individuals. The propolis group showed decreased MDA concentration and a slight increase in total antioxidant capacity, suggesting benefits in reducing lipid peroxidation and improving the antioxidant system.
Efficacy of Sub-Gingivally Delivered Propolis Nanoparticle in Non-Surgical Management of Periodontal Pocket: A Randomized Clinical Trial.
RCT evaluating the efficacy of sub-gingivally delivered propolis nanoparticles in non-surgical management of periodontal pockets. The study found significant improvements in clinical parameters such as gingival index, bleeding on probing, probing pocket depth, and relative attachment loss in the propolis group compared to the control group over a 3-month period.
The effect of Brazilian Green Propolis extract on inflammation in patients with chronic kidney disease on peritoneal dialysis: A randomised double-blind controlled clinical trial.
A randomized double-blind controlled trial evaluated the effects of Brazilian Green Propolis extract on inflammation in CKD patients on peritoneal dialysis. Propolis supplementation (400 mg/day) for two months significantly reduced plasma TNF-α levels and showed a trend to increase Nrf2 expression, suggesting a potential strategy to mitigate inflammation.
A randomized, double-blind, placebo-controlled study evaluating the efficacy of propolis and N-acetylcysteine in exacerbations of chronic obstructive pulmonary disease.
A randomized, double-blind, placebo-controlled study evaluated the efficacy of a propolis and N-acetylcysteine (NAC) combination in reducing exacerbations of chronic obstructive pulmonary disease (COPD). The study involved 46 patients with frequent exacerbations, comparing placebo with two active treatment groups. The group receiving 1,200 mg NAC + 160 mg propolis showed a significant reduction in COPD exacerbation rates compared to placebo, with no adverse events reported.
Propolis supplementation in obese patients with non-alcoholic fatty liver disease: effects on glucose homeostasis, lipid profile, liver function, anthropometric indices and meta-inflammation.
This double-blind placebo-controlled RCT assessed the effects of propolis supplementation on glucose homeostasis, lipid profile, liver function, and meta-inflammation in 44 patients with NAFLD. Propolis significantly improved glucose homeostasis, hepatic fibrosis score, and liver function compared to placebo, although between-group differences in inflammatory factors and liver enzymes were not statistically significant after adjusting for confounders.
Anti-hyperglycemic effects of propolis or metformin in type 2 diabetes mellitus.
A double-blind, randomized, placebo-controlled trial in 36 pharmacological treatment-naïve patients with type 2 diabetes mellitus evaluated the effects of propolis and metformin on glycemic control. Both propolis and metformin significantly reduced fasting plasma glucose and glycated hemoglobin A1c levels compared to placebo, with metformin also decreasing 2-hour postload glucose and increasing insulin sensitivity.
Efficacy and safety of a bioadhesive gel containing propolis extract, nanovitamin C and nanovitamin E on desquamative gingivitis: a double-blind, randomized, clinical trial.
A double-blind, randomized clinical trial evaluated the efficacy of a gel containing propolis extract, nanovitamin C, and nanovitamin E on desquamative gingivitis. The study involved 22 patients with mucocutaneous diseases. The test gel improved periodontal variables and decreased pain and oral health impact scores without side effects.
Can a Short-term Daily Oral Administration of Propolis Improve Muscle Fatigue and Recovery?
This placebo-controlled, double-blind study investigated the effect of 1-week oral administration of propolis on muscle fatigue and recovery in 18 young men. The high-dose Brazilian green propolis group showed improved recovery from muscle fatigue compared to placebo, suggesting propolis reduces central fatigue.
Propolis mouthwash for preventing radiotherapy-induced mucositis in patients with nasopharyngeal carcinoma.
RCT evaluating the efficacy and safety of a 2.5% propolis mouthwash for preventing radiotherapy-induced mucositis in patients with nasopharyngeal carcinoma. The propolis group showed significantly lower mucositis scores compared to placebo at the second, fourth, and sixth weeks.
Propolis increases Foxp3 expression and lymphocyte proliferation in HIV-infected people: A randomized, double blind, parallel-group and placebo-controlled study.
RCT of 40 asymptomatic PLWHA under ART, comparing 500 mg/day propolis to placebo for 3 months. Propolis intake increased Foxp3 expression and lymphocyte proliferation, suggesting improved immune response and decreased inflammatory status.
Effect of propolis on wound healing in sacrococcygeal pilonidal disease: A randomized controlled clinical trial.
RCT analyzing the effect of propolis on wound healing in 33 patients with sacrococcygeal pilonidal disease treated with marsupialization. Propolis accelerated wound healing, particularly between days 14 and 28, and improved complete recovery scores.
Effect of Propolis mouthwash on clinical periodontal parameters in patients with gingivitis: A double-blinded randomized clinical trial.
This double-blinded randomized clinical trial evaluated the efficacy of a propolis-containing mouthwash in 32 patients with gingivitis. The propolis group showed a significant reduction in papillary bleeding index compared to the placebo group, indicating decreased gingival inflammation. No significant difference was found in plaque index changes between the groups, and tooth discoloration was insignificant in the propolis group.
Effects of oral moisturizing gel containing propolis following head and neck radiotherapy: randomized controlled pilot trial
RCT of oral moisturizing gel containing propolis in head and neck cancer patients post-radiotherapy. Propolis gel significantly decreased Porphyromonas gingivalis in saliva and relieved oral pain in subjects with baseline oral pain.
The effect of Brazilian propolis type-3 against oral microbiota and volatile sulfur compounds in subjects with morning breath malodor.
A double-blind, crossover, randomized study with 10 individuals evaluated the effects of propolis type-3 mouthrinse on volatile sulfur compounds (VSCs) and tongue dorsum microbial profile. Propolis type-3 and chlorhexidine treatments reduced VSC levels and bacterial counts, showing no statistical difference between them. Propolis type-3 may be effective in preventing morning bad breath.
Randomized clinical trial of the effectiveness of complementary therapies for recurrent aphthous stomatitis.
RCT evaluating the efficacy and safety of silver nitrate, propolis, rhubarb extract, and walnut extract for recurrent aphthous stomatitis in 125 patients. Propolis, rhubarb, and walnut showed faster symptom resolution compared to placebo, with no adverse effects reported.
Propolis as an alternative treatment for cutaneous warts.
Single-blind, randomized trial of 135 patients with different types of warts receiving oral Propolis, Echinacea, or placebo for 3 months. Propolis achieved cure in 75% of plane warts and 73% of common warts, significantly better than Echinacea or placebo.
Red propolis supplementation does not decrease acute respiratory events in stunted preschool children: A paired nonrandomized clinical trial.
A paired non-randomized clinical trial with 70 stunted preschool children evaluated the efficacy of red propolis supplementation on acute respiratory infections. The study found that red propolis did not decrease the frequency of infections compared to the control group over one year.
Metabolic products of European-type propolis. Synthesis and analysis of glucuronides and sulfates.
The study analyzed the plasma metabolites of European-type propolis after ingestion, focusing on flavonoid metabolites. It identified sulfate and glucuronide conjugates of major flavonoids, with glucuronides being the dominant species.
Propolis-based niosomes as oromuco-adhesive films: A randomized clinical trial of a therapeutic drug delivery platform for the treatment of oral recurrent aphthous ulcers.
RCT of oromuco-adhesive films for buccal delivery of propolis extract (PPE) in 24 patients with oral recurrent aphthous ulcers. The medicated group showed ulcer size reduction within 2-3 days, complete healing within 10 days, and pain relief lasting more than 4-5 hours, compared to placebo.
Efficacy of an All-Natural Polyherbal Mouthwash in Patients With Periodontitis: A Single-Blind Randomized Controlled Trial
This single-blind randomized controlled trial evaluated the anti-inflammatory effect of a polyherbal mouthwash containing Propolis, Plantago lanceolata, Salvia officinalis, and essential oils in 34 patients with periodontitis. The study found significant reductions in bleeding and plaque scores in the test group compared to placebo after 3 months, with no adverse effects reported.
Comparative Evaluation of Clinical and Radiographic Success of Formocresol, Propolis, Turmeric Gel, and Calcium Hydroxide on Pulpotomized Primary Molars: A Preliminary Study
The study compared the clinical and radiographic success of pulpotomy in primary molars using formocresol, propolis extract, turmeric gel, and calcium hydroxide. Results showed comparable success rates for all experimental groups compared to the control group (formocresol), suggesting these materials as promising alternatives for pediatric endodontic treatment.
A Comprehensive Review on Chemical Compounds, Biological Actions and Potential Health Benefits of Stingless Bee Propolis
This review highlights the chemical composition, biological actions, and potential health benefits of stingless bee propolis. It discusses the variation in chemical composition due to factors like bee species and location, and notes the therapeutic properties such as antioxidant, antimicrobial, and antifungal effects.
Propolis: Its Role and Efficacy in Human Health and Diseases
This narrative review summarizes recent studies on the role of propolis and its biologically active compounds in the treatment of various acute and chronic diseases. Propolis contains numerous organic compounds with therapeutic properties, including antidiabetic, anti-inflammatory, antioxidant, anticancer, and neuroprotective effects.
Evaluation of potential herbal-drug interactions of a standardized propolis extract (EPP-AF®) using an in vivo cocktail approach.
The study evaluated potential herbal-drug interactions of a standardized propolis extract (EPP-AF®) using an in vivo cocktail approach in 16 healthy adult volunteers. It found that EPP-AF® caused minor changes in the pharmacokinetics of several drugs, but these changes were not clinically significant, suggesting that propolis may be safe regarding potential interactions with certain enzymes.
Antiproliferative Activity of Chemically Characterized Propolis from Turkey and Its Mechanisms of Action
The study evaluated the ethanolic extract of propolis from northern Turkey for its antiproliferative, apoptotic, and cell cycle arrest effects on MCF7, HGC27, A549 cancer cell lines and a healthy cell line (HUVEC). Propolis showed moderate antiproliferative activity with IC50 values between 58.6–90.7 μg/mL and promoted cell cycle arrest through activation of p21, resulting in accumulation at G0/G1 phase. The study also identified main components of the extract, including caffeic acid and CAPE.
Antioxidant effects and bioavailability evaluation of propolis extract and its content of pure polyphenols
The study evaluated the antioxidant effects and bioavailability of propolis extract and its pure polyphenols in vivo. Propolis extract restored homeostasis and reduced liver, kidney, and lung damage from oxidative stress, demonstrating higher antioxidant capacity and bioavailability compared to isolated polyphenols.
Activity of preparations from Spilanthes oleracea, propolis, Nigella sativa, and black garlic on different microorganisms involved in oral diseases and on total human salivary bacteria: A pilot study
In vitro study evaluating the antibacterial potential of tinctures of Spilanthes oleracea, propolis, Nigella seed oil, and black garlic extract on microorganisms involved in oral diseases. Propolis tincture showed the highest efficacy, killing more than 99% of salivary bacteria, while Spilanthes tincture and black garlic extract killed more than 90%, and Nigella seed oil more than 60% of the pathogens.
A botanical multi–orgasmic composition with maximum bioavailability for women
The paper discusses a patent-pending topical pharmaceutical nano composition for enhancing female sexual response and treating sexual dysfunctions. The composition includes natural ingredients like bee propolis, fenugreek, oregano, L-arginine orotate, and Tribulus terrestris, applied to enhance pleasure and increase orgasms in women.