Research
Potassium Iodide (KI)
25 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Effects of Preoperative Iodine Administration on Thyroidectomy for Hyperthyroidism: A Systematic Review and Meta-analysis.
Systematic review and meta-analysis of preoperative iodine administration in patients undergoing thyroidectomy for Graves' disease. Preoperative iodine was associated with decreased thyroid vascularity and intraoperative blood loss, but no significant differences in thyroid volume, operative time, or postoperative complications.
Supplemental Iodide for Preterm Infants and Developmental Outcomes at 2 Years: An RCT.
RCT of iodide supplementation versus placebo in preterm infants <31 weeks' gestation to assess neurodevelopmental outcomes at 2 years. No significant differences were found between groups in cognitive, motor, or language scores, indicating no benefit of iodide supplementation on neurodevelopment.
A Randomized Clinical Trial Comparing Itraconazole and a Combination Therapy with Itraconazole and Potassium Iodide for the Treatment of Feline Sporotrichosis
A randomized clinical trial on 166 cats with sporotrichosis compared the effectiveness and safety of itraconazole monotherapy versus a combination therapy with itraconazole and potassium iodide. The combination therapy group showed a 77% higher risk of clinical cure and achieved cure faster than the monotherapy group, suggesting it as a better treatment option.
Three-Dimensional Assessment of Radiographic Changes after Indirect Pulp Capping Using Silver Diamine Fluoride with or without Potassium Iodide in Young Permanent Teeth (12-Month RCT).
This 12-month RCT evaluated radiographic changes after indirect pulp capping using silver diamine fluoride (SDF) with or without potassium iodide (KI) and resin-modified glass ionomer cement (RMGIC) in young permanent molars. The study found no significant differences among the groups in terms of tertiary dentin formation, root length increase, and prevention of secondary caries.
The effect of galvanization and potassium iodide iontophoresis of the throat and larynx on thyroid parameters: a randomized controlled trial.
Double-blinded randomized controlled trial investigating the effect of galvanization and potassium iodide iontophoresis on thyroid parameters in 50 healthy volunteers. No significant differences in thyroid hormone levels were found between the galvanization and iontophoresis groups, and both groups maintained normal hormone levels at 2 weeks and 6 months post-treatment.
Characterization of Iodide-induced Sialadenitis: Meta-analysis of the Published Case Reports in the Medical Literature.
Meta-analysis of 77 cases of iodide-induced sialadenitis, a rare adverse reaction to iodinated contrast causing salivary gland swelling. Older age and longer time to onset of symptoms were associated with longer duration of symptoms. Symptoms resolved in a median of 3 days.
The effects of iodine blocking on thyroid cancer, hypothyroidism and benign thyroid nodules following nuclear accidents: a systematic review.
Systematic review of the effects of potassium iodide (KI) administration following accidental radioactive iodine release on thyroid cancer, hypothyroidism, and benign thyroid nodules. The review found low to very low-quality evidence suggesting that KI intake may reduce the risk of thyroid cancer in children, but no conclusions could be drawn about its effectiveness in preventing hypothyroidism and benign thyroid nodules.
The effects of iodine blocking following nuclear accidents on thyroid cancer, hypothyroidism, and benign thyroid nodules: design of a systematic review
This systematic review aims to evaluate the effects of potassium iodide (KI) administration following accidental radioactive iodine release on thyroid cancer, hypothyroidism, and benign thyroid nodules. The review will update the WHO guideline from 1999 by providing new evidence on the efficacy of KI in reducing these thyroid-related health outcomes.
Oral potassium iodide for the treatment of sporotrichosis.
Systematic review assessing the effects of oral potassium iodide for the treatment of sporotrichosis. No suitable randomised placebo-controlled trials or comparisons with other treatments were found, making it impossible to assess the effects. Further trials are needed to define the efficacy and acceptability.
Randomized trial of a short course of preoperative potassium iodide in patients undergoing thyroidectomy for Graves' disease.
Randomized trial comparing preoperative potassium iodide (SSKI) to no SSKI in patients undergoing thyroidectomy for Graves' disease. The SSKI group had significantly less mean and median estimated blood loss compared to the control group, although the decrease in operative time was not statistically significant.
New posology of potassium iodide for the treatment of cutaneous sporotrichosis: study of efficacy and safety in 102 patients.
RCT evaluating a new potassium iodide posology for treating cutaneous sporotrichosis in 102 patients. Clinical cure was achieved in 77.4% of patients, with no significant difference between conventional and reduced doses. Adverse events were similar across groups, with no serious events or recurrences.
Benefit of short-term iodide supplementation to antithyroid drug treatment of thyrotoxicosis due to Graves' disease.
RCT comparing methimazole (MMI) treatment with MMI + potassium iodide (KI) treatment in 134 untreated patients with Graves' disease. Combined treatment with MMI and KI improved short-term control of Graves' hyperthyroidism without worsening the condition or inducing thionamide resistance.
[Efficacy of thyroxine and potassium iodide treatment of benign nodular thyroid lesions].
RCT of 118 patients with benign nodular thyroid lesions comparing thyroxine (TX) and potassium iodide (PI) treatment. PI was more effective in reducing the size of the dominant node in 33.90% of patients, while TX was effective in 23.73%. Both treatments prevented growth in approximately 2/3 of cases.
Thyroid uptake and radiation dose after (131)I-lipiodol treatment: is thyroid blocking by potassium iodide necessary?
RCT investigating the influence of prophylactic potassium iodide (KI) on thyroid uptake and radiation dose in patients undergoing (131)I-lipiodol therapy for hepatocellular carcinoma. Thyroid uptake and dose were significantly lower in the KI group compared to the non-KI group, suggesting KI premedication effectively reduces thyroid radiation burden.
Intermittent oral administration of potassium iodide solution for the correction of iodine deficiency.
RCT testing various regimens of intermittent oral administration of potassium iodide in 304 schoolchildren in Zimbabwe to correct iodine deficiency. After 13 months, groups receiving 30 mg monthly or 8 mg biweekly showed normalized thyroglobulin concentrations and decreased thyroid volume, indicating effective prophylaxis for iodine deficiency.
Therapeutic efficacy and limitations of potassium iodide for patients newly diagnosed with Graves' disease.
The study investigated the efficacy and limitations of potassium iodide (KI) treatment in 122 patients newly diagnosed with mild Graves' disease. KI therapy was effective for 58.2% of patients, with FT4 levels and male sex significantly associated with responsiveness. The study found KI therapy to be effective and safe for about 60% of patients.
Inhibitory effect of low-dose inorganic iodine on thyroidal radioactive iodine uptake in healthy Japanese adults.
RCT assessing the inhibitory effect of low-dose inorganic iodine on thyroidal radioactive iodine uptake (RAIU) in 22 healthy Japanese adults. A single-dose of 10 mg inorganic iodine significantly suppressed 24-hour RAIU, while repeated doses showed diminished effects. Slight elevation in serum thyroid stimulating hormone was observed in some participants.
Administration of additional inactive iodide during radioiodine therapy for Graves' disease: who might benefit?
RCT involving 32 patients with Graves' hyperthyroidism undergoing radioiodine therapy. The study tested the administration of 600 microg inactive iodide for three days to improve 131I kinetics in patients with a short effective 131I half-life. The administration was found to be beneficial and a safe alternative to a second radioiodine capsule.
Thyroid blockade during a radiation emergency in iodine-rich areas: effect of a stable-iodine dosage.
The study examined the effect of stable iodine on thyroid gland blockade in patients with hyperthyroidism to evaluate the appropriate dose of iodine prophylaxis during a radiation emergency. Eight patients were given single doses of 50 mg or 100 mg of potassium iodide, significantly suppressing thyroid uptake of (123)I for 24 hours. The study suggests that 38 mg of iodide is as effective as 76 mg for thyroid blockade.
A randomized trial for the treatment of mild iodine deficiency during pregnancy: maternal and neonatal effects.
RCT of 180 euthyroid pregnant women with mild iodine deficiency, randomized to receive placebo, 100 micrograms potassium iodide (KI)/day, or 100 micrograms iodide plus 100 micrograms L-T4/day. Active treatments improved thyroid function and reduced goitrogenic effects in mothers and newborns compared to placebo. The combination of T4 and KI showed more rapid and marked benefits.
Levothyroxine and potassium iodide are both effective in treating benign solitary solid cold nodules of the thyroid.
RCT comparing the effectiveness of levothyroxine and potassium iodide in treating benign solitary cold thyroid nodules. Levothyroxine reduced nodule volume by 40% and potassium iodide by 23%. Nodule volume increased in untreated patients. Discontinuation of therapy led to resumed nodule growth.
[Therapy of endemic goiter with levothyroxine and iodide. A multicenter study].
RCT of 74 patients with diffuse endemic goitre treated with either levothyroxine alone or a combination of levothyroxine and potassium iodide for 6 months, followed by iodide prophylaxis. Both groups showed significant reduction in goitre size, with a more marked reduction in the combination group. Basal TSH levels were suppressed in both groups, with a tendency for thyroid enlargement in the levothyroxine-only group during iodide prophylaxis.
Treatment of endemic goitre with iodine and thyroid hormones, alone or in combination. (Preliminary report).
RCT of 108 patients with endemic nontoxic goitre treated with thyroxine (T4), triiodothyronine (T3), and potassium iodide (KI), singly or in combination, or with placebo. Goitre size decreased significantly in the actively treated groups, with the combination of T4 and KI being the most effective. Some patients developed autoantibodies against thyroglobulin and/or the thyroidal microsomal antigen.
Subclinical Hypothyroidism Post-Bariatric Surgery: A Reversible Case of Iodine Deficiency Without Autoimmune Thyroid Disease
Case report of a 39-year-old woman with elevated TSH post-bariatric surgery, attributed to iodine deficiency. Her TSH levels normalized following potassium iodide supplementation, highlighting the importance of considering iodine deficiency in managing elevated TSH in post-bariatric surgery patients.
Commercial diet induced hypothyroidism due to high iodine. A histological and radiological analysis.
Study on puppies fed different diets to assess the impact of high iodine content. Groups fed commercial diets with high iodine developed hypothyroidism and showed changes in bone metabolism, with significant decreases in styloid apophyseal surface and shorter hypertrophied cartilage.