Research
Nigella sativa (Black Seed / Black Cumin)
129 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
The Effect of Nigella sativa Supplementation on Cardiometabolic Health in Patients With Metabolic Diseases: A GRADE-Assessed Systematic Review and Meta-Analysis.
Meta-analysis of 31 trials with 2145 participants assessing the effect of Nigella sativa supplementation on cardiovascular risk factors in patients with metabolic diseases. Significant reductions were found in weight, BMI, systolic and diastolic blood pressure, fasting blood sugar, and HbA1c, but no effect on insulin resistance or central adiposity.
Systematic review of prophylactic antibacterial agents for radiation-induced oral mucositis in head and neck cancer.
Systematic review of prophylactic antibacterial agents for radiation-induced oral mucositis in head and neck cancer patients. Nigella sativa showed potential benefits in reducing RIOM incidence and severity compared with standard care and other antibacterial agents, though evidence remains insufficient to establish superiority.
Does Nigella sativa supplementation improve cardiovascular disease risk factors? A comprehensive GRADE-assessed systematic review and dose-response meta-analysis of 82 randomized controlled trials.
This systematic review and meta-analysis evaluated the effects of Nigella sativa supplementation on metabolic and cardiovascular health outcomes across 82 randomized controlled trials with 5026 participants. N. sativa supplementation significantly improved various cardiovascular disease risk factors, including body composition, blood pressure, blood glucose levels, lipid profiles, and inflammatory markers.
Effects of Nigella sativa and its constituents on inflammatory markers in ovalbumin-induced asthma model: a preclinical systematic review and meta-analysis.
This meta-analysis evaluated the effects of Nigella sativa and its constituents on inflammatory markers in an animal model of ovalbumin-induced asthma. The analysis of 18 studies with 502 animals showed that N. sativa significantly reduced levels of IL-4, IL-5, IL-13, IL-17, and IgE, but did not change IFN-γ levels, suggesting potential anti-inflammatory and antioxidant effects.
Effects of black seed (Nigella sativa L.) on cardiometabolic indices in type 2 diabetic patients: A systematic review and meta-analysis of RCTs.
Systematic review and meta-analysis of 16 RCTs assessing black seed supplementation in type 2 diabetic patients. Black seed significantly reduced fasting blood glucose, hemoglobin A1c, total cholesterol, and LDL levels, suggesting potential benefits for glycemic and lipid control.
Effect ofConsumption on Lipid Profile and Glycemic Index in Patients with Metabolic Syndrome: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
This systematic review and meta-analysis of randomized controlled trials assessed the effect of Nigella sativa consumption on lipid profile and glycemic indices in patients with metabolic syndrome. The results showed that N. sativa intake significantly decreased total cholesterol, LDL-C, HDL-C, FBS, and HbA1c concentrations, indicating improvements in lipid profile and glycemic index.
Effects of Nigella sativa supplementation on lipid profiles in adults: An updated systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis of 34 studies with 2278 participants examined the effects of Nigella sativa supplementation on lipid profiles. The results showed significant reductions in total cholesterol, triglycerides, and LDL-C, and an increase in HDL-C, suggesting Nigella sativa as a potential adjuvant anti-hyperlipidemic agent.
Effect ofIntake on Oxidative Stress and Inflammation in Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
This systematic review and meta-analysis of 16 RCTs with 1033 participants assessed the impact of Nigella sativa intake on inflammation and oxidative stress biomarkers in individuals with metabolic syndrome. Results showed significant decreases in CRP, TNF-α, IL-6, and MDA levels, and increases in SOD and TAC levels in the intervention group compared to placebo.
Systematic Review of Randomized Controlled Trials in Uses of Nigella Sativa (Black Seed) in Metabolic Syndrome.
Systematic review of randomized controlled trials assessing the effects of Nigella Sativa on metabolic syndrome parameters. Significant improvements were found in lipid profile and glycaemic indices, while results for blood pressure and anthropometric indices were inconsistent. Nigella Sativa is recommended as an adjunct therapy for metabolic syndrome.
Alleviating effects of Nigella sativa supplements on biomarkers of inflammation and oxidative stress: Results from an umbrella meta-analysis.
Umbrella meta-analysis evaluated the effects of Nigella sativa supplementation on inflammatory and oxidative markers. N. Sativa significantly decreased serum CRP, TNF-alpha, and MDA levels, and improved TAC and SOD levels, suggesting its beneficial effects as an anti-inflammatory and antioxidant agent.
The effect of Nigella sativa (black seed) on biomarkers of inflammation and oxidative stress: an updated systematic review and meta-analysis of randomized controlled trials.
This meta-analysis of 20 RCTs with 1086 participants assessed the effect of Nigella sativa supplementation on inflammatory and oxidative markers. N. sativa significantly reduced CRP, TNF-α, and MDA levels, and improved TAC, GPx, and SOD levels, but had no significant effect on IL-6 levels.
The effect of Nigella sativa on the risk of mortality in patients with COVID-19: A systematic review and meta-analysis of randomized trials.
Systematic review and meta-analysis of randomized trials examining the effect of Nigella sativa on the risk of mortality in patients with COVID-19.
Antihypertensive effects of Nigella sativa supplementation: An updated systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis of randomized controlled trials examined the effects of Nigella sativa supplementation on blood pressure in adults. The analysis found that N. sativa supplementation effectively reduced both systolic and diastolic blood pressure, suggesting its potential use in blood pressure management.
Honey and Nigella sativa against COVID-19 in Pakistan (HNS-COVID-PK): A multicenter placebo-controlled randomized clinical trial.
Multicenter, placebo-controlled RCT in Pakistan testing honey and Nigella sativa (HNS) on COVID-19 patients. HNS significantly reduced symptom duration, expedited viral clearance, and lowered mortality compared to placebo, with no adverse effects observed.
The Effect of Short Treatment with Nigella Sativa on Symptoms, the Cluster of Differentiation (CD) Profile, and Inflammatory Markers in Mild COVID-19 Patients: A Randomized, Double-Blind Controlled Trial.
This randomized, double-blind controlled trial investigated the impact of different doses of Nigella sativa seeds on symptoms, the cluster of differentiation profile, and inflammatory markers in mild COVID-19 patients. The study found no significant effect of ten days of treatment with Nigella sativa on these parameters.
Effect of Nigella Sativa in Improving Blood Glucose Level in T2DM: Systematic Literature Review of Randomized Control Trials.
Systematic review of randomized controlled trials evaluating the effects of Nigella Sativa on glucose and insulin profile status in patients with Type 2 Diabetes Mellitus. The review found significant improvements in the management of T2DM and its complications with Nigella Sativa intervention.
L. and Its Active Compound Thymoquinone in the Clinical Management of Diabetes: A Systematic Review.
This systematic review analyzes clinical studies on the efficacy, safety, and mechanism of action of Nigella sativa (NS) and its compound thymoquinone (TQ) in diabetes management. The review found that NS and TQ have potent hypoglycemic activity, improving parameters such as fasting blood glucose, postprandial blood glucose, and HbA1c. TQ combined with metformin showed greater reductions in HbA1c and blood glucose compared to metformin alone.
Effect of Nigella sativa in the treatment of nonalcoholic fatty liver disease: A systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of RCTs evaluating Nigella sativa for nonalcoholic fatty liver disease (NAFLD) treatment. NS supplementation improved levels of ALT, AST, FBS, HDL, hs-CRP, and the severity of NAFLD, but had no effect on TC, LDL, TG, insulin, and TNF-α.
The effect of nigella sativa on biomarkers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis evaluated the effects of Nigella Sativa seed and seed oil on biomarkers of inflammation and oxidative stress. The analysis of 10 RCTs showed that NS consumption significantly reduced serum hs-CRP, TNF-α, and MDA, and increased TAC and SOD levels, suggesting potential anti-inflammatory and antioxidant effects.
The effect of Nigella sativa on the measures of liver and kidney parameters: A systematic review and meta-analysis of randomized-controlled trials.
This systematic review and meta-analysis evaluated the effect of Nigella sativa supplementation on liver and kidney parameters across 19 trials with 1295 participants. N.S supplements significantly reduced alkaline-phosphatase (ALP) and blood urea nitrogen (BUN) levels, with longer interventions reducing aspartate-aminotransferase (AST) measures. Higher doses increased BUN levels, indicating dose-dependent effects on liver and kidney parameters.
Therapeutic potentials of Nigella sativa preparations and its constituents in the management of diabetes and its complications in experimental animals and patients with diabetes mellitus: A systematic review.
Systematic review evaluating the effects of Nigella sativa on diabetes management and its complications. N. sativa preparations show antidiabetic, hypoglycemic, anti-hyperlipidemic, antihypertensive, and anti-obesity effects, improving antioxidant defense, reducing inflammation, and enhancing endothelial, hepatic, kidney, heart, and immune functions.
Effect of Nigella sativa L. supplementation on inflammatory and oxidative stress indicators: A systematic review and meta-analysis of controlled clinical trials.
Systematic review and meta-analysis of RCTs assessing Nigella sativa supplementation on inflammatory and oxidative stress markers. Nigella sativa significantly reduced CRP and MDA concentrations and increased TAC levels, but did not affect TNF-α.
Effects of Nigella sativa on glycemic control, lipid profiles, and biomarkers of inflammatory and oxidative stress: A systematic review and meta-analysis of randomized controlled clinical trials.
Systematic review and meta-analysis of 50 trials evaluating the effects of Nigella sativa on glycemic control, lipid profiles, and biomarkers of inflammatory and oxidative stress. Significant reductions were found in total cholesterol, triglycerides, LDL-cholesterol, VLDL-cholesterol, fasting glucose, and HbA1C levels following supplementation with N. sativa. Effects on CRP, TNF-α, TAC, and MDA levels were insignificant.
Effects of Nigella sativa on endothelial dysfunction in diabetes mellitus: A review.
This systematic review summarizes the therapeutic effects of Nigella sativa on endothelial dysfunction in diabetes. It highlights the protective effects of Nigella sativa and Thymoquinone through mechanisms such as reducing inflammatory markers, improving hyperglycemia and hyperlipidemia, and inhibiting platelet aggregation.
Effect of Nigella sativa supplementation on obesity indices: A systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis examined the effects of Nigella sativa supplementation on obesity indices, including body weight, BMI, and waist circumference, in adults. The analysis included 13 RCTs with 875 subjects and found that Nigella sativa significantly reduced body weight and BMI compared to placebo, but had no significant effect on waist circumference.
A systematic review and meta-analysis of randomized controlled trials investigating the effects of supplementation with Nigella sativa (black seed) on blood pressure.
Systematic review and meta-analysis of 11 RCTs with 860 individuals investigating the effects of Nigella sativa on blood pressure. The analysis found that short-term treatment with N. sativa powder significantly reduced systolic and diastolic blood pressure levels. No publication bias was detected, but more evidence is needed to explore long-term effects.
Effect of Nigella sativa-L supplementation on glycemia in adolescent polycystic ovarian syndrome: secondary analysis of a randomized controlled trial study.
This secondary analysis of a randomized controlled trial evaluated the effects of Nigella sativa extract on glycemia in 116 adolescent girls with PCOS. The Nigella sativa group showed significant reductions in fasting plasma glucose and two-hour post-prandial glucose levels compared to the control group, suggesting potential benefits for managing glycemia in adolescent PCOS.
The effect of Nigella Sativa emulgel on episiotomy wound healing and pain intensity in primiparous women: A triple-blind randomized controlled trial.
A triple-blind RCT evaluated the efficacy of Nigella sativa emulgel on episiotomy wound healing and pain intensity in 74 primiparous women. The Nigella sativa group showed significantly better wound healing and lower pain scores compared to placebo, with high patient satisfaction and no adverse effects reported.
Cardioprotective Effect of Nigella sativa in Pediatric Patients with Type 1 Diabetes Mellitus: A Randomized Controlled Study.
RCT of 60 children and adolescents with type 1 diabetes comparing Nigella sativa seed oil supplementation to insulin alone for 3 months. Nigella sativa improved lipid profile, reduced inflammatory markers, and enhanced cardiac function compared to control.
Effect ofseed extract on estradiol, FSH levels, and vaginal maturity index in menopausal women: A randomized controlled trial.
RCT conducted at Haji Adam Malik Hospital in Indonesia with 50 postmenopausal women, testing the effects of Nigella sativa seed extract on estradiol, FSH levels, and vaginal maturity index. The study found significant increases in estradiol levels and vaginal maturity index with no significant effect on FSH levels after eight weeks of treatment.
The possible short-term of Nigella sativa - L in the management of adolescent polycystic ovarian syndrome: results of a randomized controlled trial.
RCT of 114 adolescents with PCOS comparing Nigella sativa supplementation to medroxyprogesterone. Nigella sativa significantly improved hirsutism scores, ovarian volume, serum LH, testosterone levels, and reduced menstrual irregularities.
The effect of Nigella sativa supplementation on glycemic status in adults: An updated systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis evaluated the effects of Nigella sativa consumption on glycemic index in adults, analyzing 30 RCTs. The results indicated that N. sativa supplementation significantly reduced fasting blood sugar (FBS) and HA1c levels, but had no significant effect on insulin or HOMA-IR.
Topical Nigella sativa L. product: a new candidate for the management of diabetic peripheral neuropathy.
Double-blind clinical trial on 120 neuropathic patients comparing topical Nigella sativa ointment, placebo, and gabapentin. The Nigella sativa group showed significant improvements in neuropathy symptoms such as numbness, burning pain, and muscle cramps compared to the other groups.
The Effect of Palm Pollen and Black Seed Pollen on Male Sex Hormones and Sperm Quality: A Single-Blind, Placebo-Controlled Clinical Trial Study.
Single-blind, placebo-controlled clinical trial of 62 infertile men testing palm pollen and black seed pollen extracts on sex hormones and sperm quality. The treatment group showed significant improvements in sperm count, motility, and hormone levels compared to placebo.
Effect of Nigella sativa L. seed oil on urinary incontinence and quality of life in menopausal women: A triple-blind randomized controlled trial.
Triple-blind RCT of 60 menopausal women in Tabriz-Iran comparing Nigella sativa L. seed oil to placebo for 8 weeks. The treatment group showed significant improvement in mixed urinary incontinence and incontinence-related quality of life, but no significant differences in stress incontinence, urge incontinence, sexual function, or menopause-specific QoL.
Effect ofon general health and immune system in young healthy volunteers; a randomized, placebo-controlled, double-blinded clinical trial.
This randomized, placebo-controlled, double-blinded clinical trial evaluated the effect of Nigella sativa on immunity-related parameters in 52 young healthy subjects. The study found that a 1 g dose of Nigella sativa significantly elevated total lymphocyte count, CD3+, and CD4+ counts, suggesting a promising immunopotentiation effect.
Nigella sativa powder for helicobacter pylori infected patients: a randomized, double-blinded, placebo-controlled clinical trial.
This double-blind, placebo-controlled clinical trial evaluated the effects of Nigella sativa powder plus conventional treatment on serum ghrelin levels and appetite in 51 H. pylori-infected patients. The treatment group showed significant improvement in appetite compared to the placebo group, although changes in serum ghrelin levels were not statistically significant.
The effect of Ni gella sativa and vitamin D3 supplementation on the clinical outcome in COVID-19 patients: A randomized controlled clinical trial
This randomized controlled trial investigated the effects of Nigella sativa and vitamin D3, both individually and in combination, on COVID-19 patients with mild to moderate symptoms. The combination of Nigella sativa and vitamin D3 significantly alleviated COVID-19 symptoms and improved viral clearance compared to other groups.
Efficacy and safety of oral Nigella sativa oil for symptomatic treatment of knee osteoarthritis: A double-blind, randomized, placebo-controlled clinical trial.
Double-blind, randomized, placebo-controlled trial evaluating the efficacy and safety of oral Nigella sativa oil in 116 patients with knee osteoarthritis. NS oil significantly reduced VAS and WOMAC scores and decreased acetaminophen use compared to placebo, with no side effects reported.
Comparative evaluation of the efficacy of Nigella sativa (75% v/v) cream and clobetasol propionate (0.05% w/w) gel in oral lichen planus-a double-blinded randomized control trial.
Double-blinded RCT comparing Nigella sativa cream to clobetasol propionate gel in 60 patients with oral lichen planus. Both treatments significantly reduced burning sensation and lesion size, with Nigella sativa showing comparable efficacy to clobetasol without side effects.
Efficacy of nigella sativa oil on endothelial function and atherogenic indices in patients with coronary artery diseases: A randomized, double-blind, placebo-control clinical trial.
RCT of 60 CAD patients comparing 2g daily Nigella sativa oil to sunflower oil placebo for 8 weeks. NS oil supplementation significantly reduced serum levels of sVCAM-1, sICAM-1, and MDA, while increasing total antioxidant capacity, suggesting potential benefits for endothelial function.
The effect of Nigella sativa oil on vascular dysfunction assessed by flow-mediated dilation and vascular-related biomarkers in subject with cardiovascular disease risk factors: A randomized controlled trial.
RCT evaluating the effect of Nigella sativa oil on vascular function in 50 subjects with cardiovascular disease risk factors. The study found significant improvements in flow-mediated dilation and plasma nitric oxide levels in the Nigella sativa group compared to placebo, but no significant differences in ICAM-1 and VCAM-1 levels.
Nigella sativa for the treatment of COVID-19: An open-label randomized controlled clinical trial.
Open-label RCT evaluating Nigella sativa oil (NSO) in 173 patients with mild COVID-19 symptoms. The NSO group showed a higher recovery rate (62%) compared to the control group (36%), with a shorter mean duration to recovery.
The effect of nanomicelle curcumin supplementation and Nigella sativa oil on the expression level of miRNA-21, miRNA-422a, and miRNA-503 gene in postmenopausal women with low bone mass density: A randomized, triple-blind, placebo-controlled clinical trial with factorial design.
This randomized, triple-blind, placebo-controlled clinical trial investigated the effect of nanomicelle curcumin and Nigella sativa oil on miRNA expression in 120 postmenopausal women with low bone mass density. The study found that Nigella sativa and its combination with curcumin significantly increased the expression level of miRNA-21, suggesting potential benefits for bone health.
Nigella sativa as a promising intervention for metabolic and inflammatory disorders in obese prediabetic subjects: A comparative study of Nigella sativa versus both lifestyle modification and metformin.
RCT comparing Nigella sativa, lifestyle modification, and metformin in 117 obese prediabetic subjects. Nigella sativa improved lipid panel, reduced TNF-α level, and Castelli risk index-I, showing similar effects to metformin on anthropometric and glycemic parameters, and improved SIRT1 gene expression.
Effects of Nigella sativa oil supplementation on selected metabolic parameters and anthropometric indices in patients with coronary artery disease: A randomized, double-blind, placebo-controlled clinical trial.
RCT of 60 CAD patients comparing 2g Nigella sativa oil to sunflower oil placebo for 8 weeks. NS significantly reduced weight, BMI, waist and hip circumference, blood pressure, and fasting blood glucose, indicating potential benefits on metabolic parameters.
A randomized, double-blind, placebo-controlled, clinical trial to evaluate the benefits of Nigella sativa seeds oil in reducing cardiovascular risks in hypertensive patients.
RCT evaluating Nigella sativa seeds oil in hypertensive patients. The intervention group showed significant reductions in systolic and diastolic blood pressure, total cholesterol, LDL, malondialdehyde, and fasting blood sugar, and increases in HDL and glutathione reductase, compared to placebo. No adverse events were reported.
The effect of food ration bar enriched with β‐alanine, L‐arginine, and Nigella sativa on performance and inflammation following intense military training: A double‐blind randomized clinical trial
This double-blind, randomized clinical trial evaluated the effect of a food ration bar enriched with β-alanine, L-arginine, and Nigella sativa on athletic performance and inflammation in 54 new cadets undergoing intense military training. The intervention group showed significant improvements in anaerobic performance and reductions in inflammation markers compared to the control group.
The effects of nigella sativa on anthropometric and biochemical indices in postmenopausal women with metabolic syndrome.
This randomized, double-blinded, placebo-controlled trial studied the effects of 500 mg nigella sativa on anthropometric and biochemical indices in 140 postmenopausal women with metabolic syndrome. The nigella sativa group showed significant decreases in low-density lipoprotein, triglyceride, total cholesterol, and fasting blood sugar compared to placebo.
The effect of a hydrogel made by Nigella sativa L. on acne vulgaris: A randomized double-blind clinical trial.
RCT of 60 patients with acne vulgaris comparing Nigella sativa hydrogel to placebo. The N. sativa group showed a 78% reduction in IGA score and significant reductions in comedones, papules, and pustules, with no adverse events.
The effect of Nigella sativa L. supplementation on serum C-reactive protein: A systematic review and meta-analysis of randomized controlled trials.
Systematic review and meta-analysis of RCTs examining the effect of Nigella sativa supplementation on plasma C-reactive protein (CRP) concentrations. The meta-analysis showed a significant reduction in serum CRP, particularly in participants with BMI ≥ 30 kg/m.
Effect of Nigella sativa and its bioactive compound on type 2 epithelial to mesenchymal transition: a systematic review.
Systematic review of 22 studies on Nigella sativa and its bioactive compound thymoquinone, focusing on their effects on type 2 epithelial to mesenchymal transition (EMT). The review found that Nigella sativa and thymoquinone promote wound healing, attenuate tissue inflammation, and prevent organ fibrosis by regulating the EMT process.
The influence of Nigella sativa for asthma control: A meta-analysis.
Meta-analysis of four RCTs assessing Nigella sativa supplementation for asthma control. Nigella sativa is associated with increased ACT scores and FEV1, but shows no significant impact on PEF, IL-4, or IFN-γ. The study suggests potential benefits for asthma treatment.
Effect of Nigella sativa (black seed) supplementation on glycemic control: A systematic review and meta-analysis of clinical trials.
Systematic review and meta-analysis of 17 randomized controlled trials assessing the antihyperglycemic effect of Nigella sativa on glycemic indices. The analysis found significant reductions in fasting plasma glucose, postprandial blood glucose, and hemoglobin A1c with Nigella sativa supplementation, with the oil form being more effective than the powder.
Carcass characteristics, chemical and fatty acid composition and oxidative stability of meat from broiler chickens fed black cumin (Nigella sativa) seeds.
The study investigated the effects of dietary supplementation of black cumin seeds on carcass characteristics, chemical and fatty acid composition, and antioxidant properties of broiler chicken meat. Results showed that black cumin seed supplementation improved slaughter body weight, beneficial fatty acid concentrations, and antioxidant properties of the meat.
The effects of Nigella sativa L. on obesity: A systematic review and meta-analysis.
Systematic review and meta-analysis of 11 studies on the effects of Nigella sativa supplementation on obesity-related anthropometric indices. N. sativa supplementation significantly reduced body weight, BMI, and waist circumference compared to placebo. The study notes moderate effects and high heterogeneity for body weight, suggesting cautious interpretation.
Role of Nigella sativa and Its Constituent Thymoquinone on Chemotherapy-Induced Nephrotoxicity: Evidences from Experimental Animal Studies.
Systematic review of experimental animal studies assessing the protective effects of Nigella sativa and its compound thymoquinone on chemotherapy-induced nephrotoxicity. The review included 12 studies and found that NS/TQ decreased lipid peroxidation and increased antioxidant enzyme activity in renal tissue, showing protective effects against nephrotoxicity.
Nigella sativa improves glucose homeostasis and serum lipids in type 2 diabetes: A systematic review and meta-analysis.
Systematic review and meta-analysis of seven trials assessing Nigella sativa supplementation in type 2 diabetes. N. sativa significantly improved fasting blood sugar, HbA1c, total cholesterol, and LDL-cholesterol. Subgroup analysis showed significant reduction in triglycerides with N. sativa seed oil, while seed powder increased triglycerides.
Nigella sativa (black seed) effects on plasma lipid concentrations in humans: A systematic review and meta-analysis of randomized placebo-controlled trials.
Systematic review and meta-analysis of 17 RCTs examining Nigella sativa's effects on plasma lipid concentrations. NS supplementation significantly reduced total cholesterol, LDL-C, and triglyceride levels, with no significant effect on HDL-C concentrations. NS seed oil showed greater effects on cholesterol and LDL-C, while NS seed powder increased HDL-C.
Effects of black seed (Nigella sativa) on metabolic parameters in diabetes mellitus: a systematic review.
Systematic review of 19 articles (2 human trials, 14 animal models, and 3 in vivo/in vitro studies) on the effects of Nigella sativa on metabolic parameters in diabetes mellitus. The review suggests that N. sativa can modulate hyperglycemia and lipid profile dysfunction through various mechanisms, including antioxidant properties and effects on insulin secretion and glucose absorption.
Effect of Nigella sativa and Allium sativum coadminstered with simvastatin in dyslipidemia patients: a prospective, randomized, double-blind trial.
A randomized, double-blind, placebo-controlled trial evaluated the effect of Nigella sativa (black seed) and Allium sativum (garlic) coadministered with simvastatin in dyslipidemia patients. The study found significant improvements in lipid profiles, including cholesterol, triglyceride, Non-HDL, and LDL levels, suggesting the combination was effective in correcting dyslipidemia.
Therapeutic Potential of Thymoquinone in Conjunction with Mechanical Debridement for Peri-Implantitis: A Prospective Clinical Evaluation.
This prospective clinical evaluation assessed the efficacy of locally applied thymoquinone gel combined with mechanical debridement in treating peri-implantitis. The study included 40 participants, with Group 2 receiving thymoquinone gel showing significantly better outcomes in clinical parameters compared to mechanical debridement alone.
A crossover randomized controlled trial examining the effects of black seed (Nigella sativa) supplementation on IL-1β, IL-6 and leptin, and insulin parameters in overweight and obese women.
Crossover RCT of 46 overweight/obese women examining the effects of Nigella sativa supplementation on inflammation and insulin parameters. NS supplementation significantly reduced mRNA expressions and serum levels of IL-1β, IL-6, and leptin, with varying effect sizes. A significant decrease in serum insulin was also observed.
Effects of thymoquinone in the lungs of rats against radiation-induced oxidative stress.
Prospective, placebo-controlled study on 40 Sprague-Dawley rats to test the radioprotective effectiveness of thymoquinone (TQ) against radiation-induced oxidative stress in lung tissue. TQ treatment resulted in lower oxidative stress parameters and higher anti-oxidative parameters, indicating its protective effects.
Comparing the efficacy of a novel mucoadhesive patch containing Nigella sativa 10% with triamcinolone 0.1% in patients with erosive-atrophic oral lichen planus: A pilot study.
Pilot RCT comparing a mucoadhesive patch containing Nigella sativa 10% extract to triamcinolone 0.1% in 20 patients with erosive-atrophic oral lichen planus. Both treatments reduced pain, burning, and lesion severity, with N. sativa showing superior results in some sessions. No significant complications were observed with N. sativa.
The effect of nigella sativa supplementation on cardiometabolic outcomes in patients with non-alcoholic fatty liver: A randomized double-blind, placebo-controlled trial.
This randomized, double-blind, placebo-controlled trial assessed the effect of 1000 mg/day Nigella sativa oil supplementation on adiponectin, leptin, and blood pressure in 44 NAFLD patients over eight weeks. No statistically significant differences were found in these cardiometabolic measures between the Nigella sativa and placebo groups.
Effect of Nigella sativa oil extract on cardiometabolic risk factors in type 2 diabetes: A randomized, double‐blind, placebo‐controlled clinical trial
A randomized, double-blind, placebo-controlled clinical trial on 43 patients with type 2 diabetes assessed the effects of Nigella sativa oil extract on cardiometabolic risk factors. The intervention group received Nigella sativa oil, which significantly improved glycemic control, serum lipid profile, blood pressure, and body weight compared to placebo.
The effect of Nigella sativa on appetite, anthropometric and body composition indices among overweight and obese women: A crossover, double-blind, placebo-controlled, randomized clinical trial.
Crossover, double-blind, placebo-controlled RCT evaluating the effect of Nigella sativa on anthropometric and body composition parameters in 45 overweight and obese women. Supplementation with 2000 mg of N. sativa oil led to improvements in body mass index, body weight, waist circumference, body fat mass, body fat percent, and visceral fat area, along with a decrease in appetite.
The effects of powdered black cumin seeds on markers of oxidative stress, intracellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 in patients with Hashimoto's thyroiditis.
RCT of 40 patients with Hashimoto's thyroiditis comparing powdered Nigella sativa seeds to placebo for 8 weeks. N. sativa significantly increased serum TAC, SOD, reduced MDA, VCAM-1, BMI, LDL cholesterol, and triglycerides, while increasing HDL cholesterol, indicating improvements in oxidative stress, endothelial dysfunction, and serum lipids.
The effect of Nigella sativa supplementation on cardiovascular risk factors in obese and overweight women: a crossover, double-blind, placebo-controlled randomized clinical trial.
Crossover, double-blind, placebo-controlled RCT assessing the effect of Nigella sativa oil supplements on cardiovascular risk factors in obese and overweight women. The study found that N.S increased HDL cholesterol, reduced LDL cholesterol, TC/HDL-C ratio, serum glutamic-oxaloacetic transaminase, and systolic blood pressure, indicating beneficial effects on cardiovascular health.
Standardized Nigella sativa seed oil ameliorates hepatic steatosis, aminotransferase and lipid levels in non-alcoholic fatty liver disease: A randomized, double-blind and placebo-controlled clinical trial.
RCT of 120 patients with non-alcoholic fatty liver disease comparing 2.5mL standardized Nigella sativa seed oil to placebo every 12 hours for 3 months. The oil group showed significant reductions in hepatic steatosis, ALT, AST, triglycerides, LDL-C, and HDL-C levels compared to placebo, with no adverse effects observed.
Nigella sativa L. for prevention of acute radiation dermatitis in breast cancer: A randomized, double-blind, placebo-controlled, clinical trial.
RCT evaluating Nigella sativa extract for preventing acute radiation dermatitis in 62 breast cancer patients undergoing radiotherapy. N. sativa gel significantly reduced the frequency of ARD, delayed the onset of moist desquamation, and reduced pain compared to placebo.
Efficacy of black seed (Nigella sativa L.) on kidney stone dissolution: A randomized, double-blind, placebo-controlled, clinical trial.
RCT of 60 patients with renal stones comparing black seed (Nigella sativa L.) capsules to placebo for 10 weeks. The black seed group showed significant positive effects on the disappearance or reduction of kidney stone size compared to placebo.
The effects of black seed supplementation on cardiovascular risk factors in patients with nonalcoholic fatty liver disease: A randomized, double-blind, placebo-controlled clinical trial.
This randomized, double-blind, placebo-controlled clinical trial evaluated the effects of Nigella sativa supplementation on cardiovascular risk factors in 50 patients with nonalcoholic fatty liver disease. N. sativa supplementation led to significant reductions in serum glucose, serum insulin, insulin resistance, and hepatic steatosis compared to placebo, but no significant changes in lipid profile.
Nigella sativa and inflammatory biomarkers in patients with non-alcoholic fatty liver disease: Results from a randomized, double-blind, placebo-controlled, clinical trial.
This randomized, double-blind, placebo-controlled clinical trial assessed the effects of Nigella sativa on inflammatory biomarkers in 50 NAFLD patients. Nigella sativa consumption significantly reduced serum levels of TNF-α, hs-CRP, and NF-κB, and decreased hepatic steatosis percentage compared to placebo.
Effect of Nigella Sativa oil versus metformin on glycemic control and biochemical parameters of newly diagnosed type 2 diabetes mellitus patients.
RCT comparing Nigella sativa oil to metformin in newly diagnosed type 2 diabetes mellitus patients over 3 months. NS was inferior to metformin in lowering FBG, 2h pp, and A1C but comparable in reducing weight, WC, and BMI. NS showed no side effects and was comparable to metformin in effects on fasting insulin, %S, IR, ALT, TC, LDL, HDL, TG, and TAC.
Efficacy of Black Seed ( Nigella sativa ) and Lemon Balm ( Melissa officinalis ) on Non-Alcoholic Fatty Liver Disease: A Randomized Controlled Clinical Trial
RCT evaluating Nigella sativa and Melissa officinalis in 50 patients with Non-Alcoholic Fatty Liver Disease. The intervention group showed significant reductions in liver enzymes, body mass index, and grade of fatty liver compared to baseline and control.
The efficacy of black cumin seed (Nigella sativa) oil and hypoglycemic drug combination to reduce HbA1c level in patients with metabolic syndrome risk
Randomized single-blind controlled trial with 99 outpatients at risk of metabolic syndrome. Patients received black cumin seed oil at doses of 1.5 mL/day and 3 mL/day for 20 days. The study found that black cumin seed oil combined with hypoglycemic drugs significantly reduced HbA1c levels.
Nigella sativa Supplementation Improves Asthma Control and Biomarkers: A Randomized, Double-Blind, Placebo-Controlled Trial.
RCT of 80 asthmatics comparing 500mg Nigella sativa oil capsules twice daily to placebo for 4 weeks. NSO group showed significant improvement in Asthma Control Test score and reduction in blood eosinophils, with a trend towards improved pulmonary function.
Effect of Nigella sativa Seed Extract for Hypertension in Elderly: a Double-blind, Randomized Controlled Trial.
Double-blind, randomized controlled trial of 76 elderly patients with hypertension comparing 300 mg Nigella sativa seed extract twice daily to placebo for 28 days. The study found no significant effect of Nigella sativa on systolic or diastolic blood pressure compared to placebo.
Effects of nigella sativa on various parameters in Patients of non-alcoholic fatty liver disease.
RCT evaluating the effects of Nigella sativa on NAFLD patients. The study found significant reductions in body weight, BMI, liver enzymes, and improved ultrasound findings of fatty liver after 12 weeks of treatment with Nigella sativa compared to placebo.
Effectiveness of Topical Nigella sativa Seed Oil in the Treatment of Cyclic Mastalgia: A Randomized, Triple-Blind, Active, and Placebo-Controlled Clinical Trial.
RCT comparing the effectiveness of topical Nigella sativa seed oil to topical diclofenac and placebo in 156 women with cyclic mastalgia. Nigella sativa seed oil significantly reduced pain scores compared to placebo and was as effective as diclofenac, with no adverse effects observed.
Nigella sativa improves glycemic control and ameliorates oxidative stress in patients with type 2 diabetes mellitus: placebo controlled participant blinded clinical trial.
RCT of 114 type 2 diabetic patients on oral hypoglycemic drugs, comparing Nigella sativa supplementation to placebo over one year. Nigella sativa improved fasting blood glucose, HbA1c, and oxidative stress markers, enhancing glucose homeostasis and antioxidant defense.
Efficacy and safety of honey based formulation of Nigella sativa seed oil in functional dyspepsia: A double blind randomized controlled clinical trial.
Double-blind randomized controlled trial of 70 patients with functional dyspepsia receiving a honey-based formulation of Nigella sativa oil or placebo for 8 weeks. The N. sativa group showed significant improvement in dyspepsia severity and reduced H. pylori infection rates compared to placebo.
Effects of Nigella sativa L. seed oil on abnormal semen quality in infertile men: a randomized, double-blind, placebo-controlled clinical trial.
RCT on Iranian infertile men with abnormal semen quality, comparing 2.5ml Nigella sativa oil to placebo twice daily for 2 months. The Nigella sativa oil group showed significant improvements in sperm count, motility, morphology, semen volume, pH, and round cells compared to placebo.
Effect of different levels of black cumin (Nigella sativa L.) on performance, intestinal Escherichia coli colonization and jejunal morphology in laying hens.
This study investigated the effects of different levels of black cumin seeds on performance, intestinal E. coli count, and jejunal morphology in 100 laying hens. Black cumin supplementation decreased ileal E. coli enumeration, improved serum lipid profile, and enhanced eggshell quality. The best intestinal health indices and performance were observed with at least 2% black cumin seeds.
Blood pressure lowering effect of Nigella sativa L. seed oil in healthy volunteers: a randomized, double-blind, placebo-controlled clinical trial.
Double-blind, randomized clinical trial of 70 healthy volunteers assessing the effect of Nigella sativa oil on blood pressure. The study found that oral administration of 5 mL N. sativa oil daily for 8 weeks significantly lowered systolic and diastolic blood pressures without adverse effects.
Treating Cryptosporidium parvum infection in calves.
The study evaluated the efficacy of azithromycin, co-trimoxazole, and Nigella sativa (kalvangi) against Cryptosporidium parvum infection in calves. Azithromycin showed the highest efficacy, while co-trimoxazole and kalvangi were found to be ineffective under the treatment regimens used.
Clinical evaluation of Nigella sativa seeds for the treatment of hyperlipidemia: a randomized, placebo controlled clinical trial.
RCT conducted in Isfahan, Iran, with 88 subjects evaluating the efficacy of Nigella sativa seeds on hyperlipidemia. Significant decreases were observed in total cholesterol, LDL, and triglycerides, with no effect on fasting blood sugar and HDL.
Comparison of therapeutic effect of topical Nigella with Betamethasone and Eucerin in hand eczema.
RCT comparing the effects of Nigella sativa, Betamethasone, and Eucerin on hand eczema severity and life quality in 60 patients. Nigella and Betamethasone showed significantly more rapid improvement in hand eczema and life quality compared to Eucerin, with no significant difference between Nigella and Betamethasone.
Effect of Nigella sativa seeds on the glycemic control of patients with type 2 diabetes mellitus.
RCT of 94 patients with type 2 diabetes mellitus testing Nigella sativa as an adjuvant therapy. Nigella sativa at 2 gm/day significantly reduced fasting blood glucose, 2-hour postprandial glucose, and HbA1c without affecting body weight. Insulin resistance decreased and beta-cell function improved. No adverse effects on renal or hepatic functions were observed.
Herbal treatment of allergic rhinitis: the use of Nigella sativa.
This clinical trial investigated the anti-inflammatory effects of Nigella sativa on 66 patients with allergic rhinitis. The study found that N. sativa reduced nasal mucosal congestion, nasal itching, runny nose, sneezing attacks, turbinate hypertrophy, and mucosal pallor during the first 2 weeks.
Efficacy of Nigella sativa on serum free testosterone and metabolic disturbances in central obese male.
Double-blind, placebo-controlled RCT studying the effects of Nigella sativa on central obese men. Significant reductions in body weight and waist circumference were observed, with no significant changes in serum free testosterone, blood pressure, or other metabolic markers. Nigella sativa may inhibit the decrease of serum free testosterone. No side effects were detected.
Effectiveness, safety, and tolerability of powdered Nigella sativa (kalonji) seed in capsules on serum lipid levels, blood sugar, blood pressure, and body weight in adults: results of a randomized, double-blind controlled trial.
RCT conducted at Aga Khan University Hospital to assess the effectiveness, safety, and tolerability of powdered Nigella sativa (Kalonji) seed in capsules on serum lipid levels, blood sugar, blood pressure, and body weight in adults. The study found a favorable impact on almost all variables, but results were not statistically significant due to small sample size.
Symptomatic treatment of acute tonsillo-pharyngitis patients with a combination of Nigella sativa and Phyllanthus niruri extract.
RCT of 186 patients with acute tonsillopharyngitis comparing NSPN extract (Nigella sativa and Phyllanthus niruri) to placebo over 7 days. NSPN group showed significant alleviation of sore throat and required less analgesic therapy. NSPN extract was safe and well tolerated.
Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension.
RCT evaluating the antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension. The study found significant reductions in both systolic and diastolic blood pressure in the treatment groups compared to placebo, with effects being dose-dependent. Additionally, there was a significant decline in total and LDL-cholesterol levels.
Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases.
Four studies on the clinical efficacy of Nigella sativa in 152 patients with allergic diseases showed that treatment with black seed oil decreased the subjective severity of symptoms. There was a slight decrease in plasma triglycerides and a discrete increase in HDL cholesterol, while lymphocyte subpopulations, endogenous cortisol levels, and ACTH release remained unchanged.
Antioxidant Properties of Thymoquinone, Thymohydroquinone and Black Cumin (Nigella sativa L.) Seed Oil: Scavenging of Superoxide Radical Studied Using Cyclic Voltammetry, DFT and Single Crystal X-ray Diffraction
The study investigates the antioxidant activities of black seed oil, thymoquinone (TQ), and thymohydroquinone (THQ) using electrochemical methods. TQ and black seed oil showed good superoxide scavenging ability, while THQ did not. The study also explores the chemical mechanism of TQ's antioxidant activity using DFT and crystal structure analysis.
In silico identification of compounds from Nigella sativa seed oil as potential inhibitors of SARS-CoV-2 targets
In silico study identifying compounds from Nigella sativa seed oil as potential inhibitors of SARS-CoV-2 targets. Caryophyllene oxide, α-bergamotene, and β-bisabolene showed promising binding affinities to various SARS-CoV-2 molecular targets, suggesting potential antiviral properties.
Development of black cumin seed oil (Nigella sativa L.) SNEDDS into solid-SNEDDS and its characterization
The study developed a solid-SNEDDS formulation of black cumin seed oil (Nigella sativa L.) to improve its absorption and overcome the limitations of liquid-SNEDDS. The solid-SNEDDS was prepared using aerosil and crospovidone as adsorbents, with aerosil showing better performance under stress conditions.