Research
Petiveria alliacea (Guinea Hen Weed / Anamú)
42 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Exploring the safety and efficacy of phytomedicine Petiveria alliacea extract (Esperanza) in patients with metastatic gastrointestinal tumors and acute leukemias: study protocol for a phase Ib/randomized double blind phase II trial (PA001).
This study protocol outlines a phase Ib/randomized double-blind phase II trial to evaluate the safety and efficacy of Petiveria alliacea extract (Esperanza) in patients with metastatic gastrointestinal tumors and acute leukemias. The trial aims to determine the maximum tolerated dose and assess safety and efficacy, with quality of life improvement as a primary outcome in the gastric tumor group.
Control of Varroa destructor in honey bees (Apis mellifera) with the aqueous extract of Petiveria alliacea and identification of its constituents by LC-MS.
The study evaluated the aqueous extract of Petiveria alliacea for controlling varroosis in honey bees caused by Varroa destructor. The extract showed potential acaricidal effects with varying LC50 values depending on the method of exposure, indicating minimal risk to bees through direct contact but greater risk through ingestion. LC-MS analysis identified 16 compounds in the extract.
Petiveria alliacea L. methanolic extract inhibits amyloid-β aggregation and enhances cell viability in SH-SY5Y cells: in vitro and in silico evidence.
In vitro study of Petiveria alliacea methanolic extract on SH-SY5Y cells, showing inhibition of amyloid-β aggregation and enhanced cell viability. The extract demonstrated anti-amyloidogenic capabilities, suggesting potential neuroprotective effects relevant to Alzheimer's disease.
Toxicity of Mucura (Petiveria alliacea) extracts from the peruvian amazon against Daphnia magna for environmental protection and sustainable development.
The study evaluated the toxicity of Petiveria alliacea extracts using Daphnia magna as a bioindicator. Three types of extracts (hexane, ethanolic, and aqueous) were tested, with the aqueous extract showing the lowest toxicity. This suggests potential for sustainable use in pest control with minimal environmental impact.
The secretome from human-derived mesenchymal stem cells augments the activity of antitumor plant extracts in vitro.
In vitro study examining the effect of Petiveria alliacea (Anamu-SC) and Caesalpinia spinosa (P2Et) extracts on human adipose-derived mesenchymal stem cells (hAMSC) and tumor cell interactions. The study found that the hAMSC secretome did not affect the cytotoxic or clonogenicity-reducing activities of the natural extracts on cancer cells and could inhibit tumor cell migration.
Triple negative breast cancer migration is modified by mitochondrial metabolism alteration induced by natural extracts of C. spinosa and P. alliacea.
The study investigates the effects of natural extracts P2Et from Caesalpinia spinosa and Anamu-SC from Petiveria alliacea on mitochondrial metabolism in a triple-negative breast cancer model. The Anamu-SC extract significantly decreased glucose consumption, ATP production, and oxygen consumption rate, reducing the cells' ability to migrate.
Neuroprotective effects of Petiveria alliacea on scopolamine-induced learning and memory impairment mouse model.
The study assessed the effects of Petiveria alliacea leaves methanol fraction (PMF) on scopolamine-induced learning and memory impairment in mice. PMF improved memory in behavioral tests, inhibited acetylcholinesterase activity, showed antioxidant potential, increased glutathione levels, and reduced oxidative stress markers without acute toxicity.
Acetylcholinesterase inhibition and antioxidant activity properties of Petiveria alliacea L.
The study investigated extracts from Petiveria alliacea for acetylcholinesterase inhibition and antioxidant activity. The methanol fraction showed significant inhibitory activity on acetylcholinesterase and antioxidant properties, suggesting potential for neurodegenerative disorder therapies.
Influence of polyvinylpyrrolidone, microcrystalline cellulose and colloidal silicon dioxide on technological characteristics of a high-dose Petiveria alliacea tablet.
The study investigated the influence of polyvinylpyrrolidone, colloidal silicon dioxide, and microcrystalline cellulose on the technological characteristics of a high-dose Petiveria alliacea tablet prepared by the wet granulation method. The optimal formulation was determined to improve the tablet's breaking force, friability, and disintegration time.
gamma-Glutamyl dipeptides in Petiveria alliacea.
The paper reports the isolation and structural determination of three gamma-glutamyl dipeptides from Petiveria alliacea L. roots, including gamma-glutamyl-S-benzylcysteine and its diastereomeric sulfoxides. Structures were confirmed using NMR, MALDI-HRMS, IR, and CD spectroscopy.
The lachrymatory principle of Petiveria alliacea.
The study isolated the lachrymatory principle of Petiveria alliacea from the root, identifying it as (Z)-thiobenzaldehyde S-oxide. The compound's structure was determined using NMR, IR, MALDI-MS, and synthesis comparison. Its antibacterial and antifungal activities are reported.
The effectiveness of tipi in the treatment of hip and knee osteoarthritis--a preliminary report.
A one-week cross-over double-blind trial evaluated the analgesic effect of tipi tea (Petiveria alliacea) in 14 patients with hip and knee osteoarthritis. Both tipi and placebo tea showed significant improvement in pain, but no statistically significant difference was found between them. Seven patients preferred tipi tea, while six preferred placebo tea.
Preferential Activity ofExtract on Primary Myeloid Leukemic Blast.
The study evaluated the sensitivity of leukemic blasts from 32 acute leukemia patients to induction chemotherapy and the modulation of this sensitivity by Anamu and P2Et extracts. Anamu was found to be more effective in inducing cell death, and the combination with chemotherapeutic agents showed synergistic or antagonistic effects.
Petiveria alliacea Suppresses Airway Inflammation and Allergen-Specific Th2 Responses in Ovalbumin-Sensitized Murine Model of Asthma.
The study examined the effect of Petiveria alliacea methanol extract on airway inflammation in a murine model of chronic asthma. The extract significantly reduced eosinophil infiltration, airway resistance, and cytokine levels, improving lung function and reducing inflammation scores.
Toxicological evaluation of an aqueous suspension from leaves and stems of Petiveria alliacea L. (Phytolaccaceae).
The study evaluated the toxicity of an aqueous suspension from leaves and stems of Petiveria alliacea in Sprague Dawley rats. The powder was classed in hazard category 5 with no toxicity signs at 1000mg/kg in the repeated dose study. Higher leukocyte levels were observed, attributed to the plant's immunomodulatory properties.
Anthelminthic activity of methanol extracts of Diospyros anisandra and Petiveria alliacea on cyathostomin (Nematoda: Cyathostominae) larval development and egg hatching.
In vitro evaluation of methanol extracts from Diospyros anisandra and Petiveria alliacea on cyathostomin larval development and egg hatching. D. anisandra bark extracts showed ≥95% egg hatch inhibition at concentrations ≥37.5μg/ml, while P. alliacea extracts showed >97% inhibition at concentrations ≥300μg/ml. Both extracts demonstrated strong anthelminthic effects, suggesting potential as control alternatives for nematodes.
Anti-inflammatory Potential ofon Activated RAW264.7 Murine Macrophages.
The study evaluated the anti-inflammatory effects of ethanol extract from Petiveria alliacea (PW) on LPS-stimulated RAW264.7 murine macrophages. PW significantly suppressed the secretion of various proinflammatory mediators and inhibited NF-κB transcriptional activity, indicating its potential as an anti-inflammatory agent.
Significant inhibitory impact of dibenzyl trisulfide and extracts of Petiveria alliacea on the activities of major drug-metabolizing enzymes in vitro: An assessment of the potential for medicinal plant-drug interactions.
In vitro study assessing the impact of dibenzyl trisulfide (DTS) and extracts of Petiveria alliacea on the activities of major drug-metabolizing enzymes, cytochromes P450. DTS showed significant inhibitory effects on CYPs 1A2, 2C19, and 3A4, suggesting potential for medicinal plant-drug interactions.
Petiveria alliacea exerts mnemonic and learning effects on rats.
The study evaluated the effects of Petiveria alliacea leaves hydroalcoholic extract on cognition in Wistar rats. The extract improved long-term, short-term, and spatial memory, as well as learning in behavioral assays.
A Petiveria alliacea standardized fraction induces breast adenocarcinoma cell death by modulating glycolytic metabolism.
The study investigates the effects of a Petiveria alliacea fraction on breast adenocarcinoma cells and tumor regression in a murine model. The fraction induces apoptosis and decreases glycolytic metabolism in vitro, and promotes tumor regression in vivo, supporting its traditional use in cancer treatment.
Evaluation of the Hypoglycaemic Activity of Petiveria alliacea (Guinea Hen Weed) Extracts in Normoglycaemic and Diabetic Rat Models.
The study evaluated the hypoglycaemic activity of Petiveria alliacea extracts in normoglycaemic and diabetic rats. Aqueous and hexane extracts were tested, showing no significant reduction in fasting blood glucose in normal rats. In diabetic rats, the hexane extract initially reduced fasting blood glucose but did not sustain the effect. The aqueous extract showed a hyperglycaemic effect in normoglycaemic rats and no hypoglycaemic activity in diabetic rats.
Potential behavioral and pro-oxidant effects of Petiveria alliacea L. extract in adult rats.
Study on the effects of Petiveria alliacea extract in adult rats, showing increased locomotor activity, anxiolytic and antidepressant effects, and memory improvement. The extract also exhibited pro-oxidant effects, decreasing antioxidant capacity and increasing methemoglobin levels.
Immunomodulatory effects of aqueous and organic fractions from Petiveria alliacea on human dendritic cells.
The study evaluated the immunomodulatory activity of aqueous and organic fractions from Petiveria alliacea on human monocyte-derived dendritic cells. The aqueous fraction induced partial dendritic cell maturation and pro-inflammatory cytokine secretion, while the organic fraction showed no activity.
Dual effects of crude extracts obtained from Petiveria alliacea L. (Phytolaccaceae) on experimental anxiety in mice.
The study investigated the effects of different extracts from Petiveria alliacea on anxiety in mice using the elevated plus maze model. The whole plant extract showed anxiolytic-like effects, while the aerial part extract induced anxiogenic-like effects. The root extract had no effect on anxiety-like behavior.
Central effects of isolated fractions from the root of Petiveria alliacea L. (tipi) in mice.
The study investigated the neuropharmacological properties of isolated fractions from the root of Petiveria alliacea L. (tipi) in mice. The fractions showed central depressant and anticonvulsant effects, decreasing locomotor activity and increasing immobility time in behavioral tests, supporting its use in folk medicine.
Petiveria alliacea extracts uses multiple mechanisms to inhibit growth of human and mouse tumoral cells.
In vitro study of Petiveria alliacea extracts on human and mouse tumor cell lines. The extract altered actin cytoskeleton organization, induced G2 cell cycle arrest, and caused apoptotic cell death in a mitochondria independent way. It also affected protein expression related to cytoskeleton, chaperone, signal transduction, and metabolic pathways.
Study of antinociceptive effect of isolated fractions from Petiveria alliacea L. (tipi) in mice.
The study evaluated the antinociceptive effects of various fractions from the root of Petiveria alliacea L. in mice using different pain models. All fractions showed inhibition of abdominal constrictions, with some fractions also reducing nociception in the formalin test. The fractions reduced locomotor activity but did not affect motor coordination.
Antibacterial and antifungal activity of sulfur-containing compounds from Petiveria alliacea L.
Study tested 18 organosulfur compounds from Petiveria alliacea roots for antibacterial and antifungal activities. Thiosulfinates, trisulfides, and benzylsulfinic acid were most active, with benzyl-containing thiosulfinates showing the broadest antimicrobial spectrum.
Antiviral activity of Petiveria alliacea against the bovine viral diarrhea virus.
In vitro study evaluating the antiviral activity of Petiveria alliacea against bovine viral diarrhea virus (BVDV). P. alliacea inhibited BVDV replication, with ethyl acetate and dichloromethane extracts showing activity. The study suggests potential for further isolation and characterization of antiviral components.
The anti-inflammatory and analgesic effects of a crude extract of Petiveria alliacea L. (Phytolaccaceae).
The study investigated the anti-inflammatory and analgesic effects of a crude lyophilized extract of Petiveria alliacea roots in rats with pleurisy. The highest dose of extract significantly reduced the number of migrating neutrophils, mononuclear cells, and eosinophils, and showed a significant analgesic effect.
Antifungal polysulphides from Petiveria alliacea L.
Bioactivity-directed fractionation of Petiveria alliacea root extract led to the isolation of several sulphide compounds, including new compounds and the first natural occurrence of dibenzyl sulphide and dibenzyl disulphide.
Cysteine sulfoxide derivatives in Petiveria alliacea.
The paper reports the isolation and structural determination of two diastereomers of S-benzyl-L-cysteine sulfoxide from Petiveria alliacea. The study identifies the presence of these compounds in various parts of the plant, with the highest concentration in the roots.
Cytokine profile and natural killer cell activity in Listeria monocytogenes infected mice treated orally with Petiveria alliacea extract.
The study investigated the effects of Petiveria alliacea extract on cytokine production and NK cell activity in normal and Listeria monocytogenes infected mice. P. alliacea administration increased IL-2 and INF-gamma levels and enhanced NK cell activity, suggesting an up-regulation of the anti-bacterial immune response.
Ethnobotany, phytochemistry and neuropharmacological effects of Petiveria alliacea L. (Phytolaccaceae): A review.
This narrative review provides an overview of the ethnobotany, phytochemistry, and neuropharmacological properties of Petiveria alliacea, focusing on its effects on the central nervous system. The review highlights the plant's potential for treating CNS disorders such as anxiety, depression, pain, epilepsy, and memory impairments, supported by modern pharmacology research.
A critical review of the therapeutic potential of dibenzyl trisulphide isolated from Petiveria alliacea L (guinea hen weed, anamu).
The review discusses the therapeutic potential of dibenzyl trisulphide (DTS) isolated from Petiveria alliacea. DTS is shown to enhance long-term memory and neuronal growth through MAPKinase pathways, exhibit potent cytotoxic activity against cancer cell lines, and modulate cytokine pathways to potentially reduce inflammation and enhance immune parameters.
Subchronic and acute preclinic toxicity and some pharmacological effects of the water extract from leaves of Petiveria alliacea (Phytolaccaceae).
The study tested the effects of aqueous extract of Petiveria alliacea leaves on acute and sub-chronic toxicity, hematocrit, blood glucose level, and intestinal motility in male albino NGP mice. Doses of 1,000 and 2,000 mg/kg were administered orally. No mortality or toxicity signs were observed. A slight increase in glucose levels was noted with the 1,000 mg/kg dose during the first three weeks.
Petiveria alliacea L. extract protects mice against Listeria monocytogenes infection--effects on bone marrow progenitor cells.
The study investigated the effects of Petiveria alliacea extract on the hematopoietic response in mice infected with Listeria monocytogenes. The extract showed a protective effect, increasing survival and enhancing granulocyte/macrophage colony formation and serum colony stimulating activity, suggesting immunomodulation and increased resistance to infection.
Antimitotic action of extracts of Petiveria alliacea on sea urchin egg development.
The study investigates the antimitotic effects of Petiveria alliacea root extracts on sea urchin egg development. The ether fraction showed the most significant inhibition of cell cleavage, with an ED50 of 12.40 micrograms/ml, compared to other fractions and the total extract.
Evaluation of the genotoxic effects of a folk medicine, Petiveria alliacea (Anamu).
The study evaluated the genotoxic effects of Petiveria alliacea (Anamu) using a sister chromatid exchange assay in vitro and in vivo. Significant dose-dependent increases in SCE were observed in human lymphocytes and mouse bone marrow cells, suggesting the presence of mutagenic and potentially carcinogenic agents in the folk medicine.
Evaluation of antinociceptive effect of Petiveria alliacea (Guiné) in animals.
The study evaluated the sedative and analgesic properties of Petiveria alliacea root crude aqueous extract in mice and rats. The extract showed an antinociceptive effect in certain induced abdominal constrictions but not in hot-plate and tail flick tests, suggesting its use as an analgesic in folk medicine.
Petiveria alleaceae L. (anamú). Study of the hypoglycemic effect.
Study of Petiveria alleaceae L. (anamú) showing that extracts from leaves and stem powder produced a decrease in blood sugar concentration of more than 60% one hour after oral administration in male Balb/C mice fasted for 48 hours.
Plants used in Guatemala for the treatment of protozoal infections: II. Activity of extracts and fractions of five Guatemalan plants against Trypanosoma cruzi.
The study evaluated the activities of crude plant extracts from five Guatemalan plants against Trypanosoma cruzi in vitro. Neurolaena lobata showed significant activity against trypomastigotes and epimastigotes, with its ethanol extract being highly active in vitro and in vivo. Petiveria alliacea and Tridax procumbens also showed marked inhibition of trypomastigotes.