Research
Moringa
50 peer-reviewed studies curated from PubMed and Semantic Scholar.
Studies
Sorted by quality and recency
Effects ofLam. Supplementation on Cardiometabolic Outcomes: A Meta-Analysis of Randomized Controlled Trials with GRADE Assessment.
Meta-analysis of nine RCTs involving 341 participants in the intervention group and 308 in the control group, evaluating moringa supplementation on cardiometabolic outcomes. Moringa showed no significant effects on most outcomes, with a modest reduction in diastolic blood pressure observed but not robust in sensitivity analyses. Overall certainty of evidence was very low.
Effects of Moringa oleifera as a Feed Supplement on Performance and Blood Lipid Profiles of Broiler Chicken: A Meta-Analysis.
Meta-analysis of 35 studies with 191 experiments evaluating Moringa oleifera as a feed supplement for broiler chickens. Moringa supplementation increased weight gain, decreased feed intake, and improved feed conversion ratio. It also decreased cholesterol, triglyceride, and LDL levels while increasing HDL.
Lipid profiles and production performance responses of laying hens to dietary Moringa oleifera leaf meal: systematic review and meta-analysis.
Systematic review and meta-analysis of 23 studies on the effects of Moringa oleifera leaf meal (MLM) in chicken diets. Results show significant improvements in feed conversion ratio, egg mass, Haugh unit, eggshell thickness, and eggshell weight, with enhanced blood cholesterol, LDL cholesterol, triglycerides, and yolk cholesterol concentrations in laying hens.
Moringa Oleifera Lam. in Cardiometabolic Disorders: A Systematic Review of Recent Studies and Possible Mechanism of Actions.
Systematic review of 108 papers on Moringa Oleifera in cardiometabolic disorders. The review highlights MO's antioxidative and anti-inflammatory actions, modulation of glucose and lipid metabolism, and preservation of target organ damage. It also discusses MO's role in regulating the gut microbiome and various molecular mechanisms.
The impact of Moringa oleifera leaf supplementation on human and animal nutrition, growth, and milk production: A systematic review.
Systematic review assessing the impact of Moringa oleifera leaf supplementation on nutrition, growth, and milk production in humans and animals. In humans, higher doses improved hemoglobin and vitamin A status, and increased BMI and breastmilk volumes. In animals, moringa increased milk production in some studies but had inconsistent effects on growth and no effect on iron status.
A double-blind, randomized controlled trial to examine the effect of Moringa oleifera leaf powder supplementation on the immune status and anthropometric parameters of adult HIV patients on antiretroviral therapy in a resource-limited setting.
Double-blind RCT of 200 HIV-positive adults on ART in Nigeria, comparing Moringa oleifera leaf powder supplementation to placebo. Moringa oleifera significantly increased CD4 cell counts but had no significant effect on viral load or anthropometric parameters.
Impact of MaternalLeaf Supplementation on Milk and Serum Vitamin A and Carotenoid Concentrations in a Cohort of Breastfeeding Kenyan Women and Their Infants.
A 3-month pilot single-blinded cluster-randomized controlled trial in breastfeeding mother-infant pairs in Kenya studied the effect of maternal moringa consumption on human milk retinol and carotenoid concentrations. Moringa consumption resulted in higher alpha-carotene concentrations in milk but did not impact milk vitamin A concentration.
Synergistic effect of Moringa oleifera and Allium sativum on BMI and lipid profile: A randomized controlled trial.
RCT investigating the synergistic effect of Moringa oleifera and Allium sativum on hyperlipidemic patients. 60 patients were divided into four groups, with one group receiving both supplements. The combination of Moringa oleifera and Allium sativum significantly improved total cholesterol, triglycerides, and low-density lipoprotein levels, as well as BMI.
Effect of Moringa Oleifera fortified porridge consumption on protein and vitamin A status of children with cerebral palsy in Nairobi, Kenya: A randomized controlled trial
A randomized controlled trial among 113 children with cerebral palsy in Nairobi, Kenya, studied the effect of consuming fermented finger millet porridge fortified with Moringa oleifera leaf powder. The intervention group showed significant improvements in vitamin A and protein intake, serum albumin and retinol levels, BMI-for-age Z-scores, and reduced morbidity prevalence compared to the control group.
The effect of Moringa oleifera capsule in increasing breast milk volume in early postpartum patients: A double-blind, randomized controlled trial
A double-blind, randomized controlled trial evaluated the efficacy of Moringa oleifera capsules in increasing breast milk volume in 88 early postpartum women. The study found no significant difference in median breast milk volume between the Moringa oleifera group and the control group, but the Moringa oleifera group had 47% more breast milk. The exclusive breastfeeding rate at 6 months in the Moringa oleifera group met WHO goals.
Impact of Moringa Oleifera leaves supplementation on quality of life of people living with HIV: A double-blind randomized controlled trial.
A double-blind randomized controlled trial assessed the impact of Moringa oleifera leaves supplementation on the quality of life of HIV-positive adults in Nigeria. The study found significant improvements in the physical, psychological, level of independence, and social relationships domains of quality of life in the Moringa Oleifera group compared to the control group after six months.
A new original nutraceutical formulation ameliorates the effect of Tadalafil on clinical score and cGMP accumulation.
This RCT assessed the efficacy of Tadalafil combined with nutritional supplements (Panax ginseng, Moringa Oleifera, and Rutin) on erectile function in men with vasculogenic ED. The combination significantly improved IIEF-5 scores compared to Tadalafil plus placebo, suggesting enhanced endothelial NO and cGMP production.
Moringa oleifera capsule and diet in young women with dropout school.
RCT examining the effect of Moringa Oleifera leaf capsules on eating patterns in school drop-out adolescent girls aged 12-18 years in South Sulawesi. The study found that Moringa leaf extract capsules improved diet quality significantly compared to the control group.
Moringa oleifera Leaf Supplementation as a Glycemic Control Strategy in Subjects with Prediabetes
A double-blind, randomized, placebo-controlled study on Moringa oleifera leaf supplementation in subjects with prediabetes. The study found significant improvements in fasting blood glucose and glycated hemoglobin levels in the Moringa group compared to placebo, suggesting its potential as a natural antihyperglycemic agent.
Effects of Moringa oleifera leaves as a substitute for alfalfa meal on nutrient digestibility, growth performance, carcass trait, meat quality, antioxidant capacity and biochemical parameters of rabbits.
The study evaluated the effects of Moringa oleifera leaves as a substitute for alfalfa meal on nutrient digestibility, growth performance, carcass trait, meat quality, antioxidant capacity, and biochemical parameters in New Zealand white rabbits. Moringa oleifera leaves improved average daily weight gain and feed conversion ratio, and had significant effects on liver and spleen indices, meat quality, and antioxidant and biochemical parameters.
Moringa oleifera leaf extracts improve exercise performance in young male adults: A pilot study.
Pilot RCT evaluating the effects of Moringa oleifera leaf aqueous extract supplements on exercise performance in 44 young male adults. The supplement group showed enhanced performance in push-ups and treadmill exhaustion tests, as well as improved serum biochemical parameters, suggesting benefits for post-exercise energy metabolism and antioxidant function.
Effectiveness of moringa biscuit (Moringa oleifera) and snakehead fish (Channa striata) in improving the nutritional status of pregnant women with chronic energy deficiency.
RCT analyzing the effectiveness of moringa biscuits and snakehead fish in improving nutritional status of pregnant women with chronic energy deficiency. The intervention group showed significant improvement in BMI, but no difference in upper arm circumference compared to control.
The Effect of Moringa Leaf (Moringa oleifera Lam.), Pandan Wangi (Pandanus amaryllifolius Roxb.) and Red Ginger (Zingiber officinale Rosc.Var) Extract Supplement Intervention on Uric Acid, Kidney, Liver Function and Perceptions of Hyperuricemia patients on health benefit
Clinical trial phase I on 40 hyperuricemia patients using a supplement formula of moringa leaf extract, pandan wangi, and red ginger for 14 days. The study assessed uric acid levels, kidney function, and liver function before and after intervention, with 65% of participants experiencing a decrease in uric acid levels.
MANAGEMENT OF URINARY CALCULUS WITH HERBAL PREPARATION (MORINGA OLEIFERA AND TRIBULUS TERRESTRIS)
RCT involving 30 patients with Urolithiasis, testing a herbal preparation of Moringa oleifera and Tribulus terrestris. The study found the herbal formulation significantly improved symptoms, and stones were expelled in 11 patients.
Impact of Moringa oleifera lam. Leaf powder supplementation versus nutritional counseling on the body mass index and immune response of HIV patients on antiretroviral therapy: a single-blind randomized control trial.
A single-blind randomized control trial in Kinshasa, DRC, assessed the impact of Moringa oleifera leaf powder supplementation versus nutritional counseling on the nutritional and immune status of 60 HIV patients on ART. The Moringa group showed a significantly greater increase in BMI and albumin levels after 6 months compared to the control group.
Effects of Moringa oleifera silage on milk yield, nutrient digestibility and serum biochemical indexes of lactating dairy cows.
This study investigated the effects of Moringa oleifera silage as a partial substitute for alfalfa hay on milk yield, nutrient digestibility, and serum biochemical indexes in dairy cows. The study found that replacing alfalfa hay and maize silage with Moringa oleifera silage had no negative effects on milk yield, nutrient digestibility, or serum biochemical indexes.
Effect of dietary inclusion of Leucaena leucocephala or Moringa oleifera leaf meal on performance of growing rabbits.
This experiment evaluated the effect of including Leucaena leucocephala or Moringa oleifera leaf meal in diets of growing rabbits. Moringa oleifera leaf meal at 30% and 40% inclusion improved growth performance, carcass traits, and economical efficiency without adverse effects.
Direct effects of Moringa oleifera Lam (Moringaceae) acetone leaf extract on broiler chickens naturally infected with Eimeria species.
RCT investigating the effects of Moringa oleifera acetone leaf extract on broiler chickens naturally infected with Eimeria species. The extract showed significant anticoccidial activity, improving body weight gains, faecal scores, and haematological indices compared to untreated controls.
Point-of-use interventions to decrease contamination of drinking water: a randomized, controlled pilot study on efficacy, effectiveness, and acceptability of closed containers, Moringa oleifera, and in-home chlorination in rural South India.
RCT assessing the effectiveness of Moringa oleifera seeds, chlorine, and closed containers for point-of-use water treatment in South India. Moringa oleifera seeds did not reduce coliform counts in water samples, while chlorine was effective but less acceptable to participants.
Chemical and sensory properties evaluations in sea salt fortified with Moringa oleifera leaf extract
The study evaluated the chemical and sensory properties of sea salt fortified with Moringa oleifera leaf extract at concentrations of 20% and 40%. The fortification increased β-carotene and vitamin C content, with the 20% treatment being more acceptable to consumers than the 40% treatment.
Comparison in Content of Total Polyphenol, Flavonoid, and Antioxidant Capacity from Different Organs and Extruded Condition of Moringa oleifera Lam
The study developed biopolymer-mediated extrudate formulations of Moringa oleifera leaves, seed, and husk to enhance phenolic, flavonoid, and antioxidant capacity. The F2 formulation, containing lecithin, ascorbyl palmitate, and vitamin E, showed persistent phenol and flavonoid contents and strong antioxidant capacity, particularly in the leaves.
Moringa oleifera Leaf Extract Enhanced Growth, Yield, and Silybin Content While Mitigating Salt-Induced Adverse Effects on the Growth of Silybum marianum
The study investigated the effects of moringa leaf extract (MLE) on the growth, yield, and silybin content of Silybum marianum under salinity stress. MLE enhanced growth, yield, and silybin content in non-salinity stressed plants and mitigated some adverse effects of salinity on growth parameters.
A Randomized Single Dose Parallel Study on Enhancement of Nitric Oxide in Serum and Saliva with the Use of Natural Sports Supplement in Healthy Adults.
A randomized, double-blind, placebo-controlled trial investigated the effects of a single oral dose of Fitnox on nitric oxide levels in serum and saliva of 24 healthy male adults. Fitnox significantly increased nitrate and nitrite levels compared to placebo, suggesting enhanced physical performance and endurance.
Effect of Incorporating Stevia and Moringa in Cookies on Postprandial Glycemia, Appetite, Palatability, and Gastrointestinal Well-Being.
RCT investigating the effect of incorporating stevia and moringa leaf powder in cookies on postprandial glycemia, appetite, palatability, and gastrointestinal well-being in 20 healthy subjects. Moringa cookies significantly decreased postprandial blood glucose and reduced hunger, while stevia cookies reduced hunger only. All cookies were well-liked without gastrointestinal discomfort.
Effect of partial replacement of alfalfa hay with Moringa species leaves on milk yield and composition of Najdi ewes.
The study investigated the effects of replacing alfalfa hay with Moringa oleifera or Moringa peregrina leaves on milk yield and composition in Najdi ewes. Ewes fed with Moringa oleifera showed increased milk yield and improved antioxidant capacity, with lower serum cholesterol and glucose levels compared to those fed alfalfa hay.
Iliac artery myointimal hyperplasia in rabbits submitted to angioplasty and treated with Moringa oleifera.
Randomized trial in rabbits assessing post-angioplasty myointimal hyperplasia in iliac arteries treated with Moringa oleifera extract. No significant difference in myointimal hyperplasia was found between the Moringa oleifera and saline groups.
Moringa Oleifera Leaf Increases Insulin Secretion after Single Dose Administration: A Preliminary Study in Healthy Subjects.
Preliminary study in 10 healthy volunteers examining the effects of Moringa oleifera leaf on plasma glucose and insulin secretion. High-dose (4 g) MO leaf powder capsules significantly increased insulin secretion without affecting plasma glucose levels, suggesting potential benefits for type 2 diabetes treatment.
Haematological and serum biochemical responses of rabbit does to crude Moringa oleifera leaf extract at gestation and lactation.
An experiment assessed the effects of crude Moringa oleifera leaf extract on the blood profile of rabbit does during gestation and lactation. The study found that Moringa oleifera had a hypocholesterolemic effect and was safe for use up to 300 mL/L for both nutritional and medicinal purposes.
Effect of supplementing crossbred Xhosa lop-eared goat castrates with Moringa oleifera leaves on growth performance, carcass and non-carcass characteristics.
The study evaluated the effect of supplementing Moringa oleifera leaves on growth performance, carcass, and non-carcass characteristics of crossbred Xhosa lop-eared goats. Over 60 days, 24 castrated goats were divided into three diet groups. Goats fed Moringa oleifera showed improved growth performance and carcass characteristics compared to the control group, indicating its potential as an alternative protein supplement.
Immunomodulatory, antioxidant, and growth-promoting activities of dietary fermented Moringa oleifera in Nile tilapia (Oreochromus niloticus) with in-vivo protection against Aeromonas hydrophila
The study investigated the effects of fermented versus non-fermented Moringa oleifera leaf and seed mixtures on immunological parameters, antioxidant activity, growth performance, and resistance to Aeromonas hydrophila infection in Nile tilapia over a 30-day feeding trial. Fermented Moringa oleifera supplementation significantly improved immunological, hepatic antioxidants, and growth performance parameters, with the highest survival rate and lowest bacterial count post-challenge.
Moringa oleifera leaf attenuate osteoporosis in ovariectomized rats by modulating gut microbiota composition and MAPK signaling pathway.
Animal study investigating the anti-osteoporotic effects of Moringa oleifera leaf (MLP) in ovariectomized rats. MLP significantly increased bone mineral density, improved bone metabolism-related indicators, and modulated gut microbiota composition. The study also explored molecular mechanisms involving MAPK signaling pathways.
Antidiabetic potential of Moringa oleifera Lam. leaf extract in type 2 diabetic rats, and its mechanism of action
The study explored the antidiabetic potential of Moringa oleifera leaf extract in type 2 diabetic rats. The extract significantly reduced glucose, insulin, and cytokine levels, improved insulin sensitivity, and increased PPARγ levels, indicating its potential for managing type 2 diabetes.
Fermentation Improves Calcium Bioavailability in Moringa oleifera leaves and Prevents Bone Loss in Calcium‐deficient Rats
The study developed a fermented Moringa oleifera leaf product (MOLF) with increased calcium content and tested its effects on calcium-deficient rats. MOLF improved calcium absorption, increased bone density, and reduced osteoclast numbers, indicating enhanced bone health and prevention of calcium deficiency.
Moringa oleifera leaf and seed inclusive diets influenced the restoration of biochemicals associated with erectile dysfunction in the penile tissue of STZ-induced diabetic male rats treated with/without Acarbose drug.
The study evaluated the effect of Moringa leaf and seed inclusive diets on biomarkers associated with erectile dysfunction in diabetic male rats treated with/without Acarbose. Results showed restoration of biochemical markers in diabetic rats fed with Moringa diets, suggesting potential benefits for managing diabetes-induced erectile dysfunction.
Upregulation of MC4R and PPAR-α expression mediates the anti-obesity activity of Moringa oleifera Lam. in high-fat diet-induced obesity in rats.
The study investigated the anti-obesity effects of Moringa oleifera leaves in high-fat diet-induced obesity in rats. Moringa oleifera extract reduced weight, adiposity index, glucose, insulin, and HOMA-IR, while increasing R-QUICKI, adiponectin, omentin, and GLUT-4 expression. It also suppressed FAS and HMG-CoA reductase and increased MC4R and PPAR-α expression. In human trials, Moringa oleifera capsules reduced BMI, TC, and LDL.
Moringa oleifera Lamk. as a Promising Adjunct Therapeutic Candidate: A Narrative Review of Human Studies and Published Case Reports.
Narrative review of human studies and case reports on Moringa oleifera, highlighting its immunomodulatory, antioxidant, and antidiabetic effects. Evidence suggests improvements in immune function, glycemic control, and antioxidant status, particularly in individuals with HIV, prediabetes, and malnutrition. Maternal supplementation enhances vitamin A content and nutritional outcomes in infants. Rare hypersensitivity and thrombotic events reported.
Exploring the Potentials of Sajana (Moringa oleifera Lam.) as a Plant‐Based Feed Ingredient to Sustainable and Good Aquaculture Practices: An Analysis of Growth Performance and Health Benefits
This narrative review evaluates the nutritional and medicinal potentials of Moringa oleifera as a plant-based feed ingredient in aquaculture. It highlights its benefits in promoting growth, enhancing immunity, and providing antimicrobial defense, while also improving nutrition and hematology in aquaculture species.
Moringa oleifera Lam.: A Nutritional Powerhouse with Multifaceted Pharmacological and Functional Applications
This review synthesizes evidence from over 200 studies on Moringa oleifera, highlighting its nutritional profile and pharmacological potential. It documents antioxidant, anti-inflammatory, antimicrobial, antidiabetic, anticancer, hepatoprotective, neuroprotective, and anti-obesity effects, and discusses its use in functional foods, dietary supplements, and cosmeceuticals.
Anticancer efficacy of biosynthesized silver nanoparticles loaded with recombinant truncated parasporin-2 protein
The study developed a novel nanotoxin composed of biosynthesized silver nanoparticles loaded with N-terminal truncated PS2Aa1 toxin, using Moringa oleifera leaf extract as a reducing and capping agent. The PS2-MOEAgNPs demonstrated dose-dependent cytotoxicity against T-cell leukemia MOLT-4 and Jurkat cell lines, with little effect on normal cell lines, suggesting potential as an alternative anticancer treatment.
Bioactive Compounds in Moringa oleifera: Mechanisms of Action, Focus on Their Anti-Inflammatory Properties
This narrative review outlines the anti-inflammatory properties and mechanisms of action of bioactive compounds from Moringa oleifera. It discusses the inhibition of pro-inflammatory enzymes, regulation of cytokine production, and antioxidant activity, highlighting the plant's potential pharmacological benefits.
Human consumption, nutritional value and health benefits of Moringa (Moringa oleifera Lam.): a review
Narrative review of Moringa oleifera, highlighting its nutritional value and health benefits. Moringa is rich in protein, vitamins, minerals, and antioxidants, and is used to boost nutrition, immune system, and antioxidant levels, lower blood sugar, and maintain inflammation. It also contains Vitamin A, which can help prevent night blindness and eye problems.
Health benefits and phenolic compounds of Moringa oleifera leaves: A comprehensive review.
This comprehensive review examines the health benefits and phenolic compounds of Moringa oleifera leaves. It highlights the protective effects of MO leaf polyphenols against neurodegenerative disorders, kidney damage, diabetes, and hypertension, emphasizing their potential as functional food additives and phytomedicine.
Efficacy of Moringa oleifera Leaf Extracts against Cariogenic Biofilm
The study investigated the antimicrobial effects of Moringa oleifera leaf extracts on Streptococcus mutans and cariogenic biofilm formation. Both distilled water and ethyl alcohol extracts showed antimicrobial activity against S. mutans and inhibited biofilm formation, with the EtOH extracts exhibiting anti-biofilm activity.
Antiplasmodial, Antipyretic, Haematological and Histological Effects of the Leaf Extracts of Moringa oleifera in Plasmodium berghei berghei Infected Mice
The study evaluated the antimalarial and antipyretic activities of aqueous and ethanolic extracts of Moringa oleifera leaves in Plasmodium berghei berghei infected mice. Both extracts showed chemosuppressive antiplasmodial activities, with the highest doses surpassing the standard drug. The ethanolic extract exhibited significant antipyretic activity at 800mg/kg. Haematological effects included higher PCV values with the ethanolic extract and lower WBC with the aqueous extract. Histological examination indicated potential toxic effects on the kidney and liver at higher doses.
Moringa oleifera Leaf Petroleum Ether Extract Inhibits Lipogenesis by Activating the AMPK Signaling Pathway
The study investigates the effect of Moringa oleifera leaf petroleum ether extract (MOPEE) on lipid accumulation. MOPEE inhibited adipogenesis in 3T3-L1 adipocytes and reduced body weight and fat accumulation in high-fat diet mice, likely through AMPK activation.