Research
Naringenin
42 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Unlocking Naringin's Potential: A Systematic Review and Meta-Analysis of Its Nephroprotective Effects in Pre-Clinical Models.
This systematic review and meta-analysis evaluated the nephroprotective effects of naringin in preclinical animal models of kidney disease. Naringin treatment improved body weight gain, kidney function markers, antioxidant parameters, and reduced inflammation and apoptosis. The findings support naringin's therapeutic potential in managing kidney diseases.
Evaluating the preclinical efficacy of naringenin in rheumatoid arthritis: a meta-analysis of in vivo studies.
This meta-analysis evaluated the efficacy of naringenin in preclinical in vivo models of rheumatoid arthritis. Naringenin significantly reduced arthritis severity, paw volume, and inflammatory cytokines while improving antioxidant defenses and reducing oxidative stress. It also improved histopathology and decreased cartilage-degrading enzymes, supporting its potential as a therapeutic agent for RA.
Endothelial and Cardiovascular Effects of Naringin: A Systematic Review.
This systematic review evaluates the effects of naringin on endothelial function and myocardial performance, focusing on ischemia-reperfusion injury. Naringin consistently exhibited antioxidant, anti-inflammatory, and vasoprotective effects across cellular, animal, and human studies. It improved endothelium-dependent vasorelaxation, reduced infarct size, and preserved myocardial function in animal models, with limited human trials showing benefits on lipid profiles and arterial stiffness.
Effects of cross-linking agents on hydroxyproline release and root caries lesion size: Systematic review and network meta-analysis of in vitro studies.
Systematic review and network meta-analysis of in vitro studies evaluating cross-linking agents for root caries management. Proanthocyanidins, naringin, quercetin, and glutaraldehyde showed significant efficacy in reducing caries lesion depth compared to controls. Cranberry extract was most effective in reducing hydroxyproline release.
The effect of immunomodulatory properties of naringenin on the inhibition of inflammation and oxidative stress in autoimmune disease models: a systematic review and meta-analysis of preclinical evidence.
This systematic review and meta-analysis evaluated the immunomodulatory effects of naringenin on inflammation and oxidative stress in animal models of autoimmune disorders. Naringenin significantly reduced levels of inflammatory biomarkers and oxidative stress factors, demonstrating its potential as an alternative treatment for autoimmune-related diseases.
Naringenin induces intrinsic and extrinsic apoptotic signaling pathways in cancer cells: A systematic review and meta-analysis of in vitro and in vivo data.
Systematic review and meta-analysis of 32 studies evaluating the effect of naringenin on cancer inhibition in vitro and in vivo. Naringenin was found to activate intrinsic and extrinsic apoptotic pathways, increasing caspase activity and Bax expression, and affecting viability and apoptosis in cancer cells.
Systematic review and pathway enrichment analysis of Chinese medicine in preventing recurrence and improving prognosis of cholelithiasis after gallbladder-preserving lithotripsy.
Systematic review and meta-analysis of 9 RCTs involving 926 participants on the use of Traditional Chinese Medicine (TCM) for preventing cholelithiasis recurrence after gallbladder-preserving lithotripsy. TCM, particularly naringin from Glycyrrhiza, was found to decrease recurrence rate and complications, with no significant differences in adverse reactions.
A Comprehensive Systematic Review of the Effects of Naringenin, a Citrus-Derived Flavonoid, on Risk Factors for Nonalcoholic Fatty Liver Disease.
Systematic review examining the therapeutic effects of naringenin on nonalcoholic fatty liver disease (NAFLD) and related risk factors. Naringenin modulates biological processes related to NAFLD, including energy balance, lipid and glucose metabolism, inflammation, and oxidative stress. The review highlights the need for future human clinical trials to establish dosage ranges and safety.
Improved HDL, LDL and total cholesterol levels following a 3-month administration of Mentha spicata leaf extract and Amaranthus caudatus seed flour extracts, flavonoids and B vitamins. A placebo-controlled, double-blind, randomized clinical trial.
RCT of 114 participants with borderline high cholesterol levels, comparing two doses of a supplement containing Mentha spicata leaf extract, Amaranthus caudatus seed flour, flavonoids, and B vitamins to placebo over 90 days. The higher dose significantly reduced LDL-C and total cholesterol, and increased HDL-C, suggesting improved lipid profiles.
Exploring the Hepatoprotective Effects of Naringin: A Systematic Review and Meta-Analysis of Preclinical Evidence.
Systematic review and meta-analysis of 20 preclinical studies on naringin's hepatoprotective effects. Naringin improved liver function by reducing elevated liver enzymes and inflammatory mediators, and enhancing antioxidant levels in animal models of liver injury.
Citrus supplementation in subjective cognitive decline: results of a 36-week, randomized, placebo-controlled trial.
This randomized controlled trial studied the effects of 400 mg Citrus peel extract supplementation on cognitive performance and inflammation in 80 participants with subjective cognitive decline over 36 weeks. The study found no significant cognitive benefits or changes in IL-8 levels compared to placebo, suggesting a high placebo response.
Cognitive and biological effects of citrus phytochemicals in subjective cognitive decline: a 36-week, randomized, placebo-controlled trial.
RCT of 80 older adults with subjective cognitive decline, testing 36-week treatment with citrus peel extract containing auraptene and naringenin. The study aims to assess cognitive effects and changes in blood-based biomarkers related to neuronal damage, oxidative stress, and inflammation.
The therapeutic effects of naringenin on bronchial pneumonia in children.
RCT evaluating the safety and therapeutic effect of naringenin in treating bronchial pneumonia in children. Naringenin inhibited inflammation, shortened the disappearance time of clinical symptoms, reduced incidences of complications and adverse reactions, and improved health conditions.
Analysis of Flavonoids Bioactivity for Cholestatic Liver Disease: Systematic Literature Search and Experimental Approaches.
Systematic review and experimental evaluation of flavonoids for cholestatic liver disease, focusing on naringenin (NG) as a representative flavonoid. NG showed beneficial effects by improving metabolic and liver damage biomarkers in an obstructive cholestasis model. The review highlights a lack of homogeneous evidence and potential bias in flavonoid efficacy studies.
Pharmacokinetic, pharmacodynamic and formulations aspects of Naringenin: An update.
This systematic review highlights the pharmacokinetics, pharmacodynamics, and formulation aspects of Naringenin, a flavanone found in citrus fruits. It discusses Naringenin's distribution, therapeutic use in various diseases, and molecular mechanisms, as well as formulation strategies to improve its solubility.
The beneficial role of Naringin- a citrus bioflavonoid, against oxidative stress-induced neurobehavioral disorders and cognitive dysfunction in rodents: A systematic review and meta-analysis.
This systematic review and meta-analysis examines the protective role of naringin against oxidative stress-induced neurological disorders in rodents. The meta-analysis found that naringin significantly inhibited neurological perturbances and restored oxidative stress markers in the rodent brain.
Effects of naringenin supplementation on cardiovascular risk factors in overweight/obese patients with nonalcoholic fatty liver disease: a pilot double-blind, placebo-controlled, randomized clinical trial.
This double-blind, placebo-controlled RCT studied the effects of naringenin supplementation on cardiovascular risk factors in 44 overweight/obese patients with NAFLD over 4 weeks. Naringenin significantly reduced atherogenic indices, BMI, and visceral fat levels compared to placebo, suggesting potential benefits for cardiovascular health and physique.
Does naringenin supplementation improve lipid profile, severity of hepatic steatosis and probability of liver fibrosis in overweight/obese patients with NAFLD? A randomised, double-blind, placebo-controlled, clinical trial.
This randomized, double-blind, placebo-controlled clinical trial assessed the effects of naringenin supplementation on lipid profile and liver health in 44 overweight/obese patients with NAFLD. Naringenin significantly improved lipid profile and reduced NAFLD grades, indicating a positive effect on hepatic steatosis severity. However, no significant changes were observed in AST, ALT, and NAFLD fibrosis score.
Naringin reduces body weight, plasma lipids and increases adiponectin levels in patients with dyslipidemia.
A double-blind, randomized clinical trial with 28 dyslipidemic patients studied the effects of 450 mg naringin daily for 90 days. The naringin group showed significant reductions in BMI, total cholesterol, LDL cholesterol, and an increase in adiponectin levels compared to placebo, suggesting potential benefits for managing metabolic disorders.
Effect of naringenin in Qianggu capsule on population pharmacokinetics in Chinese women with primary osteoporosis.
The study characterized the population pharmacokinetics of naringenin in Chinese women with primary osteoporosis using Qianggu capsules. A one compartment open model with first order degradation best fit the concentration-time profiles, and SYAX was identified as a significant covariate affecting pharmacokinetics.
Naringin supplementation lowers plasma lipids and enhances erythrocyte antioxidant enzyme activities in hypercholesterolemic subjects.
RCT investigating the effects of naringin supplementation in hypercholesterolemic subjects. Naringin lowered plasma total cholesterol by 14% and LDL cholesterol by 17% in hypercholesterolemic subjects, while increasing erythrocyte superoxide dismutase and catalase activities. No significant effects were observed in the control group.
Grapefruit-felodipine interaction: effect of unprocessed fruit and probable active ingredients.
Randomized four-way crossover study examining the interaction between grapefruit and felodipine. Grapefruit juice, segments, and extract increased felodipine AUC 3-fold compared to water. Furanocoumarins and flavonoids in grapefruit inhibited CYP3A4, with bergamottin being the most potent inhibitor.
Safety and pharmacokinetics of naringenin: A randomized, controlled, single-ascending-dose clinical trial.
A randomized crossover trial evaluated the safety and pharmacokinetics of naringenin in 18 healthy adults consuming doses of 150mg to 900mg. No relevant adverse events or changes in blood safety markers were observed. Serum concentrations were proportional to the dose, indicating safety and potential physiological effects at certain doses.
Effect of Multi-Ingredient Supplement Containing Satiereal, Naringin, and Vitamin D on Body Composition, Mood, and Satiety in Overweight Adults.
RCT of 20 overweight adults examining the effects of a supplement containing satiereal, naringin, and vitamin D3 on body composition, mood, and satiety over 28 days. No significant differences were found between the supplement and placebo groups for body mass, BMI, waist circumference, mood states, or subjective measures of food cravings.
Flavanone-rich citrus beverages counteract the transient decline in postprandial endothelial function in humans: a randomised, controlled, double-masked, cross-over intervention study.
A randomised, controlled, double-masked, cross-over intervention study assessed the impact of citrus flavanone intake on postprandial endothelial function in 28 middle-aged healthy men. Flavanone interventions effectively attenuated transient impairments in flow-mediated dilatation induced by a high-fat meal, coinciding with peak levels of naringenin/hesperetin metabolites and sustained plasma nitrite levels.
Flavanones protect from arterial stiffness in postmenopausal women consuming grapefruit juice for 6 mo: a randomized, controlled, crossover trial.
This double-blind, randomized, controlled, crossover trial studied the effects of grapefruit juice consumption, providing 210 mg naringenin glycosides, on vascular function in 48 healthy postmenopausal women. The study found that regular grapefruit juice consumption significantly reduced central aortic stiffness compared to a control drink without flavanones.
High-dose short-term administration of naringin did not alter talinolol pharmacokinetics in humans.
A controlled, open, randomized, crossover study in 10 healthy volunteers investigated the effect of high-dose naringin on the bioavailability of talinolol. After 6-day supplementation with naringin, results showed that short-term high-dose naringin supplementation did not significantly affect talinolol pharmacokinetics.
Absorption, conjugation and excretion of the flavanones, naringenin and hesperetin from alpha-rhamnosidase-treated orange juice in human subjects.
Double-blind, randomized, crossover study in 16 healthy volunteers examining the absorption, conjugation, and excretion of naringenin and hesperetin from alpha-rhamnosidase-treated orange juice. The bioavailability of naringenin increased significantly when converted from rutinoside to glucoside, with higher plasma concentrations and increased urinary excretion.
Effects of pink grapefruit juice on QT variability in patients with dilated or hypertensive cardiomyopathy and in healthy subjects.
RCT comparing the effects of pink grapefruit juice, amiodarone, and sotalol on QT variability in 32 subjects with dilated or hypertensive cardiomyopathy and healthy controls. Pink grapefruit juice significantly increased QT(c) and QT variability index, suggesting potential proarrhythmic actions due to its naringenin content.
Lipolytic effect of a polyphenolic citrus dry extract of red orange, grapefruit, orange (SINETROL) in human body fat adipocytes. Mechanism of action by inhibition of cAMP-phosphodiesterase (PDE).
The study investigated the lipolytic effect of SINETROL, a citrus-based polyphenolic dietary supplement, on human adipocytes and body fat. SINETROL significantly stimulated lipolysis and reduced body fat percentage and weight in overweight volunteers over 4 and 12 weeks. The effects are attributed to its inhibition of cAMP-phosphodiesterase.
Naringin is a major and selective clinical inhibitor of organic anion-transporting polypeptide 1A2 (OATP1A2) in grapefruit juice.
Two randomized, crossover pharmacokinetic studies investigated the effect of naringin, a flavonoid in grapefruit juice, on the bioavailability of fexofenadine. Naringin significantly inhibited OATP1A2 transport, reducing fexofenadine AUCs when ingested with grapefruit juice compared to water. The study suggests naringin as a clinical OATP1A2 inhibitor probe.
Naringin does not alter caffeine pharmacokinetics, energy expenditure, or cardiovascular haemodynamics in humans following caffeine consumption.
This study investigated the effects of naringin on caffeine pharmacokinetics, resting energy expenditure, oxygen consumption, and respiratory exchange ratio in 10 healthy individuals. The results showed that naringin did not alter these parameters, suggesting that the interaction between grapefruit juice and caffeine may involve other constituents besides naringin.
Rhizoma Drynariae-derived nanovesicles reverse osteoporosis by potentiating osteogenic differentiation of human bone marrow mesenchymal stem cells via targeting ERα signaling
The study investigates Rhizoma Drynariae-derived nanovesicles (RDNVs) for their anti-osteoporosis effects. RDNVs, containing naringin, were shown to enhance osteogenic differentiation of human bone marrow mesenchymal stem cells via ERα signaling, promoting bone formation in an ovariectomized mouse model.
Naringenin and apigenin ameliorates corticosterone-induced depressive behaviors
The study investigated the antidepressant effects of naringenin and apigenin in a corticosterone-induced depression model in mice. Treatment with these compounds improved depressive behaviors, increased neurotransmitter levels, and enhanced protein expressions related to brain health. Additionally, they reduced apoptosis in PC-12 cells and shifted microglia from a proinflammatory to an anti-inflammatory state.
Therapeutic Effects of Naringin in Rheumatoid Arthritis: Network Pharmacology and Experimental Validation
The study investigates the therapeutic effects of naringin in rheumatoid arthritis using network pharmacology and in vitro experiments. Naringin was found to promote apoptosis of RA-FLS, increase caspase-3 activation, and reduce inflammatory cytokines and MMPs production via PI3K/Akt and MAPK/ERK signaling pathways.
Pharmacokinetic Comparisons of Naringenin and Naringenin-Nicotinamide Cocrystal in Rats by LC-MS/MS
The study evaluated the pharmacokinetics and bioavailability of naringenin-nicotinamide cocrystal (NAR-NCT) in rats. NAR-NCT showed improved solubility and bioavailability compared to naringenin alone, with increased Cmax, advanced Tmax, decreased clearance, and extended half-life.
Naringenin and interindividual variability in interaction of coumarin with grapefruit juice.
The study evaluated interindividual variability in the pharmacokinetic profile of grapefruit juice components (naringenin, scopoletin, umbelliferone) and their interaction with coumarin in 18 healthy volunteers. Significant variability in renal excretion of these components was observed, and the interaction between coumarin and grapefruit juice was noted, correlating with naringenin amounts in urine.
Grapefruit juice-felodipine interaction: effect of naringin and 6',7'-dihydroxybergamottin in humans.
Randomized, 4-way crossover study in 12 healthy men assessing the effect of grapefruit juice fractions, containing naringin and 6',7'-dihydroxybergamottin, on the pharmacokinetics of oral felodipine. The study found that these compounds are not the major active ingredients in the grapefruit juice-felodipine interaction, although they may contribute. The findings highlight the importance of in vivo testing to identify the active substances responsible for cytochrome P450 3A4 inhibition.
A Comprehensive Modeling of Bioenhancers Docked to Transport Proteins to Enhance Bioavailability
The study assessed the binding of various bioenhancers, including naringin, to transport proteins like P-gp and HSA to improve drug bioavailability. Naringin showed the most optimal binding scores, suggesting its potential for further in vitro and in vivo testing.
Naringenin as a potential immunomodulator in therapeutics.
This review article discusses the potential of naringenin, a citrus flavonoid, as an immunomodulator and anti-inflammatory agent. It highlights naringenin's ability to inhibit inflammatory responses in cell cultures and animal models, and its unique mechanism of promoting lysosome-dependent cytokine protein degradation.
Biotransformation of Flavonoid Conjugates with Fatty Acids and Evaluations of Their Functionalities
The study investigated the enzymatic conjugation of omega-3 fatty acids with citrus-derived flavonoids, including naringin, grapefruit extract, and neohesperidin dihydrochalcone. The flavonoid conjugates showed comparable or higher antioxidant, anti-peroxidation, and anti-angiogenic activities compared to their original forms.
The fate of naringin in humans: a key to grapefruit juice-drug interactions?
The study investigated the renal excretion of naringin, naringenin, and its glucuronides after grapefruit juice administration in six healthy adults. Naringenin and its glucuronides appeared in urine, suggesting that intestinal bacteria cleave the sugar moiety of naringin, leading to naringenin formation, which is crucial for its bioavailability.