Research
Oleocanthal
5 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Alzheimer's Disease May Benefit from Olive Oil Polyphenols: A Systematic Review on Preclinical Evidence Supporting the Effect of Oleocanthal on Amyloid-β Load.
Systematic review of preclinical studies on oleocanthal from extra-virgin olive oil, focusing on its effects on amyloid-β load in Alzheimer's disease models. Oleocanthal was found to reduce amyloid-β load and improve metabolic and behavioral parameters in mouse models.
The impact of olive oil polyphenol supplementation on metabolic syndrome parameters The OleoMetS study: A randomized, controlled clinical trial.
RCT of 102 participants with metabolic syndrome assessing the effects of olive oil polyphenol supplementation. The intervention group showed significant improvements in fasting blood glucose, HbA1c, BMI, blood pressure, triglycerides, oxidized LDL, uric acid, ALT, and fatigue scores compared to placebo.
Evaluating the Impact of Oleocanthal and Oleacein on Skin Aging: Results of a Randomized Clinical Study.
A single-blind, randomized clinical trial with 70 participants evaluated the anti-aging efficacy of Oleocanthal and Oleacein in a skincare formulation. Participants applied a 1% serum formulation twice daily for 30 days, resulting in significant wrinkle reduction, particularly in older adults.
Rich oleocanthal and oleacein extra virgin olive oil and inflammatory and antioxidant status in people with obesity and prediabetes. The APRIL study: A randomised, controlled crossover study.
Randomised, double-blind, crossover trial in 91 people with obesity and prediabetes comparing extra virgin olive oil (EVOO) rich in oleocanthal and oleacein to common olive oil. EVOO treatment improved oxidative and inflammatory status, decreased weight, BMI, and blood glucose compared to common olive oil.
Acute Antiplatelet Effects of an Oleocanthal-Rich Olive Oil in Type II Diabetic Patients: A Postprandial Study.
Randomized, single-blinded, crossover study in 10 T2DM patients assessing the effects of oleocanthal-rich olive oil on postprandial platelet aggregation. Oleocanthal meals showed a dose-dependent reduction in platelet sensitivity to ADP and TRAP, comparable to ibuprofen, without affecting glycemic and lipidemic responses.