Research
Papaya Leaf Extract
10 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Fortification of Carica papaya fruit seeds to school meal snacks may aid Africa mass deworming programs: a preliminary survey.
RCT evaluating papaya seed fortified porridge in school children in Kenya. Papaya porridge reduced Ascaris lumbricoides egg count by 63.9% and improved hemoglobin counts and reduced Tinea capitis compared to control and albendazole groups.
Fermented soyabean and vitamin C-rich fruit: a possibility to circumvent the further decrease of iron status among iron-deficient pregnant women in Indonesia.
RCT assessing the effect of supplementary food containing tempeh and vitamin C-rich fruits on maternal iron deficiency in pregnant women in Indonesia. The study found that consumption of the optimized diet was associated with smaller decreases in Hb, ferritin, and body iron concentrations in iron-deficient women compared to no intervention.
Supplementation of Caricol®-Gastro reduces chronic gastritis disease associated pain.
RCT investigating Caricol®-Gastro, a combination of papaya and oats, as an add-on therapy for chronic gastritis. The study found that while both groups showed symptom improvement, the Caricol®-Gastro group had a significantly larger reduction in pain load.
Comparison of safety and efficacy of papaya dressing with hydrogen peroxide solution on wound bed preparation in patients with wound gape.
A randomized, open-labeled interventional study comparing papaya dressing to hydrogen peroxide solution for wound bed preparation in post-caesarean section patients with wound gape. Papaya dressing significantly reduced the time to develop healthy granulation tissue and shortened hospitalization duration compared to hydrogen peroxide, with comparable safety profiles.
A Purported Detoxification Supplement Does Not Improve Body Composition, Waist Circumference, Blood Markers, or Gastrointestinal Symptoms in Healthy Adult Females.
Double-blind, randomized, placebo-controlled trial in healthy young adult females assessing a detoxification supplement containing a proprietary blend of various herbs. No beneficial or harmful effects were found on body composition, waist circumference, gastrointestinal symptoms, or blood markers.
Papaya preparation (Caricol®) in digestive disorders.
Double-blind placebo-controlled study of papaya preparation Caricol® in volunteers with chronic indigestions. Significant improvements were observed in symptoms of constipation and bloating, with no significant improvement in heartburn due to small sample size. The study suggests Caricol® supports digestive tract physiology.
Platelet enhancement by Carica papaya L. leaf fractions in cyclophosphamide induced thrombocytopenic rats is due to elevated expression of CD110 receptor on megakaryocytes.
The study investigates the effects of Carica papaya leaf juice on thrombocytopenia induced by cyclophosphamide in rats. Papaya leaf juice and its butanol fraction significantly increased platelet counts and enhanced CD110 receptor expression on megakaryocytes, suggesting a mechanism for its platelet enhancement activity.
Carica papaya L.: A Tropical Fruit with Benefits beyond the Tropics
This review article discusses the traditional and modern medicinal uses, nutritional properties, phytochemistry, diseases, genomics, and biotechnological strategies for papaya. It highlights papaya's antioxidant, digestive, and nutraceutical benefits, as well as its potential in combination therapies for cancers and viral diseases.
Carica papaya L. Leaf: A Systematic Scoping Review on Biological Safety and Herb-Drug Interactions
This systematic scoping review collates clinical and preclinical data on the safety and herb-drug interactions of Carica papaya leaf consumption. It finds that papaya leaf is generally well tolerated for short-term use in adults, with minor gastrointestinal side effects. Concerns about hepatotoxicity and reproductive toxicity in long-term use are noted, along with potential herb-drug interactions with metformin, glimepiride, digoxin, ciprofloxacin, and artemisinin.
The treatment of paediatric burns using topical papaya.
The study discusses the use of Carica papaya in the treatment of pediatric burns at the Royal Victoria Hospital in The Gambia. Papaya pulp is applied to burns, showing effectiveness in desloughing necrotic tissue, preventing infection, and preparing wounds for skin grafts.