Research
Phosphorus
10 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
The impact of dietary phosphorus supplementation on postprandial metabolic outcomes: a systematic review.
Systematic review of 10 randomized crossover trials evaluating the effects of inorganic phosphorus supplementation on postprandial metabolic outcomes in healthy adults. Phosphorus supplementation was positively associated with diet-induced thermogenesis and satiety, and inversely associated with weight gain and energy intake. Evidence on postprandial glycaemia and lipidemia was inconsistent.
Indications for the evaluation and supplementation of hypophosphatemia: an umbrella systematic review of reviews and guidelines.
This umbrella systematic review summarizes evidence and guidelines for phosphate testing and supplementation in adults with hypophosphatemia. It highlights the heterogeneity in recommendations and emphasizes individualized approaches based on clinical context, with oral therapy preferred for chronic conditions and intravenous routes for acute, severe hypophosphatemia.
Serum Phosphorus and Progression of CKD and Mortality: A Meta-analysis of Cohort Studies.
Meta-analysis of 12 cohort studies with 25,546 non-dialysis-dependent CKD patients. Found that every 1-mg/dL increase in serum phosphorus level was independently associated with increased risk of kidney failure and mortality.
The Effect of Dietary Phosphorus Restriction on Urine Protein Excretion in Patients With Proteinuria: A Randomized Controlled Trial.
RCT of 71 patients with proteinuria comparing a phosphorus-restricted diet to a control diet for 8 weeks. The phosphorus-restricted group showed a significant decrease in urinary protein excretion, but this change was not significantly different from the control group. No significant changes in serum and urine phosphorus levels or eGFR were observed.
Effects of serum phosphorus on vascular calcification in a healthy, adult population: A systematic review.
Systematic review analyzing the association between serum phosphorus levels and cardiovascular calcification in healthy individuals. Of 10 cross-sectional studies reviewed, 8 indicated an association between serum phosphorus and vascular calcification, while 1 did not, and 1 found a significant association with prevalence but not incidence.
The efficacy and safety of diluted oral phosphate enema versus intravenous sodium glycerophosphate in the treatment of hypophosphatemia in intensive care unit patients - A non-inferiority trial.
A randomized controlled non-inferiority trial comparing diluted oral phosphate enema to IV sodium glycerophosphate in treating mild to moderate hypophosphatemia in ICU patients. The oral phosphate enema was found non-inferior, with 71.4% achieving normal phosphate levels compared to 42.8% in the IV group. Safety profiles were similar between groups.
Acute effects of dietary phosphorus intake on markers of mineral metabolism in hemodialysis patients: post hoc analysis of a randomized crossover trial.
Post hoc analysis of a randomized crossover trial evaluating short-term effects of low-phosphorus diets on mineral parameters in hemodialysis patients. Increased dietary phosphorus intake was associated with increased serum phosphate, iPTH, and iFGF23 levels, and decreased serum calcium levels.
High phosphorus intake and gut-related parameters - results of a randomized placebo-controlled human intervention study.
RCT with 62 healthy subjects examining the effects of monosodium phosphate and calcium carbonate supplementation on gut-related parameters. Faecal total SCFA and acetate concentrations were higher after 8 weeks of P1000/Ca500 and P1000/Ca1000 supplementation. The gut microbial community differed in men of the P1000/Ca1000 group, with increased abundance of Clostridium XVIII. No significant changes in faecal fat concentrations or cyto- and genotoxic activity were observed.
Phosphorus Additives and Albuminuria in Early Stages of CKD: A Randomized Controlled Trial.
Randomized, double-blind, crossover trial with 31 adults with early stages of chronic kidney disease. The study compared higher versus lower phosphorus intake for 3 weeks using diet beverages and breakfast bars. Higher phosphorus intake increased 24-hour urine phosphorus excretion but did not significantly increase albuminuria or fibroblast growth factor 23 levels.
Body phosphorus mobilization and deposition during lactation in dairy cows.
The study investigated phosphorus mobilization and deposition in dairy cows over the lactation cycle. Thirty Holsteins were given diets with varying phosphorus percentages, and phosphorus balance studies were conducted. Results showed phosphorus mobilization from bone during the late dry period and early lactation, with re-storage in late lactation, affecting dietary phosphorus requirements.