Research
Phosphatidylserine
41 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Phosphatidylserine for the Treatment of Pediatric Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analysis.
Systematic review and meta-analysis of phosphatidylserine supplementation for ADHD symptoms in children. Meta-analysis of three RCTs (n=216) showed a significant effect on inattention symptoms, but not on overall ADHD symptoms or hyperactivity-impulsivity. Evidence quality is low, suggesting further research is needed.
The cognitive effects of supplementation with sunflower phosphatidyl serine in healthy children aged 8 to 12 years: a randomized controlled trial.
RCT examining the effects of 100mg sunflower-derived phosphatidylserine supplementation on cognitive performance in healthy children aged 8-12 years. No differences were found in primary or secondary outcomes for the total cohort, but a subgroup with below median baseline performance showed benefits on a visuospatial memory task.
Effects of a food supplement containing phosphatidylserine on cognitive function in Chinese older adults with mild cognitive impairment: A randomized double-blind, placebo-controlled trial.
This randomized, double-blind, placebo-controlled trial studied the effects of a supplement containing phosphatidylserine, ALA, and other components on cognitive function in 190 Chinese older adults with mild cognitive impairment. The intervention group showed significant improvements in arithmetic testing, similarity test, and short-term memory compared to the placebo group. The supplement also increased serum levels of ALA, DHA, EPA, acetylcholine, GABA, and 5-HT.
Phosphatidylserine enriched with polyunsaturated n-3 fatty acid supplementation for attention-deficit hyperactivity disorder in children and adolescents with epilepsy: A randomized placebo-controlled trial.
A multicenter double-blind randomized placebo-controlled trial evaluated phosphatidylserine enriched with polyunsaturated n-3 fatty acids (PS-Omega3) supplementation in children with epilepsy and ADHD. The study was stopped early due to lack of participants, and no significant difference in ADHD symptoms was found between the PS-Omega3 and placebo groups after 12 and 24 weeks.
Safety of phosphatidylserine containing omega3 fatty acids in ADHD children: a double-blind placebo-controlled trial followed by an open-label extension.
Double-blind placebo-controlled trial followed by an open-label extension to evaluate the safety of phosphatidylserine enriched with omega3 fatty acids in 200 children with ADHD. No significant differences in safety parameters were observed between groups, and the supplement was well tolerated over 30 weeks.
The effect of phosphatidylserine containing Omega3 fatty-acids on attention-deficit hyperactivity disorder symptoms in children: a double-blind placebo-controlled trial, followed by an open-label extension.
A 15-week double-blind, placebo-controlled trial followed by a 15-week open-label extension studied the efficacy and safety of phosphatidylserine containing Omega3 fatty acids in reducing ADHD symptoms in children. The PS-Omega3 group showed significant reductions in ADHD symptoms and improvements in emotional impact, with sustained efficacy in the open-label phase. The treatment was well tolerated.
Brazilian passion fruit modulates vascular inflammation and gene networks of cholesterol metabolism in overweight individuals.
Randomized controlled crossover study with 16 overweight participants consuming passion fruit powder or a fiber-matched control for two weeks. Passion fruit significantly reduced aspartate aminotransferase, IL-6, and sICAM-1, and increased nitrite levels. HDL levels negatively correlated with insulin, HOMA-IR, and triglycerides. Transcriptomic analysis showed modulation of 374 genes related to lipid metabolism, inflammation, endothelial function, and insulin signaling.
A soy-based phosphatidylserine/ phosphatidic acid complex (PAS) normalizes the stress reactivity of hypothalamus-pituitary-adrenal-axis in chronically stressed male subjects: a randomized, placebo-controlled study.
This randomized, placebo-controlled study examined the effects of a soy-based phosphatidylserine/phosphatidic acid complex (PAS) on stress reactivity in 75 chronically stressed male subjects. Supplementation with PAS 400 mg per day normalized the ACTH, salivary, and serum cortisol responses to an acute stressor in highly stressed subjects, while PAS 200 mg showed no significant effects.
Positive effects of soy lecithin-derived phosphatidylserine plus phosphatidic acid on memory, cognition, daily functioning, and mood in elderly patients with Alzheimer's disease and dementia.
The study investigated the effects of a supplement containing phosphatidylserine and phosphatidic acid on memory, mood, and daily functioning in elderly patients with Alzheimer's disease and dementia. Results showed significant improvements in memory and mood among elderly subjects, and a stabilizing effect on daily functioning and emotional state in Alzheimer's patients.
Phosphatidylserine and caffeine attenuate postexercise mood disturbance and perception of fatigue in humans.
RCT investigating the effects of a supplement containing phosphatidylserine and caffeine on cognitive function, reaction time, and mood following exercise. Phosphatidylserine significantly attenuated postexercise mood disturbance and perception of fatigue, but did not affect cognitive function or reaction time.
Safety of phosphatidylserine containing omega-3 fatty acids in non-demented elderly: a double-blind placebo-controlled trial followed by an open-label extension.
Double-blind placebo-controlled trial followed by an open-label extension to evaluate the safety of phosphatidylserine containing omega-3 fatty acids (PS-DHA) in non-demented elderly with memory complaints. The study found that PS-DHA is safe and well tolerated, with no significant differences in safety parameters between groups. A reduction in resting diastolic blood pressure and slight weight gain were observed after 30 weeks of PS-DHA consumption.
Phosphatidylserine containing omega-3 fatty acids may improve memory abilities in non-demented elderly with memory complaints: a double-blind placebo-controlled trial.
Double-blind placebo-controlled trial of phosphatidylserine containing omega-3 fatty acids (PS-DHA) in 157 non-demented elderly with memory complaints. The PS-DHA group showed significant improvements in verbal immediate recall compared to placebo. Subgroup analysis indicated that participants with higher baseline cognitive status had significant improvements in cognitive performance.
Effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) on the endocrine and psychological responses to mental stress.
RCT investigating the effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) on endocrine and psychological responses to mental stress. 400 mg PAS blunted serum ACTH and cortisol responses to stress and decreased distress, suggesting potential for stress-related disorder treatment.
Safety of soy-derived phosphatidylserine in elderly people.
RCT assessing the safety of soy-derived phosphatidylserine (S-PS) in 120 elderly subjects. Participants received placebo, 300 mg, or 600 mg S-PS daily. No significant differences in safety parameters were found between groups, indicating S-PS is safe up to 200 mg three times daily.
The influence of soy-derived phosphatidylserine on cognition in age-associated memory impairment.
RCT of 120 elderly subjects with age-associated memory impairment testing 300mg and 600mg daily doses of soybean-derived phosphatidylserine (S-PS) against placebo. No significant differences were found in memory or cognitive functions between treatment groups.
Cognitive decline in the elderly: a double-blind, placebo-controlled multicenter study on efficacy of phosphatidylserine administration.
This double-blind, placebo-controlled study evaluated the efficacy and safety of phosphatidylserine (300 mg/day) in 494 elderly patients with cognitive impairment over 6 months. Statistically significant improvements in behavioral and cognitive parameters were observed in the phosphatidylserine-treated group compared to placebo, and the treatment was well tolerated.
A lecithin phosphatidylserine and phosphatidic acid complex (PAS) reduces symptoms of the premenstrual syndrome (PMS): Results of a randomized, placebo-controlled, double-blind clinical trial.
RCT of 40 women with PMS comparing PAS (phosphatidylserine and phosphatidic acid complex) to placebo over 3 menstrual cycles. PAS significantly improved PMS symptoms, including physical and depressive symptoms, and reduced cortisol levels compared to placebo.
Enhanced aerobic exercise performance in women by a combination of three mineral Chelates plus two conditionally essential nutrients.
RCT of aerobically fit young adult women taking a combination of mineral glycinates and conditionally essential nutrients (carnitine and phosphatidylserine) for 1 month. The combination improved 3 mile run time, stationary bike distance, and step test performance compared to placebo.
The effect of phosphatidylserine administration on memory and symptoms of attention-deficit hyperactivity disorder: a randomised, double-blind, placebo-controlled clinical trial.
RCT of 36 children with ADHD comparing 200 mg/day phosphatidylserine to placebo for 2 months. PS supplementation significantly improved ADHD symptoms, short-term auditory memory, and inattention, with no adverse effects.
Influence of phosphatidylserine on cognitive performance and cortical activity after induced stress.
This study investigated the effect of phosphatidylserine on cognition and cortical activity after induced stress in 16 healthy subjects. Chronic supplementation of phosphatidylserine significantly decreased Beta-1 power in right hemispheric frontal brain regions, indicating a more relaxed state compared to controls.
Effects of phosphatidylserine on exercise capacity during cycling in active males.
RCT investigating the effects of 750 mg of soybean-derived phosphatidylserine on exercise capacity in 14 active males. Supplementation significantly increased exercise time to exhaustion at 85% VO2max, suggesting potential ergogenic properties.
Phosphatidylserine supplementation and recovery following downhill running.
This RCT investigated the effects of 750 mg of soybean-derived phosphatidylserine supplementation on delayed onset muscle soreness and markers of muscle damage, inflammation, and oxidative stress following downhill running. The study found that supplementation did not significantly attenuate these responses.
Long-term effects of phosphatidylserine, pyritinol, and cognitive training in Alzheimer's disease. A neuropsychological, EEG, and PET investigation.
RCT with 70 Alzheimer's patients divided into four groups: social support, cognitive training, cognitive training with pyritinol, and cognitive training with phosphatidylserine. Phosphatidylserine showed effects on brain function measures, with neuropsychological improvements noted at 8 and 16 weeks, but benefits faded by the end of the 6-month treatment.
Effects of phosphatidylserine in Alzheimer's disease.
RCT of 51 Alzheimer's disease patients treated with bovine cortex phosphatidylserine (100 mg t.i.d.) or placebo for 12 weeks. Patients treated with phosphatidylserine improved on several cognitive measures compared to placebo, especially those with less severe cognitive impairment.
Effects of phosphatidylserine in age-associated memory impairment.
RCT of 149 patients with age-associated memory impairment treated with phosphatidylserine or placebo for 12 weeks. Patients treated with phosphatidylserine showed improved performance on learning and memory tasks compared to placebo, especially those with lower baseline performance.
Double-blind study with phosphatidylserine (PS) in parkinsonian patients with senile dementia of Alzheimer's type (SDAT).
Double-blind study on phosphatidylserine in Parkinsonian patients with senile dementia of Alzheimer's type. The study used computerized EEG to demonstrate therapeutic effects, showing improvements in anxiety, motivation, and affectivity, and changes in EEG patterns from Theta to Alpha waves.
Phosphatidylserine receptors enhance SARS-CoV-2 infection
The study investigates the role of phosphatidylserine (PS) receptors in enhancing SARS-CoV-2 infection through apoptotic mimicry. It shows that PS receptors, such as TIM and TAM families, enhance SARS-CoV-2 binding and internalization in cells with low ACE2 expression. The study also evaluates the potential of AXL receptor inhibitors like bemcentinib to inhibit SARS-CoV-2 infection.
Metformin loaded phosphatidylserine nanoliposomes improve memory deficit and reduce neuroinflammation in streptozotocin-induced Alzheimer's disease model.
The study evaluated the effects of metformin-loaded phosphatidylserine nanoliposomes (MET-PSL) on memory deficit and neuroinflammation in a rat model of Alzheimer's disease. MET-PSL significantly improved learning and memory parameters and decreased cytokine levels in hippocampal tissues, suggesting enhanced therapeutic performance compared to metformin or phosphatidylserine alone.
Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study.
Open-label extension study evaluating 100 mg/day of phosphatidylserine enriched with docosahexaenoic acid (PS-DHA) on cognitive performance in nondemented elderly individuals with memory complaints. Significant improvement in sustained attention and memory recognition was observed in the PS-DHA naïve group, while continuers maintained cognitive status.
Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men.
Placebo-controlled study in 9 healthy men examining the effect of chronic phosphatidylserine administration on neuroendocrine responses to physical stress. Phosphatidylserine 800 mg/d for 10 days significantly blunted ACTH and cortisol responses to exercise, suggesting it may counteract stress-induced activation of the hypothalamo-pituitary-adrenal axis.
Selegiline in the treatment of mild to moderate Alzheimer-type dementia.
RCT comparing selegiline and phosphatidylserine in 40 patients with mild to moderate Alzheimer-type dementia. Selegiline showed statistically significant improvements in cognitive areas and autonomy compared to phosphatidylserine. Both treatments were well-tolerated, with nausea being the only reported side effect.
Effects of phosphatidylserine therapy in geriatric patients with depressive disorders.
RCT studying the effects of phosphatidylserine (BC-PS) on cognitive, affective, and behavioural symptoms in 10 elderly women with depressive disorders. BC-PS therapy improved depressive symptoms, memory, and behaviour, with no changes in amine metabolite levels or hormonal responses.
Effects of phosphatidylserine on the neuroendocrine response to physical stress in humans.
RCT testing the effects of brain cortex-derived phosphatidylserine (BC-PS) on neuroendocrine responses to physical stress in 8 healthy men. BC-PS significantly blunted the ACTH and cortisol responses to physical stress.
Double-blind randomized controlled study of phosphatidylserine in senile demented patients.
A double-blind randomized controlled study in 42 hospitalized demented patients evaluated the effect of phosphatidylserine. Out of 35 patients who completed the trial, those treated with phosphatidylserine showed a significant improvement on the Peri Scale, indicating a positive treatment effect.
The role of phosphatidylserine on the membrane in immunity and blood coagulation
This review summarizes the role of phosphatidylserine (PtdSer) in immune and blood coagulation processes. It discusses PtdSer's exposure on cell membranes, its interaction with immune cells and coagulation factors, and its involvement in diseases like Scott syndrome and Systemic lupus erythematosus. The review also explores PtdSer's role in viral infections, including COVID-19.
Phosphatidylserine, inflammation, and central nervous system diseases
This review discusses the role of phosphatidylserine (PS) in brain functions, including its involvement in membrane signaling, neuroinflammation, neurotransmission, and synaptic refinement. It explores PS metabolism, its anti-inflammatory effects in the brain, alterations in CNS diseases, and its potential as a therapeutic agent. Clinical studies indicate PS is well tolerated, suggesting it could be a promising supplement for neurodegenerative and neurodevelopmental diseases.
Flagging fusion: Phosphatidylserine signaling in cell–cell fusion
The paper reviews data on the role of phosphatidylserine in cell fusion processes, discussing its potential function as a 'fuse me' signal that regulates the timing and location of cell-fusion events.
The effect of soybean-derived phosphatidylserine on cognitive performance in elderly with subjective memory complaints: a pilot study
Pilot study evaluating the efficacy and safety of soybean-derived phosphatidylserine (SB-PS) in improving cognitive performance in 30 elderly individuals with memory complaints over 12 weeks. SB-PS supplementation significantly improved memory recognition, recall, executive functions, and mental flexibility. It also unexpectedly reduced systolic and diastolic blood pressure, and was well tolerated with no serious adverse events.
Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer
This narrative review discusses the role of phosphatidylserine (PS) as a global immunosuppressive signal in efferocytosis, infectious disease, and cancer. It highlights how PS is exploited in pathological processes such as infection and cancer, and suggests that targeting PS could be valuable in therapeutics for these conditions.
Neurosteroid modulation of recombinant ionotropic glutamate receptors.
The study investigates the modulation of recombinant ionotropic glutamate receptors by pregnenolone sulfate (PS), a neurosteroid. PS was found to inhibit kainate and AMPA responses while potentiating NMDA responses, with the modulation dependent on receptor subunit composition.
Nootropic drugs and brain cholinergic mechanisms.
This review discusses the interaction between nootropic drugs and brain cholinergic mechanisms, focusing on substances like phosphatidylserine and pyrrolidinone derivatives. It highlights their role in preventing or reversing scopolamine-induced learning and memory disruptions and restoring acetylcholine synthesis in aging rats.