Research
Passionflower
13 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
in Neuropsychiatric Disorders-A Systematic Review.
Systematic review of nine clinical trials evaluating the effects of passionflower on neuropsychiatric disorders. The majority of studies reported reduced anxiety levels following the administration of passionflower preparations, with no adverse effects observed.
Effects of Passiflora incarnata Linnaeus on polysomnographic sleep parameters in subjects with insomnia disorder: a double-blind randomized placebo-controlled study.
Double-blind randomized placebo-controlled study investigating the effects of Passionflower on polysomnographic sleep parameters in 110 adults with insomnia disorder. Passionflower significantly increased total sleep time compared to placebo, with improvements in sleep efficiency and wake after sleep onset.
Passiflora for anxiety disorder.
Meta-analysis of two studies with 198 participants examining the effectiveness of passiflora for anxiety disorders. One study indicated no difference in efficacy between benzodiazepines and passiflora, with similar dropout rates. Passiflora showed a non-significant improvement in job performance and lower drowsiness compared to mexazolam.
Passiflora incarnata Linneaus as an anxiolytic before spinal anesthesia.
RCT investigating the effect of preoperative oral administration of Passiflora incarnata on anxiety, psychomotor functions, sedation, and hemodynamics in patients undergoing spinal anesthesia. Passiflora incarnata suppressed the increase in anxiety before spinal anesthesia without affecting psychomotor function, sedation level, or hemodynamics.
Passionflower in the treatment of opiates withdrawal: a double-blind randomized controlled trial.
Double-blind RCT of 65 opiate addicts comparing clonidine plus passiflora extract to clonidine plus placebo for 14 days. Both protocols were equally effective for physical withdrawal symptoms, but passiflora showed significant superiority in managing mental symptoms.
Passionflower (Passiflora incarnata) : Quality of Food Supplements Versus Registered Herbal Medicinal Products
The paper investigates the quality of passionflower products marketed as food supplements versus registered herbal medicinal products in Europe. Analytical methods revealed that many food supplements did not meet specified content and identity, suggesting instances of food fraud, while all registered herbal medicinal products conformed to specifications.
A double-blind, placebo-controlled investigation of the effects of Passiflora incarnata (passionflower) herbal tea on subjective sleep quality.
Double-blind, placebo-controlled study investigating the effects of Passiflora incarnata herbal tea on sleep quality in 41 participants. Passionflower tea showed significantly better sleep quality ratings compared to placebo, suggesting short-term subjective sleep benefits.
Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam.
A double-blind randomized trial compared the efficacy of Passiflora incarnata extract with oxazepam in treating generalized anxiety disorder in 36 patients. Both treatments were effective, but Passiflora extract had fewer issues with job performance impairment compared to oxazepam.
A combination of plant extracts in the treatment of outpatients with adjustment disorder with anxious mood: controlled study versus placebo.
Multicenter, double-blind, placebo-controlled study of Euphytose (a combination of six plant extracts) in 182 outpatients with adjustment disorder with anxious mood. Euphytose group showed significant improvement in Hamilton-anxiety scores compared to placebo over 28 days.
Systemic analysis of anti-stress, normothymic, and hypnotic effects of passionflower extracts standardized for luteolin-7-glucoside
Systemic analysis of 1141 publications on passionflower extracts standardized for luteolin-7-glucoside. The extracts show mild calming effects, improve stress resistance, have sedative and hypnotic effects, and provide neuroprotection and anti-inflammatory benefits.
Examining the Anxiolytic Effects of Flavonoids in Passionflower: A Gut-Brain Axis Perspective
This narrative review investigates the influence of Passiflora incarnata on the Gut-Brain Axis, focusing on flavonoids and their role in alleviating anxiety. The review suggests Passiflora incarnata as a potential alternative to modern anxiety medications and emphasizes the need for further clinical trials.
Passionflower (Passiflora incarnata L.) as an element of phytotherapy for selected, indicated by the European Medicine Agency, central nervous system disorders
Narrative review summarizing scientific data on Passiflora incarnata for treating sleep disorders and alleviating anxiety and stress. Highlights the need for further research on its pharmacodynamics, pharmacokinetics, safety, and mechanisms of action.
Passionflower in the Treatment of Anxiety Disorders
The article analyzes literature data on anxiety disorders and the use of passionflower (Passiflora incarnata) for their treatment. It describes the characteristics, composition, clinical effects, and indications for the use of passionflower in general medical practice.