Research
Pau D'Arco
5 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Safety and tolerability of Pau d' Arco (for primary dysmenorrhea: A single-arm, open-label trial on adults ages 18-45.
A single-arm, open-label trial evaluated the safety and tolerability of 1050 mg/day Pau d'Arco in 12 women aged 18-45 with primary dysmenorrhea over eight weeks. The study found significant improvements in pain intensity scores, with most adverse events being mild and no serious adverse events reported.
Pau d'arco activates Nrf2-dependent gene expression via the MEK/ERK-pathway.
The study investigated the effect of pau d'arco on the cytoprotective transcription factor Nrf2. An aqueous extract of pau d'arco stimulated Nrf2-dependent gene expression and led to nuclear localization of Nrf2 in vitro. The extract activated the MEK/ERK pathway, and pharmacological inhibition of MEK was required for Nrf2 activation. In vivo, pau d'arco increased the expression of Nrf2-target genes in the intestine.
Antinociceptive and antiedematogenic properties and acute toxicity of Tabebuia avellanedae Lor. ex Griseb. inner bark aqueous extract
The study evaluated the antinociceptive and antiedematogenic effects of Tabebuia avellanedae inner bark aqueous extract in mice and rats. The extract reduced nociception and edema in experimental models, with low acute toxicity observed in mice.
Red Lapacho (Tabebuia impetiginosa)--a global ethnopharmacological commodity?
Narrative review of Red Lapacho (Tabebuia impetiginosa), a traditional botanical drug used in South America for various conditions. The review discusses its historical use, bioactive components like lapachol and beta-lapachone, and the need for quality control and further research into its clinical effects and pharmacology.
The search for novel anticancer agents: a differentiation-based assay and analysis of a folklore product.
The study describes an in vitro assay using murine erythroleukemia cells to analyze antineoplastic activity in natural products, focusing on pau d'arco. The activity in pau d'arco extracts, identified as lapachol, was inhibited by vitamin K1, suggesting a potential mechanism involving vitamin K-dependent reactions.